GREMLIN Database
DCUB - Anaerobic C4-dicarboxylate transporter DcuB
UniProt: P0ABN9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10006
Length: 446 (430)
Sequences: 556 (277)
Seq/√Len: 13.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
245_A280_T7.1881.00
95_F183_L5.9751.00
199_D202_K5.6131.00
125_N201_D4.7141.00
188_A431_V4.3011.00
291_N294_S4.2911.00
97_T135_S3.7970.99
202_K207_Q3.6710.99
205_E208_K3.5770.99
10_I36_L3.5730.99
134_A189_I3.1380.98
208_K212_V2.9470.96
349_L391_I2.8000.95
107_G140_Q2.7650.95
98_C182_T2.7620.95
155_L159_L2.7300.95
412_I418_N2.7210.94
431_V435_F2.7170.94
145_A182_T2.6480.94
207_Q211_S2.6230.93
241_I280_T2.5600.92
206_F210_I2.5510.92
297_K302_R2.5510.92
108_H307_A2.4500.91
208_K211_S2.4430.90
114_L401_A2.3900.89
177_I380_V2.3760.89
65_L116_I2.3560.89
337_V347_V2.3300.88
283_L287_L2.3200.88
183_L187_L2.3040.88
417_I422_I2.2990.87
319_E323_G2.2430.86
107_G139_A2.2330.86
381_A437_W2.2330.86
73_V239_M2.2110.85
369_A379_I2.2060.85
101_T107_G2.1940.85
81_L92_V2.0770.81
391_I422_I2.0150.79
127_R197_G2.0050.79
60_A309_V1.9470.77
173_D176_A1.9440.77
99_T233_K1.9430.77
409_T420_S1.9370.76
135_S139_A1.9320.76
133_A193_S1.9270.76
139_A142_G1.8960.75
8_I309_V1.8550.73
81_L85_N1.8410.73
154_S362_L1.7830.70
76_Q229_K1.7810.70
101_T143_I1.7680.69
49_V53_L1.7660.69
234_S237_L1.7650.69
233_K439_F1.7620.69
68_S238_A1.7560.69
80_K99_T1.7530.69
82_L92_V1.7300.68
7_L321_M1.7190.67
108_H111_Y1.7140.67
158_M362_L1.6910.66
311_V394_T1.6770.65
64_T284_I1.6390.63
145_A175_L1.6320.63
326_M330_Q1.6250.63
343_A346_I1.6120.62
116_I123_K1.6040.61
110_V429_V1.5820.60
391_I417_I1.5810.60
116_I120_V1.5750.60
61_A401_A1.5740.60
192_F423_L1.5740.60
100_L253_G1.5740.60
202_K211_S1.5700.60
195_F276_F1.5690.60
13_C31_I1.5610.59
377_A440_A1.5370.58
102_I179_I1.5360.58
81_L99_T1.5290.58
14_L29_G1.5190.57
237_L288_T1.5130.57
310_A314_I1.5000.56
96_V113_I1.4860.55
175_L364_A1.4820.55
213_P343_A1.4680.54
56_I308_I1.4650.54
184_I435_F1.4630.54
6_Q44_P1.4530.54
41_H45_G1.4490.53
233_K237_L1.4470.53
370_L376_P1.4340.53
193_S196_R1.4290.52
133_A136_S1.4280.52
33_L284_I1.4230.52
284_I359_A1.4230.52
389_Y394_T1.3960.51
18_A114_L1.3920.50
134_A186_I1.3900.50
88_Y92_V1.3880.50
342_W400_A1.3880.50
100_L113_I1.3860.50
23_I155_L1.3780.50
118_Y407_S1.3710.49
91_I191_I1.3680.49
360_A381_A1.3670.49
311_V314_I1.3650.49
77_I81_L1.3600.49
73_V77_I1.3500.48
143_I151_A1.3340.47
209_F213_P1.3290.47
8_I198_K1.3140.46
89_V194_W1.3100.46
25_L129_E1.3090.46
134_A138_G1.3010.46
101_T140_Q1.2960.45
73_V236_W1.2960.45
97_T117_I1.2950.45
6_Q125_N1.2930.45
54_V109_V1.2900.45
155_L364_A1.2860.45
177_I181_S1.2820.45
30_G278_L1.2730.44
318_A397_S1.2720.44
