GREMLIN Database
DEOD - Purine nucleoside phosphorylase DeoD-type
UniProt: P0ABP8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10222
Length: 239 (218)
Sequences: 6899 (4915)
Seq/√Len: 332.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_D52_T3.5481.00
92_C203_V3.0381.00
190_A197_A2.9401.00
15_D84_K2.8351.00
155_F176_I2.6981.00
78_I195_A2.6781.00
108_M151_V2.5711.00
183_A199_T2.5571.00
139_V151_V2.4751.00
52_T57_K2.4341.00
131_D196_K2.4261.00
109_G153_N2.4171.00
169_D173_K2.4051.00
85_K196_K2.3351.00
16_V85_K2.2781.00
67_I158_D2.1861.00
105_V178_G2.0141.00
27_K31_E2.0061.00
107_G154_L1.9991.00
42_N47_L1.9121.00
139_V143_K1.9101.00
96_L177_L1.8671.00
166_E169_D1.8531.00
100_K103_D1.8331.00
17_V77_L1.8201.00
214_T217_E1.8031.00
76_E79_T1.7831.00
92_C178_G1.7631.00
75_K193_F1.7211.00
109_G129_I1.7141.00
38_R57_K1.7031.00
180_E183_A1.7001.00
23_P62_G1.6781.00
223_N227_K1.6461.00
67_I185_G1.6311.00
18_L29_I1.6231.00
152_G177_L1.6171.00
28_Y223_N1.5561.00
154_L178_G1.5531.00
99_V150_R1.5451.00
75_K79_T1.5151.00
136_R140_D1.5081.00
20_P26_A1.4981.00
105_V177_L1.4861.00
84_K195_A1.4381.00
30_A49_F1.4311.00
106_I149_A1.4191.00
15_D57_K1.4071.00
135_V151_V1.4031.00
61_M73_Y1.3821.00
67_I156_S1.3751.00
112_T188_G1.3711.00
74_T189_V1.3611.00
178_G203_V1.3461.00
134_M198_L1.3351.00
74_T86_I1.3291.00
79_T193_F1.3221.00
39_E50_T1.3201.00
132_F136_R1.3161.00
50_T59_S1.3141.00
70_C186_I1.2991.00
167_M171_M1.2791.00
154_L201_C1.2741.00
16_V56_R1.2661.00
19_M63_H1.2481.00
21_G88_R1.2441.00
142_A149_A1.2291.00
34_L51_G1.2171.00
220_T224_D1.2171.00
215_A218_R1.2121.00
132_F135_V1.2101.00
53_Y230_L1.2101.00
168_F172_E1.2081.00
19_M86_I1.2071.00
26_A49_F1.2021.00
103_D150_R1.2021.00
138_A198_L1.2011.00
130_A135_V1.1891.00
26_A60_V1.1851.00
135_V138_A1.1841.00
78_I86_I1.1741.00
206_H209_T1.1661.00
98_H150_R1.1651.00
109_G127_A1.1601.00
115_K119_I1.1581.00
141_A144_A1.1571.00
163_P166_E1.1541.00
126_F129_I1.1541.00
106_I135_V1.1481.00
40_V47_L1.1381.00
135_V139_V1.1371.00
94_A99_V1.1361.00
41_N81_F1.1351.00
46_M62_G1.1291.00
115_K118_R1.1291.00
213_T216_A1.1281.00
35_E52_T1.1171.00
150_R177_L1.1121.00
39_E42_N1.1111.00
94_A206_H1.1101.00
68_P158_D1.1031.00
138_A232_S1.1011.00
94_A203_V1.0921.00
170_V174_Y1.0811.00
110_A183_A1.0801.00
29_I60_V1.0681.00
169_D172_E1.0671.00
187_Y197_A1.0621.00
137_N141_A1.0571.00
88_R186_I1.0561.00
48_G61_M1.0551.00
110_A187_Y1.0501.00
34_L37_A1.0471.00
95_V179_V1.0451.00
86_I190_A1.0391.00
67_I114_S1.0341.00
141_A145_L1.0321.00
135_V198_L1.0311.00
112_T184_A1.0251.00
134_M138_A1.0081.00
48_G59_S1.0071.00
138_A141_A1.0031.00
133_D196_K1.0011.00
113_D157_A0.9951.00
227_K231_E0.9941.00
78_I83_V0.9921.00
21_G25_R0.9901.00
50_T57_K0.9871.00
78_I193_F0.9821.00
145_L231_E0.9761.00
167_M170_V0.9701.00
17_V83_V0.9691.00
106_I139_V0.9661.00
140_D143_K0.9571.00
121_F124_H0.9501.00
219_Q223_N0.9391.00
52_T55_G0.9391.00
170_V173_K0.9341.00
156_S183_A0.9301.00
120_R124_H0.9301.00
23_P27_K0.9271.00
115_K120_R0.9241.00
28_Y31_E0.9151.00
41_N50_T0.9131.00
168_F171_M0.9121.00
222_F226_I0.9081.00
105_V203_V0.9041.00
136_R139_V0.8971.00
213_T217_E0.8971.00
100_K209_T0.8911.00
71_S189_V0.8901.00
110_A199_T0.8831.00
224_D227_K0.8771.00
91_S205_D0.8751.00
33_F230_L0.8671.00
155_F170_V0.8641.00
107_G187_Y0.8621.00
140_D144_A0.8581.00
145_L227_K0.8571.00
54_K231_E0.8561.00
28_Y226_I0.8551.00
198_L232_S0.8551.00
123_D173_K0.8531.00
70_C185_G0.8511.00
92_C201_C0.8501.00
72_I189_V0.8471.00
137_N232_S0.8451.00
93_G207_I0.8421.00
133_D137_N0.8361.00
40_V61_M0.8351.00
