GREMLIN Database
DCUC - Anaerobic C4-dicarboxylate transporter DcuC
UniProt: P0ABP3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13545
Length: 461 (441)
Sequences: 392 (278)
Seq/√Len: 13.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
214_A438_V7.7011.00
215_H219_Q5.9231.00
210_G438_V5.2321.00
245_F284_L4.4341.00
175_A196_A4.3891.00
13_V34_G4.1301.00
191_S194_D3.9811.00
210_G442_I3.8010.99
276_I280_I3.4430.99
205_I209_I3.2460.98
257_V320_A3.0010.97
285_E288_R2.9950.97
220_R224_K2.9870.97
167_A428_V2.8110.95
17_V34_G2.8010.95
66_E69_K2.7850.95
75_R321_G2.6730.94
26_S300_E2.6410.93
12_V44_I2.4580.91
69_K269_H2.4460.90
164_A215_H2.4030.89
437_L441_V2.3790.89
160_G412_G2.3590.89
365_T410_V2.3580.89
219_Q223_D2.3400.88
225_K239_T2.3170.88
221_Y225_K2.2610.86
320_A415_V2.2570.86
302_A305_G2.2170.85
255_I441_V2.1710.84
393_L419_G2.1670.84
164_A212_A2.1570.84
105_L244_A2.1520.83
135_S270_I2.1490.83
72_L318_V2.1450.83
174_L399_Q2.1100.82
137_A413_V2.0980.82
316_L412_G2.0880.81
157_I162_A2.0800.81
103_V137_A2.0570.80
10_G332_F2.0460.80
141_G413_V2.0430.80
127_A169_P2.0180.79
196_A410_V2.0000.78
86_L175_A1.9940.78
418_A428_V1.9920.78
168_S215_H1.9760.78
289_S292_T1.9520.77
101_M247_A1.9480.77
90_A267_Q1.9050.75
359_M404_G1.8970.75
9_I41_I1.8590.73
402_N412_G1.8420.72
387_G411_S1.8150.71
304_R308_D1.8050.71
359_M412_G1.7810.70
180_D369_N1.7580.69
107_S342_S1.7480.68
79_L89_F1.7410.68
411_S415_V1.7340.67
218_W434_V1.7340.67
164_A219_Q1.7210.67
291_N294_K1.7160.67
179_G373_Y1.7160.67
13_V37_L1.7100.66
118_L449_L1.6820.65
79_L123_A1.6570.64
175_A416_A1.6530.64
212_A215_H1.6510.64
406_T439_G1.6460.63
256_G276_I1.6220.62
257_V364_T1.6190.62
99_N155_V1.6130.62
147_T327_L1.6110.62
8_L36_L1.5970.61
15_V283_I1.5920.61
65_V276_I1.5920.61
200_T204_S1.5520.59
168_S172_I1.5440.58
21_I327_L1.5410.58
13_V38_L1.5360.58
97_G215_H1.5260.57
203_I212_A1.5210.57
149_F418_A1.5140.57
124_Y131_S1.5030.56
148_L330_I1.4830.55
120_M161_A1.4820.55
95_H301_V1.4740.55
73_M77_G1.4680.54
104_K118_L1.4590.54
38_L432_T1.4550.54
170_A174_L1.4450.53
219_Q224_K1.4300.52
270_I420_M1.4250.52
334_Q338_S1.4240.52
102_V317_L1.4230.52
32_F322_V1.4220.52
186_Q189_E1.4200.52
252_T318_V1.4190.52
275_V360_L1.4130.51
125_F129_L1.4110.51
11_V237_E1.4100.51
338_S341_T1.3970.50
210_G283_I1.3960.50
209_I213_I1.3950.50
232_M426_F1.3820.50
131_S171_A1.3680.49
371_P374_A1.3560.48
269_H272_T1.3430.48
112_Y349_I1.3150.46
356_I437_L1.3130.46
84_M310_F1.3040.46
18_A418_A1.2900.45
248_I439_G1.2870.45
254_I400_A1.2780.44
257_V400_A1.2760.44
154_N186_Q1.2760.44
311_A315_M1.2750.44
209_I227_H1.2720.44
174_L417_V1.2710.44
227_H230_H1.2690.44
116_P369_N1.2650.44
137_A316_L1.2630.43
251_F342_S1.2570.43
138_T374_A1.2550.43
170_A316_L1.2540.43
164_A436_V1.2440.42
