GREMLIN Database
NRFA - Cytochrome c-552
UniProt: P0ABK9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11781
Length: 478 (404)
Sequences: 410 (278)
Seq/√Len: 13.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_D104_T6.0081.00
162_D182_R5.2241.00
343_V405_A4.9951.00
405_A409_A4.9621.00
231_D244_K4.8591.00
355_K359_D4.8341.00
250_W259_M4.7531.00
220_G223_K4.6451.00
83_P118_L4.5211.00
215_E263_Q4.0791.00
215_E249_D4.0471.00
238_M383_L3.9501.00
249_D263_Q3.5390.99
370_I419_L3.3920.99
121_A225_V3.2890.98
74_R345_D3.2730.98
191_A230_D3.1200.98
339_L403_G2.9550.97
234_K237_N2.7220.95
289_K297_L2.5880.93
206_S281_T2.5730.93
397_E400_R2.5260.93
127_S130_V2.4920.92
18_F24_V2.4580.91
239_E380_R2.3760.90
373_D411_D2.3690.90
272_A394_A2.2850.88
18_F25_H2.2790.88
366_E423_K2.2690.88
262_A379_W2.2670.88
18_F21_F2.2570.87
351_H374_I2.2550.87
376_H408_K2.1530.85
84_F263_Q2.1450.85
84_F215_E2.1420.84
235_V401_M2.1160.84
185_A189_M2.1100.83
189_M207_M2.1040.83
84_F88_Y2.1020.83
55_S298_Y2.0930.83
21_F24_V2.0690.82
137_D150_G2.0580.82
82_Y249_D2.0540.82
42_N159_G1.9940.80
358_L371_Q1.9650.79
248_S251_T1.9520.78
106_R249_D1.9370.78
217_Y241_Y1.9350.78
106_R263_Q1.9030.76
165_N168_S1.8940.76
367_M371_Q1.8740.75
365_A368_K1.8570.75
231_D240_Q1.8440.74
79_W119_P1.8400.74
254_L355_K1.8120.73
59_T303_I1.7770.71
202_F293_A1.7600.70
214_V229_W1.7530.70
270_W280_V1.7520.70
106_R215_E1.6970.67
39_E44_T1.6830.67
353_E416_L1.6820.67
217_Y382_D1.6480.65
350_A412_A1.6220.64
165_N179_T1.6200.64
82_Y215_E1.6150.64
290_V300_D1.5920.62
333_K391_H1.5890.62
293_A297_L1.5800.62
372_D376_H1.5800.62
261_K382_D1.5680.61
185_A207_M1.5490.60
353_E413_R1.5420.60
69_L76_V1.5400.60
369_P415_K1.5010.58
334_Q338_D1.4700.56
352_F355_K1.4640.56
274_I328_V1.4520.55
373_D408_K1.4410.54
145_G149_R1.4200.53
304_G308_D1.4160.53
273_G276_G1.4110.53
343_V406_M1.4070.53
13_S25_H1.4010.52
189_M199_A1.3940.52
84_F386_A1.3810.51
344_E380_R1.3690.51
235_V380_R1.3640.50
279_N392_M1.3580.50
388_H391_H1.3470.49
195_P198_K1.3360.49
21_F25_H1.3270.48
16_I19_F1.3250.48
309_N312_Q1.3220.48
106_R261_K1.3220.48
217_Y247_F1.3130.48
182_R188_A1.3100.47
239_E379_W1.3090.47
361_G364_E1.3060.47
368_K372_D1.3050.47
215_E261_K1.3030.47
356_A360_A1.2990.47
204_Q208_V1.2960.47
79_W386_A1.2810.46
17_P20_F1.2770.46
387_S391_H1.2700.45
252_N261_K1.2700.45
239_E243_D1.2690.45
84_F249_D1.2540.44
237_N240_Q1.2530.44
266_E388_H1.2520.44
266_E387_S1.2490.44
13_S16_I1.2410.44
350_A362_A1.2370.44
407_D411_D1.2360.43
169_P289_K1.2320.43
43_E57_K1.2250.43
