GREMLIN Database
CCMD - Heme exporter protein D
UniProt: P0ABM5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12169
Length: 69 (64)
Sequences: 219 (149)
Seq/√Len: 18.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_W12_F5.5301.00
19_F23_L2.9320.99
35_L42_Q2.2880.94
24_A53_Q2.2100.93
27_M31_P1.9920.89
50_V60_L1.8500.85
4_A52_Q1.8220.84
30_I40_V1.7690.82
30_I34_V1.6520.77
28_T64_Q1.5510.73
23_L32_L1.5430.72
16_G59_R1.5170.71
33_V36_V1.4310.66
44_R51_A1.4090.65
4_A53_Q1.3970.64
4_A8_W1.3790.63
3_P6_A1.3510.62
25_V39_S1.3320.61
38_H53_Q1.2820.58
57_E61_R1.2360.55
25_V57_E1.1810.51
4_A38_H1.1790.51
60_L63_A1.1790.51
45_A48_R1.1430.49
3_P63_A1.1260.48
4_A27_M1.1230.48
4_A19_F1.0940.46
18_A23_L1.0920.46
54_R61_R1.0910.46
9_N63_A1.0590.44
10_E13_A0.9880.39
3_P25_V0.9820.39
25_V28_T0.9660.38
37_V44_R0.9570.38
18_A44_R0.9540.37
9_N18_A0.9370.36
8_W66_Q0.9270.36
18_A28_T0.9230.36
27_M64_Q0.9110.35
29_V53_Q0.9100.35
49_G53_Q0.9000.34
19_F32_L0.8880.34
24_A54_R0.8780.33
9_N12_F0.8660.32
20_F47_L0.8660.32
19_F24_A0.8480.31
26_V54_R0.8430.31
41_M52_Q0.8300.30
36_V60_L0.8290.30
43_H58_A0.8250.30
10_E37_V0.8120.29
42_Q66_Q0.8090.29
38_H52_Q0.7970.29
24_A29_V0.7900.28
45_A52_Q0.7670.27
33_V51_A0.7230.25
9_N31_P0.7210.25
13_A55_A0.7170.25
30_I36_V0.7130.25
46_I60_L0.7120.25
25_V38_H0.6950.24
58_A62_A0.6940.24
46_I62_A0.6930.24
45_A62_A0.6860.23
43_H49_G0.6780.23
28_T31_P0.6640.22
18_A42_Q0.6620.22
27_M66_Q0.6540.22
7_S13_A0.6480.22
46_I51_A0.6470.22
50_V53_Q0.6420.21
19_F36_V0.6400.21
28_T47_L0.6380.21
6_A43_H0.6100.20
20_F31_P0.6060.20
4_A23_L0.6030.20
26_V37_V0.6030.20
47_L50_V0.6010.20
40_V62_A0.5960.20
13_A48_R0.5900.19
15_G23_L0.5880.19
10_E27_M0.5770.19
13_A60_L0.5710.19
20_F49_G0.5690.19
44_R58_A0.5670.18
20_F64_Q0.5640.18
6_A41_M0.5590.18
49_G55_A0.5580.18
6_A32_L0.5520.18
13_A39_S0.5480.18
3_P26_V0.5440.18
41_M46_I0.5400.17
25_V46_I0.5380.17
29_V54_R0.5360.17
46_I58_A0.5090.16
16_G32_L0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v8kA 3 0 19.5 0.907 Contact Map
4oh3A 2 0.8261 14.1 0.913 Contact Map
3pieA 1 0.7536 12 0.916 Contact Map
2y35A 1 0.7971 10.1 0.919 Contact Map
4i5sA 2 0.4783 8.8 0.921 Contact Map
4tphA 2 0.6667 8.3 0.922 Contact Map
4dzoA 2 0.4638 7.7 0.923 Contact Map
3x29A 1 0.5362 7.6 0.923 Contact Map
3fqdA 1 0.8406 6.9 0.924 Contact Map
5amrA 1 0 6.8 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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