37_L294_K1.2400.42
44_I209_I1.2320.42
37_L237_E1.2230.41
352_L444_I1.2170.41
83_I103_V1.2170.41
252_T439_G1.2160.41
127_A168_S1.2060.40
123_A188_S1.2040.40
126_V309_A1.1970.40
27_A89_F1.1890.40
218_W222_L1.1870.40
257_V343_F1.1870.40
211_M227_H1.1730.39
116_P316_L1.1700.39
248_I438_V1.1650.38
289_S294_K1.1560.38
317_L423_I1.1520.38
57_T66_E1.1460.37
172_I208_I1.1360.37
355_V388_I1.1350.37
202_P208_I1.1340.37
169_P415_V1.1320.37
152_M261_D1.1320.37
80_G396_P1.1300.37
190_M291_N1.1290.37
237_E360_L1.1280.37
17_V374_A1.1280.37
243_P380_P1.1250.36
225_K279_L1.1240.36
125_F283_I1.1190.36
72_L130_M1.1190.36
389_N441_V1.1170.36
195_F398_L1.1160.36
15_V18_A1.1140.36
196_A416_A1.1120.36
400_A427_E1.1090.36
49_V410_V1.1060.36
17_V266_P1.1060.36
144_L166_C1.1040.35
245_F441_V1.1000.35
211_M439_G1.0980.35
130_M152_M1.0970.35
35_G326_G1.0890.35
199_T256_G1.0870.35
22_I68_V1.0870.35
326_G425_P1.0860.35
175_A180_D1.0850.35
16_G233_L1.0850.35
131_S406_T1.0820.34
107_S155_V1.0790.34
187_A320_A1.0760.34
215_H218_W1.0740.34
8_L12_V1.0740.34
11_V37_L1.0730.34
118_L239_T1.0720.34
38_L326_G1.0720.34
419_G436_V1.0700.34
259_I265_G1.0660.34
133_A180_D1.0650.34
105_L283_I1.0640.34
58_G358_T1.0590.33
283_I349_I1.0580.33
172_I403_L1.0570.33
110_L252_T1.0520.33
15_V237_E1.0520.33
72_L146_A1.0510.33
276_I295_V1.0500.33
8_L231_E1.0390.32
48_K335_S1.0370.32
119_L199_T1.0330.32
209_I283_I1.0330.32
78_D333_I1.0310.32
9_I172_I1.0300.32
125_F213_I1.0280.32
89_F139_G1.0270.32
197_F201_L1.0200.31
152_M157_I1.0190.31
189_E281_A1.0160.31
422_K430_K1.0140.31
65_V279_L1.0130.31
212_A354_L1.0130.31
194_D213_I1.0070.31
16_G441_V1.0010.31
316_L369_N0.9980.30
194_D248_I0.9940.30
59_Y62_T0.9810.30
329_T387_G0.9800.30
367_S375_F0.9770.30
147_T432_T0.9730.29
79_L139_G0.9730.29
108_K224_K0.9720.29
183_L417_V0.9700.29
320_A365_T0.9690.29
90_A324_A0.9680.29
291_N295_V0.9660.29
111_Q255_I0.9660.29
312_N320_A0.9640.29
161_A223_D0.9600.29
179_G429_V0.9530.29
315_M320_A0.9530.29
128_C178_S0.9500.28
239_T384_H0.9500.28
371_P411_S0.9480.28
400_A407_L0.9450.28
156_G352_L0.9450.28
213_I231_E0.9450.28
363_V439_G0.9420.28
276_I428_V0.9380.28
39_L322_V0.9340.28
25_Y110_L0.9340.28
320_A410_V0.9320.28
12_V283_I0.9310.28
132_L356_I0.9270.27
57_T159_R0.9270.27
121_I181_V0.9270.27
27_A382_L0.9270.27
187_A295_V0.9260.27
46_G49_V0.9250.27
277_C386_S0.9240.27
32_F414_V0.9230.27
87_C142_V0.9210.27
82_M420_M0.9210.27
131_S172_I0.9210.27
165_I213_I0.9200.27
361_A365_T0.9200.27
221_Y256_G0.9190.27
108_K111_Q0.9180.27
318_V412_G0.9120.27
174_L412_G0.9120.27
144_L432_T0.9060.27
112_Y225_K0.9000.26
384_H426_F0.8990.26
175_A402_N0.8980.26
254_I320_A0.8980.26
164_A168_S0.8960.26
180_D376_V0.8960.26
221_Y260_F0.8890.26
232_M235_V0.8860.26
106_A121_I0.8860.26
218_W221_Y0.8860.26
