GREMLIN Database
CORA - Magnesium transport protein CorA
UniProt: P0ABI4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11463
Length: 316 (292)
Sequences: 5419 (3802)
Seq/√Len: 222.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
281_E287_K9.5461.00
97_R100_R4.1331.00
285_E292_Y4.1051.00
296_I300_I3.3821.00
293_P297_I3.0641.00
52_T95_T2.9351.00
275_S296_I2.8401.00
290_F294_G2.8171.00
28_W103_T2.7881.00
294_G298_F2.7661.00
76_S137_F2.6821.00
94_F101_L2.6141.00
40_L44_S2.4551.00
308_L312_R2.4461.00
290_F293_P2.4421.00
280_F286_L2.4291.00
30_D105_R2.4001.00
291_G295_A2.3971.00
304_L308_L2.3911.00
161_V177_T2.3831.00
94_F103_T2.3061.00
282_F289_S2.3061.00
283_M286_L2.3031.00
266_F271_L2.2491.00
46_L102_F2.2051.00
154_D177_T2.1771.00
31_L42_V2.1751.00
272_V295_A2.1631.00
43_Q53_R2.1281.00
283_M292_Y2.1071.00
271_L275_S2.0661.00
289_S293_P2.0581.00
101_L132_L2.0521.00
288_W294_G2.0381.00
141_I219_I1.9691.00
253_N256_I1.9671.00
142_E222_D1.8791.00
275_S299_M1.8481.00
52_T71_G1.7901.00
292_Y296_I1.7501.00
288_W291_G1.7261.00
74_I133_L1.6991.00
305_A309_Y1.6831.00
101_L133_L1.6441.00
293_P296_I1.6311.00
189_R231_E1.6271.00
278_M295_A1.6261.00
263_S267_L1.6071.00
52_T68_D1.5971.00
79_F188_V1.5971.00
276_Y292_Y1.5891.00
64_R221_R1.5711.00
48_Q95_T1.5271.00
295_A299_M1.5171.00
276_Y286_L1.4661.00
56_L95_T1.4581.00
307_Y311_K1.4491.00
138_E142_E1.4341.00
280_F291_G1.4321.00
138_E222_D1.4211.00
276_Y285_E1.4131.00
155_L237_V1.3901.00
272_V276_Y1.3711.00
257_K261_V1.3621.00
288_W292_Y1.3571.00
280_F283_M1.3531.00
285_E288_W1.3501.00
134_L216_A1.3451.00
51_A54_P1.3401.00
101_L129_A1.3361.00
283_M293_P1.3351.00
296_I299_M1.3331.00
49_S68_D1.3331.00
162_I240_L1.3321.00
61_A75_H1.3311.00
73_H95_T1.3211.00
254_R257_K1.3191.00
96_I133_L1.3081.00
309_Y313_K1.3061.00
280_F292_Y1.2991.00
116_R120_R1.2991.00
295_A298_F1.2981.00
280_F295_A1.2961.00
74_I94_F1.2921.00
286_L292_Y1.2911.00
220_L224_E1.2741.00
249_N252_Q1.2551.00
267_L271_L1.2381.00
128_N131_E1.2381.00
118_R135_D1.2371.00
26_A129_A1.2311.00
260_S263_S1.2301.00
297_I301_L1.2281.00
291_G294_G1.2271.00
92_V140_K1.2211.00
275_S292_Y1.2171.00
61_A91_T1.2161.00
36_D40_L1.2121.00
55_E64_R1.2031.00
268_P271_L1.1891.00
269_P299_M1.1781.00
276_Y282_F1.1771.00
32_V108_E1.1711.00
40_L43_Q1.1661.00
41_R45_E1.1641.00
26_A132_L1.1541.00
94_F133_L1.1521.00
306_P310_F1.1501.00
191_C195_T1.1471.00
200_N220_L1.1461.00
196_Q224_E1.1451.00
282_F293_P1.1411.00
35_D38_E1.1241.00
276_Y283_M1.1211.00
141_I222_D1.1161.00
256_I263_S1.1071.00
48_Q102_F1.1021.00
182_E242_Q1.0941.00
203_V217_R1.0911.00
182_E234_F1.0901.00
34_P38_E1.0861.00
275_S278_M1.0811.00
255_I260_S1.0721.00
82_D86_H1.0721.00
37_D40_L1.0721.00
25_N99_G1.0681.00
266_F269_P1.0631.00
285_E293_P1.0521.00
151_I181_L1.0501.00
67_E72_L1.0481.00
248_I252_Q1.0321.00
303_G307_Y1.0311.00
117_M120_R1.0291.00
260_S267_L1.0291.00
280_F285_E1.0251.00
56_L93_A1.0231.00
159_S183_D1.0221.00
294_G297_I1.0151.00
269_P272_V1.0051.00
281_E286_L1.0011.00
67_E205_K0.9991.00
199_L223_I0.9821.00
218_E221_R0.9821.00
273_A296_I0.9781.00
301_L305_A0.9781.00
65_F74_I0.9761.00
