GREMLIN Database
CISY - Citrate synthase
UniProt: P0ABH7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10402
Length: 427 (369)
Sequences: 4094 (1947)
Seq/√Len: 101.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
242_A255_A7.1621.00
76_Q420_D4.1381.00
239_V256_G3.8551.00
94_E100_Q3.5071.00
98_Q102_D3.4531.00
292_A299_F3.3271.00
196_G217_E3.1921.00
73_P76_Q3.0991.00
213_N329_E3.0521.00
151_D154_N3.0191.00
81_S421_F2.9931.00
79_T321_E2.9241.00
342_E345_N2.9241.00
193_S196_G2.7401.00
284_H287_E2.6821.00
242_A259_S2.6341.00
97_T100_Q2.6241.00
324_H341_M2.6061.00
247_A261_W2.5801.00
280_S284_H2.4901.00
85_E101_Y2.4791.00
234_A245_S2.4581.00
216_L373_M2.4231.00
277_E371_K2.3741.00
139_T257_I2.3551.00
94_E419_R2.3451.00
295_K299_F2.3161.00
286_P342_E2.3001.00
241_T407_A2.2821.00
197_N201_M2.1421.00
238_T259_S2.1081.00
162_A393_I2.0651.00
195_A221_D2.0241.00
173_A386_M2.0011.00
87_C390_V1.9611.00
287_E291_R1.9351.00
321_E325_E1.9221.00
245_S259_S1.9111.00
286_P346_I1.9091.00
88_Y94_E1.8441.00
48_T405_K1.8441.00
178_K183_Q1.8361.00
215_I329_E1.8321.00
243_G252_C1.8101.00
192_L196_G1.8091.00
82_N101_Y1.7911.00
120_R123_H1.7891.00
282_V342_E1.7621.00
290_R294_D1.7501.00
324_H328_K1.7381.00
218_R221_D1.7331.00
340_A368_I1.7301.00
375_I383_I1.7211.00
116_E120_R1.7201.00
72_F419_R1.7151.00
193_S217_E1.7151.00
138_I172_M1.7121.00
154_N157_H1.7111.00
243_G396_W1.7101.00
223_I370_L1.6771.00
169_M389_T1.6761.00
102_D106_T1.6681.00
270_E274_K1.6651.00
277_E377_S1.6611.00
342_E346_I1.6571.00
137_G140_G1.6231.00
136_C258_A1.6171.00
58_T229_D1.6051.00
291_R295_K1.5971.00
75_D317_T1.5861.00
202_M375_I1.5721.00
351_P355_E1.5661.00
214_P218_R1.5541.00
334_D371_K1.5391.00
136_C140_G1.5371.00
91_L166_L1.5231.00
99_E103_E1.5121.00
222_R322_T1.4991.00
134_V176_C1.4821.00
189_R200_N1.4721.00
107_T163_F1.4671.00
213_N216_L1.4631.00
139_T169_M1.4581.00
189_R211_E1.4481.00
255_A259_S1.4431.00
86_V225_I1.4401.00
223_I319_M1.4281.00
88_Y100_Q1.4261.00
321_E324_H1.4241.00
84_L108_V1.4241.00
111_H164_R1.4231.00
174_A198_F1.4161.00
328_K334_D1.4051.00
188_P197_N1.4011.00
218_R222_R1.3841.00
121_L141_A1.3720.99
234_A259_S1.3610.99
189_R192_L1.3560.99
279_I292_A1.3540.99
76_Q80_D1.3490.99
66_I73_P1.3460.99
106_T110_R1.3410.99
238_T255_A1.3310.99
120_R124_A1.3290.99
112_T194_Y1.3120.99
188_P201_M1.3100.99
282_V345_N1.2930.99
265_H268_A1.2910.99
119_T175_M1.2900.99
323_C368_I1.2770.99
228_A390_V1.2670.99
186_V201_M1.2610.99
112_T190_N1.2580.99
312_Y317_T1.2540.99
180_S378_S1.2520.99
70_R93_G1.2380.99
283_K287_E1.2310.99
48_T307_R1.2250.99
249_P393_I1.2240.99
238_T242_A1.2200.99
72_F95_K1.2180.99
304_F347_A1.2040.99
320_R344_E1.2000.99
251_A261_W1.1840.98
69_H228_A1.1830.98
247_A251_A1.1790.98
289_V347_A1.1780.98
107_T160_I1.1770.98
157_H161_A1.1750.98
161_A249_P1.1700.98
102_D105_K1.1700.98
294_D298_S1.1610.98
238_T241_T1.1580.98
90_L390_V1.1580.98
91_L393_I1.1530.98
89_I95_K1.1490.98
