CORA - ECOLI - GREMLIN Contacts

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CORA - Magnesium transport protein CorA

UniProt:	P0ABI4	Sequences: MLSAFQLENNRLTRLEVEESQPLVNAVWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHSFFFFEDAEDHAGNSTVAFTIRDGRLFTLRERELPAFRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHQGDEYDEALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11463
Length:	316 (292)
Sequences:	5419 (3802)
Seq/√Len:	222.5

ECOLI - CORA ZNTB
BACSU - YFJQ CORA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
281_E	287_K	9.546	1.00
97_R	100_R	4.133	1.00
285_E	292_Y	4.105	1.00
296_I	300_I	3.382	1.00
293_P	297_I	3.064	1.00
52_T	95_T	2.935	1.00
275_S	296_I	2.840	1.00
290_F	294_G	2.817	1.00
28_W	103_T	2.788	1.00
294_G	298_F	2.766	1.00
76_S	137_F	2.682	1.00
94_F	101_L	2.614	1.00
40_L	44_S	2.455	1.00
308_L	312_R	2.446	1.00
290_F	293_P	2.442	1.00
280_F	286_L	2.429	1.00
30_D	105_R	2.400	1.00
291_G	295_A	2.397	1.00
304_L	308_L	2.391	1.00
161_V	177_T	2.383	1.00
94_F	103_T	2.306	1.00
282_F	289_S	2.306	1.00
283_M	286_L	2.303	1.00
266_F	271_L	2.249	1.00
46_L	102_F	2.205	1.00
154_D	177_T	2.177	1.00
31_L	42_V	2.175	1.00
272_V	295_A	2.163	1.00
43_Q	53_R	2.128	1.00
283_M	292_Y	2.107	1.00
271_L	275_S	2.066	1.00
289_S	293_P	2.058	1.00
101_L	132_L	2.052	1.00
288_W	294_G	2.038	1.00
141_I	219_I	1.969	1.00
253_N	256_I	1.967	1.00
142_E	222_D	1.879	1.00
275_S	299_M	1.848	1.00
52_T	71_G	1.790	1.00
292_Y	296_I	1.750	1.00
288_W	291_G	1.726	1.00
74_I	133_L	1.699	1.00
305_A	309_Y	1.683	1.00
101_L	133_L	1.644	1.00
293_P	296_I	1.631	1.00
189_R	231_E	1.627	1.00
278_M	295_A	1.626	1.00
263_S	267_L	1.607	1.00
52_T	68_D	1.597	1.00
79_F	188_V	1.597	1.00
276_Y	292_Y	1.589	1.00
64_R	221_R	1.571	1.00
48_Q	95_T	1.527	1.00
295_A	299_M	1.517	1.00
276_Y	286_L	1.466	1.00
56_L	95_T	1.458	1.00
307_Y	311_K	1.449	1.00
138_E	142_E	1.434	1.00
280_F	291_G	1.432	1.00
138_E	222_D	1.421	1.00
276_Y	285_E	1.413	1.00
155_L	237_V	1.390	1.00
272_V	276_Y	1.371	1.00
257_K	261_V	1.362	1.00
288_W	292_Y	1.357	1.00
280_F	283_M	1.353	1.00
285_E	288_W	1.350	1.00
134_L	216_A	1.345	1.00
51_A	54_P	1.340	1.00
101_L	129_A	1.336	1.00
283_M	293_P	1.335	1.00
296_I	299_M	1.333	1.00
49_S	68_D	1.333	1.00
162_I	240_L	1.332	1.00
61_A	75_H	1.331	1.00
73_H	95_T	1.321	1.00
254_R	257_K	1.319	1.00
96_I	133_L	1.308	1.00
309_Y	313_K	1.306	1.00
280_F	292_Y	1.299	1.00
116_R	120_R	1.299	1.00
295_A	298_F	1.298	1.00
280_F	295_A	1.296	1.00
74_I	94_F	1.292	1.00
286_L	292_Y	1.291	1.00
220_L	224_E	1.274	1.00
249_N	252_Q	1.255	1.00
267_L	271_L	1.238	1.00
128_N	131_E	1.238	1.00
118_R	135_D	1.237	1.00
26_A	129_A	1.231	1.00
260_S	263_S	1.230	1.00
297_I	301_L	1.228	1.00
291_G	294_G	1.227	1.00
92_V	140_K	1.221	1.00
275_S	292_Y	1.217	1.00
61_A	91_T	1.216	1.00
