GREMLIN Database
CYDB - Cytochrome bd-I ubiquinol oxidase subunit 2
UniProt: P0ABK2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10174
Length: 379 (325)
Sequences: 3274 (2019)
Seq/√Len: 112.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_N169_G3.5301.00
34_M181_I3.4681.00
128_F177_V3.1551.00
360_W363_F2.9801.00
86_F145_V2.8781.00
275_L297_L2.8121.00
344_A348_V2.7381.00
132_L177_V2.7221.00
181_I207_A2.7001.00
268_I308_I2.6831.00
24_V296_S2.6551.00
45_E199_R2.6251.00
202_A206_V2.6201.00
334_Q338_N2.5961.00
168_F222_V2.5901.00
132_L173_G2.5891.00
34_M177_V2.5491.00
205_Q284_R2.4071.00
47_R51_N2.3101.00
107_R120_D2.2721.00
32_V49_M2.2551.00
13_L17_V2.2061.00
178_G214_C2.1841.00
92_L133_V2.1821.00
193_V367_T2.1491.00
287_K290_W2.1341.00
186_T204_A2.1111.00
48_I366_I2.0721.00
131_P176_S2.0441.00
19_L71_L2.0261.00
353_L356_A2.0241.00
342_W346_V2.0151.00
8_R331_T2.0121.00
174_V178_G2.0071.00
136_V173_G1.9721.00
356_A360_W1.9471.00
160_N163_Q1.9321.00
139_G172_A1.8941.00
178_G210_V1.8871.00
124_F128_F1.8811.00
99_F122_G1.8671.00
74_A340_M1.8651.00
204_A283_A1.8551.00
118_M121_W1.8541.00
43_D116_R1.8421.00
49_M188_L1.8391.00
131_P180_I1.8241.00
17_V21_G1.8231.00
170_L174_V1.8061.00
313_F326_T1.7851.00
10_I341_T1.7721.00
58_D105_D1.7581.00
126_G130_P1.7531.00
143_Q166_N1.7421.00
216_A273_V1.7411.00
282_T294_F1.7341.00
121_W125_I1.7341.00
274_V278_L1.6981.00
185_A204_A1.6691.00
276_P298_T1.6421.00
42_N45_E1.6271.00
148_N158_T1.6271.00
183_Q296_S1.5931.00
50_I104_F1.5811.00
341_T345_V1.5581.00
215_F305_T1.5571.00
215_F302_I1.5361.00
122_G126_G1.5351.00
35_L185_A1.5131.00
174_V214_C1.5071.00
93_V134_I1.4961.00
275_L301_C1.4931.00
271_L301_C1.4921.00
34_M128_F1.4751.00
259_F263_P1.4651.00
197_H288_A1.4591.00
32_V188_L1.4531.00
175_V214_C1.4521.00
347_L350_I1.4511.00
96_S126_G1.4501.00
201_R205_Q1.4311.00
133_V165_L1.4301.00
48_I196_L1.4261.00
142_L310_M1.4161.00
28_F359_Y1.4131.00
275_L294_F1.4111.00
81_A315_M1.4101.00
96_S129_V1.4041.00
338_N342_W1.3741.00
90_M137_A1.3731.00
15_V70_A1.3701.00
85_G145_V1.3661.00
46_R120_D1.3641.00
208_A279_T1.3441.00
32_V53_I1.3281.00
179_M299_L1.3211.00
30_M131_P1.3181.00
189_Q197_H1.3040.99
117_N121_W1.3040.99
132_L136_V1.3000.99
213_V217_L1.3000.99
44_T368_K1.2980.99
221_W225_G1.2980.99
190_M289_A1.2910.99
209_L213_V1.2900.99
18_L21_G1.2890.99
140_N169_G1.2800.99
86_F89_A1.2790.99
8_R337_L1.2680.99
45_E368_K1.2630.99
195_E198_L1.2590.99
212_L276_P1.2580.99
28_F56_H1.2530.99
133_V136_V1.2510.99
91_I95_A1.2430.99
186_T291_A1.2400.99
278_L294_F1.2340.99
28_F292_F1.2340.99
