GREMLIN Database
DCUA - Anaerobic C4-dicarboxylate transporter DcuA
UniProt: P0ABN5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11225
Length: 433 (429)
Sequences: 556 (279)
Seq/√Len: 13.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
233_G269_V7.2551.00
93_I176_L6.0001.00
193_K196_D5.5681.00
123_G195_S4.7111.00
280_D283_N4.5961.00
181_V420_L4.3671.00
95_T133_A3.9551.00
199_I202_K3.8370.99
196_D201_R3.7070.99
9_V35_L3.4050.99
132_T182_M3.1790.98
202_K206_E3.0350.97
153_M157_M3.0080.97
420_L424_F2.9270.96
170_V369_V2.7600.95
338_F380_I2.7460.95
105_G138_Q2.7220.95
96_Y175_T2.7200.95
401_I407_N2.7030.94
286_N291_K2.6250.93
202_K205_E2.5810.93
201_R205_E2.5690.93
143_A175_T2.5450.92
200_Y204_L2.5290.92
176_L180_L2.4800.91
112_L390_A2.4730.91
229_L269_V2.3940.90
106_N296_A2.3880.90
406_F411_F2.3350.89
308_D312_S2.3280.88
326_I336_I2.3260.88
272_L276_I2.3210.88
63_M114_V2.3080.88
71_Y227_V2.3030.88
370_A426_F2.2810.87
105_G137_A2.2060.85
358_A368_A2.1840.85
99_T105_G2.1640.84
79_L90_L2.1050.83
156_V351_A2.0080.79
79_L83_N2.0070.79
380_I411_F1.9790.78
398_T409_P1.9780.78
66_A226_S1.9670.78
166_H169_S1.9580.78
125_K191_N1.9460.77
99_T141_I1.9410.77
222_G225_T1.9390.77
97_F221_S1.9340.77
332_L335_V1.9260.76
137_A140_A1.9220.76
58_A298_I1.9200.76
80_L90_L1.8320.73
7_I298_I1.8290.72
133_A137_A1.8150.72
47_F51_S1.8020.71
152_Y351_A1.7420.69
221_S428_L1.7390.68
114_V118_V1.7080.67
106_N109_L1.6920.66
62_A273_T1.6900.66
100_I172_I1.6820.66
6_L310_F1.6730.65
182_M186_V1.6510.64
315_I319_K1.6420.64
300_I303_V1.6220.63
13_I28_G1.6100.62
78_K97_F1.5970.62
225_T277_C1.5850.61
207_G332_L1.5810.61
114_V121_E1.5730.60
98_L241_A1.5670.60
300_I383_T1.5660.60
177_L424_F1.5540.59
86_Y90_L1.5510.59
299_C303_V1.5470.59
54_M297_C1.5340.58
108_S418_V1.5320.58
156_V359_L1.5310.58
141_I149_A1.5220.58
189_L265_I1.5070.57
131_S134_V1.5050.57
143_A168_L1.5000.57
12_A30_L1.4990.57
196_D205_E1.4860.56
380_I406_F1.4750.55
168_L353_A1.4680.55
59_A390_A1.4630.55
359_L365_P1.4610.55
32_V273_T1.4300.53
71_Y75_Q1.4270.53
4_V119_A1.4250.53
94_V111_T1.4240.53
349_A370_A1.4110.52
186_V233_G1.4080.52
221_S225_T1.3960.51
5_E123_G1.3900.51
378_L383_T1.3870.51
22_I153_M1.3860.51
98_L111_T1.3790.50
17_A112_L1.3730.50
75_Q79_L1.3680.50
366_L429_G1.3650.49
428_L431_F1.3630.49
89_I184_F1.3550.49
124_V367_T1.3520.49
176_L179_V1.3360.48
5_E42_P1.3350.48
273_T348_A1.3280.47
308_D401_I1.3260.47
170_V318_I1.3250.47
132_T136_S1.3190.47
52_I107_I1.3090.46
192_S196_D1.3060.46
424_F428_L1.3060.46
132_T179_V1.2980.46
24_I127_C1.2970.46
153_M353_A1.2940.46
74_H219_I1.2910.46
199_I369_V1.2870.45
99_T138_Q1.2850.45
336_I354_L1.2840.45
29_G267_L1.2820.45
39_G43_G1.2710.44
