FTSA - ECOLI - GREMLIN Contacts

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FTSA - Cell division protein FtsA

UniProt:	P0ABH0	Sequences: MIKATDRKLVVGLEIGTAKVAALVGEVLPDGMVNIIGVGSCPSRGMDKGGVNDLESVVKCVQRAIDQAELMADCQISSVYLALSGKHISCQNEIGMVPISEEEVTQEDVENVVHTAKSVRVRDEHRVLHVIPQEYAIDYQEGIKNPVGLSGVRMQAKVHLITCHNDMAKNIVKAVERCGLKVDQLIFAGLASSYSVLTEDERELGVCVVDIGGGTMDIAVYTGGALRHTKVIPYAGNVVTSDIAYAFGTPPSDAEAIKVRHGCALGSIVGKDESVEVPSVGGRPPRSLQRQTLAEVIEPRYTELLNLVNEEILQLQEKLRQQGVKHHLAAGIVLTGGAAQIEGLAACAQRVFHTQVRIGAPLNITGLTDYAQEPYYSTAVGLLHYGKESHLNGEAEVEKRVTASVGSWIKRLNSWLRKEF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10339
Length:	420 (338)
Sequences:	8167 (4630)
Seq/√Len:	251.8

ECOLI - FTSA DNAK HSCA HSCC YEGD MREB
BACSU - FTSA DNAK MBL MREB MREBH
HALSA - DNAK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
154_M	181_K	4.012	1.00
242_D	299_P	3.881	1.00
231_V	303_E	3.738	1.00
255_E	259_V	3.513	1.00
209_V	304_L	3.061	1.00
18_A	213_G	2.885	1.00
346_A	350_R	2.748	1.00
378_T	382_L	2.715	1.00
379_A	382_L	2.630	1.00
360_A	363_N	2.503	1.00
243_I	288_L	2.477	1.00
338_A	341_I	2.474	1.00
292_T	295_E	2.454	1.00
220_V	311_E	2.449	1.00
379_A	383_L	2.413	1.00
176_E	181_K	2.392	1.00
380_V	383_L	2.372	1.00
17_T	214_G	2.359	1.00
378_T	383_L	2.296	1.00
158_V	369_D	2.294	1.00
377_S	380_V	2.270	1.00
298_E	302_T	2.258	1.00
301_Y	343_G	2.228	1.00
256_A	260_R	2.221	1.00
84_S	87_H	2.217	1.00
20_V	140_Q	2.165	1.00
246_A	296_V	2.157	1.00
207_C	218_I	2.130	1.00
289_Q	292_T	2.106	1.00
239_V	300_R	2.095	1.00
43_S	46_M	2.092	1.00
211_I	239_V	2.077	1.00
239_V	301_Y	2.068	1.00
85_G	88_I	2.030	1.00
377_S	383_L	2.025	1.00
135_Y	138_D	2.017	1.00
207_C	220_V	1.996	1.00
377_S	382_L	1.991	1.00
141_E	145_N	1.972	1.00
377_S	381_G	1.966	1.00
345_A	357_R	1.948	1.00
23_L	370_Y	1.935	1.00
253_D	256_A	1.920	1.00
347_C	350_R	1.913	1.00
305_L	351_V	1.902	1.00
309_N	351_V	1.886	1.00
169_K	173_K	1.884	1.00
87_H	90_C	1.883	1.00
378_T	381_G	1.809	1.00
242_D	300_R	1.795	1.00
274_S	287_S	1.794	1.00
297_I	301_Y	1.791	1.00
84_S	88_I	1.789	1.00
142_G	146_P	1.780	1.00
211_I	216_M	1.779	1.00
205_G	222_T	1.772	1.00
247_F	254_A	1.769	1.00
236_G	338_A	1.747	1.00
293_L	341_I	1.745	1.00
11_V	22_A	1.731	1.00
90_C	95_G	1.723	1.00
53_D	56_S	1.719	1.00
247_F	286_R	1.715	1.00
280_V	283_R	1.687	1.00
244_A	251_P	1.649	1.00
157_K	175_V	1.647	1.00
246_A	292_T	1.636	1.00
272_D	287_S	1.633	1.00
243_I	254_A	1.601	1.00
294_A	346_A	1.597	1.00
15_I	171_I	1.587	1.00
244_A	254_A	1.585	1.00
154_M	183_D	1.584	1.00
242_D	297_I	1.579	1.00
290_R	294_A	1.561	1.00
