GREMLIN Database
DEDA - Protein DedA
UniProt: P0ABP6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10216
Length: 219 (190)
Sequences: 6749 (4803)
Seq/√Len: 348.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_A153_Y3.4711.00
202_P206_E3.0851.00
70_N73_M3.0711.00
79_L165_L2.8271.00
83_I161_V2.5271.00
124_H127_K2.5111.00
126_G155_H2.3881.00
62_A176_Y2.3651.00
130_I162_I2.3431.00
193_V197_V2.3271.00
75_V169_L2.2971.00
152_S155_H2.2471.00
87_A157_A2.2391.00
38_F88_V2.1851.00
110_R113_Y2.1241.00
77_L81_A1.9901.00
78_M168_V1.9881.00
118_H122_E1.9761.00
25_Y29_V1.9401.00
71_V173_Y1.9021.00
126_G159_Y1.8921.00
30_Y70_N1.8121.00
94_R150_H1.7401.00
75_V172_T1.7401.00
34_F81_A1.7341.00
55_L172_T1.7231.00
98_E118_H1.7171.00
173_Y177_F1.7171.00
37_L81_A1.7031.00
204_V208_I1.6821.00
153_Y157_A1.6231.00
203_G207_I1.6121.00
207_I211_K1.5991.00
71_V75_V1.5901.00
91_T95_L1.5861.00
38_F84_V1.5661.00
58_A74_M1.5611.00
64_L68_D1.5571.00
33_L78_M1.5471.00
115_D119_Q1.5201.00
102_S111_R1.5141.00
86_D133_R1.5071.00
187_N190_L1.4851.00
71_V172_T1.4831.00
30_Y73_M1.4711.00
74_M172_T1.4691.00
208_I212_R1.4631.00
206_E210_H1.4521.00
34_F77_L1.4441.00
134_F166_L1.4421.00
205_I209_R1.4351.00
40_E51_G1.4141.00
34_F80_I1.4061.00
91_T153_Y1.4031.00
28_W32_I1.4001.00
62_A71_V1.3771.00
112_S116_K1.3631.00
111_R115_D1.3561.00
93_G148_M1.3461.00
127_K131_L1.3341.00
185_Q189_K1.3201.00
132_A142_A1.3031.00
23_A26_G1.2881.00
30_Y77_L1.2831.00
201_L205_I1.2781.00
98_E102_S1.2771.00
73_M77_L1.2761.00
154_R158_A1.2751.00
203_G206_E1.2591.00
83_I164_A1.2391.00
118_H149_G1.2141.00
72_H173_Y1.1981.00
19_A23_A1.1661.00
129_I151_M1.1591.00
59_G175_G1.1541.00
72_H76_V1.1531.00
52_D139_R1.1511.00
55_L78_M1.1401.00
69_L74_M1.1251.00
46_T89_N1.1221.00
204_V207_I1.1211.00
79_L83_I1.1111.00
202_P205_I1.0971.00
76_V80_I1.0831.00
206_E209_R1.0641.00
130_I166_L1.0521.00
89_N144_F1.0471.00
121_Y146_A1.0441.00
191_L194_G1.0421.00
79_L168_V1.0391.00
106_S109_F1.0381.00
83_I157_A1.0381.00
190_L194_G1.0331.00
95_L99_K1.0321.00
139_R167_W1.0231.00
33_L74_M1.0161.00
63_S176_Y0.9961.00
115_D118_H0.9841.00
75_V173_Y0.9791.00
97_G101_F0.9741.00
199_S202_P0.9701.00
120_F128_T0.9571.00
23_A27_V0.9561.00
101_F114_L0.9541.00
143_P160_N0.9481.00
55_L59_G0.9471.00
87_A91_T0.9441.00
73_M76_V0.9381.00
209_R212_R0.9311.00
119_Q123_K0.9311.00
59_G172_T0.9261.00
210_H213_A0.9261.00
75_V79_L0.9251.00
86_D160_N0.9201.00
166_L169_L0.9201.00
25_Y32_I0.9191.00
29_V32_I0.9171.00
206_E211_K0.9151.00
207_I210_H0.9141.00
198_V202_P0.9101.00
39_C47_P0.9091.00
113_Y116_K0.9081.00
99_K103_N0.9081.00
34_F84_V0.9081.00
82_A164_A0.9061.00
158_A162_I0.9051.00
76_V79_L0.9031.00
125_G151_M0.9011.00
192_I196_I0.8991.00
63_S180_T0.8991.00
91_T94_R0.8971.00
184_V187_N0.8961.00
28_W31_A0.8911.00
160_N164_A0.8901.00
154_R157_A0.8871.00
194_G198_V0.8851.00
82_A133_R0.8641.00
186_D190_L0.8571.00
170_L173_Y0.8521.00
24_E29_V0.8521.00
169_L173_Y0.8501.00
80_I84_V0.8501.00
192_I206_E0.8451.00
30_Y69_L0.8391.00
117_T149_G0.8371.00
27_V31_A0.8351.00
87_A160_N0.8291.00
96_F100_L0.8281.00
78_M172_T0.8271.00
20_E23_A0.8261.00