36_D	40_L	1.212	1.00
55_E	64_R	1.203	1.00
268_P	271_L	1.189	1.00
269_P	299_M	1.178	1.00
276_Y	282_F	1.177	1.00
32_V	108_E	1.171	1.00
40_L	43_Q	1.166	1.00
41_R	45_E	1.164	1.00
26_A	132_L	1.154	1.00
94_F	133_L	1.152	1.00
306_P	310_F	1.150	1.00
191_C	195_T	1.147	1.00
200_N	220_L	1.146	1.00
196_Q	224_E	1.145	1.00
282_F	293_P	1.141	1.00
35_D	38_E	1.124	1.00
276_Y	283_M	1.121	1.00
141_I	222_D	1.116	1.00
256_I	263_S	1.107	1.00
48_Q	102_F	1.102	1.00
182_E	242_Q	1.094	1.00
203_V	217_R	1.091	1.00
182_E	234_F	1.090	1.00
34_P	38_E	1.086	1.00
275_S	278_M	1.081	1.00
255_I	260_S	1.072	1.00
82_D	86_H	1.072	1.00
37_D	40_L	1.072	1.00
25_N	99_G	1.068	1.00
266_F	269_P	1.063	1.00
285_E	293_P	1.052	1.00
151_I	181_L	1.050	1.00
67_E	72_L	1.048	1.00
248_I	252_Q	1.032	1.00
303_G	307_Y	1.031	1.00
117_M	120_R	1.029	1.00
260_S	267_L	1.029	1.00
280_F	285_E	1.025	1.00
56_L	93_A	1.023	1.00
159_S	183_D	1.022	1.00
294_G	297_I	1.015	1.00
269_P	272_V	1.005	1.00
281_E	286_L	1.001	1.00
67_E	205_K	0.999	1.00
199_L	223_I	0.982	1.00
218_E	221_R	0.982	1.00
273_A	296_I	0.978	1.00
301_L	305_A	0.978	1.00
65_F	74_I	0.976	1.00
281_E	288_W	0.976	1.00
39_R	43_Q	0.975	1.00
62_S	194_D	0.974	1.00
115_Y	132_L	0.972	1.00
185_G	233_L	0.970	1.00
54_P	142_E	0.968	1.00
61_A	218_E	0.965	1.00
154_D	184_I	0.965	1.00
22_P	25_N	0.962	1.00
62_S	228_P	0.962	1.00
155_L	233_L	0.959	1.00
272_V	299_M	0.959	1.00
59_I	106_E	0.956	1.00
109_L	112_F	0.954	1.00
196_Q	231_E	0.953	1.00
255_I	259_F	0.953	1.00
175_L	244_A	0.952	1.00
264_V	267_L	0.950	1.00
41_R	44_S	0.944	1.00
276_Y	288_W	0.944	1.00
284_P	291_G	0.941	1.00
179_A	241_M	0.936	1.00
115_Y	139_T	0.936	1.00
22_P	99_G	0.932	1.00
270_T	274_S	0.925	1.00
66_F	217_R	0.920	0.99
49_S	52_T	0.920	0.99
145_A	226_L	0.919	0.99
21_Q	24_V	0.914	0.99
112_F	136_L	0.913	0.99
276_Y	284_P	0.910	0.99
75_H	93_A	0.910	0.99
114_L	139_T	0.907	0.99
47_G	50_L	0.903	0.99
269_P	295_A	0.898	0.99
182_E	241_M	0.897	0.99
209_P	212_Q	0.896	0.99
238_N	242_Q	0.893	0.99
77_F	91_T	0.891	0.99
81_E	84_E	0.890	0.99
186_W	236_K	0.889	0.99
299_M	303_G	0.887	0.99
163_M	247_F	0.885	0.99
285_E	291_G	0.882	0.99
224_E	228_P	0.881	0.99
117_M	121_S	0.876	0.99
243_A	257_K	0.871	0.99
113_R	117_M	0.869	0.99
269_P	303_G	0.867	0.99
185_G	237_V	0.864	0.99
87_A	184_I	0.863	0.99
74_I	96_I	0.863	0.99
141_I	223_I	0.858	0.99
80_F	88_G	0.858	0.99
115_Y	135_D	0.858	0.99
276_Y	295_A	0.857	0.99
263_S	266_F	0.856	0.99
161_V	174_A	0.855	0.99
99_G	129_A	0.852	0.99
33_E	106_E	0.851	0.99
285_E	296_I	0.848	0.99
210_G	213_L	0.847	0.99
283_M	288_W	0.842	0.99
265_V	303_G	0.838	0.99
276_Y	279_N	0.837	0.99
24_V	27_V	0.836	0.99
276_Y	310_F	0.836	0.99
181_L	237_V	0.827	0.99
193_M	228_P	0.827	0.99
283_M	291_G	0.825	0.99
286_L	296_I	0.819	0.99
231_E	235_Q	0.813	0.99