8_K	154_M	1.559	1.00
86_K	90_C	1.547	1.00
297_I	341_I	1.541	1.00
60_C	237_N	1.514	1.00
239_V	293_L	1.500	1.00
241_S	251_P	1.485	1.00
127_V	132_P	1.484	1.00
305_L	309_N	1.480	1.00
305_L	344_L	1.478	1.00
302_T	347_C	1.467	1.00
239_V	297_I	1.457	1.00
310_E	321_Q	1.457	1.00
309_N	320_R	1.441	1.00
10_V	183_D	1.430	1.00
332_I	352_F	1.424	1.00
134_E	177_R	1.420	1.00
22_A	64_A	1.405	1.00
93_E	96_M	1.388	1.00
76_I	79_V	1.385	1.00
343_G	346_A	1.382	1.00
139_Y	143_I	1.378	1.00
49_G	53_D	1.370	1.00
204_L	331_G	1.360	1.00
306_N	309_N	1.354	1.00
306_N	310_E	1.353	1.00
220_V	329_A	1.331	1.00
234_Y	238_V	1.284	1.00
15_I	137_I	1.284	1.00
243_I	293_L	1.280	1.00
301_Y	347_C	1.278	1.00
253_D	257_I	1.274	1.00
297_I	300_R	1.270	1.00
276_E	285_P	1.262	1.00
172_V	185_L	1.261	1.00
214_G	217_D	1.240	1.00
90_C	94_I	1.234	1.00
37_G	49_G	1.234	1.00
204_L	330_A	1.232	1.00
242_D	245_Y	1.208	1.00
85_G	90_C	1.207	1.00
216_M	304_L	1.202	1.00
188_A	217_D	1.201	1.00
133_Q	171_I	1.198	1.00
92_N	96_M	1.191	1.00
279_S	282_G	1.185	1.00
211_I	344_L	1.185	1.00
10_V	373_E	1.184	1.00
81_L	84_S	1.183	1.00
78_S	82_A	1.178	1.00
73_D	76_I	1.169	1.00
257_I	288_L	1.167	1.00
298_E	343_G	1.161	1.00
295_E	298_E	1.153	1.00
205_G	324_V	1.145	1.00
127_V	135_Y	1.143	1.00
239_V	338_A	1.133	1.00
293_L	338_A	1.130	1.00
240_T	258_K	1.129	1.00
343_G	347_C	1.114	1.00
88_I	91_Q	1.112	1.00
38_V	135_Y	1.108	1.00
279_S	283_R	1.107	1.00
62_Q	66_D	1.106	1.00
241_S	245_Y	1.105	1.00
159_H	185_L	1.105	1.00
372_Q	375_Y	1.101	1.00
140_Q	143_I	1.098	1.00
82_A	85_G	1.098	1.00
95_G	98_P	1.095	1.00
174_A	178_C	1.089	1.00
83_L	88_I	1.086	1.00
79_V	84_S	1.083	1.00
187_F	190_L	1.081	1.00
46_M	49_G	1.080	1.00
307_L	311_E	1.072	1.00
273_E	277_V	1.066	1.00
77_S	80_Y	1.064	1.00
340_Q	362_L	1.049	1.00
291_Q	295_E	1.044	1.00
218_I	311_E	1.031	1.00
42_P	46_M	1.030	1.00
33_V	36_I	1.028	1.00
278_P	283_R	1.027	1.00
33_V	38_V	1.017	1.00
86_K	98_P	1.016	1.00
257_I	275_V	1.011	1.00
168_A	187_F	1.009	1.00
276_E	279_S	1.008	1.00
197_L	200_D	1.007	1.00
276_E	280_V	1.007	1.00
172_V	176_E	1.003	1.00
249_T	277_V	1.002	1.00
143_I	146_P	1.001	1.00
90_C	97_V	1.000	1.00
186_I	191_A	0.995	1.00
305_L	348_A	0.995	1.00
290_R	342_E	0.993	1.00
257_I	273_E	0.989	1.00
94_I	97_V	0.983	1.00
78_S	183_D	0.982	1.00
302_T	306_N	0.978	1.00
88_I	95_G	0.978	1.00
23_L	366_G	0.978	1.00
73_D	79_V	0.976	1.00
277_V	280_V	0.976	1.00
141_E	180_L	0.972	1.00
173_K	176_E	0.966	1.00
345_A	349_Q	0.963	1.00
93_E	98_P	0.958	1.00
308_V	348_A	0.954	1.00
167_M	170_N	0.953	1.00
93_E	97_V	0.951	1.00
240_T	255_E	0.941	1.00