174_A177_F0.8231.00
195_I199_S0.8171.00
37_L168_V0.8111.00
133_R139_R0.8101.00
19_A22_V0.8071.00
59_G74_M0.8061.00
157_A161_V0.8011.00
92_I96_F0.7941.00
158_A161_V0.7891.00
72_H75_V0.7821.00
182_P186_D0.7801.00
193_V196_I0.7751.00
185_Q188_L0.7691.00
205_I208_I0.7681.00
41_T133_R0.7681.00
208_I211_K0.7681.00
196_I199_S0.7591.00
101_F109_F0.7501.00
33_L58_A0.7491.00
41_T45_V0.7441.00
128_T142_A0.7421.00
26_G29_V0.7411.00
178_F181_I0.7391.00
86_D153_Y0.7340.99
83_I160_N0.7330.99
90_Y153_Y0.7330.99
22_V61_L0.7310.99
96_F99_K0.7280.99
24_E28_W0.7260.99
89_N140_T0.7240.99
209_R213_A0.7180.99
128_T131_L0.7140.99
97_G100_L0.7120.99
161_V165_L0.7020.99
55_L168_V0.7000.99
186_D189_K0.6980.99
36_I54_L0.6980.99
105_N111_R0.6860.99
57_V60_A0.6860.99
191_L206_E0.6850.99
60_A63_S0.6840.99
146_A151_M0.6810.99
62_A74_M0.6800.99
127_K159_Y0.6760.99
48_F137_I0.6700.99
104_P107_K0.6680.99
33_L77_L0.6670.99
116_K119_Q0.6640.99
49_L140_T0.6610.99
60_A181_I0.6610.99
182_P185_Q0.6600.99
57_V61_L0.6580.99
104_P109_F0.6580.99
189_K193_V0.6550.99
194_G197_V0.6540.99
136_P140_T0.6540.99
39_C46_T0.6530.99
119_Q122_E0.6510.99
135_V138_V0.6420.99
25_Y28_W0.6390.99
139_R164_A0.6350.99
105_N110_R0.6340.99
105_N109_F0.6230.98
62_A172_T0.6220.98
20_E24_E0.6220.98
52_D163_G0.6210.98
37_L140_T0.6180.98
40_E133_R0.6170.98
176_Y180_T0.6150.98
199_S206_E0.6130.98
47_P89_N0.6120.98
41_T86_D0.6110.98
165_L169_L0.6050.98
133_R160_N0.6040.98
52_D171_F0.6030.98
203_G210_H0.6010.98
90_Y147_G0.5990.98
51_G136_P0.5990.98
187_N191_L0.5990.98
183_M187_N0.5980.98
40_E139_R0.5960.98
140_T171_F0.5930.98
24_E27_V0.5880.98
132_A136_P0.5870.98
121_Y128_T0.5840.98
58_A69_L0.5840.98
37_L163_G0.5780.97
155_H159_Y0.5690.97
40_E167_W0.5680.97
71_V169_L0.5670.97
118_H150_H0.5670.97
166_L170_L0.5640.97
52_D133_R0.5630.97
147_G150_H0.5620.97
41_T160_N0.5620.97
113_Y117_T0.5620.97
40_E140_T0.5600.97
205_I211_K0.5580.97
41_T143_P0.5560.97
129_I146_A0.5550.97
98_E101_F0.5530.97
200_I204_V0.5530.97
197_V201_L0.5500.96
183_M186_D0.5500.96
188_L191_L0.5490.96
100_L103_N0.5450.96
200_I203_G0.5430.96
21_L29_V0.5430.96
189_K192_I0.5390.96
57_V188_L0.5390.96
144_F148_M0.5370.96
22_V29_V0.5350.96
140_T144_F0.5340.96
112_S115_D0.5340.96
41_T136_P0.5330.96
29_V69_L0.5320.96
82_A141_F0.5290.96
37_L78_M0.5280.96
51_G54_L0.5270.95
107_K114_L0.5250.95
38_F81_A0.5200.95
99_K102_S0.5200.95
51_G167_W0.5190.95
78_M81_A0.5160.95
117_T138_V0.5160.95
89_N136_P0.5150.95
82_A140_T0.5140.95
33_L54_L0.5130.95
52_D136_P0.5120.95
128_T163_G0.5110.95
24_E32_I0.5070.94
168_V172_T0.5070.94
156_F160_N0.5060.94
40_E143_P0.5040.94
51_G160_N0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kluA 1 0.1872 50.2 0.925 Contact Map
2m20A 2 0.1689 42.8 0.928 Contact Map
2l2tA 2 0.1963 39.8 0.93 Contact Map
2kv5A 1 0.1507 30 0.934 Contact Map
2jwaA 2 0.2009 28 0.935 Contact Map
3w9iA 3 0.8037 24 0.937 Contact Map
2ks1B 1 0.1963 19.8 0.939 Contact Map
3m73A 3 0.3151 19.2 0.94 Contact Map
4dx5A 3 0.8402 16.6 0.941 Contact Map
2h3oA 1 0.2009 15.7 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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