33_G127_S1.2330.99
220_V224_Y1.2270.99
11_W74_A1.2270.99
9_F328_W1.2230.99
37_R124_F1.2210.99
269_P305_T1.2120.99
104_F119_W1.2100.99
179_M302_I1.2030.99
279_T294_F1.1980.99
139_G218_A1.1980.99
223_M256_L1.1940.99
86_F140_N1.1860.99
171_L221_W1.1800.99
34_M124_F1.1730.99
265_L308_I1.1500.99
263_P267_A1.1470.99
208_A280_I1.1420.99
114_R118_M1.1390.99
333_S336_T1.1350.99
20_I300_A1.1350.99
334_Q337_L1.1300.99
71_L78_V1.1210.98
118_M122_G1.1200.98
78_V314_V1.1140.98
39_L200_T1.1050.98
201_R286_D1.1050.98
182_T208_A1.1040.98
176_S180_I1.1000.98
164_L167_P1.0970.98
78_V82_A1.0940.98
56_H187_Y1.0830.98
48_I51_N1.0780.98
335_L339_V1.0750.98
20_I303_I1.0670.98
335_L338_N1.0580.98
125_I129_V1.0570.98
281_L285_M1.0570.98
89_A136_V1.0540.98
317_S324_S1.0480.98
12_W16_G1.0420.97
41_R45_E1.0350.97
86_F315_M1.0350.97
110_I115_W1.0340.97
203_T206_V1.0250.97
183_Q295_S1.0220.97
313_F317_S1.0220.97
189_Q201_R1.0210.97
346_V350_I1.0190.97
44_T48_I1.0170.97
18_L66_T1.0170.97
145_V315_M1.0090.97
277_L281_L1.0060.97
157_Y163_Q0.9920.97
68_G83_F0.9760.96
261_N265_L0.9720.96
195_E199_R0.9700.96
134_I180_I0.9650.96
17_V69_G0.9630.96
81_A147_F0.9630.96
265_L268_I0.9630.96
140_N164_L0.9630.96
268_I301_C0.9610.96
141_L315_M0.9600.96
48_I192_T0.9600.96
182_T186_T0.9520.96
39_L49_M0.9460.96
264_I308_I0.9450.95
42_N368_K0.9440.95
108_S116_R0.9440.95
175_V215_F0.9400.95
36_T50_I0.9400.95
190_M292_F0.9390.95
313_F324_S0.9330.95
47_R108_S0.9230.95
68_G79_Y0.9210.95
138_F306_A0.9210.95
186_T295_S0.9210.95
178_G207_A0.9210.95
212_L216_A0.9200.95
129_V133_V0.9180.95
36_T124_F0.9140.95
182_T204_A0.9120.95
306_A310_M0.9120.95
17_V348_V0.9100.94
203_T207_A0.9090.94
189_Q283_A0.9040.94
128_F132_L0.9030.94
47_R50_I0.9000.94
282_T290_W0.8990.94
268_I272_G0.8960.94
212_L273_V0.8950.94
83_F90_M0.8930.94
59_G358_C0.8920.94
11_W340_M0.8920.94
26_D30_M0.8910.94
21_G352_L0.8790.93
34_M127_S0.8780.93
271_L275_L0.8760.93
48_I368_K0.8740.93
182_T279_T0.8650.93
187_Y363_F0.8540.92
332_S336_T0.8520.92
202_A205_Q0.8480.92
258_N261_N0.8470.92
14_L17_V0.8470.92
197_H201_R0.8450.92
23_A355_T0.8430.92
69_G348_V0.8400.92
178_G211_T0.8370.92
121_W124_F0.8330.91
289_A293_V0.8320.91
136_V170_L0.8300.91
84_S87_Y0.8280.91
198_L202_A0.8200.91
132_L170_L0.8170.91
268_I271_L0.8120.90
40_G49_M0.8120.90
98_F331_T0.8120.90
51_N54_A0.8110.90
150_D156_Y0.8090.90
212_L280_I0.8080.90
216_A220_V0.8080.90
209_L280_I0.8060.90
114_R117_N0.8040.90
14_L69_G0.8020.90
101_P104_F0.8010.90
198_L286_D0.7950.89
93_V133_V0.7910.89
18_L69_G0.7910.89
265_L269_P0.7910.89
219_G269_P0.7910.89
96_S130_P0.7880.89