74_C	77_S	0.940	1.00
163_C	167_M	0.939	1.00
138_D	142_G	0.933	1.00
249_T	253_D	0.927	1.00
349_Q	355_Q	0.923	1.00
334_L	348_A	0.922	1.00
38_V	41_C	0.921	1.00
239_V	341_I	0.921	1.00
220_V	324_V	0.918	1.00
34_N	38_V	0.917	1.00
160_L	163_C	0.917	1.00
305_L	308_V	0.915	1.00
21_A	31_G	0.911	1.00
258_K	338_A	0.907	1.00
220_V	322_Q	0.905	1.00
82_A	88_I	0.904	1.00
79_V	82_A	0.904	1.00
272_D	278_P	0.901	1.00
325_K	328_L	0.900	1.00
173_K	177_R	0.897	1.00
91_Q	95_G	0.893	1.00
61_V	133_Q	0.892	1.00
340_Q	373_E	0.891	1.00
61_V	174_A	0.887	1.00
79_V	85_G	0.886	1.00
22_A	140_Q	0.885	1.00
262_G	297_I	0.884	1.00
301_Y	304_L	0.883	1.00
175_V	182_V	0.881	1.00
255_E	258_K	0.880	1.00
211_I	304_L	0.875	1.00
346_A	349_Q	0.871	1.00
83_L	90_C	0.865	0.99
161_I	171_I	0.863	0.99
273_E	278_P	0.860	0.99
83_L	87_H	0.860	0.99
249_T	278_P	0.859	0.99
331_G	356_V	0.857	0.99
292_T	296_V	0.849	0.99
87_H	91_Q	0.840	0.99
166_D	170_N	0.839	0.99
9_L	150_S	0.837	0.99
305_L	347_C	0.835	0.99
86_K	95_G	0.834	0.99
83_L	86_K	0.831	0.99
79_V	87_H	0.828	0.99
246_A	288_L	0.827	0.99
347_C	351_V	0.827	0.99
82_A	86_K	0.824	0.99
30_D	363_N	0.820	0.99
175_V	185_L	0.817	0.99
278_P	282_G	0.815	0.99
205_G	330_A	0.815	0.99
86_K	89_S	0.815	0.99
76_I	83_L	0.813	0.99
31_G	34_N	0.813	0.99
12_G	383_L	0.813	0.99
304_L	307_L	0.812	0.99
276_E	282_G	0.810	0.99
85_G	93_E	0.809	0.99
84_S	90_C	0.809	0.99
272_D	277_V	0.809	0.99
87_H	95_G	0.807	0.99
358_I	361_P	0.806	0.99
55_E	86_K	0.805	0.99
131_I	177_R	0.804	0.99
91_Q	96_M	0.801	0.99
364_I	368_T	0.801	0.99
320_R	325_K	0.801	0.99
356_V	364_I	0.800	0.99
74_C	80_Y	0.800	0.99
85_G	89_S	0.796	0.99
229_T	307_L	0.795	0.99
324_V	328_L	0.790	0.99
96_M	99_I	0.788	0.99
26_E	34_N	0.788	0.99
11_V	155_Q	0.787	0.99
303_E	307_L	0.786	0.99
224_G	227_R	0.785	0.99
79_V	90_C	0.781	0.99
79_V	83_L	0.781	0.99
303_E	306_N	0.780	0.99
206_V	333_V	0.780	0.99
374_P	381_G	0.773	0.99
92_N	95_G	0.770	0.99
25_G	374_P	0.769	0.99
298_E	347_C	0.765	0.99
214_G	236_G	0.763	0.99
357_R	360_A	0.762	0.99
76_I	88_I	0.762	0.99
58_V	61_V	0.761	0.99
161_I	217_D	0.760	0.99
189_G	217_D	0.760	0.99
211_I	338_A	0.757	0.99
53_D	57_V	0.757	0.99
76_I	84_S	0.754	0.99
247_F	288_L	0.753	0.99
98_P	126_R	0.752	0.99
288_L	293_L	0.751	0.99
276_E	283_R	0.751	0.99
243_I	246_A	0.751	0.99
319_L	326_H	0.742	0.98
58_V	132_P	0.741	0.98
131_I	135_Y	0.739	0.98
77_S	81_L	0.738	0.98
80_Y	86_K	0.737	0.98
85_G	92_N	0.735	0.98
211_I	339_A	0.732	0.98
273_E	283_R	0.732	0.98
274_S	280_V	0.730	0.98
165_N	169_K	0.730	0.98
89_S	93_E	0.730	0.98
159_H	187_F	0.729	0.98
31_G	35_I	0.728	0.98
