GREMLIN Database
NAPC - Cytochrome c-type protein NapC
UniProt: P0ABL5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12060
Length: 200 (171)
Sequences: 788 (484)
Seq/√Len: 37.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_E113_K5.7931.00
52_N92_V2.8361.00
143_N178_T2.7411.00
135_E142_N2.6071.00
127_H130_T2.4911.00
110_L114_I2.4351.00
95_E98_P2.3881.00
170_D174_K2.2310.99
111_Y115_F2.1270.99
34_F40_F2.1020.99
117_V127_H2.0780.99
24_L28_T2.0740.99
140_K181_D2.0700.99
39_V43_G1.9990.99
54_E86_T1.9970.99
127_H131_M1.9800.98
102_R109_E1.9780.98
169_H178_T1.9700.98
96_F100_M1.8760.98
21_P27_G1.8700.98
85_A89_D1.8700.98
48_M100_M1.8510.98
108_K112_G1.8320.97
40_F44_F1.8230.97
167_K170_D1.7940.97
75_V80_R1.6940.96
160_A169_H1.6710.96
51_A110_L1.6640.95
169_H173_V1.6610.95
30_L33_G1.6570.95
131_M134_N1.6250.95
21_P25_A1.5930.94
74_S187_A1.5470.93
137_R141_D1.5360.93
130_T134_N1.5330.93
112_G115_F1.5310.93
101_I104_L1.4160.90
132_A136_W1.3910.89
46_T50_K1.3790.88
22_S29_L1.3690.88
29_L33_G1.3540.87
142_N145_Q1.2980.85
67_V109_E1.2940.85
153_F172_A1.2850.84
105_K109_E1.2730.84
22_S27_G1.2700.84
58_I86_T1.2580.83
46_T96_F1.2530.83
66_T121_P1.2510.83
158_T169_H1.2440.82
57_C60_C1.2310.82
120_T123_K1.2140.81
31_L35_V1.2130.81
177_Q181_D1.1960.80
98_P145_Q1.1960.80
165_A168_M1.1840.79
51_A56_F1.1460.77
48_M88_P1.1240.76
163_S166_A1.1000.74
62_E109_E1.0980.74
119_D123_K1.0750.72
94_H99_K1.0720.72
168_M171_Q1.0700.72
129_L133_Q1.0470.70
25_A31_L1.0440.70
43_G47_G1.0390.70
124_F136_W1.0360.69
103_K188_H1.0290.69
85_A93_P1.0270.69
73_D77_Y1.0080.67
23_R32_I1.0080.67
107_S110_L0.9820.65
25_A32_I0.9810.65
61_H87_C0.9810.65
61_H183_H0.9810.65
61_H182_C0.9810.65
147_C151_H0.9810.65
61_H90_C0.9810.65
61_H91_H0.9810.65
90_C147_C0.9810.65
61_H147_C0.9810.65
147_C182_C0.9810.65
61_H151_H0.9810.65
61_H179_C0.9810.65
147_C183_H0.9810.65
147_C179_C0.9810.65
87_C182_C0.9810.65
91_H179_C0.9810.65
91_H147_C0.9810.65
90_C183_H0.9810.65
90_C182_C0.9810.65
91_H182_C0.9810.65
90_C179_C0.9810.65
90_C151_H0.9810.65
91_H151_H0.9810.65
87_C183_H0.9810.65
87_C179_C0.9810.65
87_C151_H0.9810.65
151_H183_H0.9810.65
87_C147_C0.9810.65
87_C91_H0.9810.65
87_C90_C0.9810.65
91_H183_H0.9810.65
179_C183_H0.9810.65
179_C182_C0.9810.65
151_H179_C0.9810.65
151_H182_C0.9810.65
76_H188_H0.9790.65
35_V97_V0.9730.64
112_G135_E0.9730.64
58_I63_M0.9660.64
144_S180_I0.9660.64
162_K165_A0.9620.64
44_F48_M0.9590.63
134_N137_R0.9560.63
45_N49_E0.9410.62
67_V124_F0.9380.62
124_F187_A0.9290.61
66_T74_S0.9280.61
166_A170_D0.9270.61
41_W44_F0.9130.59
104_L107_S0.9060.59
98_P142_N0.9060.59
121_P125_E0.9050.59
95_E175_D0.8800.57
76_H103_K0.8760.56
150_C179_C0.8680.56
150_C183_H0.8680.56
61_H150_C0.8680.56
90_C150_C0.8680.56
87_C150_C0.8680.56
147_C150_C0.8680.56
91_H150_C0.8680.56
150_C182_C0.8680.56