116_A396_T1.2690.44
112_L389_A1.2630.44
221_S403_K1.2430.43
95_T115_I1.2330.42
96_Y100_I1.2300.42
134_V426_F1.2270.42
79_L97_F1.2200.42
416_L420_L1.2170.42
225_T280_D1.2150.42
64_Q70_D1.2130.41
307_G386_T1.2040.41
65_V287_S1.1960.41
121_E207_G1.1910.40
331_W389_A1.1890.40
170_V370_A1.1880.40
114_V385_P1.1860.40
46_P304_A1.1840.40
127_C398_T1.1720.39
333_L358_A1.1570.39
59_A175_T1.1470.38
355_M405_V1.1470.38
11_L34_V1.1440.38
314_N373_A1.1290.37
228_W232_L1.1290.37
63_M306_L1.1260.37
170_V202_K1.1220.37
52_I148_A1.1170.37
386_T390_A1.1120.36
58_A69_L1.1080.36
56_V266_M1.1080.36
345_Y386_T1.1070.36
132_T183_S1.1040.36
72_L75_Q1.1000.36
71_Y224_K1.1000.36
193_K275_V1.0970.36
62_A343_L1.0970.36
174_S373_A1.0890.35
125_K128_R1.0860.35
170_V174_S1.0860.35
287_S398_T1.0830.35
151_V331_W1.0760.35
147_S291_K1.0750.35
2_L284_I1.0750.35
182_M417_G1.0740.34
186_V416_L1.0700.34
423_C427_V1.0630.34
289_T311_V1.0600.34
36_A256_M1.0580.34
225_T276_I1.0570.34
203_R207_G1.0520.33
170_V265_I1.0520.33
142_T227_V1.0500.33
4_V320_D1.0480.33
184_F278_K1.0470.33
237_V316_D1.0470.33
221_S335_V1.0470.33
77_E187_T1.0460.33
233_G353_A1.0460.33
279_V284_I1.0440.33
119_A221_S1.0430.33
343_L381_L1.0430.33
174_S335_V1.0390.33
108_S140_A1.0340.33
202_K209_V1.0320.32
112_L186_V1.0300.32
289_T304_A1.0250.32
28_G390_A1.0230.32
78_K201_R1.0230.32
12_A323_G1.0220.32
28_G59_A1.0220.32
180_L272_L1.0210.32
150_V372_F1.0120.32
180_L183_S1.0090.31
348_A384_Y1.0070.31
44_N48_D1.0050.31
316_D320_D1.0010.31
203_R209_V0.9910.31
15_L256_M0.9880.30
192_S195_S0.9850.30
303_V336_I0.9820.30
358_A389_A0.9760.30
35_L57_I0.9720.30
89_I116_A0.9710.30
99_T151_V0.9670.30
134_V396_T0.9630.29
250_L294_M0.9620.29
109_L389_A0.9620.29
13_I36_A0.9610.29
300_I373_A0.9580.29
50_I301_L0.9550.29
361_L368_A0.9540.29
109_L271_T0.9530.29
338_F379_F0.9510.29
93_I101_F0.9490.29
170_V342_A0.9480.29
205_E235_V0.9460.29
10_L170_V0.9440.29
321_T324_E0.9400.28
61_S261_A0.9370.28
411_F415_T0.9370.28
24_I258_T0.9350.28
130_L396_T0.9330.28
223_A361_L0.9280.28
177_L420_L0.9280.28
324_E327_Q0.9280.28
151_V233_G0.9270.28
367_T426_F0.9240.28
169_S173_P0.9190.27
106_N378_L0.9140.27
303_V392_Q0.9140.27
72_L231_L0.9140.27
100_I142_T0.9110.27
28_G31_G0.9100.27
234_V365_P0.9090.27
191_N196_D0.9090.27
28_G112_L0.9090.27
72_L388_V0.9090.27
203_R223_A0.9040.27
87_I327_Q0.9030.27
180_L184_F0.9020.27
139_I417_G0.9020.27
13_I73_V0.9010.27
63_M311_V0.9000.27
179_V353_A0.8980.27
23_G310_F0.8970.27
77_E81_R0.8950.26
72_L367_T0.8940.26
170_V427_V0.8920.26
130_L306_L0.8890.26
308_D341_S0.8880.26
248_M377_G0.8860.26
26_F270_A0.8860.26
191_N197_D0.8830.26
41_K44_N0.8790.26
7_I192_S0.8750.26
3_V78_K0.8750.26
