CCMC - ECOLI - GREMLIN Contacts

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CCMC - Heme exporter protein C

UniProt:	P0ABM1	Sequences: MWKTLHQLAIPPRLYQICGWFIPWLAIASVVVLTVGWIWGFGFAPADYQQGNSYRIIYLHVPAAIWSMGIYASMAVAAFIGLVWQMKMANLAVAAMAPIGAVFTFIALVTGSAWGKPMWGTWWVWDARLTSELVLLFLYVGVIALWHAFDDRRLAGRAAGILVLIGVVNLPIIHYSVEWWNTLHQGSTRMQQSIDPAMRSPLRWSIFGFLLLSATLTLMRMRNLILLMEKRRPWVSELILKRGRK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12057
Length:	245 (215)
Sequences:	1806 (1031)
Seq/√Len:	70.3

ECOLI - CCMC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
64_A	107_A	4.058	1.00
105_F	136_L	3.104	1.00
78_A	93_V	2.926	1.00
96_M	213_S	2.738	1.00
79_F	164_L	2.678	1.00
121_T	124_V	2.632	1.00
75_A	167_V	2.619	1.00
29_S	215_T	2.532	1.00
54_Y	57_I	2.512	1.00
79_F	83_V	2.428	1.00
135_L	170_L	2.396	1.00
96_M	217_T	2.366	1.00
124_V	129_L	2.289	1.00
212_L	216_L	2.243	1.00
47_D	50_Q	2.204	1.00
142_V	166_G	2.165	1.00
90_N	156_G	2.120	1.00
33_L	208_G	2.106	1.00
90_N	146_W	2.053	1.00
105_F	109_V	2.046	1.00
74_M	97_A	2.032	1.00
72_A	170_L	2.031	1.00
199_R	203_R	2.029	1.00
26_A	215_T	2.023	1.00
38_I	42_G	1.986	1.00
174_H	178_E	1.985	1.00
70_I	213_S	1.976	1.00
67_S	132_E	1.957	1.00
92_A	221_M	1.917	1.00
91_L	221_M	1.911	1.00
132_E	136_L	1.905	1.00
72_A	167_V	1.824	1.00
74_M	163_V	1.815	1.00
133_L	137_F	1.806	1.00
207_F	211_L	1.804	1.00
22_I	26_A	1.774	1.00
78_A	163_V	1.767	1.00
67_S	107_A	1.757	1.00
90_N	160_G	1.728	1.00
54_Y	58_Y	1.717	1.00
100_G	139_Y	1.697	1.00
93_V	163_V	1.679	1.00
70_I	96_M	1.678	1.00
127_A	182_T	1.674	1.00
14_L	18_C	1.672	1.00
81_G	90_N	1.606	0.99
107_A	132_E	1.588	0.99
63_A	106_I	1.582	0.99
39_W	43_F	1.567	0.99
172_I	179_W	1.565	0.99
38_I	43_F	1.520	0.99
167_V	170_L	1.520	0.99
93_V	142_V	1.517	0.99
36_G	205_S	1.478	0.99
97_A	142_V	1.439	0.99
35_V	38_I	1.424	0.98
16_Q	20_W	1.410	0.98
10_I	13_R	1.406	0.98
142_V	163_V	1.390	0.98
13_R	17_I	1.364	0.98
35_V	204_W	1.360	0.98
81_G	160_G	1.350	0.98
65_I	210_L	1.346	0.98
57_I	202_L	1.341	0.98
215_T	219_M	1.331	0.98
44_A	54_Y	1.322	0.97
195_D	199_R	1.315	0.97
146_W	159_A	1.301	0.97
189_R	199_R	1.289	0.97
196_P	200_S	1.287	0.97
104_T	132_E	1.274	0.97
85_Q	157_R	1.269	0.97
101_A	143_I	1.261	0.97
53_S	118_M	1.254	0.96
36_G	40_G	1.243	0.96
205_S	208_G	1.231	0.96
75_A	164_L	1.226	0.96
7_Q	10_I	1.216	0.96
34_T	37_W	1.213	0.96
108_L	136_L	1.212	0.96
94_A	146_W	1.211	0.96
82_L	164_L	1.169	0.95
168_V	172_I	1.152	0.94
7_Q	12_P	1.151	0.94
136_L	140_V	1.139	0.94
170_L	173_I	1.133	0.94
141_G	145_L	1.122	0.94
24_W	27_I	1.122	0.94
28_A	211_L	1.121	0.93
142_V	159_A	1.119	0.93
213_S	217_T	1.103	0.93
9_A	13_R	1.098	0.93
192_Q	199_R	1.097	0.93
200_S	204_W	1.083	0.92
206_I	210_L	1.079	0.92
12_P	16_Q	1.076	0.92
71_Y	100_G	1.063	0.92