240_Q244_K1.2160.42
116_G148_A1.2150.42
12_F21_F1.2090.42
44_T47_P1.2080.42
206_S210_G1.2050.42
202_F210_G1.2040.42
199_A207_M1.2030.42
118_L266_E1.2010.42
189_M210_G1.2010.42
67_D70_A1.1990.42
218_F241_Y1.1950.41
101_V147_W1.1910.41
82_Y263_Q1.1890.41
123_W151_G1.1870.41
66_V200_G1.1780.40
58_A302_K1.1680.40
218_F382_D1.1650.40
166_T341_I1.1610.40
376_H404_T1.1570.39
92_R275_H1.1550.39
49_H297_L1.1520.39
86_R117_P1.1510.39
45_F48_Q1.1510.39
194_K267_Y1.1490.39
202_F297_L1.1490.39
45_F50_P1.1430.39
378_Q382_D1.1380.38
18_F23_S1.1350.38
260_L379_W1.1330.38
255_S351_H1.1220.38
346_Q406_M1.1080.37
218_F261_K1.1070.37
121_A224_A1.1030.37
196_F204_Q1.1020.37
274_I278_N1.1020.37
89_N104_T1.0970.36
22_T26_A1.0930.36
253_S257_T1.0920.36
256_K358_L1.0920.36
189_M196_F1.0820.36
260_L378_Q1.0790.35
210_G270_W1.0750.35
273_G394_A1.0750.35
83_P248_S1.0740.35
15_L18_F1.0730.35
146_K149_R1.0600.34
28_Q31_A1.0600.34
97_A255_S1.0570.34
21_F55_S1.0570.34
255_S374_I1.0560.34
194_K207_M1.0550.34
373_D415_K1.0550.34
56_W300_D1.0540.34
35_P49_H1.0530.34
329_V407_D1.0470.34
306_P329_V1.0440.34
383_L401_M1.0420.34
23_S26_A1.0410.34
82_Y106_R1.0390.33
101_V158_L1.0350.33
202_F205_Q1.0290.33
289_K293_A1.0260.33
28_Q356_A1.0240.33
12_F18_F1.0220.33
357_A361_G1.0210.33
218_F263_Q1.0190.33
252_N279_N1.0190.33
371_Q419_L1.0180.32
363_T366_E1.0170.32
277_K324_A1.0160.32
231_D274_I1.0150.32
270_W370_I1.0140.32
109_A117_P1.0130.32
140_D144_H1.0110.32
299_T303_I1.0030.32
117_P148_A1.0020.32
332_R391_H0.9970.31
75_L99_T0.9900.31
192_I196_F0.9870.31
281_T327_K0.9850.31
58_A144_H0.9840.31
68_A389_G0.9830.31
375_R382_D0.9750.30
58_A61_E0.9740.30
419_L423_K0.9730.30
214_V227_F0.9720.30
53_Y93_G0.9720.30
281_T319_T0.9670.30
30_A49_H0.9630.30
343_V347_L0.9620.30
243_D353_E0.9610.30
156_N159_G0.9530.29
350_A357_A0.9520.29
238_M267_Y0.9440.29
375_R378_Q0.9420.29
236_E400_R0.9370.29
248_S266_E0.9340.29
86_R116_G0.9340.29
59_T93_G0.9290.28
178_L412_A0.9270.28
239_E397_E0.9250.28
350_A416_L0.9220.28
396_E399_L0.9160.28
274_I332_R0.9120.28
55_S300_D0.9120.28
269_T398_G0.9110.28
192_I197_E0.9090.28
206_S270_W0.9080.27
223_K226_K0.9040.27
373_D412_A0.9000.27
129_D156_N0.8970.27
200_G322_K0.8960.27
290_V298_Y0.8900.27
269_T397_E0.8890.27
97_A161_A0.8880.27
255_S379_W0.8840.26
17_P22_T0.8800.26
192_I195_P0.8780.26
328_V332_R0.8770.26
305_N333_K0.8770.26
350_A353_E0.8760.26
217_Y378_Q0.8760.26
93_G232_G0.8700.26
14_L368_K0.8670.26
234_K397_E0.8650.26
16_I20_F0.8630.26
255_S378_Q0.8610.26
13_S18_F0.8560.25
106_R381_W0.8550.25