281_E288_W0.9761.00
39_R43_Q0.9751.00
62_S194_D0.9741.00
115_Y132_L0.9721.00
185_G233_L0.9701.00
54_P142_E0.9681.00
61_A218_E0.9651.00
154_D184_I0.9651.00
22_P25_N0.9621.00
62_S228_P0.9621.00
155_L233_L0.9591.00
272_V299_M0.9591.00
59_I106_E0.9561.00
109_L112_F0.9541.00
196_Q231_E0.9531.00
255_I259_F0.9531.00
175_L244_A0.9521.00
264_V267_L0.9501.00
41_R44_S0.9441.00
276_Y288_W0.9441.00
284_P291_G0.9411.00
179_A241_M0.9361.00
115_Y139_T0.9361.00
22_P99_G0.9321.00
270_T274_S0.9251.00
66_F217_R0.9200.99
49_S52_T0.9200.99
145_A226_L0.9190.99
21_Q24_V0.9140.99
112_F136_L0.9130.99
276_Y284_P0.9100.99
75_H93_A0.9100.99
114_L139_T0.9070.99
47_G50_L0.9030.99
269_P295_A0.8980.99
182_E241_M0.8970.99
209_P212_Q0.8960.99
238_N242_Q0.8930.99
77_F91_T0.8910.99
81_E84_E0.8900.99
186_W236_K0.8890.99
299_M303_G0.8870.99
163_M247_F0.8850.99
285_E291_G0.8820.99
224_E228_P0.8810.99
117_M121_S0.8760.99
243_A257_K0.8710.99
113_R117_M0.8690.99
269_P303_G0.8670.99
185_G237_V0.8640.99
87_A184_I0.8630.99
74_I96_I0.8630.99
141_I223_I0.8580.99
80_F88_G0.8580.99
115_Y135_D0.8580.99
276_Y295_A0.8570.99
263_S266_F0.8560.99
161_V174_A0.8550.99
99_G129_A0.8520.99
33_E106_E0.8510.99
285_E296_I0.8480.99
210_G213_L0.8470.99
283_M288_W0.8420.99
265_V303_G0.8380.99
276_Y279_N0.8370.99
24_V27_V0.8360.99
276_Y310_F0.8360.99
181_L237_V0.8270.99
193_M228_P0.8270.99
283_M291_G0.8250.99
286_L296_I0.8190.99
231_E235_Q0.8130.99
273_A292_Y0.8040.99
254_R267_L0.8040.99
148_I151_I0.8030.99
264_V269_P0.7980.99
270_T275_S0.7950.99
49_S71_G0.7940.98
279_N284_P0.7920.98
90_S105_R0.7890.98
298_F302_A0.7880.98
30_D103_T0.7870.98
89_N187_K0.7820.98
271_L299_M0.7810.98
55_E218_E0.7710.98
249_N256_I0.7690.98
49_S55_E0.7680.98
124_M127_G0.7660.98
262_V268_P0.7620.98
30_D116_R0.7620.98
80_F83_A0.7610.98
291_G298_F0.7520.98
20_S23_L0.7520.98
247_F250_I0.7500.98
54_P138_E0.7490.98
20_S24_V0.7470.98
192_L226_L0.7440.98
92_V112_F0.7380.98
29_I102_F0.7360.98
118_R139_T0.7350.98
152_Y233_L0.7340.97
261_V268_P0.7340.97
305_A308_L0.7320.97
179_A243_A0.7290.97
283_M295_A0.7250.97
251_E260_S0.7240.97
192_L227_L0.7240.97
252_Q256_I0.7230.97
78_F109_L0.7160.97
51_A215_Q0.7150.97
131_E215_Q0.7150.97
154_D157_Q0.7140.97
130_Y212_Q0.7140.97
200_N224_E0.7130.97
37_D41_R0.7110.97
51_A66_F0.7100.97
269_P302_A0.7050.97
138_E141_I0.7030.97
268_P302_A0.7020.97
196_Q200_N0.6990.97
114_L117_M0.6970.97
229_H233_L0.6960.97
249_N253_N0.6950.97
269_P273_A0.6930.96
55_E222_D0.6930.96
258_I262_V0.6890.96
103_T136_L0.6890.96
137_F219_I0.6890.96
77_F89_N0.6860.96
196_Q227_L0.6850.96
62_S142_E0.6840.96
50_L54_P0.6800.96
128_N212_Q0.6760.96
266_F273_A0.6730.96
76_S94_F0.6690.96
278_M283_M0.6680.96
65_F198_A0.6630.95
34_P105_R0.6600.95
234_F242_Q0.6590.95
300_I304_L0.6580.95
288_W293_P0.6580.95
21_Q25_N0.6570.95
55_E221_R0.6560.95
311_K314_N0.6560.95
289_S308_L0.6540.95
74_I198_A0.6530.95
78_F90_S0.6520.95
119_A124_M0.6500.95
51_A55_E0.6470.95
250_I257_K0.6460.95
297_I304_L0.6460.95
302_A305_A0.6440.95
285_E290_F0.6440.95
81_E88_G0.6440.95
72_L96_I0.6430.95
203_V220_L0.6430.95
161_V167_Q0.6410.95
20_S27_V0.6410.95
276_Y280_F0.6390.94
