GREMLIN Database
CYOC - Cytochrome bo(3) ubiquinol oxidase subunit 3
UniProt: P0ABJ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10180
Length: 204 (183)
Sequences: 5377 (2680)
Seq/√Len: 198.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_L111_G4.0061.00
82_T105_T3.3601.00
103_A161_M3.2501.00
94_N97_Q3.1721.00
98_V164_I3.0431.00
175_T179_C2.9381.00
85_M101_W2.8801.00
38_I41_S2.7841.00
95_K99_I2.5981.00
50_L134_G2.4821.00
106_W154_L2.4241.00
68_F115_M2.2511.00
89_A97_Q2.1971.00
114_G118_Y2.1171.00
120_F143_V2.0991.00
156_W180_L2.0271.00
158_A162_V2.0191.00
68_F118_Y1.9971.00
142_L198_V1.9851.00
70_L74_F1.9681.00
113_I151_T1.9611.00
82_T104_L1.9401.00
117_I121_H1.9131.00
96_S100_S1.9101.00
99_I165_A1.7941.00
118_Y122_H1.7751.00
86_A98_V1.7701.00
157_M180_L1.7171.00
75_L115_M1.6951.00
142_L194_V1.6911.00
83_Y157_M1.6761.00
39_L145_T1.6601.00
83_Y181_S1.6411.00
160_L180_L1.6391.00
46_T138_A1.6171.00
95_K167_R1.6141.00
86_A102_L1.5771.00
33_L182_L1.5441.00
185_H188_D1.5351.00
103_A107_L1.5241.00
99_I161_M1.5181.00
74_F78_F1.4931.00
99_I164_I1.4851.00
106_W158_A1.4831.00
72_E115_M1.4491.00
177_I181_S1.4361.00
80_S185_H1.4281.00
113_I147_G1.4231.00
113_I154_L1.4151.00
109_G154_L1.3861.00
67_P71_V1.3791.00
48_A197_V1.3581.00
100_S104_L1.3321.00
81_I85_M1.3221.00
114_G117_I1.3141.00
85_M89_A1.2901.00
65_E122_H1.2841.00
82_T108_F1.2781.00
91_Y178_M1.2601.00
93_N171_S1.2491.00
95_K164_I1.2381.00
97_Q101_W1.1861.00
110_A154_L1.1611.00
90_M98_V1.1541.00
86_A177_I1.1501.00
68_F72_E1.1441.00
148_L152_S1.1431.00
22_G26_I1.1391.00
100_S103_A1.1301.00
138_A142_L1.1131.00
196_T200_L1.1121.00
151_T155_I1.1051.00
88_I92_K1.0921.00
36_D119_E1.0901.00
154_L158_A1.0891.00
21_A24_T1.0801.00
89_A101_W1.0681.00
90_M177_I1.0671.00
94_N100_S1.0631.00
84_G88_I1.0571.00
51_V54_T1.0571.00
86_A164_I1.0551.00
97_Q100_S1.0551.00
45_A49_V1.0531.00
78_F81_I1.0531.00
43_L145_T1.0511.00
119_E199_Y1.0461.00
84_G87_A1.0411.00
162_V166_R1.0331.00
107_L111_G1.0331.00
183_F187_L1.0201.00
57_G136_L1.0151.00
71_V115_M1.0141.00
90_M174_R0.9991.00
47_Y51_V0.9881.00
72_E194_V0.9841.00
38_I42_I0.9831.00
89_A94_N0.9770.99
139_F147_G0.9740.99
75_L108_F0.9730.99
16_H20_D0.9700.99
29_F33_L0.9660.99
101_W104_L0.9650.99
155_I159_V0.9590.99
106_W157_M0.9520.99
32_Y183_F0.9460.99
128_M136_L0.9410.99
163_Q168_G0.9390.99
163_Q176_R0.9370.99
87_A91_Y0.9270.99
50_L138_A0.9240.99
23_G27_F0.9240.99
20_D23_G0.9210.99
86_A101_W0.9140.99
43_L142_L0.9090.99
129_G136_L0.9000.99
82_T101_W0.8980.99
43_L141_A0.8910.99
38_I48_A0.8900.99
116_E196_T0.8890.99
19_H23_G0.8850.99
152_S156_W0.8780.99
141_A145_T0.8730.99
100_S165_A0.8710.99
69_V116_E0.8690.99
139_F143_V0.8560.99
123_L139_F0.8550.99
85_M97_Q0.8540.99
110_A114_G0.8510.99
120_F140_F0.8490.99
106_W161_M0.8380.98
132_R136_L0.8370.98
169_L176_R0.8260.98
87_A178_M0.8070.98
21_A25_K0.8060.98
30_W34_M0.8060.98
152_S183_F0.8060.98
98_V102_L0.8050.98
96_S99_I0.8000.98
32_Y36_D0.7940.98
128_M132_R0.7930.98
103_A165_A0.7820.98
159_V162_V0.7810.98