27_A142_V0.8850.26
129_L186_Q0.8830.26
133_A321_G0.8780.25
292_T296_F0.8780.25
414_V418_A0.8760.25
353_V410_V0.8730.25
316_L359_M0.8710.25
145_M320_A0.8690.25
8_L32_F0.8690.25
66_E189_E0.8680.25
158_S414_V0.8680.25
79_L376_V0.8650.25
325_Q328_S0.8630.25
149_F277_C0.8620.25
177_T180_D0.8610.25
109_P158_S0.8600.25
83_I89_F0.8600.25
272_T352_L0.8580.25
119_L155_V0.8570.25
313_V424_S0.8560.25
270_I371_P0.8550.24
283_I348_I0.8540.24
103_V400_A0.8530.24
329_T411_S0.8520.24
151_V347_S0.8520.24
151_V441_V0.8520.24
378_M397_M0.8510.24
22_I428_V0.8480.24
148_L245_F0.8480.24
361_A410_V0.8460.24
157_I406_T0.8450.24
103_V401_S0.8430.24
77_G334_Q0.8430.24
10_G304_R0.8410.24
97_G219_Q0.8400.24
202_P205_I0.8390.24
104_K242_A0.8360.24
280_I449_L0.8340.24
135_S398_L0.8330.24
155_V315_M0.8320.24
405_R408_S0.8310.24
208_I211_M0.8300.24
414_V429_V0.8300.24
193_I386_S0.8280.23
209_I395_I0.8280.23
174_L178_S0.8270.23
148_L281_A0.8260.23
173_I403_L0.8240.23
37_L188_S0.8240.23
161_A165_I0.8240.23
80_G98_A0.8230.23
317_L418_A0.8190.23
42_S97_G0.8180.23
386_S399_Q0.8170.23
169_P175_A0.8160.23
80_G316_L0.8120.23
175_A178_S0.8110.23
293_Q424_S0.8080.23
126_V292_T0.8040.23
22_I163_A0.8030.23
213_I338_S0.8030.23
131_S218_W0.8020.22
172_I178_S0.8020.22
140_L402_N0.7990.22
314_V416_A0.7990.22
186_Q267_Q0.7980.22
310_F398_L0.7970.22
204_S218_W0.7970.22
33_V418_A0.7950.22
21_I410_V0.7950.22
24_G254_I0.7950.22
163_A417_V0.7930.22
274_L370_A0.7920.22
18_A21_I0.7910.22
190_M199_T0.7870.22
88_G320_A0.7870.22
420_M428_V0.7810.22
80_G314_V0.7790.22
94_T154_N0.7770.22
82_M145_M0.7770.22
369_N380_P0.7730.21
129_L252_T0.7720.21
42_S332_F0.7720.21
102_V273_I0.7720.21
149_F163_A0.7710.21
268_L276_I0.7690.21
359_M363_V0.7680.21
128_C173_I0.7680.21
69_K339_I0.7670.21
207_A392_Y0.7670.21
57_T357_L0.7660.21
139_G375_F0.7650.21
89_F377_E0.7650.21
94_T413_V0.7650.21
323_F421_A0.7650.21
127_A254_I0.7630.21
285_E289_S0.7630.21
105_L109_P0.7620.21
192_L328_S0.7620.21
180_D374_A0.7580.21
224_K227_H0.7560.21
215_H223_D0.7550.21
424_S445_V0.7550.21
87_C257_V0.7550.21
125_F212_A0.7550.21
198_K275_V0.7530.21
252_T276_I0.7510.21
37_L205_I0.7480.21
350_L410_V0.7470.21
38_L330_I0.7470.21
229_S445_V0.7470.21
135_S168_S0.7450.20
313_V360_L0.7450.20
160_G303_Y0.7430.20
189_E357_L0.7420.20
231_E234_D0.7420.20
83_I137_A0.7390.20
107_S119_L0.7370.20
158_S166_C0.7340.20
268_L427_E0.7340.20
11_V442_I0.7340.20
29_G332_F0.7330.20
21_I340_A0.7310.20
79_L169_P0.7300.20
120_M168_S0.7270.20
11_V228_I0.7260.20
231_E236_S0.7240.20
90_A365_T0.7240.20
57_T295_V0.7240.20
227_H333_I0.7230.20
90_A381_K0.7220.20
124_Y310_F0.7200.20
208_I212_A0.7200.20
63_D68_V0.7190.20
102_V175_A0.7180.20
12_V226_E0.7170.20
315_M427_E0.7160.19
89_F415_V0.7160.19
178_S196_A0.7140.19
80_G84_M0.7130.19