273_A	292_Y	0.804	0.99
254_R	267_L	0.804	0.99
148_I	151_I	0.803	0.99
264_V	269_P	0.798	0.99
270_T	275_S	0.795	0.99
49_S	71_G	0.794	0.98
279_N	284_P	0.792	0.98
90_S	105_R	0.789	0.98
298_F	302_A	0.788	0.98
30_D	103_T	0.787	0.98
89_N	187_K	0.782	0.98
271_L	299_M	0.781	0.98
55_E	218_E	0.771	0.98
249_N	256_I	0.769	0.98
49_S	55_E	0.768	0.98
124_M	127_G	0.766	0.98
262_V	268_P	0.762	0.98
30_D	116_R	0.762	0.98
80_F	83_A	0.761	0.98
291_G	298_F	0.752	0.98
20_S	23_L	0.752	0.98
247_F	250_I	0.750	0.98
54_P	138_E	0.749	0.98
20_S	24_V	0.747	0.98
192_L	226_L	0.744	0.98
92_V	112_F	0.738	0.98
29_I	102_F	0.736	0.98
118_R	139_T	0.735	0.98
152_Y	233_L	0.734	0.97
261_V	268_P	0.734	0.97
305_A	308_L	0.732	0.97
179_A	243_A	0.729	0.97
283_M	295_A	0.725	0.97
251_E	260_S	0.724	0.97
192_L	227_L	0.724	0.97
252_Q	256_I	0.723	0.97
78_F	109_L	0.716	0.97
51_A	215_Q	0.715	0.97
131_E	215_Q	0.715	0.97
154_D	157_Q	0.714	0.97
130_Y	212_Q	0.714	0.97
200_N	224_E	0.713	0.97
37_D	41_R	0.711	0.97
51_A	66_F	0.710	0.97
269_P	302_A	0.705	0.97
138_E	141_I	0.703	0.97
268_P	302_A	0.702	0.97
196_Q	200_N	0.699	0.97
114_L	117_M	0.697	0.97
229_H	233_L	0.696	0.97
249_N	253_N	0.695	0.97
269_P	273_A	0.693	0.96
55_E	222_D	0.693	0.96
258_I	262_V	0.689	0.96
103_T	136_L	0.689	0.96
137_F	219_I	0.689	0.96
77_F	89_N	0.686	0.96
196_Q	227_L	0.685	0.96
62_S	142_E	0.684	0.96
50_L	54_P	0.680	0.96
128_N	212_Q	0.676	0.96
266_F	273_A	0.673	0.96
76_S	94_F	0.669	0.96
278_M	283_M	0.668	0.96
65_F	198_A	0.663	0.95
34_P	105_R	0.660	0.95
234_F	242_Q	0.659	0.95
300_I	304_L	0.658	0.95
288_W	293_P	0.658	0.95
21_Q	25_N	0.657	0.95
55_E	221_R	0.656	0.95
311_K	314_N	0.656	0.95
289_S	308_L	0.654	0.95
74_I	198_A	0.653	0.95
78_F	90_S	0.652	0.95
119_A	124_M	0.650	0.95
51_A	55_E	0.647	0.95
250_I	257_K	0.646	0.95
297_I	304_L	0.646	0.95
302_A	305_A	0.644	0.95
285_E	290_F	0.644	0.95
81_E	88_G	0.644	0.95
72_L	96_I	0.643	0.95
203_V	220_L	0.643	0.95
161_V	167_Q	0.641	0.95
20_S	27_V	0.641	0.95
276_Y	280_F	0.639	0.94
80_F	86_H	0.638	0.94
193_M	227_L	0.638	0.94
82_D	85_D	0.635	0.94
49_S	215_Q	0.633	0.94
258_I	309_Y	0.633	0.94
272_V	302_A	0.632	0.94
150_N	154_D	0.632	0.94
220_L	223_I	0.629	0.94
290_F	296_I	0.625	0.94
281_E	289_S	0.625	0.94
239_F	242_Q	0.623	0.94
274_S	277_G	0.623	0.94
271_L	306_P	0.620	0.94
251_E	255_I	0.618	0.93
195_T	225_S	0.616	0.93
280_F	288_W	0.615	0.93
132_L	136_L	0.614	0.93
123_S	126_D	0.613	0.93
308_L	311_K	0.612	0.93
32_V	107_R	0.612	0.93
81_E	86_H	0.611	0.93
32_V	105_R	0.610	0.93
176_S	247_F	0.609	0.93
39_R	53_R	0.607	0.93
165_G	168_G	0.607	0.93
80_F	85_D	0.606	0.93
97_R	129_A	0.606	0.93
78_F	92_V	0.603	0.93
107_R	113_R	0.602	0.93
51_A	219_I	0.598	0.92
31_L	104_L	0.597	0.92
53_R	56_L	0.596	0.92
81_E	87_A	0.595	0.92
273_A	278_M	0.595	0.92
179_A	183_D	0.592	0.92