231_E410_R1.1470.98
132_M269_N1.1400.98
301_L347_A1.1390.98
260_L385_A1.1360.98
155_P401_S1.1360.98
81_S225_I1.1320.98
215_I325_E1.1280.98
103_E107_T1.1280.98
123_H184_P1.1260.98
54_E412_L1.1200.98
173_A382_V1.1140.98
105_K109_T1.1120.98
88_Y92_N1.1110.98
92_N159_E1.1100.98
135_M173_A1.1090.98
111_H163_F1.1090.98
281_S284_H1.1060.98
282_V339_V1.1040.98
72_F89_I1.0970.97
320_R324_H1.0940.97
319_M369_I1.0900.97
322_T325_E1.0890.97
253_I393_I1.0870.97
281_S335_D1.0800.97
75_D318_V1.0790.97
203_F216_L1.0780.97
83_Y390_V1.0690.97
387_A390_V1.0670.97
165_L253_I1.0630.97
160_I164_R1.0590.97
264_A300_R1.0540.97
184_P187_Y1.0430.97
253_I389_T1.0420.97
186_V200_N1.0360.96
81_S85_E1.0340.96
397_S401_S1.0300.96
76_Q79_T1.0300.96
239_V396_W1.0300.96
285_I342_E1.0290.96
99_E102_D1.0290.96
371_K377_S1.0280.96
54_E414_T1.0250.96
279_I285_I1.0190.96
182_G186_V1.0070.96
279_I288_F0.9970.96
221_D225_I0.9970.96
82_N221_D0.9940.95
331_G334_D0.9930.95
114_I175_M0.9920.95
247_A252_C0.9910.95
341_M345_N0.9900.95
286_P290_R0.9890.95
275_M292_A0.9890.95
186_V204_S0.9870.95
320_R341_M0.9850.95
113_M187_Y0.9830.95
249_P396_W0.9730.95
159_E397_S0.9720.95
130_H270_E0.9700.95
69_H86_V0.9680.95
114_I172_M0.9680.95
340_A367_G0.9600.95
171_T188_P0.9580.94
276_L343_L0.9570.94
278_E299_F0.9560.94
289_V346_I0.9550.94
196_G214_P0.9540.94
74_I318_V0.9530.94
85_E421_F0.9460.94
94_E97_T0.9450.94
197_N200_N0.9410.94
288_F292_A0.9380.94
136_C254_A0.9370.94
45_P402_D0.9330.94
290_R351_P0.9250.93
240_R399_M0.9240.93
279_I343_L0.9220.93
44_D414_T0.9210.93
292_A298_S0.9210.93
122_F176_C0.9110.93
180_S184_P0.9080.93
277_E336_L0.9060.93
216_L326_V0.9000.92
280_S335_D0.8990.92
271_A274_K0.8970.92
338_E341_M0.8910.92
53_C232_Q0.8790.91
274_K377_S0.8790.91
91_L390_V0.8770.91
140_G258_A0.8750.91
195_A217_E0.8740.91
287_E290_R0.8730.91
340_A364_F0.8720.91
227_H362_V0.8710.91
100_Q103_E0.8690.91
72_F77_L0.8680.91
192_L197_N0.8660.91
90_L228_A0.8660.91
58_T231_E0.8640.91
88_Y104_F0.8580.90
179_Y183_Q0.8560.90
177_Y181_I0.8560.90
269_N363_D0.8560.90
246_G264_A0.8550.90
125_F144_A0.8440.90
64_E311_N0.8420.90
119_T123_H0.8410.90
245_S406_I0.8370.89
224_L386_M0.8370.89
230_H309_Y0.8350.89
348_L352_Y0.8340.89
195_A220_M0.8340.89
118_I138_I0.8320.89
122_F138_I0.8300.89
101_Y105_K0.8300.89
84_L195_A0.8290.89
268_A361_N0.8210.88
218_R322_T0.8210.88
232_Q410_R0.8200.88
166_L194_Y0.8190.88
108_V163_F0.8190.88
323_C340_A0.8180.88
161_A250_F0.8160.88
257_I385_A0.8160.88
272_A276_L0.8130.88
260_L384_F0.8110.88
280_S283_K0.8110.88
282_V286_P0.8090.88
235_S265_H0.8080.88
282_V338_E0.8050.87
354_I357_K0.8050.87
272_A339_V0.8050.87
68_L418_K0.8030.87
192_L217_E0.7990.87
85_E95_K0.7940.87
334_D338_E0.7940.87
68_L417_E0.7920.87
352_Y355_E0.7910.87
266_G384_F0.7900.86
82_N85_E0.7900.86
151_D157_H0.7890.86
237_S241_T0.7860.86
125_F141_A0.7850.86
111_H160_I0.7830.86
121_L124_A0.7820.86
322_T369_I0.7820.86
62_G65_G0.7800.86
218_R325_E0.7790.86