273_E	281_G	0.726	0.98
100_S	124_E	0.725	0.98
46_M	50_G	0.722	0.98
302_T	351_V	0.720	0.98
86_K	91_Q	0.718	0.98
81_L	85_G	0.717	0.98
14_E	214_G	0.714	0.98
192_S	213_G	0.714	0.98
81_L	175_V	0.709	0.98
63_R	66_D	0.709	0.98
159_H	168_A	0.708	0.98
270_G	273_E	0.708	0.98
274_S	277_V	0.706	0.98
83_L	89_S	0.705	0.98
80_Y	83_L	0.703	0.98
229_T	311_E	0.701	0.98
230_K	311_E	0.701	0.98
46_M	57_V	0.695	0.98
49_G	52_N	0.693	0.98
76_I	82_A	0.689	0.97
311_E	322_Q	0.689	0.97
300_R	303_E	0.689	0.97
76_I	80_Y	0.689	0.97
21_A	366_G	0.689	0.97
90_C	96_M	0.683	0.97
183_D	376_Y	0.680	0.97
209_V	216_M	0.680	0.97
237_N	251_P	0.679	0.97
310_E	320_R	0.677	0.97
236_G	258_K	0.676	0.97
263_C	270_G	0.676	0.97
31_G	36_I	0.674	0.97
92_N	97_V	0.674	0.97
207_C	308_V	0.674	0.97
78_S	81_L	0.674	0.97
189_G	219_A	0.673	0.97
11_V	152_V	0.672	0.97
274_S	283_R	0.670	0.97
42_P	45_G	0.669	0.97
249_T	280_V	0.669	0.97
80_Y	88_I	0.666	0.97
334_L	344_L	0.666	0.97
335_T	364_I	0.662	0.97
80_Y	87_H	0.661	0.97
17_T	215_T	0.659	0.97
302_T	305_L	0.652	0.97
210_D	214_G	0.650	0.96
34_N	41_C	0.649	0.96
243_I	248_G	0.646	0.96
156_A	373_E	0.645	0.96
62_Q	65_I	0.644	0.96
33_V	37_G	0.641	0.96
72_A	79_V	0.640	0.96
274_S	285_P	0.640	0.96
219_A	226_L	0.639	0.96
48_K	52_N	0.637	0.96
311_E	321_Q	0.635	0.96
241_S	244_A	0.635	0.96
38_V	127_V	0.632	0.96
209_V	218_I	0.631	0.96
238_V	241_S	0.629	0.96
235_A	238_V	0.628	0.96
372_Q	376_Y	0.626	0.96
79_V	88_I	0.625	0.96
88_I	98_P	0.623	0.95
79_V	86_K	0.622	0.95
245_Y	248_G	0.622	0.95
90_C	93_E	0.621	0.95
130_V	173_K	0.621	0.95
247_F	275_V	0.621	0.95
192_S	335_T	0.615	0.95
272_D	282_G	0.614	0.95
190_L	194_Y	0.614	0.95
233_P	238_V	0.613	0.95
74_C	78_S	0.612	0.95
78_S	83_L	0.612	0.95
75_Q	79_V	0.612	0.95
13_L	175_V	0.611	0.95
98_P	124_E	0.610	0.95
86_K	92_N	0.608	0.95
301_Y	344_L	0.608	0.95
209_V	230_K	0.608	0.95
138_D	151_G	0.608	0.95
277_V	281_G	0.608	0.95
297_I	343_G	0.607	0.95
213_G	217_D	0.607	0.95
184_Q	372_Q	0.605	0.95
194_Y	372_Q	0.605	0.95
365_T	368_T	0.604	0.95
8_K	27_V	0.602	0.95
61_V	64_A	0.601	0.95
47_D	52_N	0.601	0.95
157_K	171_I	0.600	0.94
193_S	221_Y	0.599	0.94
309_N	326_H	0.598	0.94
14_E	210_D	0.596	0.94
366_G	369_D	0.596	0.94
161_I	189_G	0.594	0.94
260_R	270_G	0.592	0.94
79_V	180_L	0.591	0.94
168_A	185_L	0.591	0.94
146_P	149_L	0.591	0.94
24_V	147_V	0.589	0.94
210_D	217_D	0.587	0.94
249_T	279_S	0.584	0.94
76_I	90_C	0.584	0.94
15_I	133_Q	0.583	0.94
88_I	96_M	0.582	0.94
92_N	159_H	0.582	0.94
130_V	138_D	0.579	0.93
368_T	371_A	0.578	0.93
85_G	91_Q	0.578	0.93
356_V	359_G	0.577	0.93
81_L	86_K	0.577	0.93