358_A361_L0.8750.26
17_A237_V0.8730.26
125_K194_L0.8670.25
85_K91_A0.8670.25
96_Y146_I0.8670.25
128_R191_N0.8660.25
19_L28_G0.8640.25
12_A34_V0.8640.25
85_K140_A0.8630.25
147_S290_F0.8600.25
170_V228_W0.8600.25
39_G181_V0.8580.25
314_N317_W0.8570.25
107_I289_T0.8560.25
163_S166_H0.8550.25
133_A201_R0.8540.25
351_A377_G0.8540.25
385_P390_A0.8500.25
57_I108_S0.8470.24
44_N308_D0.8460.24
228_W278_K0.8450.24
363_V368_A0.8430.24
274_T298_I0.8420.24
270_A307_G0.8400.24
426_F430_S0.8350.24
76_T110_A0.8330.24
128_R389_A0.8300.24
70_D421_A0.8290.24
47_F50_I0.8280.24
26_F58_A0.8280.24
97_F172_I0.8280.24
303_V357_M0.8250.24
192_S201_R0.8230.24
110_A115_I0.8220.24
44_N209_V0.8200.23
237_V261_A0.8180.23
241_A393_M0.8170.23
80_L107_I0.8160.23
421_A425_G0.8150.23
109_L378_L0.8100.23
10_L243_I0.8090.23
139_I418_V0.8040.23
351_A355_M0.8010.23
82_R85_K0.7960.23
316_D335_V0.7940.22
98_L248_M0.7940.22
200_Y203_R0.7940.22
109_L117_E0.7920.22
129_P133_A0.7900.22
156_V352_K0.7900.22
116_A120_K0.7890.22
303_V383_T0.7850.22
111_T383_T0.7830.22
200_Y209_V0.7830.22
74_H121_E0.7830.22
376_S422_V0.7810.22
123_G191_N0.7810.22
17_A80_L0.7810.22
38_I51_S0.7790.22
215_K232_L0.7770.22
168_L266_M0.7770.22
78_K419_A0.7770.22
224_K278_K0.7740.22
29_G114_V0.7740.22
292_A300_I0.7730.22
274_T284_I0.7730.22
380_I383_T0.7730.22
333_L371_S0.7710.22
344_L372_F0.7700.22
44_N319_K0.7690.22
40_V313_N0.7680.22
72_L161_G0.7670.21
345_Y383_T0.7670.21
152_Y156_V0.7670.21
34_V312_S0.7670.21
295_S386_T0.7660.21
40_V309_T0.7650.21
133_A235_V0.7630.21
214_E221_S0.7620.21
246_P377_G0.7610.21
82_R283_N0.7590.21
108_S137_A0.7590.21
133_A195_S0.7560.21
86_Y133_A0.7530.21
337_F354_L0.7530.21
181_V424_F0.7510.21
206_E332_L0.7510.21
73_V114_V0.7510.21
16_G35_L0.7500.21
350_T375_V0.7480.21
335_V364_S0.7480.21
8_I280_D0.7470.21
258_T296_A0.7470.21
325_V336_I0.7470.21
348_A352_K0.7460.21
154_S322_A0.7420.21
94_V117_E0.7410.21
28_G310_F0.7410.21
107_I377_G0.7400.21
34_V40_V0.7400.21
97_F215_K0.7390.20
141_I347_Q0.7390.20
301_L358_A0.7380.20
114_V311_V0.7370.20
108_S387_L0.7350.20
36_A254_P0.7340.20
28_G344_L0.7330.20
263_L301_L0.7330.20
75_Q268_S0.7320.20
369_V379_F0.7310.20
141_I334_A0.7260.20
239_I275_V0.7260.20
200_Y307_G0.7250.20
71_Y228_W0.7240.20
105_G146_I0.7230.20
87_I112_L0.7200.20
117_E376_S0.7190.20
14_F89_I0.7180.20
187_T306_L0.7180.20
150_V357_M0.7170.20
295_S392_Q0.7170.20
179_V306_L0.7160.20
106_N348_A0.7140.20
15_L425_G0.7130.20
189_L328_G0.7120.20
74_H217_I0.7110.20
154_S167_L0.7100.20
50_I250_L0.7090.19
85_K324_E0.7090.19
198_P332_L0.7090.19
79_L179_V0.7080.19
170_V423_C0.7080.19
5_E9_V0.7060.19
28_G114_V0.7050.19
135_V287_S0.7050.19
18_R46_P0.7010.19
