GREMLIN Database
CYSK - Cysteine synthase A
UniProt: P0ABK5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10192
Length: 323 (284)
Sequences: 21327 (11067)
Seq/√Len: 656.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_A88_L4.0261.00
27_R294_N3.4591.00
126_K129_E3.3151.00
19_R27_R3.1001.00
254_E283_K2.6981.00
161_I296_V2.5991.00
98_I102_K2.5931.00
261_R265_E2.5891.00
91_T130_I2.5871.00
171_V201_V2.4841.00
52_D56_R2.4741.00
87_K110_N2.4701.00
134_N138_Y2.4701.00
14_H163_E2.4161.00
64_E89_T2.4021.00
206_T251_T2.3761.00
199_I246_K2.3231.00
54_E86_Y2.3151.00
129_E133_S2.3121.00
52_D148_A2.2611.00
94_E115_E2.2591.00
89_T110_N2.1921.00
290_F293_K2.1061.00
14_H164_D2.0721.00
51_W84_R2.0601.00
277_A297_V2.0461.00
186_S243_L2.0311.00
29_L294_N2.0201.00
207_D252_N1.9541.00
251_T254_E1.9491.00
89_T112_V1.9441.00
145_S237_A1.9351.00
159_P188_Y1.9351.00
193_K198_L1.9291.00
154_E191_G1.9161.00
17_L296_V1.9021.00
54_E57_G1.8861.00
172_F189_I1.8531.00
186_S200_S1.8361.00
130_I134_N1.8191.00
201_V246_K1.7861.00
176_V202_A1.7831.00
203_V280_A1.7821.00
262_L270_A1.7741.00
128_E132_A1.7631.00
38_S79_Y1.7301.00
209_P213_Q1.6621.00
154_E187_R1.6581.00
169_V296_V1.6561.00
142_Q145_S1.6371.00
29_L165_T1.6311.00
246_K287_D1.6201.00
19_R29_L1.6201.00
258_T279_A1.6101.00
170_D294_N1.6031.00
262_L278_V1.5931.00
190_K245_D1.5911.00
170_D293_K1.5731.00
261_R282_L1.5721.00
172_F185_V1.5631.00
182_L244_V1.5551.00
230_I276_A1.5481.00
69_T74_G1.5461.00
101_R113_L1.4861.00
102_K105_K1.4761.00
54_E84_R1.4751.00
19_R24_G1.4751.00
158_G185_V1.4691.00
30_A299_L1.4651.00
47_A51_W1.4581.00
162_W192_T1.4471.00
171_V290_F1.4241.00
134_N137_K1.4101.00
101_R105_K1.3911.00
171_V293_K1.3891.00
158_G189_I1.3731.00
49_M146_N1.3681.00
173_I284_L1.3621.00
64_E87_K1.3401.00
131_V140_L1.3341.00
26_G261_R1.3311.00
258_T282_L1.3291.00
112_V126_K1.3041.00
119_G122_G1.2921.00
171_V199_I1.2881.00
173_I203_V1.2721.00
104_L109_A1.2481.00
124_I128_E1.2481.00
22_R266_E1.2441.00
270_A299_L1.2411.00
98_I101_R1.2361.00
212_A249_G1.2311.00
92_M104_L1.2311.00
187_R240_D1.2271.00
254_E279_A1.2271.00
51_W55_K1.2271.00
165_T169_V1.2261.00
279_A283_K1.2261.00
158_G188_Y1.2251.00
52_D55_K1.2251.00
189_I198_L1.2241.00
284_L287_D1.2101.00
283_K286_E1.1971.00
182_L200_S1.1931.00
258_T278_V1.1871.00
20_L30_A1.1831.00
74_G104_L1.1811.00
95_T116_G1.1751.00
50_I65_L1.1721.00
188_Y192_T1.1631.00
18_V32_V1.1631.00
206_T249_G1.1611.00
162_W188_Y1.1541.00
91_T126_K1.1501.00
274_S299_L1.1491.00
159_P163_E1.1401.00
48_N155_K1.1401.00
17_L165_T1.1391.00
257_S261_R1.1391.00
26_G265_E1.1371.00
121_K125_Q1.1321.00
101_R111_L1.1241.00
16_P35_R1.1231.00
254_E257_S1.1171.00
94_E116_G1.1081.00
126_K130_I1.1061.00
209_P249_G1.1021.00
17_L161_I1.0971.00
168_Q294_N1.0891.00
213_Q217_G1.0881.00
250_I279_A1.0761.00
48_N152_I1.0751.00
125_Q129_E1.0671.00
221_K225_H1.0641.00
227_I255_A1.0611.00
56_R148_A1.0511.00
253_E257_S1.0431.00
202_A247_V1.0381.00
183_T238_N1.0361.00
248_I280_A1.0361.00
65_L81_A1.0331.00
201_V248_I1.0321.00