383_A425_P0.7120.19
183_L376_V0.7110.19
121_I155_V0.7110.19
16_G34_G0.7110.19
194_D211_M0.7110.19
268_L361_A0.7090.19
320_A411_S0.7090.19
21_I206_A0.7070.19
386_S393_L0.7070.19
58_G397_M0.7070.19
204_S213_I0.7070.19
73_M79_L0.7040.19
304_R311_A0.7000.19
146_A358_T0.6980.19
80_G373_Y0.6970.19
119_L146_A0.6940.19
94_T157_I0.6900.19
29_G299_L0.6900.19
285_E435_P0.6900.19
316_L367_S0.6890.19
151_V161_A0.6890.19
121_I394_T0.6880.19
79_L133_A0.6860.19
140_L301_V0.6850.18
116_P380_P0.6840.18
18_A327_L0.6840.18
32_F319_A0.6840.18
164_A320_A0.6840.18
102_V402_N0.6820.18
32_F353_V0.6810.18
191_S262_G0.6800.18
352_L448_E0.6790.18
31_L316_L0.6780.18
7_L234_D0.6780.18
160_G423_I0.6780.18
128_C174_L0.6760.18
26_S313_V0.6750.18
77_G134_V0.6750.18
256_G280_I0.6730.18
268_L277_C0.6720.18
217_F360_L0.6710.18
138_T303_Y0.6710.18
8_L205_I0.6710.18
348_I356_I0.6700.18
368_G405_R0.6690.18
10_G319_A0.6670.18
20_Y388_I0.6650.18
118_L194_D0.6620.18
143_L260_F0.6610.18
281_A360_L0.6600.18
112_Y290_F0.6580.18
102_V177_T0.6580.18
314_V352_L0.6570.18
139_G143_L0.6570.18
142_V273_I0.6570.18
80_G249_L0.6560.18
113_I330_I0.6530.17
41_I198_K0.6530.17
255_I407_L0.6530.17
248_I265_G0.6520.17
281_A284_L0.6510.17
255_I384_H0.6490.17
59_Y321_G0.6490.17
72_L142_V0.6470.17
291_N360_L0.6460.17
124_Y215_H0.6440.17
13_V126_V0.6440.17
154_N373_Y0.6430.17
173_I410_V0.6430.17
284_L393_L0.6420.17
178_S181_V0.6420.17
142_V180_D0.6420.17
14_I235_V0.6390.17
142_V146_A0.6390.17
85_M417_V0.6380.17
135_S258_L0.6370.17
11_V353_V0.6370.17
195_F395_I0.6360.17
226_E430_K0.6360.17
287_L291_N0.6350.17
311_A319_A0.6350.17
92_Y96_I0.6350.17
313_V351_M0.6340.17
177_T404_G0.6330.17
193_I258_L0.6300.17
371_P415_V0.6300.17
85_M323_F0.6300.17
413_V443_V0.6300.17
26_S39_L0.6290.17
344_G394_T0.6280.17
86_L403_L0.6280.17
157_I439_G0.6270.17
297_S449_L0.6260.17
36_L74_S0.6250.17
140_L260_F0.6240.17
86_L180_D0.6220.17
137_A169_P0.6210.17
158_S222_L0.6210.17
80_G246_Y0.6210.17
99_N358_T0.6210.17
27_A71_L0.6200.16
290_F307_A0.6170.16
35_G375_F0.6170.16
189_E232_M0.6170.16
24_G251_F0.6160.16
21_I254_I0.6160.16
214_A218_W0.6150.16
20_Y378_M0.6150.16
19_R37_L0.6140.16
44_I248_I0.6130.16
339_I406_T0.6130.16
187_A284_L0.6120.16
99_N121_I0.6120.16
212_A216_F0.6120.16
125_F209_I0.6110.16
324_A365_T0.6090.16
96_I103_V0.6080.16
41_I233_L0.6060.16
217_F441_V0.6060.16
59_Y411_S0.6060.16
225_K333_I0.6060.16
320_A371_P0.6050.16
90_A429_V0.6050.16
209_I241_T0.6050.16
145_M420_M0.6030.16
91_A171_A0.6030.16
28_T274_L0.6030.16
368_G374_A0.6030.16
179_G208_I0.6020.16
332_F344_G0.6000.16
258_L327_L0.5980.16
332_F447_T0.5980.16
42_S164_A0.5970.16
22_I129_L0.5970.16
8_L20_Y0.5960.16
279_L283_I0.5960.16
36_L111_Q0.5900.16
133_A369_N0.5890.16
210_G214_A0.5890.16
199_T266_P0.5880.16
