GREMLIN Database
NRFB - Cytochrome c-type protein NrfB
UniProt: P0ABL1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11945
Length: 188 (151)
Sequences: 390 (298)
Seq/√Len: 24.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_T84_Q2.6290.99
128_P131_V1.7570.89
119_P122_L1.7460.89
120_E130_D1.5370.82
119_P129_H1.4770.79
79_T83_G1.4590.78
125_A131_V1.4360.77
119_P131_V1.3320.72
119_P130_D1.3030.70
119_P126_F1.3010.70
120_E125_A1.3000.70
79_T88_Q1.2940.69
126_F129_H1.2880.69
127_W132_H1.2750.68
120_E131_V1.2640.67
60_M65_A1.2270.65
158_G162_I1.2120.64
119_P128_P1.2090.64
81_C113_C1.2030.64
116_C163_C1.2030.64
116_C167_H1.2030.64
117_H138_C1.2030.64
117_H141_C1.2030.64
117_H142_H1.2030.64
53_H142_H1.2030.64
53_H163_C1.2030.64
53_H166_C1.2030.64
53_H167_H1.2030.64
82_H163_C1.2030.64
117_H167_H1.2030.64
117_H163_C1.2030.64
117_H166_C1.2030.64
81_C116_C1.2030.64
81_C117_H1.2030.64
116_C166_C1.2030.64
116_C142_H1.2030.64
116_C141_C1.2030.64
116_C138_C1.2030.64
113_C167_H1.2030.64
113_C166_C1.2030.64
113_C163_C1.2030.64
113_C142_H1.2030.64
113_C141_C1.2030.64
113_C138_C1.2030.64
113_C117_H1.2030.64
82_H167_H1.2030.64
82_H166_C1.2030.64
82_H142_H1.2030.64
81_C138_C1.2030.64
81_C141_C1.2030.64
81_C142_H1.2030.64
81_C163_C1.2030.64
81_C166_C1.2030.64
81_C167_H1.2030.64
82_H113_C1.2030.64
82_H116_C1.2030.64
82_H117_H1.2030.64
82_H138_C1.2030.64
82_H141_C1.2030.64
113_C116_C1.2030.64
53_H141_C1.2030.64
163_C167_H1.2030.64
49_C82_H1.2030.64
49_C113_C1.2030.64
49_C117_H1.2030.64
49_C138_C1.2030.64
49_C141_C1.2030.64
49_C142_H1.2030.64
49_C163_C1.2030.64
49_C166_C1.2030.64
49_C167_H1.2030.64
142_H163_C1.2030.64
52_C81_C1.2030.64
49_C81_C1.2030.64
49_C53_H1.2030.64
49_C52_C1.2030.64
163_C166_C1.2030.64
142_H167_H1.2030.64
142_H166_C1.2030.64
141_C167_H1.2030.64
141_C166_C1.2030.64
141_C163_C1.2030.64
138_C167_H1.2030.64
138_C166_C1.2030.64
138_C163_C1.2030.64
138_C142_H1.2030.64
138_C141_C1.2030.64
49_C116_C1.2030.64
52_C113_C1.2030.64
52_C141_C1.2030.64
52_C117_H1.2030.64
52_C116_C1.2030.64
52_C142_H1.2030.64
53_H81_C1.2030.64
53_H82_H1.2030.64
52_C82_H1.2030.64
52_C163_C1.2030.64
52_C138_C1.2030.64
53_H138_C1.2030.64
53_H117_H1.2030.64
53_H116_C1.2030.64
53_H113_C1.2030.64
52_C167_H1.2030.64
52_C166_C1.2030.64
54_K57_T1.1940.63
119_P123_Q1.1600.61
127_W130_D1.1580.61
173_N178_P1.1560.60
125_A129_H1.1510.60
79_T85_P1.1440.60
119_P124_K1.1270.58
126_F131_V1.1240.58
119_P125_A1.1060.57
78_C81_C1.0630.54
53_H78_C1.0630.54
78_C166_C1.0630.54
78_C163_C1.0630.54
78_C141_C1.0630.54
78_C138_C1.0630.54
78_C116_C1.0630.54