198_K205_E1.2670.44
98_C102_I1.2640.44
136_S437_W1.2610.44
76_Q231_L1.2570.43
249_V327_S1.2540.43
129_E409_T1.2510.43
344_Y369_A1.2430.43
11_L177_I1.2350.42
58_V277_M1.2290.42
183_L186_I1.2280.42
177_I438_I1.2250.42
61_A182_T1.2250.42
5_I121_A1.2200.41
80_K207_Q1.2200.41
126_I378_Y1.2180.41
123_K213_P1.2140.41
439_F442_M1.2130.41
48_P315_A1.2010.40
127_R130_R1.1960.40
3_F295_I1.1930.40
198_K202_K1.1860.40
237_L291_N1.1850.40
205_E380_V1.1840.40
427_I431_V1.1780.39
435_F439_F1.1710.39
114_L400_A1.1700.39
347_V365_I1.1620.38
127_R198_K1.1520.38
198_K207_Q1.1510.38
319_E412_I1.1420.37
211_S247_A1.1410.37
67_A298_N1.1380.37
181_S346_I1.1370.37
116_I396_P1.1270.37
66_Q72_D1.1240.37
206_F209_F1.1180.36
189_I428_G1.1180.36
74_M77_I1.1180.36
233_K414_R1.1170.36
354_F392_L1.1140.36
65_L317_M1.1090.36
29_G401_A1.1040.36
54_V150_V1.0990.35
177_I381_A1.0950.35
177_I329_I1.0940.35
434_V438_I1.0860.35
134_A190_G1.0860.35
191_I289_K1.0810.35
149_S302_R1.0810.35
245_A364_A1.0810.35
356_N397_S1.0790.34
177_I208_K1.0770.34
60_A71_L1.0720.34
12_I35_I1.0690.34
237_L287_L1.0690.34
325_H384_P1.0600.34
366_V416_V1.0410.33
46_K330_Q1.0410.33
298_N409_T1.0400.33
199_D286_I1.0390.33
233_K346_I1.0390.33
87_K142_G1.0380.32
327_S331_G1.0370.32
132_M407_S1.0320.32
181_S384_P1.0300.32
91_I118_Y1.0210.32
240_W244_G1.0200.32
92_V185_G1.0170.32
300_V322_F1.0090.31
397_S401_A1.0080.31
438_I442_M1.0010.31
187_L190_G1.0010.31
192_F427_I1.0000.31
422_I426_L0.9990.31
177_I353_K0.9980.31
312_Y369_A0.9980.31
187_L283_L0.9970.31
378_Y437_W0.9940.30
144_I239_M0.9920.30
184_I431_V0.9850.30
186_I364_A0.9810.30
372_I379_I0.9790.30
15_F324_A0.9780.30
64_T354_F0.9750.30
189_I192_F0.9710.29
130_R197_G0.9670.29
136_S407_S0.9640.29
300_V315_A0.9590.29
98_C148_V0.9570.29
235_N372_I0.9560.29
153_V342_W0.9560.29
110_V142_G0.9550.29
111_Y282_A0.9540.29
193_S245_A0.9530.29
132_M317_M0.9520.29
208_K215_N0.9480.28
80_K430_S0.9440.28
25_L269_M0.9430.28
59_V110_V0.9400.28
24_A321_M0.9380.28
314_I347_V0.9370.28
108_H389_Y0.9360.28
369_A400_A0.9320.28
335_E338_K0.9320.28
187_L191_I0.9320.28
149_S301_F0.9310.28
290_T295_I0.9310.28
5_I331_G0.9300.28
101_T153_V0.9290.28
6_Q39_V0.9290.28
13_C334_G0.9280.28
141_M428_G0.9270.28
176_A180_P0.9260.28
29_G61_A0.9250.27
42_L324_A0.9240.27
177_I240_W0.9170.27
374_V379_I0.9140.27
177_I276_F0.9140.27
167_R324_A0.9080.27
111_Y400_A0.9070.27
45_G320_T0.9050.27
52_M312_Y0.9050.27
46_K319_E0.9040.27
29_G114_L0.9010.26
121_A233_K0.9010.26
4_T80_K0.8990.26
226_L240_W0.8990.26
362_L388_G0.8930.26
29_G321_M0.8910.26
195_F339_E0.8910.26
72_D432_S0.8900.26
158_M370_L0.8840.26
74_M378_Y0.8830.26
152_V383_A0.8830.26
46_K50_D0.8820.26
102_I144_I0.8810.26