229_L276_I0.7010.19
242_I288_S0.7000.19
246_P250_L0.7000.19
19_L390_A0.6990.19
186_V353_A0.6980.19
98_L234_V0.6960.19
86_Y93_I0.6950.19
236_G276_I0.6930.19
134_V140_A0.6930.19
390_A410_F0.6930.19
175_T178_A0.6920.19
21_G178_A0.6910.19
229_L277_C0.6900.19
80_L290_F0.6870.19
229_L272_L0.6870.19
109_L258_T0.6870.19
63_M263_L0.6860.19
90_L178_A0.6860.19
238_V358_A0.6860.19
105_G378_L0.6840.19
313_N419_A0.6840.19
281_T412_I0.6830.19
82_R243_I0.6830.19
113_P382_P0.6820.19
225_T228_W0.6820.19
368_A373_A0.6820.19
50_I306_L0.6800.19
75_Q421_A0.6790.18
72_L100_I0.6790.18
187_T190_F0.6760.18
112_L116_A0.6760.18
113_P399_T0.6750.18
5_E165_L0.6740.18
167_L265_I0.6740.18
283_N286_N0.6730.18
386_T396_T0.6710.18
205_E213_G0.6700.18
27_A80_L0.6690.18
345_Y387_L0.6660.18
154_S306_L0.6620.18
26_F72_L0.6620.18
125_K193_K0.6620.18
179_V234_V0.6610.18
49_V384_Y0.6600.18
29_G105_G0.6600.18
157_M418_V0.6590.18
232_L272_L0.6590.18
29_G99_T0.6580.18
344_L390_A0.6570.18
114_V207_G0.6540.18
138_Q378_L0.6510.18
263_L418_V0.6510.18
164_Y333_L0.6480.18
199_I400_R0.6480.18
376_S387_L0.6470.17
148_A350_T0.6470.17
123_G202_K0.6470.17
8_I179_V0.6460.17
89_I189_L0.6450.17
58_A226_S0.6450.17
160_H313_N0.6430.17
32_V233_G0.6420.17
169_S226_S0.6420.17
99_T143_A0.6420.17
73_V310_F0.6410.17
34_V37_A0.6350.17
190_F263_L0.6350.17
341_S344_L0.6350.17
79_L93_I0.6340.17
50_I391_V0.6340.17
210_E213_G0.6330.17
269_V343_L0.6320.17
3_V34_V0.6310.17
106_N384_Y0.6290.17
167_L306_L0.6290.17
154_S303_V0.6280.17
61_S295_S0.6240.17
134_V386_T0.6230.17
4_V7_I0.6220.17
204_L223_A0.6220.17
124_V155_S0.6220.17
43_G167_L0.6210.17
96_Y143_A0.6180.17
93_I232_L0.6170.17
203_R208_L0.6150.17
250_L377_G0.6140.16
370_A390_A0.6130.16
30_L257_N0.6120.16
264_I306_L0.6110.16
236_G239_I0.6110.16
231_L404_F0.6110.16
296_A385_P0.6100.16
181_V360_A0.6080.16
127_C191_N0.6080.16
164_Y167_L0.6060.16
19_L275_V0.6060.16
133_A245_S0.6030.16
9_V307_G0.6020.16
100_I140_A0.6000.16
19_L386_T0.6000.16
237_V329_H0.6000.16
73_V148_A0.5980.16
105_G175_T0.5980.16
23_G61_S0.5980.16
371_S426_F0.5980.16
253_K317_W0.5970.16
219_I222_G0.5960.16
100_I412_I0.5930.16
120_K263_L0.5930.16
5_E400_R0.5930.16
378_L387_L0.5900.16
7_I11_L0.5890.16
20_G105_G0.5880.16
76_T94_V0.5880.16
170_V422_V0.5860.16
165_L193_K0.5860.16
43_G309_T0.5840.16
300_I384_Y0.5840.16
72_L101_F0.5820.16
99_T277_C0.5820.16
3_V229_L0.5810.16
341_S378_L0.5800.16
307_G383_T0.5790.15
43_G312_S0.5790.15
224_K366_L0.5780.15
214_E256_M0.5750.15
427_V431_F0.5750.15
3_V11_L0.5750.15
19_L59_A0.5740.15
78_K166_H0.5730.15
200_Y375_V0.5720.15
106_N271_T0.5710.15
110_A227_V0.5700.15
81_R170_V0.5700.15
99_T293_G0.5690.15
342_A380_I0.5690.15
21_G31_G0.5680.15