138_L	163_V	1.062	0.92
66_W	210_L	1.056	0.91
73_S	92_A	1.051	0.91
15_Y	19_G	1.051	0.91
26_A	30_V	1.050	0.91
15_Y	18_C	1.048	0.91
137_F	141_G	1.047	0.91
25_L	211_L	1.045	0.91
73_S	96_M	1.041	0.91
107_A	112_S	1.037	0.91
17_I	20_W	1.035	0.90
108_L	133_L	1.033	0.90
26_A	29_S	1.032	0.90
58_Y	198_M	1.023	0.90
68_M	173_I	1.019	0.90
109_V	113_A	1.012	0.89
65_I	69_G	1.004	0.89
46_A	52_N	1.003	0.89
86_M	89_A	0.992	0.88
116_K	122_W	0.986	0.88
178_E	186_G	0.986	0.88
138_L	166_G	0.984	0.88
40_G	55_R	0.972	0.87
138_L	173_I	0.965	0.87
41_F	55_R	0.962	0.87
96_M	99_I	0.960	0.87
74_M	78_A	0.935	0.85
32_V	207_F	0.934	0.85
185_Q	188_T	0.931	0.85
95_A	220_R	0.927	0.85
132_E	174_H	0.927	0.85
27_I	31_V	0.925	0.85
69_G	210_L	0.924	0.85
96_M	216_L	0.909	0.84
175_Y	178_E	0.907	0.84
203_R	207_F	0.880	0.82
203_R	206_I	0.880	0.82
13_R	16_Q	0.879	0.82
62_P	120_G	0.878	0.82
5_L	12_P	0.870	0.81
20_W	23_P	0.868	0.81
197_A	201_P	0.867	0.81
11_P	18_C	0.861	0.80
124_V	127_A	0.859	0.80
209_F	212_L	0.845	0.79
22_I	29_S	0.844	0.79
178_E	187_S	0.840	0.79
125_W	130_T	0.840	0.79
52_N	55_R	0.833	0.78
186_G	195_D	0.831	0.78
199_R	202_L	0.826	0.77
32_V	211_L	0.820	0.77
214_A	217_T	0.819	0.77
92_A	200_S	0.816	0.77
103_F	213_S	0.807	0.76
76_V	80_I	0.807	0.76
55_R	59_L	0.806	0.76
10_I	14_L	0.805	0.76
49_Q	118_M	0.800	0.75
37_W	40_G	0.797	0.75
99_I	217_T	0.795	0.75
5_L	17_I	0.790	0.74
128_R	176_S	0.789	0.74
35_V	40_G	0.787	0.74
116_K	121_T	0.786	0.74
65_I	206_I	0.778	0.73
23_P	27_I	0.773	0.73
57_I	107_A	0.767	0.72
169_N	172_I	0.764	0.72
8_L	17_I	0.763	0.72
104_T	136_L	0.762	0.71
56_I	110_T	0.761	0.71
188_T	194_I	0.756	0.71
101_A	140_V	0.754	0.71
78_A	142_V	0.750	0.70
189_R	206_I	0.750	0.70
142_V	146_W	0.746	0.70
14_L	221_M	0.736	0.69
125_W	129_L	0.736	0.69
169_N	173_I	0.734	0.69
194_I	198_M	0.728	0.68
61_V	177_V	0.727	0.68
152_R	155_A	0.721	0.67
174_H	187_S	0.720	0.67
19_G	22_I	0.719	0.67
128_R	131_S	0.717	0.67
35_V	39_W	0.717	0.67
214_A	218_L	0.715	0.67
12_P	17_I	0.713	0.66
207_F	217_T	0.712	0.66
84_W	89_A	0.712	0.66
8_L	13_R	0.712	0.66
174_H	186_G	0.709	0.66
77_A	89_A	0.709	0.66
58_Y	97_A	0.707	0.66
12_P	15_Y	0.707	0.66
66_W	70_I	0.705	0.66
46_A	54_Y	0.703	0.65
79_F	168_V	0.703	0.65
95_A	195_D	0.700	0.65
78_A	164_L	0.700	0.65
75_A	138_L	0.699	0.65
81_G	146_W	0.696	0.65
145_L	155_A	0.695	0.64
37_W	42_G	0.694	0.64
205_S	212_L	0.691	0.64
73_S	213_S	0.688	0.64
34_T	38_I	0.686	0.63
173_I	176_S	0.685	0.63
181_N	187_S	0.684	0.63
158_A	162_L	0.682	0.63
52_N	118_M	0.675	0.62
5_L	8_L	0.675	0.62
34_T	207_F	0.674	0.62
61_V	183_L	0.671	0.62
190_M	193_S	0.670	0.62
33_L	212_L	0.670	0.62
18_C	22_I	0.667	0.61
176_S	181_N	0.665	0.61
40_G	44_A	0.659	0.60
61_V	128_R	0.656	0.60
5_L	43_F	0.654	0.60
65_I	189_R	0.648	0.59
33_L	37_W	0.647	0.59
29_S	212_L	0.645	0.59