100_K211_E0.8291.00
185_G189_V0.8281.00
160_F181_M0.8251.00
134_M137_N0.8241.00
121_F125_D0.8201.00
100_K206_H0.8191.00
202_T218_R0.8161.00
108_M153_N0.8111.00
179_V207_I0.8081.00
77_L83_V0.8081.00
74_T186_I0.7991.00
118_R125_D0.7911.00
139_V149_A0.7901.00
26_A62_G0.7891.00
133_D136_R0.7871.00
116_V121_F0.7811.00
85_K134_M0.7801.00
116_V119_I0.7791.00
106_I198_L0.7711.00
111_C155_F0.7671.00
72_I76_E0.7661.00
95_V171_M0.7661.00
164_D168_F0.7651.00
61_M77_L0.7641.00
122_K125_D0.7611.00
95_V176_I0.7611.00
48_G81_F0.7591.00
117_N120_R0.7571.00
72_I75_K0.7561.00
34_L60_V0.7541.00
46_M73_Y0.7500.99
102_R221_T0.7490.99
20_P89_V0.7470.99
107_G201_C0.7430.99
131_D138_A0.7420.99
147_I227_K0.7360.99
113_D159_L0.7350.99
17_V59_S0.7340.99
43_V80_D0.7310.99
137_N140_D0.7260.99
106_I151_V0.7240.99
30_A37_A0.7240.99
95_V207_I0.7220.99
30_A60_V0.7150.99
104_V202_T0.7140.99
126_F132_F0.7070.99
23_P30_A0.7060.99
107_G178_G0.7040.99
102_R213_T0.7000.99
127_A153_N0.6990.99
214_T218_R0.6950.99
59_S81_F0.6920.99
113_D155_F0.6920.99
70_C74_T0.6910.99
27_K30_A0.6890.99
92_C105_V0.6870.99
141_A232_S0.6860.99
166_E170_V0.6820.99
220_T223_N0.6820.99
106_I225_M0.6780.99
15_D56_R0.6750.99
120_R123_D0.6750.99
127_A130_A0.6750.99
132_F139_V0.6730.99
187_Y199_T0.6700.99
165_G168_F0.6650.99
142_A228_I0.6640.99
96_L99_V0.6610.99
165_G169_D0.6610.99
44_R76_E0.6540.99
221_T225_M0.6530.99
119_I125_D0.6490.99
91_S204_S0.6470.99
119_I123_D0.6450.98
161_Y179_V0.6400.98
71_S116_V0.6390.98
153_N176_I0.6350.98
96_L150_R0.6310.98
45_G76_E0.6270.98
103_D148_D0.6250.98
69_S72_I0.6250.98
129_I132_F0.6240.98
213_T218_R0.6230.98
219_Q222_F0.6230.98
144_A231_E0.6210.98
141_A231_E0.6200.98
99_V105_V0.6180.98
128_A132_F0.6160.98
53_Y58_I0.6150.98
119_I122_K0.6130.98
163_P192_E0.6120.98
93_G179_V0.6120.98
43_V79_T0.6100.98
139_V142_A0.6090.98
180_E199_T0.6000.98
71_S185_G0.5990.98
22_D25_R0.5980.98
86_I186_I0.5940.97
131_D134_M0.5940.97
136_R143_K0.5920.97
71_S75_K0.5920.97
119_I124_H0.5910.97
118_R124_H0.5900.97
157_A161_Y0.5880.97
223_N226_I0.5880.97
86_I195_A0.5880.97
88_R91_S0.5830.97
166_E171_M0.5820.97
129_I191_A0.5640.96
200_I229_A0.5620.96
20_P29_I0.5590.96
181_M205_D0.5590.96
138_A142_A0.5580.96
24_L27_K0.5560.96
31_E223_N0.5560.96
26_A30_A0.5530.96
100_K148_D0.5530.96
64_G188_G0.5520.96
19_M186_I0.5510.96
33_F227_K0.5480.96
116_V189_V0.5460.96
132_F138_A0.5450.96
171_M174_Y0.5450.96
206_H210_H0.5430.96
111_C127_A0.5380.95
212_Q215_A0.5370.95
104_V221_T0.5360.95
24_L42_N0.5340.95
111_C114_S0.5330.95
179_V205_D0.5310.95
107_G130_A0.5300.95
183_A201_C0.5280.95
20_P62_G0.5270.95
33_F223_N0.5270.95
24_L217_E0.5260.95
44_R193_F0.5250.95
212_Q216_A0.5240.95
99_V203_V0.5240.95
66_G181_M0.5220.95
132_F140_D0.5210.95
104_V147_I0.5200.94
104_V228_I0.5180.94
29_I89_V0.5170.94
78_I84_K0.5160.94
16_V233_V0.5140.94
19_M74_T0.5140.94
20_P60_V0.5100.94
54_K230_L0.5090.94
48_G76_E0.5070.94
204_S222_F0.5060.94
64_G69_S0.5060.94
130_A187_Y0.5040.94
110_A114_S0.5040.94
51_G59_S0.5030.93
37_A49_F0.5010.93
51_G58_I0.5000.93
160_F211_E0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ldnA 3 0.9958 100 0.197 Contact Map
1odkA 3 0.9749 100 0.198 Contact Map
1je0A 3 0.9331 100 0.199 Contact Map
3phcA 5 0.9874 100 0.206 Contact Map
4mchA 3 0.9582 100 0.207 Contact Map
4lkrA 3 0.9749 100 0.21 Contact Map
1z34A 3 0.9623 100 0.212 Contact Map
4tymA 5 0.9791 100 0.213 Contact Map
2b94A 4 0.9498 100 0.214 Contact Map
3u40A 4 0.9749 100 0.215 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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