GREMLIN Database
MRED - Rod shape-determining protein MreD
UniProt: P0ABH4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10610
Length: 162 (151)
Sequences: 735 (523)
Seq/√Len: 42.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_I85_A5.3191.00
111_S141_N5.1951.00
108_M142_G5.0631.00
19_A42_I3.4611.00
56_V82_S2.9641.00
43_L54_V2.7641.00
49_A153_R2.4971.00
44_L107_V2.3801.00
11_V155_V2.1841.00
149_F156_R2.1420.99
94_L98_L2.1140.99
49_A156_R2.0920.99
60_F82_S2.0220.99
22_L38_W2.0020.99
96_R156_R1.9590.99
20_L39_V1.8730.99
24_I72_S1.8630.99
34_F136_W1.7570.98
43_L85_A1.7560.98
115_D138_S1.7500.98
45_Y153_R1.7390.98
45_Y156_R1.6860.97
66_L81_M1.6650.97
55_N85_A1.6570.97
40_L84_I1.6500.97
40_L111_S1.6380.97
153_R156_R1.6030.96
137_S140_V1.5620.96
13_W62_M1.5270.95
16_F62_M1.4900.94
87_L113_V1.4580.94
58_T62_M1.4410.93
23_Q66_L1.4380.93
48_L88_V1.4140.93
24_I69_I1.4020.92
13_W58_T1.3980.92
27_W34_F1.3710.91
72_S79_L1.3470.91
99_A102_Q1.3400.90
15_S46_W1.3370.90
77_R131_R1.3340.90
37_N81_M1.3130.89
76_V119_F1.3090.89
38_W102_Q1.2890.89
44_L88_V1.2710.88
15_S19_A1.2650.88
25_M30_N1.2640.88
51_P55_N1.2620.88
47_I111_S1.2420.87
68_L73_T1.2390.87
37_N98_L1.2340.86
80_A118_V1.1930.84
37_N141_N1.1790.84
49_A149_F1.1760.83
45_Y96_R1.1450.82
112_L141_N1.1370.81
29_D105_L1.1340.81
17_L155_V1.1300.81
25_M34_F1.1170.80
8_G14_L1.1150.80
137_S141_N1.1110.80
122_E126_I1.1050.79
10_W101_W1.1030.79
50_L153_R1.0920.79
39_V62_M1.0620.77
15_S152_M1.0460.76
47_I90_L1.0370.75
90_L135_F1.0250.74
86_Y111_S1.0220.74
83_I117_I1.0190.74
96_R153_R1.0140.73
86_Y121_A1.0130.73
79_L143_V0.9970.72
50_L156_R0.9940.72
12_I15_S0.9750.70
74_L82_S0.9740.70
76_V136_W0.9700.70
29_D32_I0.9530.68
60_F78_V0.9520.68
56_V110_L0.9470.68
70_S77_R0.9340.67
94_L103_Q0.9320.67
77_R129_S0.9220.66
14_L18_I0.9210.66
110_L118_V0.9170.65
95_F111_S0.9150.65
149_F153_R0.9140.65
11_V16_F0.9140.65
45_Y97_N0.9000.64
88_V98_L0.8990.64
55_N89_A0.8940.63
48_L152_M0.8890.63
139_V143_V0.8830.63
13_W23_Q0.8810.62
27_W35_R0.8700.61
8_G15_S0.8700.61
17_L71_G0.8690.61
45_Y49_A0.8630.61
50_L53_R0.8620.61
45_Y149_F0.8500.60
23_Q81_M0.8380.58
40_L55_N0.8360.58
49_A157_Q0.8320.58
41_L106_V0.8300.58
120_W123_F0.8240.57
46_W152_M0.8170.57
112_L115_D0.8120.56
115_D134_V0.8090.56
49_A96_R0.8070.56
76_V97_N0.7990.55
113_V158_Q0.7980.55
84_I114_V0.7940.54
70_S117_I0.7820.53
100_L150_L0.7770.53
60_F158_Q0.7720.52
134_V140_V0.7720.52
79_L82_S0.7700.52
59_G87_L0.7690.52
14_L41_L0.7680.52
28_P147_W0.7580.51
87_L91_K0.7570.51