182_L202_A1.0301.00
125_Q128_E1.0291.00
153_H157_T1.0291.00
46_G76_A1.0281.00
48_N52_D1.0241.00
127_A131_V1.0171.00
263_M269_L1.0161.00
209_P220_I1.0101.00
129_E132_A1.0081.00
48_N51_W1.0071.00
161_I169_V1.0071.00
165_T296_V1.0041.00
50_I84_R1.0021.00
171_V295_I0.9951.00
92_M113_L0.9931.00
66_V138_Y0.9901.00
82_A88_L0.9841.00
122_G125_Q0.9801.00
120_M123_A0.9781.00
49_M141_L0.9731.00
260_R264_E0.9671.00
209_P212_A0.9551.00
22_R25_N0.9521.00
21_N25_N0.9511.00
76_A80_V0.9481.00
77_L88_L0.9441.00
50_I80_V0.9431.00
28_I281_A0.9411.00
128_E131_V0.9401.00
79_Y107_L0.9341.00
105_K110_N0.9271.00
78_A109_A0.9231.00
162_W193_K0.9211.00
259_A275_G0.9211.00
53_A57_G0.9161.00
66_V130_I0.9151.00
199_I245_D0.9081.00
22_R265_E0.9071.00
226_K256_I0.9031.00
185_V298_I0.9031.00
248_I283_K0.9021.00
67_E90_L0.8951.00
176_V182_L0.8941.00
173_I281_A0.8921.00
154_E188_Y0.8851.00
289_S293_K0.8811.00
281_A297_V0.8761.00
130_I133_S0.8711.00
15_T36_N0.8671.00
66_V127_A0.8661.00
270_A274_S0.8631.00
278_V299_L0.8621.00
277_A300_P0.8611.00
159_P192_T0.8531.00
11_T47_A0.8511.00
64_E138_Y0.8511.00
174_A185_V0.8471.00
269_L303_G0.8471.00
89_T134_N0.8451.00
53_A139_L0.8451.00
150_P238_N0.8411.00
89_T130_I0.8371.00
32_V299_L0.8361.00
188_Y191_G0.8341.00
230_I273_S0.8331.00
212_A247_V0.8211.00
27_R292_N0.8191.00
199_I293_K0.8181.00
274_S300_P0.8171.00
173_I280_A0.8131.00
173_I201_V0.8051.00
20_L278_V0.7971.00
131_V138_Y0.7961.00
258_T261_R0.7941.00
171_V284_L0.7911.00
225_H231_G0.7911.00
75_I104_L0.7891.00
89_T138_Y0.7891.00
102_K106_A0.7871.00
226_K252_N0.7781.00
187_R191_G0.7711.00
176_V247_V0.7701.00
157_T185_V0.7691.00
152_I155_K0.7671.00
169_V198_L0.7591.00
155_K159_P0.7571.00
278_V297_V0.7531.00
105_K113_L0.7501.00
142_Q146_N0.7481.00
88_L109_A0.7471.00
205_P230_I0.7451.00
162_W189_I0.7431.00
63_V87_K0.7431.00
64_E134_N0.7421.00
157_T181_T0.7411.00
82_A107_L0.7341.00
48_N148_A0.7331.00
282_L286_E0.7331.00
175_G300_P0.7311.00
66_V131_V0.7301.00
211_I247_V0.7301.00
30_A297_V0.7291.00
54_E58_V0.7281.00
100_R228_Q0.7281.00
157_T298_I0.7271.00
79_Y83_A0.7251.00
20_L266_E0.7251.00
150_P187_R0.7231.00
210_V233_G0.7221.00
58_V86_Y0.7211.00
157_T161_I0.7211.00
127_A140_L0.7201.00
165_T294_N0.7181.00
241_L244_V0.7171.00
32_V35_R0.7161.00
65_L86_Y0.7151.00
63_V137_K0.7101.00
75_I103_L0.7101.00
185_V189_I0.7101.00
65_L141_L0.7081.00
287_D290_F0.7061.00
128_E140_L0.7051.00
68_P120_M0.7051.00
24_G27_R0.7031.00
147_P150_P0.7001.00
38_S107_L0.6971.00
211_I235_I0.6971.00
68_P140_L0.6961.00
283_K287_D0.6941.00
162_W167_G0.6931.00
162_W166_D0.6921.00
255_A276_A0.6921.00
90_L104_L0.6881.00
41_V181_T0.6861.00
23_I282_L0.6851.00
259_A304_E0.6841.00
12_I43_C0.6821.00
24_G28_I0.6811.00
116_G122_G0.6781.00
172_F298_I0.6761.00
114_T126_K0.6731.00
234_F237_A0.6711.00
139_L146_N0.6671.00
248_I287_D0.6671.00
270_A275_G0.6661.00
256_I272_I0.6661.00
163_E192_T0.6641.00
246_K284_L0.6631.00
20_L23_I0.6601.00
98_I105_K0.6561.00
30_A278_V0.6561.00
168_Q193_K0.6551.00
218_E241_L0.6551.00
52_D58_V0.6481.00
172_F198_L0.6481.00
