GREMLIN Database
CCMC - Heme exporter protein C
UniProt: P0ABM1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12057
Length: 245 (215)
Sequences: 1806 (1031)
Seq/√Len: 70.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_A107_A4.0581.00
105_F136_L3.1041.00
78_A93_V2.9261.00
96_M213_S2.7381.00
79_F164_L2.6781.00
121_T124_V2.6321.00
75_A167_V2.6191.00
29_S215_T2.5321.00
54_Y57_I2.5121.00
79_F83_V2.4281.00
135_L170_L2.3961.00
96_M217_T2.3661.00
124_V129_L2.2891.00
212_L216_L2.2431.00
47_D50_Q2.2041.00
142_V166_G2.1651.00
90_N156_G2.1201.00
33_L208_G2.1061.00
90_N146_W2.0531.00
105_F109_V2.0461.00
74_M97_A2.0321.00
72_A170_L2.0311.00
199_R203_R2.0291.00
26_A215_T2.0231.00
38_I42_G1.9861.00
174_H178_E1.9851.00
70_I213_S1.9761.00
67_S132_E1.9571.00
92_A221_M1.9171.00
91_L221_M1.9111.00
132_E136_L1.9051.00
72_A167_V1.8241.00
74_M163_V1.8151.00
133_L137_F1.8061.00
207_F211_L1.8041.00
22_I26_A1.7741.00
78_A163_V1.7671.00
67_S107_A1.7571.00
90_N160_G1.7281.00
54_Y58_Y1.7171.00
100_G139_Y1.6971.00
93_V163_V1.6791.00
70_I96_M1.6781.00
127_A182_T1.6741.00
14_L18_C1.6721.00
81_G90_N1.6060.99
107_A132_E1.5880.99
63_A106_I1.5820.99
39_W43_F1.5670.99
172_I179_W1.5650.99
38_I43_F1.5200.99
167_V170_L1.5200.99
93_V142_V1.5170.99
36_G205_S1.4780.99
97_A142_V1.4390.99
35_V38_I1.4240.98
16_Q20_W1.4100.98
10_I13_R1.4060.98
142_V163_V1.3900.98
13_R17_I1.3640.98
35_V204_W1.3600.98
81_G160_G1.3500.98
65_I210_L1.3460.98
57_I202_L1.3410.98
215_T219_M1.3310.98
44_A54_Y1.3220.97
195_D199_R1.3150.97
146_W159_A1.3010.97
189_R199_R1.2890.97
196_P200_S1.2870.97
104_T132_E1.2740.97
85_Q157_R1.2690.97
101_A143_I1.2610.97
53_S118_M1.2540.96
36_G40_G1.2430.96
205_S208_G1.2310.96
75_A164_L1.2260.96
7_Q10_I1.2160.96
34_T37_W1.2130.96
108_L136_L1.2120.96
94_A146_W1.2110.96
82_L164_L1.1690.95
168_V172_I1.1520.94
7_Q12_P1.1510.94
136_L140_V1.1390.94
170_L173_I1.1330.94
141_G145_L1.1220.94
24_W27_I1.1220.94
28_A211_L1.1210.93
142_V159_A1.1190.93
213_S217_T1.1030.93
9_A13_R1.0980.93
192_Q199_R1.0970.93
200_S204_W1.0830.92
206_I210_L1.0790.92
12_P16_Q1.0760.92
71_Y100_G1.0630.92
138_L163_V1.0620.92
66_W210_L1.0560.91
73_S92_A1.0510.91
15_Y19_G1.0510.91
26_A30_V1.0500.91
15_Y18_C1.0480.91
137_F141_G1.0470.91
25_L211_L1.0450.91
73_S96_M1.0410.91
107_A112_S1.0370.91
17_I20_W1.0350.90
108_L133_L1.0330.90
26_A29_S1.0320.90
58_Y198_M1.0230.90
68_M173_I1.0190.90
109_V113_A1.0120.89
65_I69_G1.0040.89
46_A52_N1.0030.89
86_M89_A0.9920.88
116_K122_W0.9860.88
178_E186_G0.9860.88
138_L166_G0.9840.88
40_G55_R0.9720.87
138_L173_I0.9650.87
41_F55_R0.9620.87
96_M99_I0.9600.87
74_M78_A0.9350.85
32_V207_F0.9340.85
185_Q188_T0.9310.85
95_A220_R0.9270.85
132_E174_H0.9270.85
27_I31_V0.9250.85
69_G210_L0.9240.85
96_M216_L0.9090.84
175_Y178_E0.9070.84
203_R207_F0.8800.82
203_R206_I0.8800.82
13_R16_Q0.8790.82
62_P120_G0.8780.82
5_L12_P0.8700.81
20_W23_P0.8680.81
197_A201_P0.8670.81
11_P18_C0.8610.80
124_V127_A0.8590.80
209_F212_L0.8450.79
22_I29_S0.8440.79
178_E187_S0.8400.79
125_W130_T0.8400.79
52_N55_R0.8330.78
186_G195_D0.8310.78
199_R202_L0.8260.77
32_V211_L0.8200.77
214_A217_T0.8190.77
92_A200_S0.8160.77
103_F213_S0.8070.76
76_V80_I0.8070.76
55_R59_L0.8060.76
10_I14_L0.8050.76
49_Q118_M0.8000.75
37_W40_G0.7970.75
99_I217_T0.7950.75
5_L17_I0.7900.74
128_R176_S0.7890.74
35_V40_G0.7870.74
116_K121_T0.7860.74
65_I206_I0.7780.73
23_P27_I0.7730.73
57_I107_A0.7670.72
169_N172_I0.7640.72
8_L17_I0.7630.72
104_T136_L0.7620.71