78_C113_C1.0630.54
78_C167_H1.0630.54
52_C78_C1.0630.54
78_C82_H1.0630.54
78_C117_H1.0630.54
49_C78_C1.0630.54
78_C142_H1.0630.54
103_M108_E1.0410.52
120_E129_H1.0400.52
143_S150_T1.0230.51
139_A169_D1.0160.51
124_K129_H1.0130.50
121_Q128_P1.0130.50
176_F180_S1.0130.50
177_N180_S1.0070.50
121_Q124_K0.9960.49
125_A128_P0.9920.49
123_Q132_H0.9780.48
85_P89_H0.9640.47
122_L125_A0.9640.47
83_G88_Q0.9540.46
35_D42_Q0.9540.46
120_E128_P0.9330.45
112_V179_A0.9310.45
109_Q137_A0.9260.44
173_N176_F0.9120.43
35_D41_Q0.9090.43
35_D115_S0.8950.42
42_Q48_A0.8850.41
92_G99_F0.8590.40
121_Q125_A0.8580.39
110_N127_W0.8490.39
89_H92_G0.8460.39
62_G65_A0.8330.38
93_V98_R0.8300.38
105_K108_E0.8300.38
96_V99_F0.8220.37
164_V168_S0.8210.37
33_S108_E0.8100.36
34_D43_R0.8100.36
137_A140_S0.8020.36
120_E123_Q0.7990.36
122_L130_D0.7960.35
174_P179_A0.7870.35
120_E126_F0.7770.34
122_L127_W0.7560.33
121_Q131_V0.7390.32
171_R179_A0.7370.32
121_Q130_D0.7060.30
95_D112_V0.7030.30
121_Q126_F0.6970.29
55_P74_L0.6800.28
176_F179_A0.6780.28
70_P93_V0.6770.28
28_P31_Q0.6730.28
122_L129_H0.6650.27
172_T179_A0.6610.27
32_A84_Q0.6610.27
94_K176_F0.6550.27
164_V169_D0.6550.27
123_Q128_P0.6540.27
48_A140_S0.6530.27
98_R101_E0.6500.26
119_P132_H0.6500.26
32_A77_T0.6430.26
68_I164_V0.6400.26
175_N178_P0.6330.26
124_K130_D0.6260.25
123_Q130_D0.6220.25
86_S90_R0.6210.25
76_V145_H0.6160.25
162_I168_S0.6090.24
86_S97_M0.6060.24
122_L128_P0.6060.24
80_N84_Q0.6030.24
64_H93_V0.6000.24
55_P59_G0.5980.24
126_F130_D0.5960.24
104_Y169_D0.5800.23
72_N172_T0.5770.23
96_V100_N0.5760.23
32_A40_T0.5720.22
61_H80_N0.5660.22
84_Q88_Q0.5650.22
80_N88_Q0.5620.22
62_G66_S0.5580.22
168_S179_A0.5550.22
136_V145_H0.5540.21
103_M134_T0.5530.21
83_G145_H0.5500.21
134_T143_S0.5490.21
175_N179_A0.5450.21
43_R74_L0.5410.21
70_P95_D0.5390.21
87_P93_V0.5390.21
80_N91_E0.5380.21
100_N133_V0.5310.20
45_P79_T0.5290.20
97_M100_N0.5290.20
95_D104_Y0.5290.20
88_Q136_V0.5240.20
35_D48_A0.5200.20
73_K84_Q0.5180.20
85_P174_P0.5180.20
83_G136_V0.5010.19
47_A109_Q0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ozyA 1 0.75 99.8 0.483 Contact Map
3fo3A 4 0.9894 99.4 0.629 Contact Map
3bnjA 2 0.9787 99.4 0.63 Contact Map
2j7aA 5 0.9734 99.3 0.643 Contact Map
3ubrA 2 0.9947 99.3 0.643 Contact Map
1oahA 2 0.9947 99.3 0.649 Contact Map
2rdzA 4 0.9787 99.2 0.652 Contact Map
4lm8A 1 0.9043 99.2 0.658 Contact Map
1z1nX 1 0.7766 99.1 0.671 Contact Map
1qo8A 2 0.5266 99.1 0.672 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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