359_A395_Y0.8790.26
311_V384_P0.8780.26
332_V335_E0.8770.25
9_I291_N0.8760.25
16_Y267_L0.8720.25
95_F103_L0.8700.25
36_L59_V0.8680.25
306_I397_S0.8670.25
314_I403_Q0.8650.25
29_G32_G0.8650.25
246_I376_P0.8640.25
135_S207_Q0.8620.25
65_L322_F0.8620.25
74_M399_L0.8610.25
209_F215_N0.8600.25
96_V119_D0.8570.25
325_H328_E0.8530.25
324_A430_S0.8500.24
281_G318_A0.8500.24
319_E352_S0.8450.24
42_L320_T0.8440.24
109_V300_V0.8440.24
20_K29_G0.8390.24
87_K93_A0.8380.24
143_I358_Q0.8370.24
259_R272_V0.8350.24
74_M243_L0.8340.24
27_L281_G0.8300.24
66_Q260_P0.8260.24
18_A249_V0.8220.23
22_G185_G0.8180.23
349_L390_Y0.8180.23
133_A217_E0.8170.23
30_G107_G0.8170.23
78_A112_T0.8160.23
111_Y389_Y0.8150.23
49_V52_M0.8140.23
43_Q46_K0.8100.23
59_V256_S0.8070.23
63_A272_V0.8070.23
236_W289_K0.8050.23
209_F235_N0.8010.23
89_V338_K0.8010.23
52_M262_F0.8000.23
130_R400_A0.8000.23
127_R199_D0.8000.23
75_L116_I0.7990.22
391_I394_T0.7990.22
27_L60_A0.7990.22
314_I394_T0.7990.22
118_Y122_I0.7980.22
84_R294_S0.7910.22
82_L109_V0.7900.22
112_T117_I0.7890.22
35_I42_L0.7890.22
74_M102_I0.7880.22
294_S297_K0.7870.22
175_L277_M0.7870.22
74_M168_H0.7860.22
174_L317_M0.7850.22
41_H53_L0.7820.22
30_G101_T0.7800.22
206_F318_A0.7790.22
344_Y382_S0.7790.22
51_V395_Y0.7790.22
269_M307_A0.7780.22
13_C35_I0.7760.22
355_V383_A0.7740.22
303_S311_V0.7720.22
396_P401_A0.7710.21
107_G148_V0.7690.21
359_A363_A0.7670.21
143_I345_A0.7660.21
29_G355_V0.7640.21
387_Y433_C0.7620.21
7_L378_Y0.7610.21
75_L321_M0.7610.21
14_L75_L0.7610.21
361_A386_C0.7600.21
251_L257_D0.7570.21
14_L37_V0.7560.21
292_P423_L0.7560.21
82_L301_F0.7550.21
30_G116_I0.7540.21
65_L274_Q0.7540.21
76_Q227_L0.7530.21
274_Q312_Y0.7520.21
110_V398_D0.7510.21
81_L186_I0.7510.21
156_V333_L0.7490.21
307_A396_P0.7490.21
156_V317_M0.7470.21
88_Y135_S0.7440.21
327_S346_I0.7440.21
109_V388_G0.7440.21
253_G404_F0.7430.20
20_K401_A0.7420.20
186_I246_I0.7410.20
40_F53_L0.7410.20
241_I287_L0.7410.20
211_S233_K0.7410.20
356_N394_T0.7400.20
99_T179_I0.7390.20
204_E343_A0.7370.20
240_W289_K0.7360.20
369_A372_I0.7350.20
35_I323_G0.7350.20
212_V343_A0.7350.20
100_L246_I0.7350.20
348_L365_I0.7330.20
285_I309_V0.7320.20
84_R291_N0.7310.20
362_L366_V0.7310.20
34_V275_M0.7300.20
17_G36_L0.7290.20
31_I268_S0.7280.20
6_Q172_L0.7280.20
110_V139_A0.7280.20
244_G247_A0.7270.20
29_G116_I0.7270.20
401_A421_F0.7260.20
352_S355_V0.7250.20
336_M347_V0.7240.20
250_A369_A0.7240.20
113_I394_T0.7230.20
77_I279_L0.7230.20
253_G260_P0.7220.20
37_V267_L0.7210.20
111_Y119_D0.7210.20
141_M429_V0.7200.20
18_A82_L0.7200.20
111_Y269_M0.7190.20
52_M402_I0.7180.20
102_I423_L0.7170.20
198_K201_D0.7140.20
314_I368_V0.7110.19
153_V245_A0.7110.19
119_D387_Y0.7090.19