56_I110_T0.7610.71
188_T194_I0.7560.71
101_A140_V0.7540.71
78_A142_V0.7500.70
189_R206_I0.7500.70
142_V146_W0.7460.70
14_L221_M0.7360.69
125_W129_L0.7360.69
169_N173_I0.7340.69
194_I198_M0.7280.68
61_V177_V0.7270.68
152_R155_A0.7210.67
174_H187_S0.7200.67
19_G22_I0.7190.67
128_R131_S0.7170.67
35_V39_W0.7170.67
214_A218_L0.7150.67
12_P17_I0.7130.66
207_F217_T0.7120.66
84_W89_A0.7120.66
8_L13_R0.7120.66
174_H186_G0.7090.66
77_A89_A0.7090.66
58_Y97_A0.7070.66
12_P15_Y0.7070.66
66_W70_I0.7050.66
46_A54_Y0.7030.65
79_F168_V0.7030.65
95_A195_D0.7000.65
78_A164_L0.7000.65
75_A138_L0.6990.65
81_G146_W0.6960.65
145_L155_A0.6950.64
37_W42_G0.6940.64
205_S212_L0.6910.64
73_S213_S0.6880.64
34_T38_I0.6860.63
173_I176_S0.6850.63
181_N187_S0.6840.63
158_A162_L0.6820.63
52_N118_M0.6750.62
5_L8_L0.6750.62
34_T207_F0.6740.62
61_V183_L0.6710.62
190_M193_S0.6700.62
33_L212_L0.6700.62
18_C22_I0.6670.61
176_S181_N0.6650.61
40_G44_A0.6590.60
61_V128_R0.6560.60
5_L43_F0.6540.60
65_I189_R0.6480.59
33_L37_W0.6470.59
29_S212_L0.6450.59
216_L220_R0.6450.59
196_P199_R0.6440.59
162_L166_G0.6420.58
62_P128_R0.6370.58
10_I15_Y0.6350.57
47_D180_W0.6330.57
5_L13_R0.6320.57
37_W205_S0.6270.57
43_F58_Y0.6250.56
82_L160_G0.6250.56
18_C21_F0.6200.56
57_I61_V0.6190.56
187_S190_M0.6140.55
121_T129_L0.6140.55
170_L174_H0.6120.55
20_W29_S0.6120.55
75_A79_F0.6090.54
68_M132_E0.6070.54
209_F213_S0.6050.54
125_W133_L0.6050.54
101_A105_F0.6040.54
115_G129_L0.6000.53
217_T220_R0.5990.53
61_V202_L0.5990.53
34_T41_F0.5990.53
88_M221_M0.5990.53
63_A209_F0.5980.53
145_L162_L0.5980.53
68_M186_G0.5960.53
93_V159_A0.5960.53
5_L18_C0.5960.53
191_Q195_D0.5960.53
42_G82_L0.5950.53
46_A109_V0.5930.52
17_I21_F0.5920.52
7_Q11_P0.5910.52
67_S70_I0.5910.52
198_M201_P0.5900.52
130_T139_Y0.5900.52
19_G30_V0.5880.52
176_S180_W0.5860.52
169_N180_W0.5830.51
73_S217_T0.5790.51
210_L214_A0.5780.51
57_I188_T0.5770.50
66_W69_G0.5760.50
74_M96_M0.5720.50
8_L16_Q0.5710.50
135_L173_I0.5670.49
7_Q16_Q0.5660.49
143_I147_H0.5590.48
82_L161_I0.5580.48
139_Y171_P0.5570.48
141_G162_L0.5550.48
20_W26_A0.5530.48
38_I208_G0.5520.47
6_H137_F0.5510.47
69_G214_A0.5500.47
19_G23_P0.5500.47
21_F25_L0.5480.47
130_T169_N0.5480.47
44_A49_Q0.5470.47
138_L169_N0.5470.47
20_W27_I0.5430.46
217_T221_M0.5420.46
126_D203_R0.5400.46
66_W153_R0.5370.46
128_R135_L0.5350.45
7_Q15_Y0.5340.45
5_L22_I0.5320.45
80_I89_A0.5300.45
210_L213_S0.5280.45
106_I147_H0.5260.44
208_G212_L0.5230.44
19_G26_A0.5210.44
81_G153_R0.5190.43
153_R215_T0.5190.43
122_W219_M0.5190.43
7_Q13_R0.5160.43
156_G213_S0.5150.43
191_Q212_L0.5140.43
5_L9_A0.5130.43
204_W209_F0.5130.43
15_Y107_A0.5130.43
139_Y182_T0.5100.42
146_W156_G0.5100.42
16_Q21_F0.5090.42
61_V178_E0.5090.42
176_S183_L0.5080.42
57_I113_A0.5070.42
127_A174_H0.5060.42
105_F173_I0.5050.42
83_V87_K0.5040.42
6_H15_Y0.5040.42
123_W130_T0.5040.42
151_D154_L0.5040.42
133_L214_A0.5030.42
62_P188_T0.5030.42
57_I193_S0.5020.41
134_V151_D0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.8449 24.8 0.955 Contact Map
4ev6A 3 0.302 18.2 0.958 Contact Map
4o6yA 2 0.8041 13.8 0.96 Contact Map
2kluA 1 0.2204 13.3 0.96 Contact Map
4tphA 2 0.7837 10.4 0.962 Contact Map
4i0uA 4 0.2898 10.2 0.962 Contact Map
4j05A 3 0.8041 7.7 0.964 Contact Map
4uvmA 1 0.8776 7.6 0.964 Contact Map
4pypA 1 0.7837 7.4 0.965 Contact Map
2k21A 1 0.3347 6.2 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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