GREMLIN Database
CCMB - Heme exporter protein B
UniProt: P0ABL8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12058
Length: 220 (212)
Sequences: 1130 (722)
Seq/√Len: 49.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_R12_R5.7371.00
7_F98_M4.9381.00
139_T200_L3.9641.00
146_P207_S3.6801.00
97_V145_A3.6471.00
55_W136_G3.4221.00
6_I95_A3.3501.00
127_Q131_L3.1601.00
7_F102_M3.0671.00
70_F145_A2.9941.00
31_V57_A2.8351.00
66_L144_G2.8131.00
89_L212_A2.7561.00
131_L134_L2.5041.00
132_T176_A2.3891.00
47_A119_L2.3181.00
94_L204_A2.2351.00
147_G165_V2.1991.00
52_G163_I2.1781.00
201_A205_T2.1661.00
128_V189_V2.1441.00
109_L130_A2.1211.00
93_V145_A2.0141.00
5_R10_E1.9861.00
7_F95_A1.9690.99
58_A137_T1.9190.99
72_D75_Q1.8790.99
55_W176_A1.8610.99
83_M89_L1.8320.99
62_S65_A1.7830.99
178_A192_Y1.7790.99
93_V215_L1.7720.99
35_F53_I1.7520.99
151_T154_L1.7070.98
138_P204_A1.6870.98
129_M180_M1.6580.98
144_G176_A1.6130.98
143_L169_T1.5850.97
54_I115_V1.5670.97
10_E18_S1.5660.97
59_L140_L1.5600.97
52_G177_T1.5530.97
6_I82_L1.5430.97
69_L100_H1.5230.97
24_P71_R1.5170.97
148_V176_A1.4830.96
125_G184_S1.4580.96
67_E156_R1.4180.95
175_F192_Y1.4140.95
141_G164_L1.4100.95
151_T197_G1.3650.94
18_S81_Q1.3410.93
12_R16_R1.3380.93
7_F11_L1.3210.93
136_G176_A1.3000.92
138_P200_L1.2830.92
30_I33_T1.2800.92
10_E67_E1.2730.92
45_L48_R1.2700.91
109_L134_L1.2660.91
147_G157_G1.2420.91
142_F204_A1.2380.90
97_V141_G1.2290.90
23_N31_V1.2020.89
164_L203_T1.1730.88
97_V142_F1.1680.88
47_A120_G1.1680.88
124_Y127_Q1.1660.87
98_M131_L1.1580.87
40_G45_L1.1530.87
70_F79_L1.1470.87
101_W137_T1.1420.86
105_G109_L1.1420.86
10_E96_K1.1250.86
54_I67_E1.1030.84
53_I164_L1.0990.84
52_G56_V1.0970.84
14_A103_V1.0900.84
109_L138_P1.0850.83
196_L205_T1.0610.82
199_L203_T1.0550.82
28_F58_A1.0350.80
93_V97_V1.0340.80
198_A206_L1.0330.80
94_L110_I1.0310.80
17_H20_E1.0250.80
211_T214_A1.0200.79
152_V156_R1.0160.79
62_S93_V1.0090.79
145_A211_T1.0080.79
161_L192_Y0.9960.78
95_A206_L0.9960.78
140_L173_L0.9900.77
113_P117_M0.9880.77
135_L197_G0.9860.77
25_L150_L0.9830.77
134_L138_P0.9820.77
39_I53_I0.9740.76
39_I49_I0.9680.76
84_L209_F0.9670.76
26_W120_G0.9660.76
25_L110_I0.9590.75
148_V161_L0.9580.75
7_F10_E0.9540.75
50_A119_L0.9480.74
10_E211_T0.9420.74
168_L191_G0.9300.73
151_T161_L0.9230.72
65_A169_T0.9200.72
139_T172_L0.9150.72
23_N37_L0.9090.71
110_I114_L0.9080.71
61_S196_L0.9060.71
30_I35_F0.9050.71
25_L173_L0.9050.71
50_A121_M0.8970.70
184_S187_L0.8970.70
32_I213_A0.8940.70
142_F203_T0.8920.70
20_E56_V0.8820.69
29_L200_L0.8780.68
72_D162_S0.8770.68
32_I119_L0.8730.68
25_L136_G0.8710.68
66_L115_V0.8700.68
58_A108_L0.8680.67
142_F159_V0.8670.67
97_V202_G0.8660.67
65_A86_P0.8660.67
67_E118_L0.8640.67
46_L101_W0.8640.67
20_E24_P0.8620.67
36_P46_L0.8590.67
62_S216_R0.8550.66
202_G206_L0.8520.66
80_E207_S0.8470.66
52_G155_K0.8470.66
110_I209_F0.8420.65
27_F148_V0.8390.65
67_E75_Q0.8370.65
136_G148_V0.8370.65
185_M189_V0.8360.65
7_F99_A0.8260.64
193_L198_A0.8260.64
83_M216_R0.8140.62
173_L208_P0.8120.62
127_Q130_A0.8120.62
11_L99_A0.8110.62
83_M199_L0.8070.62
37_L173_L0.8070.62
88_P216_R0.7960.61
36_P52_G0.7930.60
175_F208_P0.7840.60
92_V165_V0.7760.59
94_L178_A0.7750.59
115_V126_W0.7730.58
36_P208_P0.7730.58
72_D84_L0.7680.58
18_S82_L0.7670.58
28_F158_G0.7630.57
28_F36_P0.7630.57
35_F161_L0.7620.57
37_L111_L0.7600.57
114_L188_P0.7590.57
97_V211_T0.7560.57
99_A129_M0.7470.56