168_M172_A0.8570.55
63_M68_Y0.8560.54
44_F99_K0.8540.54
68_Y72_M0.8540.54
70_E124_F0.8390.53
79_N83_V0.8290.52
133_Q137_R0.8230.52
41_W46_T0.8230.52
157_D166_A0.8210.51
27_G31_L0.7970.49
118_I121_P0.7940.49
60_C183_H0.7850.48
57_C61_H0.7850.48
57_C91_H0.7850.48
60_C91_H0.7850.48
60_C90_C0.7850.48
57_C182_C0.7850.48
60_C87_C0.7850.48
57_C147_C0.7850.48
57_C151_H0.7850.48
57_C179_C0.7850.48
57_C183_H0.7850.48
60_C147_C0.7850.48
57_C90_C0.7850.48
60_C182_C0.7850.48
60_C179_C0.7850.48
60_C151_H0.7850.48
57_C87_C0.7850.48
84_R155_Y0.7830.48
33_G114_I0.7790.48
23_R30_L0.7780.48
127_H134_N0.7750.47
63_M67_V0.7690.47
161_Q169_H0.7650.46
165_A170_D0.7630.46
64_R175_D0.7630.46
153_F169_H0.7620.46
137_R140_K0.7510.45
41_W96_F0.7380.44
152_N160_A0.7310.44
123_K176_G0.7280.43
45_N99_K0.7180.42
79_N82_G0.7150.42
156_M161_Q0.7150.42
54_E71_Y0.7100.42
160_A173_V0.7060.41
158_T170_D0.7060.41
48_M56_F0.7000.41
153_F158_T0.6970.41
58_I68_Y0.6940.40
140_K143_N0.6910.40
23_R28_T0.6810.39
42_G96_F0.6800.39
97_V141_D0.6720.38
60_C150_C0.6710.38
57_C150_C0.6710.38
85_A188_H0.6610.38
27_G193_M0.6550.37
78_N84_R0.6540.37
96_F110_L0.6540.37
37_G93_P0.6510.37
163_S168_M0.6490.37
70_E128_R0.6440.36
21_P33_G0.6420.36
74_S186_I0.6410.36
36_G40_F0.6320.35
109_E146_E0.6250.35
164_V173_V0.6150.34
108_K127_H0.6030.33
64_R133_Q0.6030.33
144_S148_R0.6030.33
41_W45_N0.6000.33
62_E66_T0.5990.33
89_D93_P0.5970.32
148_R178_T0.5960.32
124_F131_M0.5890.32
89_D181_D0.5870.32
144_S187_A0.5860.32
107_S111_Y0.5810.31
83_V180_I0.5750.31
137_R152_N0.5700.30
67_V71_Y0.5690.30
97_V100_M0.5650.30
30_L104_L0.5630.30
75_V174_K0.5610.30
22_S25_A0.5600.30
56_F188_H0.5590.30
25_A29_L0.5590.30
50_K190_L0.5590.30
35_V160_A0.5560.29
24_L31_L0.5520.29
96_F99_K0.5460.29
100_M109_E0.5460.29
110_L115_F0.5450.29
21_P29_L0.5400.28
176_G187_A0.5400.28
137_R162_K0.5380.28
40_F114_I0.5370.28
50_K130_T0.5330.28
51_A103_K0.5290.27
21_P28_T0.5280.27
153_F181_D0.5280.27
80_R162_K0.5270.27
125_E128_R0.5240.27
67_V113_K0.5230.27
68_Y71_Y0.5220.27
26_L31_L0.5210.27
64_R113_K0.5190.27
32_I114_I0.5190.27
164_V168_M0.5190.27
111_Y173_V0.5150.26
129_L193_M0.5080.26
108_K117_V0.5080.26
21_P45_N0.5050.26
32_I167_K0.5040.26
82_G188_H0.5040.26
52_N88_P0.5030.26
37_G181_D0.5020.26
64_R110_L0.5020.26
148_R180_I0.5010.25
54_E88_P0.5000.25
162_K174_K0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j7aC 2 0.705 100 0.512 Contact Map
4fasA 3 0.78 99.7 0.68 Contact Map
4lm8A 1 0.88 99.3 0.741 Contact Map
1sp3A 1 0.775 99.3 0.743 Contact Map
3ucpA 1 0.91 99.2 0.762 Contact Map
2ozyA 1 0.58 99.2 0.763 Contact Map
1oahA 2 0.835 99.1 0.772 Contact Map
4n4jA 3 0.905 99 0.779 Contact Map
2j7aA 5 0.895 99 0.781 Contact Map
1y0pA 1 0.44 98.3 0.824 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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