326_T329_D0.7880.89
82_A145_V0.7870.89
198_L201_R0.7860.89
171_L217_L0.7840.89
300_A304_L0.7840.89
115_W118_M0.7830.89
210_V213_V0.7810.89
24_V300_A0.7740.88
92_L129_V0.7730.88
278_L282_T0.7730.88
72_F79_Y0.7730.88
182_T295_S0.7720.88
33_G131_P0.7710.88
89_A164_L0.7690.88
298_T302_I0.7690.88
147_F315_M0.7680.88
357_W361_K0.7620.87
28_F191_R0.7600.87
78_V81_A0.7590.87
85_G89_A0.7590.87
293_V297_L0.7560.87
325_L329_D0.7540.87
268_I305_T0.7520.87
58_D354_Y0.7520.87
122_G125_I0.7490.86
279_T282_T0.7470.86
131_P134_I0.7470.86
15_V343_V0.7440.86
185_A203_T0.7440.86
30_M101_P0.7410.86
108_S111_E0.7380.86
219_G305_T0.7380.86
192_T365_R0.7370.86
206_V209_L0.7350.85
49_M110_I0.7330.85
26_D191_R0.7330.85
52_S187_Y0.7310.85
339_V343_V0.7310.85
35_L188_L0.7300.85
23_A180_I0.7300.85
188_L200_T0.7300.85
273_V277_L0.7300.85
325_L330_A0.7250.85
297_L301_C0.7230.84
116_R120_D0.7210.84
30_M97_L0.7200.84
128_F131_P0.7150.84
186_T279_T0.7100.83
51_N108_S0.7100.83
12_W327_M0.7100.83
126_G131_P0.7050.83
35_L181_I0.7030.83
110_I113_T0.7010.83
19_L67_A0.6990.82
57_W79_Y0.6970.82
20_I24_V0.6960.82
324_S329_D0.6940.82
20_I296_S0.6910.82
132_L174_V0.6840.81
188_L192_T0.6840.81
353_L358_C0.6840.81
38_F203_T0.6830.81
119_W122_G0.6830.81
101_P305_T0.6810.81
113_T116_R0.6800.81
272_G276_P0.6800.81
70_A73_A0.6790.81
182_T207_A0.6770.80
146_P163_Q0.6720.80
45_E195_E0.6700.80
305_T332_S0.6680.79
111_E118_M0.6670.79
147_F317_S0.6660.79
263_P266_W0.6650.79
40_G45_E0.6650.79
199_R202_A0.6620.79
197_H365_R0.6590.79
186_T283_A0.6580.78
159_G162_F0.6570.78
279_T298_T0.6560.78
301_C308_I0.6550.78
223_M266_W0.6550.78
29_D32_V0.6530.78
341_T344_A0.6520.78
18_L340_M0.6470.77
50_I108_S0.6450.77
98_F103_G0.6440.77
14_L344_A0.6430.77
77_M330_A0.6430.77
17_V344_A0.6410.77
14_L348_V0.6380.76
111_E115_W0.6380.76
49_M196_L0.6340.76
8_R334_Q0.6340.76
356_A363_F0.6330.76
205_Q208_A0.6310.75
88_V92_L0.6300.75
16_G307_G0.6290.75
56_H358_C0.6270.75
273_V280_I0.6260.75
192_T292_F0.6250.75
43_D120_D0.6240.75
213_V274_V0.6230.75
181_I185_A0.6230.75
185_A189_Q0.6230.75
92_L95_A0.6220.74
196_L200_T0.6200.74
23_A134_I0.6190.74
22_F362_M0.6190.74
68_G340_M0.6180.74
279_T295_S0.6170.74
277_L280_I0.6160.74
355_T358_C0.6130.73
270_A284_R0.6120.73
341_T365_R0.6120.73
174_V199_R0.6120.73
66_T343_V0.6110.73
58_D61_Q0.6100.73
270_A274_V0.6090.73
348_V352_L0.6060.73
135_G173_G0.6060.73
103_G122_G0.6060.73
342_W345_V0.6050.72
125_I367_T0.6050.72
278_L281_L0.6020.72
164_L169_G0.6010.72
41_R199_R0.5990.72
15_V203_T0.5980.72
53_I104_F0.5970.71
12_W80_A0.5960.71
140_N167_P0.5960.71