51_D292_N0.8540.25
260_L375_R0.8500.25
261_K378_Q0.8440.25
283_I299_T0.8440.25
83_P266_E0.8430.25
63_S334_Q0.8410.25
17_P21_F0.8410.25
255_S389_G0.8400.25
257_T412_A0.8400.25
92_R100_D0.8360.25
13_S21_F0.8330.24
169_P205_Q0.8320.24
189_M192_I0.8290.24
206_S237_N0.8260.24
390_I398_G0.8250.24
68_A388_H0.8240.24
249_D261_K0.8230.24
54_L152_P0.8210.24
37_T167_A0.8210.24
315_A325_L0.8200.24
358_L367_M0.8200.24
13_S17_P0.8190.24
307_F325_L0.8190.24
77_I352_F0.8190.24
205_Q283_I0.8180.24
74_R341_I0.8180.24
18_F55_S0.8180.24
18_F22_T0.8180.24
369_P372_D0.8180.24
137_D145_G0.8150.24
96_F121_A0.8140.24
205_Q289_K0.8120.24
373_D376_H0.8120.24
186_A189_M0.8100.23
295_G298_Y0.8090.23
233_M271_T0.8080.23
13_S23_S0.8010.23
340_K385_I0.7980.23
217_Y261_K0.7980.23
20_F26_A0.7960.23
169_P392_M0.7950.23
369_P373_D0.7950.23
346_Q410_A0.7930.23
354_A358_L0.7920.23
14_L25_H0.7920.23
270_W276_G0.7910.23
168_S204_Q0.7910.23
202_F289_K0.7880.23
250_W266_E0.7880.23
402_L405_A0.7850.23
46_A297_L0.7840.22
12_F19_F0.7830.22
218_F378_Q0.7830.22
119_P273_G0.7820.22
300_D309_N0.7820.22
75_L426_T0.7800.22
143_F224_A0.7780.22
44_T331_E0.7770.22
220_G244_K0.7760.22
217_Y375_R0.7760.22
12_F28_Q0.7710.22
127_S272_A0.7700.22
35_P281_T0.7690.22
119_P263_Q0.7680.22
397_E401_M0.7650.22
136_K386_A0.7630.22
97_A381_W0.7630.22
129_D151_G0.7620.22
79_W382_D0.7610.22
315_A322_K0.7610.22
273_G306_P0.7590.22
128_P161_A0.7590.22
88_Y418_R0.7560.21
159_G395_P0.7550.21
15_L21_F0.7540.21
256_K351_H0.7520.21
203_D208_V0.7510.21
272_A383_L0.7500.21
15_L29_T0.7490.21
100_D275_H0.7450.21
12_F16_I0.7450.21
180_L189_M0.7450.21
75_L345_D0.7450.21
169_P297_L0.7430.21
156_N298_Y0.7410.21
202_F319_T0.7400.21
77_I254_L0.7390.21
196_F200_G0.7370.21
95_A158_L0.7360.21
131_A220_G0.7360.21
106_R242_Y0.7350.21
83_P277_K0.7350.21
235_V272_A0.7300.21
35_P46_A0.7270.20
16_I30_A0.7270.20
38_V49_H0.7250.20
12_F22_T0.7240.20
12_F15_L0.7240.20
257_T371_Q0.7220.20
351_H412_A0.7190.20
120_M146_K0.7180.20
241_Y261_K0.7160.20
243_D375_R0.7120.20
191_A421_A0.7080.20
336_I406_M0.7070.20
135_Q198_K0.7050.20
274_I409_A0.7030.20
14_L18_F0.7020.20
139_E143_F0.7020.20
203_D293_A0.6990.19
28_Q365_A0.6990.19
186_A266_E0.6990.19
20_F24_V0.6990.19
149_R421_A0.6980.19
269_T384_A0.6950.19
214_V348_V0.6950.19
18_F30_A0.6930.19
99_T124_S0.6910.19
267_Y299_T0.6910.19
52_Q374_I0.6890.19
17_P24_V0.6880.19
323_A368_K0.6870.19
200_G297_L0.6870.19
219_D226_K0.6860.19
47_P54_L0.6810.19
143_F225_V0.6810.19
339_L406_M0.6780.19
354_A367_M0.6780.19
55_S271_T0.6760.19