269_N381_T0.7790.86
319_M366_S0.7760.85
107_T111_H0.7740.85
215_I219_A0.7730.85
113_M190_N0.7730.85
171_T201_M0.7720.85
162_A397_S0.7720.85
157_H160_I0.7710.85
183_Q186_V0.7700.85
324_H337_L0.7690.85
312_Y320_R0.7680.85
337_L341_M0.7680.85
205_T212_V0.7670.85
227_H269_N0.7670.85
273_L380_F0.7660.85
265_H363_D0.7650.85
237_S407_A0.7640.85
56_K414_T0.7640.85
148_D151_D0.7630.85
158_R161_A0.7630.85
192_L212_V0.7620.84
146_Y164_R0.7610.84
260_L266_G0.7590.84
58_T68_L0.7590.84
113_M160_I0.7580.84
61_D64_E0.7570.84
216_L330_L0.7550.84
195_A224_L0.7540.84
275_M288_F0.7510.84
87_C104_F0.7500.84
78_A225_I0.7480.83
62_G311_N0.7480.83
252_C396_W0.7420.83
265_H384_F0.7410.83
178_K186_V0.7400.83
87_C166_L0.7400.83
118_I141_A0.7390.83
351_P354_I0.7330.82
294_D351_P0.7330.82
148_D160_I0.7310.82
274_K277_E0.7290.82
181_I376_P0.7280.82
292_A295_K0.7260.81
193_S221_D0.7250.81
304_F360_P0.7240.81
82_N218_R0.7240.81
117_Q120_R0.7200.81
246_G263_P0.7190.81
284_H291_R0.7190.81
278_E292_A0.7150.80
167_S170_P0.7110.80
283_K286_P0.7080.80
83_Y87_C0.7070.80
121_L125_F0.7060.80
118_I121_L0.7050.80
164_R168_K0.7050.80
110_R190_N0.7050.80
290_R355_E0.7040.79
227_H366_S0.7010.79
69_H89_I0.7000.79
47_F237_S0.6990.79
122_F185_F0.6980.79
179_Y184_P0.6970.79
117_Q145_F0.6960.79
135_M257_I0.6940.79
291_R299_F0.6930.78
179_Y182_G0.6900.78
285_I346_I0.6900.78
276_L340_A0.6870.78
336_L371_K0.6870.78
59_F413_Y0.6870.78
82_N105_K0.6860.78
212_V217_E0.6860.78
86_V228_A0.6840.77
175_M201_M0.6820.77
109_T190_N0.6800.77
165_L249_P0.6790.77
158_R400_H0.6790.77
323_C369_I0.6780.77
77_L86_V0.6750.77
333_K338_E0.6740.76
114_I119_T0.6720.76
52_S237_S0.6670.76
77_L95_K0.6660.76
260_L269_N0.6650.76
140_G254_A0.6620.75
123_H175_M0.6600.75
47_F50_T0.6600.75
68_L73_P0.6570.75
115_H118_I0.6560.75
223_I227_H0.6560.75
107_T110_R0.6550.74
59_F64_E0.6540.74
116_E187_Y0.6530.74
353_F358_L0.6530.74
242_A252_C0.6520.74
235_S266_G0.6510.74
148_D164_R0.6490.74
175_M185_F0.6440.73
233_N362_V0.6410.73
301_L356_K0.6400.73
289_V339_V0.6380.72
230_H384_F0.6370.72
402_D405_K0.6370.72
83_Y221_D0.6350.72
192_L200_N0.6340.72
338_E342_E0.6330.72
389_T393_I0.6320.72
362_V366_S0.6310.72
55_S60_I0.6310.72
231_E411_Q0.6300.72
108_V167_S0.6270.71
248_N251_A0.6270.71
416_Y419_R0.6250.71
122_F179_Y0.6240.71
271_A302_M0.6230.71
230_H233_N0.6220.71
222_R225_I0.6220.71
287_E294_D0.6190.70
224_L387_A0.6190.70
286_P289_V0.6190.70
47_F52_S0.6180.70
246_G400_H0.6170.70
300_R406_I0.6160.70
74_I226_L0.6140.70
377_S380_F0.6130.69
236_T395_H0.6110.69
81_S221_D0.6110.69
227_H363_D0.6090.69
139_T165_L0.6090.69
233_N384_F0.6090.69
111_H168_K0.6090.69
335_D338_E0.6080.69
180_S183_Q0.6070.69
174_A178_K0.6070.69
72_F94_E0.6070.69
272_A362_V0.6050.68
320_R365_Y0.6040.68
286_P354_I0.6040.68
162_A249_P0.6020.68
248_N261_W0.6000.68
218_R225_I0.5990.68
230_H266_G0.5990.68
375_I379_M0.5990.68
233_N309_Y0.5980.68
309_Y392_W0.5980.68
236_T381_T0.5960.67
44_D50_T0.5950.67