328_S432_T0.5870.16
430_K433_S0.5830.15
102_V421_A0.5820.15
308_D410_V0.5810.15
112_Y231_E0.5810.15
202_P209_I0.5800.15
254_I395_I0.5790.15
10_G352_L0.5790.15
124_Y314_V0.5790.15
213_I335_S0.5780.15
180_D196_A0.5780.15
258_L438_V0.5740.15
21_I373_Y0.5740.15
315_M345_S0.5730.15
128_C398_L0.5720.15
81_M126_V0.5720.15
25_Y30_V0.5700.15
23_K441_V0.5700.15
68_V322_V0.5700.15
399_Q411_S0.5680.15
61_A189_E0.5670.15
166_C195_F0.5650.15
13_V17_V0.5640.15
163_A416_A0.5630.15
155_V401_S0.5630.15
39_L168_S0.5620.15
117_Y220_R0.5610.15
17_V388_I0.5610.15
284_L288_R0.5610.15
120_M181_V0.5600.15
168_S432_T0.5600.15
31_L162_A0.5590.15
34_G85_M0.5550.15
101_M116_P0.5550.15
254_I358_T0.5540.15
36_L411_S0.5540.15
133_A149_F0.5530.15
127_A144_L0.5520.15
84_M243_P0.5500.15
24_G227_H0.5490.15
359_M374_A0.5490.15
222_L226_E0.5490.15
31_L305_G0.5480.15
286_F291_N0.5480.15
323_F418_A0.5480.15
231_E437_L0.5470.14
181_V362_A0.5460.14
233_L239_T0.5430.14
139_G326_G0.5420.14
131_S137_A0.5420.14
167_A414_V0.5410.14
192_L277_C0.5400.14
170_A432_T0.5400.14
184_A372_F0.5400.14
9_I258_L0.5400.14
309_A377_E0.5390.14
347_S393_L0.5390.14
157_I319_A0.5380.14
130_M140_L0.5370.14
18_A186_Q0.5370.14
318_V362_A0.5350.14
191_S233_L0.5330.14
91_A206_A0.5330.14
90_A126_V0.5320.14
186_Q285_E0.5320.14
374_A393_L0.5310.14
329_T377_E0.5310.14
356_I445_V0.5300.14
229_S233_L0.5290.14
285_E432_T0.5280.14
174_L177_T0.5280.14
216_F219_Q0.5270.14
96_I143_L0.5260.14
233_L284_L0.5250.14
245_F283_I0.5250.14
67_Y301_V0.5240.14
237_E297_S0.5240.14
173_I178_S0.5230.14
90_A142_V0.5230.14
153_V350_L0.5220.14
66_E70_I0.5220.14
163_A180_D0.5220.14
191_S293_Q0.5220.14
327_L419_G0.5210.14
41_I424_S0.5200.14
27_A320_A0.5200.14
388_I430_K0.5190.14
20_Y110_L0.5190.14
155_V363_V0.5190.14
376_V394_T0.5180.14
82_M357_L0.5180.14
212_A219_Q0.5170.14
210_G213_I0.5150.14
14_I322_V0.5150.14
192_L283_I0.5150.14
365_T393_L0.5150.14
17_V437_L0.5150.14
17_V415_V0.5140.14
85_M333_I0.5140.14
86_L102_V0.5130.14
245_F338_S0.5130.14
377_E419_G0.5120.14
80_G117_Y0.5120.14
76_G252_T0.5110.14
141_G281_A0.5100.14
44_I294_K0.5080.13
310_F404_G0.5080.13
211_M214_A0.5070.13
206_A418_A0.5060.13
8_L16_G0.5060.13
367_S370_A0.5060.13
120_M131_S0.5060.13
9_I294_K0.5060.13
71_L321_G0.5010.13
137_A399_Q0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.8633 100 0.833 Contact Map
4r1iA 2 0.9371 99.9 0.838 Contact Map
4r0cA 3 0.9349 99.9 0.844 Contact Map
2kv5A 1 0.0716 12.3 0.983 Contact Map
3giaA 1 0.4642 11.7 0.983 Contact Map
2kncA 1 0.115 10.4 0.984 Contact Map
1jb0K 1 0.0846 7.9 0.984 Contact Map
4ikvA 1 0.397 7.7 0.985 Contact Map
4dx5A 3 0.3427 7.3 0.985 Contact Map
2qi9A 2 0.4382 7.2 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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