16_I22_T0.6750.19
196_F199_A0.6730.19
47_P326_Q0.6730.19
215_E382_D0.6720.19
200_G289_K0.6720.19
14_L27_E0.6700.19
80_A254_L0.6670.18
169_P293_A0.6670.18
84_F261_K0.6650.18
83_P89_N0.6630.18
241_Y382_D0.6620.18
247_F261_K0.6600.18
258_P375_R0.6590.18
68_A90_K0.6570.18
364_E383_L0.6560.18
126_K178_L0.6540.18
250_W386_A0.6540.18
299_T411_D0.6540.18
133_L231_D0.6530.18
281_T372_D0.6510.18
161_A267_Y0.6510.18
43_E46_A0.6480.18
50_P309_N0.6470.18
80_A253_S0.6460.18
99_T103_E0.6460.18
281_T297_L0.6460.18
65_R103_E0.6450.18
60_S407_D0.6420.18
208_V299_T0.6420.18
70_A236_E0.6420.18
78_L347_L0.6400.18
81_G307_F0.6370.17
217_Y242_Y0.6370.17
59_T300_D0.6350.17
13_S19_F0.6320.17
346_Q409_A0.6310.17
342_K407_D0.6300.17
88_Y91_P0.6300.17
117_P256_K0.6280.17
234_K419_L0.6280.17
357_A377_A0.6260.17
123_W367_M0.6250.17
221_K365_A0.6240.17
199_A204_Q0.6240.17
15_L25_H0.6230.17
12_F20_F0.6210.17
23_S32_P0.6190.17
86_R109_A0.6180.17
207_M267_Y0.6170.17
339_L343_V0.6160.17
83_P101_V0.6160.17
252_N382_D0.6150.17
298_Y330_A0.6150.17
55_S290_V0.6140.17
276_G351_H0.6100.17
270_W274_I0.6090.17
425_I429_I0.6080.17
104_T211_Q0.6070.17
205_Q208_V0.6070.17
274_I430_Q0.6060.17
84_F106_R0.6060.17
49_H205_Q0.6030.16
74_R348_V0.6020.16
274_I403_G0.6010.16
339_L402_L0.6010.16
77_I85_S0.5990.16
182_R420_L0.5980.16
421_A426_T0.5980.16
249_D273_G0.5960.16
94_H264_H0.5950.16
297_L392_M0.5950.16
19_F27_E0.5940.16
37_T135_Q0.5920.16
13_S29_T0.5870.16
202_F299_T0.5860.16
106_R382_D0.5850.16
247_F382_D0.5850.16
184_Y227_F0.5850.16
165_N386_A0.5850.16
330_A334_Q0.5850.16
293_A296_K0.5820.16
55_S310_F0.5820.16
322_K326_Q0.5810.16
45_F276_G0.5800.16
232_G375_R0.5790.16
222_N415_K0.5790.16
221_K323_A0.5780.16
102_R151_G0.5760.16
328_V391_H0.5750.16
47_P133_L0.5750.16
263_Q382_D0.5750.16
169_P307_F0.5750.16
51_D296_K0.5750.16
119_P215_E0.5740.16
42_N46_A0.5740.16
78_L344_E0.5730.16
134_I290_V0.5730.16
384_A401_M0.5720.16
281_T398_G0.5710.15
336_I343_V0.5700.15
252_N351_H0.5680.15
136_K235_V0.5680.15
54_L315_A0.5670.15
302_K394_A0.5660.15
90_K391_H0.5660.15
248_S258_P0.5640.15
153_E412_A0.5630.15
60_S281_T0.5620.15
79_W118_L0.5600.15
336_I399_L0.5600.15
307_F329_V0.5600.15
247_F327_K0.5600.15
25_H29_T0.5590.15
298_Y377_A0.5580.15
80_A397_E0.5580.15
130_V183_P0.5570.15
354_A416_L0.5570.15
346_Q413_R0.5560.15
16_I26_A0.5550.15
242_Y261_K0.5550.15
347_L409_A0.5530.15
136_K197_E0.5530.15
284_D306_P0.5530.15
165_N253_S0.5530.15
210_G313_T0.5530.15
80_A130_V0.5520.15
210_G279_N0.5510.15
207_M246_A0.5510.15
380_R397_E0.5500.15