273_L377_S0.5950.67
195_A199_L0.5940.67
221_D405_K0.5930.67
331_G422_K0.5920.67
143_A248_N0.5920.67
232_Q240_R0.5920.67
158_R162_A0.5920.67
319_M323_C0.5900.67
226_L318_V0.5880.66
285_I339_V0.5880.66
273_L371_K0.5870.66
166_L390_V0.5860.66
385_A392_W0.5850.66
235_S384_F0.5830.66
72_F76_Q0.5830.66
67_L74_I0.5830.66
274_K278_E0.5810.65
344_E360_P0.5810.65
103_E106_T0.5810.65
290_R293_K0.5800.65
246_G403_G0.5800.65
327_L337_L0.5800.65
111_H256_G0.5790.65
174_A201_M0.5790.65
282_V285_I0.5780.65
326_V369_I0.5770.65
163_F167_S0.5750.65
362_V369_I0.5740.64
169_M172_M0.5730.64
144_A175_M0.5730.64
222_R325_E0.5730.64
166_L393_I0.5720.64
323_C337_L0.5690.64
358_L364_F0.5690.64
235_S363_D0.5690.64
182_G185_F0.5690.64
236_T240_R0.5670.63
348_L355_E0.5660.63
70_R87_C0.5660.63
294_D299_F0.5650.63
279_I289_V0.5650.63
275_M279_I0.5640.63
123_H127_R0.5630.63
156_R160_I0.5620.63
310_K357_K0.5620.63
291_R294_D0.5620.63
367_G384_F0.5610.63
263_P268_A0.5610.63
347_A352_Y0.5580.62
223_I383_I0.5570.62
233_N306_H0.5570.62
265_H305_G0.5570.62
49_S417_E0.5550.62
53_C60_I0.5530.62
286_P324_H0.5520.61
121_L138_I0.5510.61
47_F407_A0.5510.61
42_T294_D0.5500.61
55_S58_T0.5500.61
277_E380_F0.5490.61
189_R197_N0.5490.61
288_F299_F0.5470.61
165_L389_T0.5430.60
231_E358_L0.5390.60
273_L340_A0.5380.59
305_G361_N0.5360.59
87_C91_L0.5350.59
59_F62_G0.5350.59
238_T356_K0.5330.59
199_L217_E0.5330.59
273_L368_I0.5320.59
182_G187_Y0.5320.59
132_M260_L0.5310.59
198_F386_M0.5300.58
125_F137_G0.5290.58
319_M370_L0.5290.58
230_H235_S0.5280.58
114_I171_T0.5280.58
47_F51_A0.5270.58
158_R397_S0.5260.58
278_E282_V0.5260.58
140_G143_A0.5240.58
66_I75_D0.5240.58
116_E184_P0.5230.57
290_R354_I0.5230.57
73_P420_D0.5230.57
168_K171_T0.5230.57
128_D147_H0.5210.57
229_D393_I0.5200.57
114_I118_I0.5200.57
396_W411_Q0.5200.57
205_T211_E0.5200.57
118_I186_V0.5200.57
49_S60_I0.5190.57
219_A369_I0.5190.57
252_C259_S0.5170.57
149_S161_A0.5170.57
69_H226_L0.5170.57
232_Q302_M0.5160.56
312_Y316_A0.5140.56
66_I418_K0.5140.56
124_A128_D0.5130.56
183_Q187_Y0.5130.56
87_C240_R0.5130.56
52_S60_I0.5120.56
307_R310_K0.5100.55
77_L89_I0.5100.55
292_A301_L0.5090.55
98_Q205_T0.5090.55
381_T384_F0.5080.55
235_S260_L0.5080.55
240_R276_L0.5060.55
199_L220_M0.5040.55
244_S318_V0.5040.55
293_K352_Y0.5040.55
67_L71_G0.5020.54
283_K331_G0.5020.54
295_K298_S0.5010.54
200_N211_E0.5000.54
188_P192_L0.5000.54
81_S101_Y0.5000.54
61_D66_I0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xghA 5 0.904 100 0.076 Contact Map
2h12A 4 0.9859 100 0.078 Contact Map
4jadA 5 0.993 100 0.088 Contact Map
4tvmA 2 0.8806 100 0.093 Contact Map
3msuA 2 0.9719 100 0.105 Contact Map
2ibpA 2 0.9251 100 0.122 Contact Map
1iomA 2 0.8735 100 0.128 Contact Map
1aj8A 2 0.8665 100 0.132 Contact Map
1o7xA 2 0.8665 100 0.134 Contact Map
1vgpA 2 0.8712 100 0.134 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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