43_Q362_L0.7090.19
397_S407_S0.7080.19
324_A327_S0.7080.19
18_A245_A0.7070.19
188_A371_A0.7070.19
244_G283_L0.7070.19
131_P135_S0.7060.19
136_S142_G0.7050.19
257_D442_M0.7040.19
41_H188_A0.7000.19
121_A411_H0.7000.19
380_V390_Y0.7000.19
31_I411_H0.6990.19
131_P307_A0.6980.19
135_S201_D0.6970.19
251_L286_I0.6970.19
212_V217_E0.6960.19
170_E173_D0.6930.19
379_I384_P0.6910.19
85_N158_M0.6880.19
156_V174_L0.6870.19
108_H395_Y0.6820.18
79_E83_R0.6780.18
108_H359_A0.6770.18
21_G107_G0.6760.18
77_I432_S0.6760.18
306_I403_Q0.6750.18
76_Q123_K0.6730.18
98_C278_L0.6720.18
432_S436_G0.6710.18
437_W441_A0.6710.18
10_I318_A0.6700.18
253_G258_L0.6690.18
16_Y436_G0.6680.18
114_L118_Y0.6660.18
249_V272_V0.6660.18
274_Q429_V0.6660.18
381_A401_A0.6660.18
95_F244_G0.6650.18
137_I298_N0.6650.18
107_G389_Y0.6650.18
135_S247_A0.6640.18
318_A394_T0.6640.18
52_M317_M0.6600.18
4_T241_I0.6590.18
33_L245_A0.6580.18
35_I230_K0.6580.18
140_Q389_Y0.6530.18
356_N398_D0.6530.18
20_K397_S0.6520.18
73_V240_W0.6500.17
15_F91_I0.6500.17
24_A63_A0.6500.17
285_I295_I0.6490.17
63_A179_I0.6480.17
6_Q10_I0.6460.17
122_I274_Q0.6430.17
88_Y95_F0.6430.17
211_S286_I0.6420.17
352_S418_N0.6410.17
275_M317_M0.6390.17
174_L276_F0.6380.17
110_V134_A0.6360.17
387_Y398_D0.6360.17
158_M363_A0.6360.17
116_I322_F0.6350.17
346_I375_D0.6350.17
45_G50_D0.6340.17
303_S315_A0.6330.17
193_S197_G0.6310.17
84_R87_K0.6290.17
359_A428_G0.6270.17
136_S397_S0.6250.17
171_F344_Y0.6240.17
84_R231_L0.6230.17
20_K286_I0.6230.17
183_L364_A0.6230.17
243_L442_M0.6220.17
75_L150_V0.6220.17
158_M177_I0.6210.17
241_I288_T0.6200.17
19_R48_P0.6200.17
140_Q273_I0.6200.17
393_P410_T0.6190.17
82_L153_V0.6190.17
355_V401_A0.6180.17
112_T361_A0.6160.16
227_L286_I0.6160.16
287_L352_S0.6150.16
41_H352_S0.6140.16
430_S434_V0.6140.16
249_V340_Y0.6130.16
4_T12_I0.6110.16
188_A435_F0.6100.16
101_T288_T0.6090.16
103_L183_L0.6080.16
331_G335_E0.6080.16
19_R283_L0.6080.16
182_T185_G0.6080.16
176_A238_A0.6030.16
80_K263_G0.6030.16
98_C144_I0.6020.16
6_Q411_H0.6000.16
45_G323_G0.5960.16
260_P420_S0.5960.16
337_V420_S0.5960.16
28_L82_L0.5960.16
177_I434_V0.5960.16
27_L74_M0.5950.16
152_V399_L0.5950.16
17_G115_P0.5920.16
89_V114_L0.5910.16
156_V314_I0.5910.16
303_S362_L0.5910.16
20_K61_A0.5890.16
186_I317_M0.5880.16
90_S400_A0.5870.16
107_G182_T0.5850.16
98_C145_A0.5850.16
115_P393_P0.5850.16
27_L295_I0.5850.16
108_H282_A0.5840.16
352_S389_Y0.5840.16
398_D412_I0.5820.15
115_P410_T0.5820.15
352_S365_I0.5820.15
9_I186_I0.5800.15
112_T239_M0.5800.15
152_V368_V0.5780.15
396_P399_L0.5780.15
103_L246_I0.5760.15
196_R246_I0.5760.15
108_H135_S0.5750.15
122_I406_R0.5740.15
346_I430_S0.5740.15
208_K303_S0.5730.15