42_I148_I0.7550.51
127_N131_R0.7480.50
88_V155_V0.7400.49
98_L130_F0.7380.49
89_A119_F0.7360.49
30_N61_V0.7340.49
26_P156_R0.7270.48
151_L154_K0.7230.48
83_I133_E0.7210.47
53_R85_A0.7110.47
115_D148_I0.7070.46
132_P144_L0.7040.46
77_R123_F0.7020.46
76_V118_V0.7010.46
17_L139_V0.6970.45
58_T61_V0.6920.45
19_A144_L0.6900.45
21_L105_L0.6770.43
119_F122_E0.6760.43
44_L113_V0.6700.43
120_W137_S0.6690.43
38_W50_L0.6670.42
82_S92_Y0.6640.42
27_W69_I0.6640.42
135_F138_S0.6630.42
79_L105_L0.6600.42
100_L121_A0.6570.41
114_V135_F0.6560.41
112_L116_I0.6550.41
119_F130_F0.6540.41
49_A53_R0.6440.40
70_S111_S0.6430.40
122_E131_R0.6380.40
84_I106_V0.6310.39
82_S107_V0.6270.39
144_L147_W0.6240.38
48_L151_L0.6230.38
44_L48_L0.6220.38
72_S147_W0.6200.38
123_F129_S0.6180.38
53_R73_T0.6120.37
13_W18_I0.6120.37
49_A92_Y0.6120.37
82_S109_L0.6110.37
83_I121_A0.6110.37
116_I120_W0.6040.37
112_L143_V0.6030.37
88_V94_L0.5970.36
64_A137_S0.5960.36
12_I108_M0.5940.36
21_L90_L0.5930.36
29_D139_V0.5930.36
36_P63_G0.5910.36
41_L71_G0.5890.35
83_I113_V0.5880.35
27_W62_M0.5870.35
64_A73_T0.5840.35
85_A107_V0.5830.35
76_V126_I0.5820.35
67_D75_G0.5820.35
80_A114_V0.5810.35
56_V85_A0.5750.34
43_L74_L0.5740.34
117_I133_E0.5740.34
50_L155_V0.5740.34
18_I65_I0.5740.34
107_V150_L0.5700.34
43_L110_L0.5680.34
74_L144_L0.5630.33
17_L61_V0.5610.33
42_I95_F0.5600.33
11_V88_V0.5600.33
71_G93_Q0.5580.33
73_T121_A0.5570.33
34_F124_L0.5570.33
41_L61_V0.5550.33
112_L120_W0.5530.32
37_N111_S0.5520.32
43_L65_I0.5500.32
98_L112_L0.5480.32
30_N143_V0.5460.32
35_R102_Q0.5450.32
63_G67_D0.5400.31
76_V130_F0.5350.31
73_T150_L0.5350.31
86_Y89_A0.5340.31
21_L147_W0.5330.31
16_F98_L0.5330.31
107_V143_V0.5240.30
77_R86_Y0.5220.30
37_N135_F0.5220.30
59_G152_M0.5150.29
84_I113_V0.5120.29
124_L129_S0.5110.29
61_V108_M0.5100.29
47_I139_V0.5090.29
28_P38_W0.5080.29
107_V116_I0.5080.29
19_A124_L0.5070.29
126_I154_K0.5050.29
42_I143_V0.5040.28
31_L104_A0.5030.28
69_I143_V0.5020.28
32_I144_L0.5000.28
67_D145_W0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hzuS 1 0.9568 72 0.911 Contact Map
4rfsS 1 0.9321 47.6 0.923 Contact Map
3p5nA 2 0.9074 32.7 0.93 Contact Map
4z7fA 2 0.9198 20.2 0.937 Contact Map
3rlbA 1 0.9506 18.4 0.938 Contact Map
4tkrA 2 0.9444 14.9 0.94 Contact Map
4huqS 1 0.9136 10.9 0.944 Contact Map
4brcA 2 0.3457 2.8 0.958 Contact Map
4dveA 3 0.963 2.7 0.958 Contact Map
3tx3A 2 0.3333 2.6 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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