216_L	220_R	0.645	0.59
196_P	199_R	0.644	0.59
162_L	166_G	0.642	0.58
62_P	128_R	0.637	0.58
10_I	15_Y	0.635	0.57
47_D	180_W	0.633	0.57
5_L	13_R	0.632	0.57
37_W	205_S	0.627	0.57
43_F	58_Y	0.625	0.56
82_L	160_G	0.625	0.56
18_C	21_F	0.620	0.56
57_I	61_V	0.619	0.56
187_S	190_M	0.614	0.55
121_T	129_L	0.614	0.55
170_L	174_H	0.612	0.55
20_W	29_S	0.612	0.55
75_A	79_F	0.609	0.54
68_M	132_E	0.607	0.54
209_F	213_S	0.605	0.54
125_W	133_L	0.605	0.54
101_A	105_F	0.604	0.54
115_G	129_L	0.600	0.53
217_T	220_R	0.599	0.53
61_V	202_L	0.599	0.53
34_T	41_F	0.599	0.53
88_M	221_M	0.599	0.53
63_A	209_F	0.598	0.53
145_L	162_L	0.598	0.53
68_M	186_G	0.596	0.53
93_V	159_A	0.596	0.53
5_L	18_C	0.596	0.53
191_Q	195_D	0.596	0.53
42_G	82_L	0.595	0.53
46_A	109_V	0.593	0.52
17_I	21_F	0.592	0.52
7_Q	11_P	0.591	0.52
67_S	70_I	0.591	0.52
198_M	201_P	0.590	0.52
130_T	139_Y	0.590	0.52
19_G	30_V	0.588	0.52
176_S	180_W	0.586	0.52
169_N	180_W	0.583	0.51
73_S	217_T	0.579	0.51
210_L	214_A	0.578	0.51
57_I	188_T	0.577	0.50
66_W	69_G	0.576	0.50
74_M	96_M	0.572	0.50
8_L	16_Q	0.571	0.50
135_L	173_I	0.567	0.49
7_Q	16_Q	0.566	0.49
143_I	147_H	0.559	0.48
82_L	161_I	0.558	0.48
139_Y	171_P	0.557	0.48
141_G	162_L	0.555	0.48
20_W	26_A	0.553	0.48
38_I	208_G	0.552	0.47
6_H	137_F	0.551	0.47
69_G	214_A	0.550	0.47
19_G	23_P	0.550	0.47
21_F	25_L	0.548	0.47
130_T	169_N	0.548	0.47
44_A	49_Q	0.547	0.47
138_L	169_N	0.547	0.47
20_W	27_I	0.543	0.46
217_T	221_M	0.542	0.46
126_D	203_R	0.540	0.46
66_W	153_R	0.537	0.46
128_R	135_L	0.535	0.45
7_Q	15_Y	0.534	0.45
5_L	22_I	0.532	0.45
80_I	89_A	0.530	0.45
210_L	213_S	0.528	0.45
106_I	147_H	0.526	0.44
208_G	212_L	0.523	0.44
19_G	26_A	0.521	0.44
81_G	153_R	0.519	0.43
153_R	215_T	0.519	0.43
122_W	219_M	0.519	0.43
7_Q	13_R	0.516	0.43
156_G	213_S	0.515	0.43
191_Q	212_L	0.514	0.43
5_L	9_A	0.513	0.43
204_W	209_F	0.513	0.43
15_Y	107_A	0.513	0.43
139_Y	182_T	0.510	0.42
146_W	156_G	0.510	0.42
16_Q	21_F	0.509	0.42
61_V	178_E	0.509	0.42
176_S	183_L	0.508	0.42
57_I	113_A	0.507	0.42
127_A	174_H	0.506	0.42
105_F	173_I	0.505	0.42
83_V	87_K	0.504	0.42
6_H	15_Y	0.504	0.42
123_W	130_T	0.504	0.42
151_D	154_L	0.504	0.42
133_L	214_A	0.503	0.42
62_P	188_T	0.503	0.42
57_I	193_S	0.502	0.41
134_V	151_D	0.500	0.41

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2cfqA	1	0.8449	24.8	0.955	Contact Map
4ev6A	3	0.302	18.2	0.958	Contact Map
4o6yA	2	0.8041	13.8	0.96	Contact Map
2kluA	1	0.2204	13.3	0.96	Contact Map
4tphA	2	0.7837	10.4	0.962	Contact Map
4i0uA	4	0.2898	10.2	0.962	Contact Map
4j05A	3	0.8041	7.7	0.964	Contact Map
4uvmA	1	0.8776	7.6	0.964	Contact Map
4pypA	1	0.7837	7.4	0.965	Contact Map
2k21A	1	0.3347	6.2	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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