353_K391_I0.5730.15
280_T354_F0.5720.15
114_L193_S0.5710.15
101_T304_G0.5710.15
246_I311_V0.5700.15
51_V359_A0.5700.15
183_L432_S0.5690.15
112_T136_S0.5690.15
206_F215_N0.5680.15
150_V361_A0.5660.15
430_S439_F0.5650.15
331_G336_M0.5650.15
213_P217_E0.5650.15
10_I100_L0.5640.15
38_F252_L0.5630.15
26_G36_L0.5630.15
95_F187_L0.5630.15
91_I195_F0.5620.15
101_T145_A0.5620.15
84_R295_I0.5570.15
83_R177_I0.5560.15
262_F368_V0.5560.15
243_L282_A0.5540.15
248_V287_L0.5540.15
4_T35_I0.5530.15
273_I289_K0.5510.15
59_V149_S0.5510.15
31_I49_V0.5510.15
311_V395_Y0.5470.15
153_V156_V0.5470.15
37_V275_M0.5470.15
153_V356_N0.5450.14
19_R315_A0.5450.14
389_Y398_D0.5450.14
174_L369_A0.5440.14
116_I213_P0.5410.14
253_G388_G0.5410.14
30_G300_V0.5400.14
368_V417_I0.5400.14
132_M409_T0.5400.14
75_L356_N0.5390.14
78_A142_G0.5390.14
54_V361_A0.5390.14
353_K394_T0.5390.14
71_L177_I0.5380.14
126_I157_A0.5380.14
152_V253_G0.5360.14
206_F386_C0.5360.14
120_V161_N0.5360.14
257_D260_P0.5350.14
45_G52_M0.5340.14
274_Q319_E0.5340.14
71_L409_T0.5330.14
63_A306_I0.5320.14
125_N342_W0.5320.14
109_V270_V0.5310.14
120_V278_L0.5310.14
117_I135_S0.5310.14
75_L213_P0.5310.14
172_L199_D0.5300.14
74_M96_V0.5300.14
369_A374_V0.5300.14
140_Q412_I0.5290.14
337_V409_T0.5280.14
206_F213_P0.5280.14
80_K173_D0.5270.14
28_L110_V0.5240.14
26_G250_A0.5240.14
92_V193_S0.5240.14
245_A342_W0.5230.14
209_F214_E0.5220.14
60_A435_F0.5220.14
150_V344_Y0.5210.14
111_Y342_W0.5210.14
54_V236_W0.5210.14
150_V209_F0.5190.14
24_A296_S0.5190.14
10_I370_L0.5190.14
415_F430_S0.5180.14
331_G339_E0.5180.14
80_K210_I0.5170.14
254_A270_V0.5160.14
197_G202_K0.5160.14
148_V245_A0.5160.14
168_H271_L0.5160.14
231_L234_S0.5150.14
291_N331_G0.5130.14
273_I436_G0.5130.14
65_L93_A0.5120.14
91_I186_I0.5120.14
193_S342_W0.5120.14
154_S158_M0.5120.14
56_I309_V0.5120.14
47_P214_E0.5110.14
125_N197_G0.5100.14
296_S306_I0.5090.14
8_I263_G0.5090.14
171_F174_L0.5080.14
100_L259_R0.5080.14
248_V251_L0.5080.14
97_T395_Y0.5070.14
149_S329_I0.5070.14
130_R198_K0.5060.13
250_A386_C0.5050.13
98_C142_G0.5030.13
189_I427_I0.5030.13
42_L251_L0.5030.13
375_D378_Y0.5020.13
93_A151_A0.5010.13
171_F369_A0.5000.13
243_L415_F0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.8767 99.7 0.902 Contact Map
4r1iA 2 0.9507 99.4 0.922 Contact Map
4r0cA 3 0.9081 98.8 0.94 Contact Map
3nd0A 2 0.796 67.2 0.978 Contact Map
4ogqG 1 0.083 61 0.979 Contact Map
1q90G 1 0.0673 54.3 0.98 Contact Map
2m20A 2 0.1256 20.8 0.984 Contact Map
4zw9A 1 0.4126 19.1 0.984 Contact Map
2nwlA 3 0.4148 12.4 0.986 Contact Map
4xnjA 1 0.8363 12.2 0.986 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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