26_W71_R0.7460.56
96_K170_I0.7450.56
38_S180_M0.7450.56
19_A135_L0.7430.55
15_F22_A0.7390.55
142_F177_T0.7360.55
26_W31_V0.7350.55
62_S84_L0.7320.54
58_A157_G0.7310.54
38_S169_T0.7310.54
17_H61_S0.7280.54
30_I59_L0.7180.53
154_L162_S0.7170.53
106_L109_L0.7150.53
25_L109_L0.7130.52
119_L155_K0.7090.52
134_L190_D0.7060.52
61_S149_A0.7050.52
17_H74_L0.7030.51
31_V56_V0.7020.51
207_S214_A0.7000.51
28_F157_G0.6990.51
30_I34_L0.6980.51
10_E120_G0.6930.50
104_T156_R0.6910.50
26_W148_V0.6850.50
8_R92_V0.6830.49
107_P164_L0.6820.49
24_P207_S0.6820.49
5_R62_S0.6750.49
112_S131_L0.6710.48
119_L174_I0.6710.48
135_L200_L0.6690.48
191_G213_A0.6640.47
66_L100_H0.6630.47
140_L169_T0.6610.47
130_A199_L0.6580.47
11_L44_Q0.6570.47
53_I135_L0.6540.46
100_H141_G0.6500.46
15_F199_L0.6500.46
61_S137_T0.6490.46
11_L173_L0.6470.46
47_A216_R0.6460.46
139_T203_T0.6450.45
74_L152_V0.6450.45
88_P94_L0.6440.45
20_E31_V0.6440.45
51_P95_A0.6430.45
114_L126_W0.6380.45
79_L152_V0.6380.45
9_L69_L0.6370.45
195_I199_L0.6370.45
20_E80_E0.6310.44
63_L151_T0.6300.44
132_T183_A0.6290.44
181_D207_S0.6280.44
76_D159_V0.6270.44
159_V170_I0.6260.44
119_L181_D0.6230.43
43_P128_V0.6230.43
82_L92_V0.6220.43
174_I212_A0.6200.43
132_T179_A0.6170.43
97_V189_V0.6160.43
82_L146_P0.6160.43
73_D107_P0.6160.43
122_D142_F0.6160.43
62_S162_S0.6150.42
88_P168_L0.6150.42
202_G205_T0.6120.42
37_L119_L0.6090.42
143_L204_A0.6080.42
76_D156_R0.6060.42
53_I143_L0.6040.41
27_F31_V0.6020.41
39_I74_L0.6020.41
54_I57_A0.5980.41
190_D205_T0.5960.41
194_A198_A0.5940.40
68_R72_D0.5930.40
96_K161_L0.5930.40
95_A99_A0.5930.40
120_G126_W0.5850.39
35_F56_V0.5840.39
45_L49_I0.5830.39
140_L153_G0.5810.39
31_V79_L0.5770.39
43_P209_F0.5770.39
22_A195_I0.5770.39
112_S117_M0.5730.38
18_S75_Q0.5720.38
120_G130_A0.5710.38
53_I57_A0.5710.38
86_P89_L0.5710.38
41_P133_L0.5700.38
78_S82_L0.5690.38
26_W216_R0.5660.38
25_L163_I0.5660.38
187_L191_G0.5650.38
88_P134_L0.5620.37
23_N71_R0.5620.37
135_L157_G0.5610.37
13_V178_A0.5600.37
124_Y130_A0.5590.37
159_V164_L0.5590.37
161_L172_L0.5590.37
68_R71_R0.5590.37
70_F149_A0.5570.37
18_S119_L0.5530.36
56_V197_G0.5520.36
177_T198_A0.5520.36
15_F146_P0.5510.36
68_R172_L0.5500.36
110_I124_Y0.5490.36
35_F159_V0.5490.36
138_P201_A0.5490.36
27_F68_R0.5480.36
22_A160_L0.5480.36
83_M202_G0.5470.36
9_L100_H0.5470.36
46_L137_T0.5460.36
40_G68_R0.5420.35
48_R68_R0.5400.35
112_S130_A0.5390.35
114_L190_D0.5380.35
116_A157_G0.5370.35
158_G162_S0.5360.35
112_S133_L0.5350.35
183_A210_A0.5330.35
92_V188_P0.5320.34
110_I149_A0.5280.34
51_P159_V0.5270.34
94_L187_L0.5260.34
162_S209_F0.5250.34
62_S140_L0.5210.33
109_L122_D0.5200.33
63_L212_A0.5200.33
50_A122_D0.5200.33
10_E180_M0.5190.33
180_M184_S0.5180.33
105_G146_P0.5150.33
79_L140_L0.5130.33
128_V191_G0.5130.33
188_P191_G0.5130.33
85_L207_S0.5120.33
32_I38_S0.5100.32
39_I170_I0.5090.32
27_F62_S0.5090.32
94_L155_K0.5040.32
33_T118_L0.5030.32
131_L138_P0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.5864 13.8 0.947 Contact Map
3d31C 2 0.5773 6.6 0.955 Contact Map
2ksfA 1 0.4682 6.5 0.955 Contact Map
2p9xA 4 0.15 2.1 0.964 Contact Map
1pi7A 1 0.0318 1.6 0.967 Contact Map
3tuiA 2 0.4273 1.4 0.968 Contact Map
3pjzA 2 0.3273 1.4 0.968 Contact Map
3rlfG 1 0.5545 1.1 0.97 Contact Map
2zxeB 1 0.15 1.1 0.97 Contact Map
4ymuD 2 0.4682 1 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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