GREMLIN Database
KDGL - Diacylglycerol kinase
UniProt: P0ABN1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10224
Length: 122 (111)
Sequences: 2394 (1748)
Seq/√Len: 165.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_V91_S3.3921.00
20_K92_G3.2821.00
25_A71_I2.8811.00
26_W36_G2.6251.00
69_V72_L2.5211.00
64_M108_V2.3101.00
23_R27_I2.1111.00
39_V63_V2.0331.00
69_V105_A1.9971.00
82_R91_S1.8981.00
46_A56_R1.8411.00
26_W37_V1.8331.00
51_V116_L1.8021.00
22_L100_A1.7361.00
68_I105_A1.7321.00
78_A93_R1.7271.00
65_L105_A1.7261.00
79_V94_A1.6951.00
50_D56_R1.6551.00
52_D55_T1.5111.00
25_A32_F1.4841.00
71_I97_M1.4401.00
90_L94_A1.4271.00
54_I58_L1.4231.00
58_L62_S1.3971.00
55_T116_L1.3951.00
32_F35_E1.3741.00
79_V83_I1.3611.00
74_S97_M1.3551.00
67_M104_I1.3501.00
114_C118_W1.3421.00
66_V109_A1.3321.00
13_K16_G1.3301.00
32_F67_M1.3131.00
25_A97_M1.2801.00
43_V63_V1.2571.00
18_S99_S1.2501.00
71_I100_A1.2471.00
28_N93_R1.2401.00
61_S108_V1.2351.00
11_I15_A1.2311.00
17_Y20_K1.2241.00
69_V101_A1.2211.00
11_I34_Q1.1951.00
66_V102_V1.1941.00
60_I108_V1.1861.00
44_V48_W1.1861.00
11_I30_A1.1821.00
42_A63_V1.1711.00
14_A31_A1.1661.00
35_E102_V1.1481.00
24_A93_R1.1361.00
53_A57_V1.1011.00
15_A103_L1.0811.00
62_S112_T1.0751.00
110_V114_C1.0700.99
57_V112_T1.0420.99
51_V59_L1.0350.99
66_V105_A1.0340.99
68_I72_L0.9940.99
84_G91_S0.9900.99
31_A34_Q0.9730.99
71_I104_I0.9600.99
64_M104_I0.9590.99
57_V115_I0.9590.99
29_E78_A0.9580.99
53_A115_I0.9560.99
49_L117_L0.9540.99
74_S78_A0.9500.99
10_R30_A0.9210.98
75_A94_A0.9120.98
14_A18_S0.9090.98
34_Q38_A0.8980.98
84_G88_H0.8970.98
31_A35_E0.8900.98
78_A81_D0.8890.98
74_S93_R0.8850.98
65_L68_I0.8830.98
83_I91_S0.8800.98
19_W23_R0.8690.98
13_K17_Y0.8640.98
62_S109_A0.8350.97
46_A59_L0.8330.97
9_T13_K0.8310.97
12_I16_G0.8300.97
59_L62_S0.8290.97
24_A29_E0.8280.97
98_G101_A0.8210.97
103_L107_I0.8210.97
28_N74_S0.8190.97
24_A28_N0.8080.97
32_F71_I0.8060.96
80_V94_A0.8040.96
36_G67_M0.8040.96
54_I57_V0.7940.96
72_L101_A0.7940.96
82_R94_A0.7870.96
111_I114_C0.7840.96
82_R88_H0.7670.95
106_I110_V0.7670.95
46_A60_I0.7550.95
15_A19_W0.7500.95
35_E66_V0.7500.95
15_A34_Q0.7420.94
35_E106_I0.7230.94
53_A116_L0.7130.93
111_I115_I0.6950.92
57_V111_I0.6940.92
39_V42_A0.6890.92
82_R90_L0.6860.92
107_I111_I0.6810.91
64_M111_I0.6740.91
59_L117_L0.6640.90
24_A92_G0.6640.90
38_A106_I0.6600.90
94_A98_G0.6590.90
35_E39_V0.6530.90
16_G20_K0.6480.89
20_K24_A0.6470.89
102_V109_A0.6460.89
93_R97_M0.6450.89
58_L108_V0.6440.89
81_D95_K0.6430.89
89_E93_R0.6400.89
75_A101_A0.6250.88
83_I87_Y0.6240.87
43_V47_C0.6190.87
28_N78_A0.6160.87
84_G92_G0.6140.87
47_C56_R0.5990.85
17_Y24_A0.5940.85
66_V106_I0.5920.85
30_A33_R0.5900.84
26_W32_F0.5840.84
78_A94_A0.5700.82
51_V56_R0.5680.82
62_S105_A0.5680.82
44_V47_C0.5660.82
30_A34_Q0.5570.81
78_A97_M0.5540.81
75_A79_V0.5530.80
42_A109_A0.5520.80
17_Y31_A0.5490.80
89_E92_G0.5440.79
41_L45_I0.5410.79
14_A17_Y0.5390.79
41_L48_W0.5370.78
60_I115_I0.5360.78
19_W103_L0.5350.78
16_G19_W0.5330.78
83_I90_L0.5330.78
29_E96_D0.5300.78
79_V91_S0.5270.77
62_S66_V0.5220.77
45_I49_L0.5210.76
22_L103_L0.5210.76
34_Q37_V0.5180.76
83_I94_A0.5150.76
61_S65_L0.5150.76
109_A112_T0.5140.75
10_R34_Q0.5130.75
63_V109_A0.5080.75
24_A97_M0.5070.74
47_C115_I0.5010.74
61_S112_T0.5010.74
99_S106_I0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ze3A 4 0.9426 100 0.063 Contact Map
3mp7B 1 0.3525 5.6 0.943 Contact Map
4ldsA 2 0.4918 4.6 0.945 Contact Map
1rh5C 1 0.2213 4.2 0.946 Contact Map
3b8cA 1 0.918 3.8 0.947 Contact Map
4k1cA 4 0.8607 3.3 0.949 Contact Map
1mhsA 2 0.918 2.9 0.95 Contact Map
2gfpA 2 0.5164 2.7 0.951 Contact Map
2lzrA 1 0.3197 2.5 0.952 Contact Map
4b03D 5 0.582 2.3 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0061 seconds.