208_V	333_V	0.576	0.93
302_T	350_R	0.576	0.93
81_L	88_I	0.575	0.93
271_K	274_S	0.575	0.93
345_A	358_I	0.575	0.93
50_G	53_D	0.575	0.93
74_C	79_V	0.575	0.93
24_V	148_G	0.575	0.93
52_N	55_E	0.573	0.93
271_K	278_P	0.572	0.93
308_V	351_V	0.572	0.93
87_H	93_E	0.568	0.93
274_S	282_G	0.568	0.93
64_A	97_V	0.567	0.93
334_L	357_R	0.566	0.93
144_K	148_G	0.564	0.92
76_I	85_G	0.560	0.92
11_V	24_V	0.559	0.92
273_E	279_S	0.558	0.92
260_R	273_E	0.557	0.92
326_H	353_H	0.556	0.92
164_H	167_M	0.556	0.92
189_G	215_T	0.555	0.92
77_S	82_A	0.555	0.92
161_I	214_G	0.554	0.92
36_I	39_G	0.554	0.92
252_S	256_A	0.553	0.92
277_V	283_R	0.552	0.92
188_A	213_G	0.550	0.92
93_E	99_I	0.549	0.91
95_G	99_I	0.548	0.91
88_I	93_E	0.548	0.91
88_I	97_V	0.546	0.91
256_A	259_V	0.546	0.91
189_G	192_S	0.546	0.91
242_D	296_V	0.544	0.91
272_D	280_V	0.544	0.91
32_M	38_V	0.543	0.91
257_I	293_L	0.542	0.91
51_V	252_S	0.540	0.91
75_Q	80_Y	0.540	0.91
45_G	51_V	0.540	0.91
297_I	338_A	0.540	0.91
44_R	56_S	0.538	0.91
278_P	281_G	0.537	0.91
61_V	136_A	0.534	0.90
308_V	352_F	0.533	0.90
61_V	132_P	0.533	0.90
169_K	172_V	0.533	0.90
254_A	259_V	0.531	0.90
94_I	98_P	0.531	0.90
12_G	23_L	0.530	0.90
32_M	37_G	0.529	0.90
277_V	282_G	0.529	0.90
301_Y	341_I	0.528	0.90
13_L	157_K	0.526	0.90
33_V	46_M	0.526	0.90
145_N	151_G	0.525	0.90
152_V	155_Q	0.523	0.89
142_G	145_N	0.523	0.89
85_G	97_V	0.522	0.89
294_A	343_G	0.519	0.89
247_F	284_P	0.519	0.89
138_D	141_E	0.517	0.89
261_H	290_R	0.517	0.89
270_G	277_V	0.516	0.89
72_A	76_I	0.514	0.89
13_L	22_A	0.514	0.89
79_V	91_Q	0.512	0.88
46_M	53_D	0.511	0.88
216_M	307_L	0.510	0.88
14_E	17_T	0.509	0.88
247_F	257_I	0.508	0.88
168_A	172_V	0.507	0.88
60_C	63_R	0.506	0.88
229_T	321_Q	0.506	0.88
65_I	171_I	0.505	0.88
76_I	81_L	0.505	0.88
77_S	83_L	0.505	0.88
58_V	99_I	0.504	0.88
73_D	77_S	0.503	0.88
91_Q	97_V	0.503	0.88
249_T	257_I	0.503	0.88
145_N	152_V	0.502	0.87
363_N	368_T	0.502	0.87
96_M	153_R	0.501	0.87
84_S	91_Q	0.501	0.87
19_K	259_V	0.501	0.87
263_C	290_R	0.501	0.87
79_V	95_G	0.500	0.87
60_C	65_I	0.500	0.87

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3wqtA	2	0.8571	100	0.352	Contact Map
4a2aA	1	0.8738	100	0.358	Contact Map
3d2fA	1	0.9	100	0.375	Contact Map
4jneA	2	0.8952	100	0.39	Contact Map
4fl9A	1	0.8881	100	0.391	Contact Map
3wt0A	1	0.8786	100	0.393	Contact Map
2v7yA	1	0.8357	100	0.416	Contact Map
3i33A	1	0.7952	100	0.419	Contact Map
4kboA	1	0.7881	100	0.425	Contact Map
4rtfD	1	0.7262	100	0.431	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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