120_M124_I0.6481.00
13_G37_P0.6471.00
91_T112_V0.6471.00
169_V294_N0.6451.00
39_F302_S0.6431.00
213_Q221_K0.6411.00
87_K138_Y0.6401.00
262_L268_I0.6341.00
162_W165_T0.6341.00
45_I49_M0.6341.00
96_M101_R0.6331.00
112_V130_I0.6331.00
8_N11_T0.6291.00
96_M228_Q0.6291.00
229_G273_S0.6261.00
91_T114_T0.6261.00
23_I258_T0.6251.00
175_G277_A0.6241.00
21_N24_G0.6241.00
201_V284_L0.6221.00
223_G226_K0.6221.00
17_L29_L0.6191.00
71_G74_G0.6171.00
92_M101_R0.6161.00
65_L88_L0.6161.00
49_M149_N0.6161.00
120_M143_Q0.6151.00
23_I266_E0.6141.00
110_N134_N0.6131.00
131_V134_N0.6121.00
46_G80_V0.6101.00
176_V211_I0.6101.00
173_I295_I0.6051.00
62_G87_K0.6041.00
204_E210_V0.6031.00
17_L164_D0.6021.00
49_M148_A0.6001.00
78_A104_L0.5991.00
122_G126_K0.5981.00
286_E289_S0.5971.00
262_L266_E0.5961.00
32_V268_I0.5941.00
161_I185_V0.5931.00
94_E113_L0.5891.00
203_V248_I0.5851.00
221_K224_P0.5851.00
190_K242_K0.5841.00
23_I278_V0.5831.00
13_G36_N0.5831.00
222_P234_F0.5831.00
37_P43_C0.5821.00
20_L24_G0.5811.00
43_C79_Y0.5801.00
203_V276_A0.5801.00
174_A182_L0.5791.00
252_N256_I0.5781.00
262_L299_L0.5771.00
259_A272_I0.5771.00
152_I187_R0.5761.00
280_A284_L0.5761.00
221_K226_K0.5761.00
74_G90_L0.5751.00
190_K243_L0.5751.00
66_V91_T0.5731.00
126_K133_S0.5731.00
194_G198_L0.5681.00
278_V282_L0.5621.00
115_E122_G0.5621.00
12_I47_A0.5601.00
87_K134_N0.5601.00
103_L106_A0.5591.00
31_K160_E0.5571.00
172_F200_S0.5571.00
274_S277_A0.5571.00
202_A244_V0.5561.00
78_A88_L0.5541.00
34_S302_S0.5531.00
195_K198_L0.5531.00
281_A285_Q0.5501.00
92_M96_M0.5501.00
55_K62_G0.5501.00
49_M139_L0.5501.00
257_S260_R0.5491.00
68_P141_L0.5491.00
45_I73_T0.5481.00
77_L90_L0.5481.00
26_G282_L0.5471.00
23_I261_R0.5441.00
30_A262_L0.5421.00
130_I138_Y0.5421.00
123_A127_A0.5401.00
240_D243_L0.5401.00
53_A58_V0.5401.00
150_P183_T0.5391.00
183_T187_R0.5381.00
34_S268_I0.5381.00
210_V213_Q0.5371.00
165_T168_Q0.5361.00
152_I156_T0.5361.00
222_P225_H0.5290.99
57_G139_L0.5280.99
171_V289_S0.5280.99
210_V235_I0.5270.99
252_N255_A0.5250.99
67_E77_L0.5230.99
11_T35_R0.5210.99
250_I276_A0.5210.99
57_G63_V0.5190.99
251_T283_K0.5190.99
73_T141_L0.5190.99
119_G123_A0.5180.99
185_V188_Y0.5170.99
220_I237_A0.5170.99
204_E212_A0.5170.99
11_T51_W0.5160.99
66_V140_L0.5160.99
124_I127_A0.5150.99
239_L247_V0.5150.99
73_T154_E0.5130.99
23_I265_E0.5130.99
68_P124_I0.5120.99
69_T90_L0.5120.99
227_I230_I0.5120.99
183_T239_L0.5110.99
161_I298_I0.5100.99
64_E110_N0.5090.99
271_G301_S0.5080.99
37_P79_Y0.5050.99
33_E36_N0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pqmA 2 0.969 100 0.158 Contact Map
1y7lA 2 0.9505 100 0.162 Contact Map
3pc3A 2 0.9845 100 0.167 Contact Map
3tbhA 2 0.9567 100 0.169 Contact Map
4ofxA 2 0.8762 100 0.171 Contact Map
3vc3A 2 0.9721 100 0.174 Contact Map
4cooA 2 0.9845 100 0.175 Contact Map
4aecA 2 0.9721 100 0.175 Contact Map
2v03A 2 0.8947 100 0.175 Contact Map
2q3bA 2 0.9195 100 0.18 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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