93_V179_M0.5960.71
170_L324_S0.5930.71
101_P106_Y0.5930.71
34_M96_S0.5920.71
22_F30_M0.5910.71
109_K355_T0.5910.71
67_A71_L0.5900.71
66_T70_A0.5900.71
14_L18_L0.5890.70
304_L308_I0.5860.70
123_I127_S0.5860.70
15_V78_V0.5840.70
52_S367_T0.5830.70
20_I304_L0.5820.70
45_E49_M0.5820.70
51_N109_K0.5820.70
45_E48_I0.5810.69
217_L266_W0.5800.69
148_N156_Y0.5790.69
9_F311_F0.5780.69
161_F164_L0.5770.69
207_A210_V0.5760.69
348_V353_L0.5750.69
211_T302_I0.5720.68
259_F262_T0.5720.68
46_R116_R0.5710.68
189_Q291_A0.5700.68
163_Q169_G0.5680.68
49_M195_E0.5680.68
68_G90_M0.5670.68
181_I203_T0.5650.67
90_M299_L0.5610.67
205_Q285_M0.5610.67
179_M298_T0.5600.67
80_A141_L0.5590.66
18_L70_A0.5570.66
201_R288_A0.5570.66
17_V65_I0.5570.66
83_F87_Y0.5530.66
138_F218_A0.5510.65
189_Q288_A0.5510.65
16_G303_I0.5500.65
290_W293_V0.5490.65
260_N266_W0.5480.65
33_G100_R0.5470.65
77_M325_L0.5470.65
148_N151_E0.5460.65
113_T117_N0.5450.64
172_A218_A0.5450.64
55_P344_A0.5440.64
49_M170_L0.5430.64
68_G354_Y0.5410.64
37_R121_W0.5410.64
286_D289_A0.5390.64
182_T211_T0.5380.63
139_G169_G0.5380.63
227_D256_L0.5350.63
267_A270_A0.5330.63
215_F274_V0.5330.63
77_M151_E0.5320.63
117_N261_N0.5310.62
165_L169_G0.5310.62
259_F269_P0.5300.62
52_S64_L0.5280.62
23_A176_S0.5270.62
12_W340_M0.5260.62
167_P171_L0.5260.62
198_L297_L0.5230.61
46_R107_R0.5230.61
49_M52_S0.5230.61
314_V327_M0.5220.61
276_P280_I0.5220.61
8_R328_W0.5220.61
285_M345_V0.5220.61
273_V278_L0.5210.61
64_L134_I0.5210.61
254_A309_A0.5200.61
311_F337_L0.5190.61
54_A74_A0.5180.61
9_F13_L0.5180.61
19_L176_S0.5170.60
12_W19_L0.5170.60
220_V223_M0.5170.60
27_G60_N0.5160.60
139_G364_G0.5160.60
14_L341_T0.5150.60
169_G172_A0.5150.60
9_F327_M0.5130.60
88_V191_R0.5130.60
15_V307_G0.5120.60
142_L306_A0.5110.60
110_I114_R0.5110.60
168_F309_A0.5110.60
195_E202_A0.5090.59
37_R117_N0.5090.59
44_T274_V0.5090.59
46_R176_S0.5070.59
14_L340_M0.5060.59
80_A84_S0.5060.59
73_A79_Y0.5050.59
73_A349_P0.5040.59
272_G275_L0.5030.58
60_N63_W0.5030.58
72_F80_A0.5020.58
62_V65_I0.5010.58
68_G165_L0.5010.58
130_P138_F0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wajA 1 0.6966 57 0.965 Contact Map
2mfrA 1 0.1504 49.6 0.967 Contact Map
4b4aA 1 0.533 21.8 0.973 Contact Map
2m20A 2 0.1214 15.1 0.974 Contact Map
2l8sA 1 0.1214 14.8 0.975 Contact Map
2kncA 1 0.1372 11.8 0.976 Contact Map
2m3eA 1 0.1266 10.6 0.976 Contact Map
3wdoA 1 0.8074 10.5 0.976 Contact Map
3rkoM 1 0.2797 9.7 0.977 Contact Map
1pw4A 1 0.7968 8.9 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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