134_L	218_E	0.589	0.92
87_A	147_E	0.589	0.92
185_G	230_N	0.589	0.92
271_L	303_G	0.587	0.92
65_F	72_L	0.585	0.91
122_Q	125_V	0.584	0.91
256_I	274_S	0.584	0.91
60_E	63_A	0.582	0.91
238_N	241_M	0.576	0.91
134_L	215_Q	0.575	0.91
76_S	140_K	0.574	0.91
219_I	222_D	0.572	0.91
242_Q	245_M	0.570	0.90
251_E	254_R	0.568	0.90
258_I	266_F	0.568	0.90
55_E	66_F	0.567	0.90
261_V	307_Y	0.567	0.90
265_V	269_P	0.566	0.90
273_A	299_M	0.565	0.90
292_Y	295_A	0.564	0.90
192_L	230_N	0.563	0.90
44_S	47_G	0.563	0.90
158_L	177_T	0.561	0.90
56_L	71_G	0.557	0.89
51_A	68_D	0.556	0.89
167_Q	174_A	0.555	0.89
288_W	298_F	0.555	0.89
29_I	100_R	0.554	0.89
285_E	298_F	0.552	0.89
143_Q	146_D	0.552	0.89
148_I	201_F	0.549	0.89
71_G	100_R	0.548	0.89
235_Q	239_F	0.548	0.89
183_D	236_K	0.547	0.88
260_S	269_P	0.547	0.88
144_L	191_C	0.546	0.88
238_N	243_A	0.545	0.88
196_Q	220_L	0.544	0.88
278_M	299_M	0.542	0.88
285_E	294_G	0.539	0.88
166_H	173_E	0.539	0.88
51_A	64_R	0.537	0.88
36_D	39_R	0.537	0.88
62_S	224_E	0.537	0.88
264_V	268_P	0.537	0.88
273_A	285_E	0.537	0.88
281_E	285_E	0.537	0.88
260_S	310_F	0.536	0.87
48_Q	71_G	0.536	0.87
265_V	307_Y	0.535	0.87
130_Y	209_P	0.533	0.87
39_R	57_E	0.532	0.87
252_Q	257_K	0.532	0.87
189_R	196_Q	0.531	0.87
257_K	295_A	0.531	0.87
271_L	274_S	0.531	0.87
144_L	226_L	0.531	0.87
54_P	64_R	0.531	0.87
138_E	215_Q	0.530	0.87
93_A	104_L	0.530	0.87
252_Q	255_I	0.528	0.87
77_F	191_C	0.527	0.87
235_Q	240_L	0.527	0.87
174_A	178_L	0.527	0.87
78_F	105_R	0.526	0.87
299_M	310_F	0.526	0.87
197_R	200_N	0.526	0.87
308_L	314_N	0.525	0.86
211_G	214_E	0.525	0.86
208_L	212_Q	0.521	0.86
113_R	177_T	0.519	0.86
91_T	106_E	0.519	0.86
34_P	104_L	0.518	0.86
118_R	122_Q	0.517	0.86
148_I	193_M	0.516	0.85
134_L	145_A	0.515	0.85
66_F	218_E	0.515	0.85
149_E	226_L	0.514	0.85
68_D	217_R	0.513	0.85
193_M	231_E	0.512	0.85
309_Y	312_R	0.512	0.85
259_F	263_S	0.511	0.85
134_L	219_I	0.511	0.85
163_M	176_S	0.510	0.85
156_E	196_Q	0.510	0.85
267_L	270_T	0.510	0.85
65_F	205_K	0.509	0.85
39_R	104_L	0.508	0.85
275_S	283_M	0.507	0.84
151_I	184_I	0.507	0.84
260_S	264_V	0.506	0.84
178_L	227_L	0.505	0.84
110_P	116_R	0.505	0.84
300_I	303_G	0.503	0.84
94_F	136_L	0.501	0.84
164_E	167_Q	0.501	0.84
291_G	299_M	0.501	0.84
21_Q	27_V	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i0uA	4	0.981	100	0.101	Contact Map
4ev6A	3	0.9778	100	0.107	Contact Map
4egwA	1	0.7658	100	0.444	Contact Map
3ck6A	3	0.75	100	0.479	Contact Map
3nvoA	2	0.7468	100	0.48	Contact Map
2bbhA	2	0.6234	100	0.526	Contact Map
2hn1A	2	0.6994	100	0.541	Contact Map
3rkgA	1	0.7089	88	0.927	Contact Map
4jo7E	2	0.2816	32.9	0.952	Contact Map
4yayA	1	0.4905	19.9	0.956	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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