63_I123_L0.7770.97
16_H19_H0.7750.97
47_Y50_L0.7750.97
76_L139_F0.7710.97
161_M165_A0.7700.97
146_H149_H0.7690.97
162_V165_A0.7650.97
18_H21_A0.7620.97
70_L195_F0.7570.97
111_G115_M0.7550.97
19_H22_G0.7550.97
34_M38_I0.7520.97
28_G32_Y0.7480.97
116_E139_F0.7470.97
87_A181_S0.7430.97
184_W191_W0.7410.97
193_C197_V0.7400.97
63_I128_M0.7230.96
66_L195_F0.7190.96
102_L161_M0.7190.96
89_A92_K0.7070.96
47_Y61_K0.6950.95
17_G21_A0.6930.95
25_K175_T0.6910.95
49_V53_G0.6870.95
141_A144_G0.6810.95
53_G192_I0.6800.95
113_I117_I0.6770.94
27_F31_I0.6700.94
22_G173_N0.6670.94
103_A162_V0.6670.94
79_S108_F0.6650.94
133_S136_L0.6650.94
119_E187_L0.6620.94
52_N201_M0.6610.94
26_I178_M0.6590.94
121_H127_G0.6580.94
119_E188_D0.6580.94
41_S45_A0.6560.93
69_V72_E0.6540.93
79_S105_T0.6540.93
57_G132_R0.6500.93
116_E147_G0.6490.93
49_V52_N0.6450.93
80_S200_L0.6430.93
67_P70_L0.6430.93
34_M37_C0.6390.93
60_G133_S0.6390.93
77_L81_I0.6390.93
36_D199_Y0.6370.92
28_G44_F0.6340.92
102_L164_I0.6320.92
91_Y174_R0.6310.92
37_C186_F0.6300.92
160_L177_I0.6290.92
189_V196_T0.6220.91
29_F179_C0.6200.91
79_S188_D0.6180.91
72_E119_E0.6120.91
197_V201_M0.6080.91
56_G133_S0.6070.90
35_S42_I0.6070.90
116_E136_L0.5980.90
186_F190_V0.5980.90
130_P136_L0.5970.90
83_Y86_A0.5960.90
87_A177_I0.5950.90
110_A151_T0.5900.89
94_N118_Y0.5900.89
63_I67_P0.5890.89
29_F32_Y0.5890.89
103_A158_A0.5880.89
37_C190_V0.5870.89
61_K107_L0.5850.89
136_L140_F0.5840.89
76_L199_Y0.5820.89
150_V187_L0.5820.89
59_T63_I0.5810.89
164_I169_L0.5800.88
133_S137_S0.5780.88
96_S114_G0.5720.88
164_I167_R0.5710.88
59_T62_D0.5690.87
66_L70_L0.5670.87
23_G34_M0.5660.87
43_L182_L0.5660.87
16_H22_G0.5630.87
128_M133_S0.5610.87
102_L177_I0.5590.87
153_G184_W0.5580.86
16_H27_F0.5540.86
80_S188_D0.5480.85
47_Y198_V0.5480.85
145_T150_V0.5470.85
63_I136_L0.5470.85
153_G186_F0.5460.85
60_G64_F0.5410.85
176_R179_C0.5410.85
75_L79_S0.5380.84
71_V75_L0.5380.84
44_F193_C0.5380.84
167_R171_S0.5360.84
119_E135_F0.5360.84
72_E116_E0.5350.84
147_G190_V0.5320.84
32_Y76_L0.5290.83
36_D187_L0.5290.83
37_C41_S0.5270.83
44_F135_F0.5270.83
79_S187_L0.5240.83
160_L176_R0.5240.83
110_A158_A0.5230.83
64_F67_P0.5190.82
153_G185_H0.5190.82
78_F108_F0.5180.82
29_F156_W0.5180.82
76_L119_E0.5180.82
106_W109_G0.5160.82
108_F111_G0.5130.82
96_S107_L0.5130.82
28_G36_D0.5100.81
61_K65_E0.5100.81
118_Y121_H0.5090.81
167_R170_T0.5090.81
21_A80_S0.5080.81
20_D24_T0.5080.81
131_D183_F0.5070.81
120_F194_V0.5050.81
41_S189_V0.5040.80
51_V128_M0.5020.80
48_A183_F0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fftC 1 0.9069 100 0.147 Contact Map
1qleC 1 0.9804 100 0.156 Contact Map
1m56C 2 0.9804 100 0.157 Contact Map
1v54C 1 0.9804 100 0.16 Contact Map
2yevA 1 0.9755 100 0.164 Contact Map
2jafA 3 0.8431 26.5 0.943 Contact Map
4phzK 1 0.5294 12.5 0.951 Contact Map
3qbgA 3 0.8873 9.9 0.953 Contact Map
1xioA 2 0.7941 6.3 0.957 Contact Map
3ddlA 2 0.7402 4.5 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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