80_F86_H0.6380.94
193_M227_L0.6380.94
82_D85_D0.6350.94
49_S215_Q0.6330.94
258_I309_Y0.6330.94
272_V302_A0.6320.94
150_N154_D0.6320.94
220_L223_I0.6290.94
290_F296_I0.6250.94
281_E289_S0.6250.94
239_F242_Q0.6230.94
274_S277_G0.6230.94
271_L306_P0.6200.94
251_E255_I0.6180.93
195_T225_S0.6160.93
280_F288_W0.6150.93
132_L136_L0.6140.93
123_S126_D0.6130.93
308_L311_K0.6120.93
32_V107_R0.6120.93
81_E86_H0.6110.93
32_V105_R0.6100.93
176_S247_F0.6090.93
39_R53_R0.6070.93
165_G168_G0.6070.93
80_F85_D0.6060.93
97_R129_A0.6060.93
78_F92_V0.6030.93
107_R113_R0.6020.93
51_A219_I0.5980.92
31_L104_L0.5970.92
53_R56_L0.5960.92
81_E87_A0.5950.92
273_A278_M0.5950.92
179_A183_D0.5920.92
134_L218_E0.5890.92
87_A147_E0.5890.92
185_G230_N0.5890.92
271_L303_G0.5870.92
65_F72_L0.5850.91
122_Q125_V0.5840.91
256_I274_S0.5840.91
60_E63_A0.5820.91
238_N241_M0.5760.91
134_L215_Q0.5750.91
76_S140_K0.5740.91
219_I222_D0.5720.91
242_Q245_M0.5700.90
251_E254_R0.5680.90
258_I266_F0.5680.90
55_E66_F0.5670.90
261_V307_Y0.5670.90
265_V269_P0.5660.90
273_A299_M0.5650.90
292_Y295_A0.5640.90
192_L230_N0.5630.90
44_S47_G0.5630.90
158_L177_T0.5610.90
56_L71_G0.5570.89
51_A68_D0.5560.89
167_Q174_A0.5550.89
288_W298_F0.5550.89
29_I100_R0.5540.89
285_E298_F0.5520.89
143_Q146_D0.5520.89
148_I201_F0.5490.89
71_G100_R0.5480.89
235_Q239_F0.5480.89
183_D236_K0.5470.88
260_S269_P0.5470.88
144_L191_C0.5460.88
238_N243_A0.5450.88
196_Q220_L0.5440.88
278_M299_M0.5420.88
285_E294_G0.5390.88
166_H173_E0.5390.88
51_A64_R0.5370.88
36_D39_R0.5370.88
62_S224_E0.5370.88
264_V268_P0.5370.88
273_A285_E0.5370.88
281_E285_E0.5370.88
260_S310_F0.5360.87
48_Q71_G0.5360.87
265_V307_Y0.5350.87
130_Y209_P0.5330.87
39_R57_E0.5320.87
252_Q257_K0.5320.87
189_R196_Q0.5310.87
257_K295_A0.5310.87
271_L274_S0.5310.87
144_L226_L0.5310.87
54_P64_R0.5310.87
138_E215_Q0.5300.87
93_A104_L0.5300.87
252_Q255_I0.5280.87
77_F191_C0.5270.87
235_Q240_L0.5270.87
174_A178_L0.5270.87
78_F105_R0.5260.87
299_M310_F0.5260.87
197_R200_N0.5260.87
308_L314_N0.5250.86
211_G214_E0.5250.86
208_L212_Q0.5210.86
113_R177_T0.5190.86
91_T106_E0.5190.86
34_P104_L0.5180.86
118_R122_Q0.5170.86
148_I193_M0.5160.85
134_L145_A0.5150.85
66_F218_E0.5150.85
149_E226_L0.5140.85
68_D217_R0.5130.85
193_M231_E0.5120.85
309_Y312_R0.5120.85
259_F263_S0.5110.85
134_L219_I0.5110.85
163_M176_S0.5100.85
156_E196_Q0.5100.85
267_L270_T0.5100.85
65_F205_K0.5090.85
39_R104_L0.5080.85
275_S283_M0.5070.84
151_I184_I0.5070.84
260_S264_V0.5060.84
178_L227_L0.5050.84
110_P116_R0.5050.84
300_I303_G0.5030.84
94_F136_L0.5010.84
164_E167_Q0.5010.84
291_G299_M0.5010.84
21_Q27_V0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i0uA 4 0.981 100 0.101 Contact Map
4ev6A 3 0.9778 100 0.107 Contact Map
4egwA 1 0.7658 100 0.444 Contact Map
3ck6A 3 0.75 100 0.479 Contact Map
3nvoA 2 0.7468 100 0.48 Contact Map
2bbhA 2 0.6234 100 0.526 Contact Map
2hn1A 2 0.6994 100 0.541 Contact Map
3rkgA 1 0.7089 88 0.927 Contact Map
4jo7E 2 0.2816 32.9 0.952 Contact Map
4yayA 1 0.4905 19.9 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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