72_D345_D0.5500.15
16_I31_A0.5500.15
121_A184_Y0.5500.15
351_H354_A0.5490.15
235_V303_I0.5480.15
283_I414_T0.5470.15
186_A379_W0.5470.15
35_P38_V0.5460.15
34_K244_K0.5450.15
22_T34_K0.5440.15
27_E31_A0.5410.15
86_R247_F0.5390.15
120_M145_G0.5370.15
126_K147_W0.5370.15
168_S289_K0.5370.15
187_R196_F0.5370.15
141_G411_D0.5370.15
291_Q297_L0.5350.15
24_V28_Q0.5340.14
13_S26_A0.5340.14
297_L316_N0.5340.14
97_A101_V0.5330.14
104_T137_D0.5320.14
420_L424_G0.5320.14
77_I380_R0.5310.14
20_F23_S0.5310.14
355_K368_K0.5260.14
157_N262_A0.5250.14
178_L350_A0.5250.14
418_R421_A0.5230.14
309_N324_A0.5220.14
130_V155_V0.5210.14
83_P124_S0.5210.14
166_T392_M0.5210.14
354_A381_W0.5190.14
116_G146_K0.5190.14
12_F24_V0.5180.14
127_S131_A0.5160.14
310_F326_Q0.5160.14
249_D260_L0.5150.14
206_S234_K0.5140.14
46_A202_F0.5140.14
49_H405_A0.5140.14
134_I143_F0.5140.14
262_A382_D0.5100.14
61_E390_I0.5090.14
50_P162_D0.5080.14
52_Q328_V0.5080.14
253_S273_G0.5070.14
82_Y382_D0.5060.14
12_F23_S0.5060.14
204_Q333_K0.5030.14
68_A346_Q0.5030.14
121_A134_I0.5030.14
98_V398_G0.5020.14
120_M142_Y0.5020.14
13_S20_F0.5010.14
416_L419_L0.5000.14
274_I313_T0.5000.14
122_C314_C0.5000.14
122_C317_C0.5000.14
122_C318_H0.5000.14
125_C160_C0.5000.14
125_C164_H0.5000.14
301_H318_H0.5000.14
125_C163_C0.5000.14
301_H314_C0.5000.14
301_H317_C0.5000.14
314_C318_H0.5000.14
122_C209_C0.5000.14
164_H301_H0.5000.14
122_C164_H0.5000.14
122_C163_C0.5000.14
122_C212_C0.5000.14
122_C282_C0.5000.14
122_C285_C0.5000.14
122_C286_H0.5000.14
122_C301_H0.5000.14
122_C160_C0.5000.14
122_C125_C0.5000.14
314_C317_C0.5000.14
125_C209_C0.5000.14
125_C212_C0.5000.14
212_C318_H0.5000.14
164_H212_C0.5000.14
164_H209_C0.5000.14
163_C318_H0.5000.14
163_C317_C0.5000.14
163_C314_C0.5000.14
163_C301_H0.5000.14
163_C286_H0.5000.14
163_C285_C0.5000.14
163_C282_C0.5000.14
163_C212_C0.5000.14
163_C209_C0.5000.14
164_H317_C0.5000.14
160_C318_H0.5000.14
160_C317_C0.5000.14
160_C314_C0.5000.14
160_C301_H0.5000.14
160_C286_H0.5000.14
164_H282_C0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bnjA 2 0.9205 100 0.279 Contact Map
2rdzA 4 0.9059 100 0.313 Contact Map
3ubrA 2 0.9121 100 0.317 Contact Map
1oahA 2 0.8975 100 0.394 Contact Map
2j7aA 5 0.9247 100 0.412 Contact Map
3fo3A 4 0.8661 100 0.434 Contact Map
4n4jA 3 0.8264 100 0.736 Contact Map
4rknA 4 0.7699 100 0.737 Contact Map
1ft5A 1 0.4331 100 0.835 Contact Map
4fasA 3 0.7741 99.9 0.884 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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