214_E228_W0.5680.15
194_L197_D0.5680.15
387_L401_I0.5680.15
73_V207_G0.5670.15
357_M406_F0.5670.15
326_I409_P0.5660.15
73_V345_Y0.5660.15
205_E275_V0.5650.15
14_F313_N0.5650.15
106_N133_A0.5650.15
107_I259_T0.5640.15
6_L367_T0.5640.15
138_Q262_I0.5640.15
128_R192_S0.5630.15
110_A134_V0.5620.15
419_A428_L0.5610.15
201_R216_Q0.5600.15
148_A333_L0.5590.15
234_V300_I0.5590.15
351_A391_V0.5580.15
129_P296_A0.5580.15
382_P399_T0.5580.15
18_R272_L0.5580.15
17_A233_G0.5570.15
16_G113_P0.5570.15
63_M91_A0.5570.15
151_V154_S0.5560.15
110_A350_T0.5540.15
341_S354_L0.5540.15
247_S415_T0.5530.15
130_L190_F0.5530.15
147_S318_I0.5510.15
26_F284_I0.5500.15
80_L151_V0.5500.15
108_S132_T0.5500.15
96_Y142_T0.5500.15
202_K369_V0.5490.15
313_N316_D0.5480.15
57_I147_S0.5450.15
364_S367_T0.5430.15
36_A40_V0.5420.14
114_V296_A0.5420.14
267_L281_T0.5410.14
348_A417_G0.5400.14
156_V313_N0.5400.14
49_V348_A0.5390.14
276_I341_S0.5390.14
176_L353_A0.5380.14
166_H170_V0.5380.14
151_V345_Y0.5380.14
109_L331_W0.5370.14
27_A108_S0.5360.14
320_D324_E0.5360.14
294_M383_T0.5340.14
23_G285_L0.5330.14
303_V387_L0.5330.14
192_S199_I0.5330.14
37_A354_L0.5320.14
342_A383_T0.5320.14
82_R284_I0.5320.14
101_F234_V0.5320.14
61_S172_I0.5310.14
72_L239_I0.5300.14
161_G165_L0.5300.14
257_N295_S0.5290.14
150_V388_V0.5290.14
29_G289_T0.5280.14
11_L328_G0.5250.14
156_V170_V0.5240.14
118_V267_L0.5240.14
41_K351_A0.5220.14
43_G48_D0.5220.14
9_V359_L0.5220.14
57_I244_N0.5220.14
263_L308_D0.5210.14
51_S69_L0.5210.14
78_K214_E0.5200.14
119_A400_R0.5190.14
35_L70_D0.5190.14
9_V98_L0.5190.14
52_I350_T0.5190.14
240_Y261_A0.5180.14
379_F404_F0.5180.14
320_D328_G0.5160.14
358_A363_V0.5160.14
285_L295_S0.5140.14
96_Y267_L0.5140.14
170_V329_H0.5130.14
138_Q401_I0.5130.14
30_L400_R0.5130.14
236_G423_C0.5130.14
82_R280_D0.5120.14
233_G331_W0.5120.14
7_I228_W0.5120.14
202_K292_A0.5110.14
58_A424_F0.5110.14
231_L425_G0.5110.14
146_I298_I0.5100.14
186_V190_F0.5100.14
33_L264_I0.5090.14
229_L284_I0.5090.14
3_V63_M0.5090.14
220_K280_D0.5070.14
236_G271_T0.5060.14
64_Q248_M0.5040.14
2_L326_I0.5040.14
34_V232_L0.5020.13
301_L326_I0.5020.13
88_T118_V0.5010.13
119_A282_D0.5010.13
164_Y340_A0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.8915 99.7 0.899 Contact Map
4r1iA 2 0.9469 99.4 0.92 Contact Map
4r0cA 3 0.9192 98.9 0.938 Contact Map
4ogqG 1 0.0855 44.7 0.981 Contact Map
1q90G 1 0.0693 39 0.981 Contact Map
2m20A 2 0.1201 17.4 0.984 Contact Map
4mt1A 3 0.2656 13.1 0.985 Contact Map
3nd0A 2 0.8014 11.4 0.986 Contact Map
2kncB 1 0.1801 8.4 0.986 Contact Map
3w9iA 3 0.3487 7.1 0.987 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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