GREMLIN Database
FTSW - Lipid II flippase FtsW
UniProt: P0ABG4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10344
Length: 414 (355)
Sequences: 8072 (5556)
Seq/√Len: 294.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
326_A349_G3.8311.00
45_D325_R3.7291.00
326_A394_L3.5711.00
140_D143_L3.2461.00
210_A350_I3.1641.00
131_S136_S2.8201.00
56_A89_L2.7511.00
51_L321_F2.7421.00
304_G312_V2.6951.00
104_M341_S2.6911.00
252_N255_E2.6691.00
271_F304_G2.6531.00
256_D259_G2.6061.00
345_A394_L2.5581.00
118_S155_S2.5261.00
114_M155_S2.4521.00
92_A388_S2.4271.00
99_T389_T2.3931.00
52_T391_I2.3831.00
77_D83_K2.2821.00
51_L322_V2.2391.00
348_I394_L2.1531.00
303_I315_A2.1481.00
118_S152_T2.1051.00
300_F312_V2.0641.00
189_A201_V2.0631.00
376_L391_I2.0551.00
96_A395_L2.0461.00
214_L346_C2.0401.00
293_E296_T2.0221.00
323_A353_S1.9771.00
62_M303_I1.9501.00
376_L387_M1.9111.00
254_W265_T1.8861.00
60_F82_A1.8861.00
133_K293_E1.8831.00
80_F84_R1.8781.00
124_I139_I1.8331.00
328_S332_K1.8181.00
62_M307_L1.8091.00
108_Q340_F1.8081.00
140_D145_R1.8051.00
234_V237_I1.8031.00
211_M347_S1.7971.00
185_I208_T1.7521.00
362_A369_T1.7501.00
361_G367_L1.7471.00
264_L369_T1.7411.00
281_L307_L1.7261.00
124_I128_V1.7151.00
333_A397_I1.7141.00
326_A345_A1.6731.00
356_A360_V1.6671.00
348_I390_A1.6381.00
257_P265_T1.6371.00
190_V194_A1.6261.00
86_G90_I1.6181.00
313_V317_L1.6071.00
158_C344_L1.5801.00
245_R260_S1.5801.00
58_I303_I1.5771.00
122_L152_T1.5611.00
60_F85_D1.5541.00
116_L120_I1.5461.00
164_L211_M1.5461.00
341_S397_I1.5441.00
345_A397_I1.5401.00
65_S306_E1.5361.00
110_Y113_T1.5331.00
125_V139_I1.5311.00
284_S302_I1.5241.00
277_W310_V1.4891.00
316_L360_V1.4851.00
149_A200_T1.4821.00
300_F360_V1.4671.00
83_K86_G1.4531.00
203_V372_L1.4411.00
115_L188_L1.4291.00
303_I377_I1.4291.00
266_Q286_Q1.4281.00
146_I151_L1.4271.00
66_A302_I1.4231.00
123_M127_V1.4201.00
330_G345_A1.4171.00
279_Q285_V1.4161.00
56_A388_S1.4081.00
130_S140_D1.4021.00
157_F347_S1.3991.00
88_Y381_G1.3981.00
319_V356_A1.3911.00
211_M343_F1.3831.00
113_T117_G1.3751.00
207_T351_W1.3681.00
240_E243_R1.3581.00
276_L309_Y1.3551.00
51_L318_M1.3491.00
96_A392_M1.3471.00
373_T383_S1.3391.00
352_F387_M1.3361.00
62_M299_I1.3351.00
130_S145_R1.3341.00
338_H341_S1.3311.00
156_L204_L1.3291.00
95_L389_T1.3281.00
323_A356_A1.3261.00
241_P244_I1.3251.00
120_I124_I1.3231.00
52_T388_S1.3121.00
58_I315_A1.2961.00
323_A349_G1.2951.00
396_R400_E1.2941.00
192_L204_L1.2931.00
119_I187_V1.2881.00
162_N166_R1.2631.00
206_V354_F1.2621.00
137_R149_A1.2591.00
104_M396_R1.2581.00
174_N177_G1.2511.00
89_L384_L1.2491.00
90_I94_I1.2491.00
264_L365_G1.2481.00
256_D260_S1.2461.00
298_F369_T1.2451.00
60_F86_G1.2441.00
261_G265_T1.2361.00
284_S306_E1.2281.00
64_T82_A1.2281.00
267_S363_A1.2181.00
223_I227_G1.2031.00
218_K221_Q1.2011.00
94_I98_I1.1941.00
152_T188_L1.1921.00
48_L322_V1.1801.00
55_L377_I1.1791.00
239_A243_R1.1771.00
269_M286_Q1.1691.00
244_I248_T1.1651.00
309_Y313_V1.1631.00
83_K87_V1.1591.00
241_P245_R1.1591.00
329_I345_A1.1571.00
61_I281_L1.1501.00
160_I208_T1.1401.00
124_I127_V1.1371.00
106_F109_R1.1371.00
327_M349_G1.1311.00
107_W393_M1.1251.00
174_N180_K1.1151.00
322_V391_I1.1151.00
111_S162_N1.1141.00
125_V148_P1.1141.00
157_F207_T1.1021.00
64_T79_F1.0981.00
108_Q162_N1.0961.00
262_Y292_P1.0891.00
316_L356_A1.0881.00
186_L190_V1.0871.00
183_G187_V1.0821.00
104_M338_H1.0821.00
108_Q165_V1.0801.00
273_R279_Q1.0801.00
112_A116_L1.0741.00
91_L385_L1.0731.00
110_Y114_M1.0691.00
161_A211_M1.0691.00
150_E153_K1.0681.00
81_F295_H1.0641.00
47_T321_F1.0621.00
92_A384_L1.0621.00
224_A228_M1.0591.00
291_L301_A1.0551.00
245_R248_T1.0501.00
81_F379_Y1.0501.00
344_L397_I1.0501.00
119_I188_L1.0491.00
315_A377_I1.0481.00
355_Q383_S1.0461.00
157_F351_W1.0451.00
49_L395_L1.0441.00
238_L241_P1.0431.00
100_L392_M1.0371.00
395_L398_D1.0351.00
132_V145_R1.0331.00
351_W390_A1.0321.00
113_T116_L1.0291.00
93_F97_I1.0161.00
349_G394_L1.0151.00
158_C340_F1.0121.00
160_I181_P1.0111.00
266_Q269_M1.0111.00
44_Y49_L1.0101.00
96_A99_T1.0061.00
225_I229_G0.9981.00
276_L310_V0.9911.00
48_L329_I0.9901.00
296_T379_Y0.9891.00
50_W54_G0.9881.00
199_G370_K0.9851.00
329_I398_D0.9791.00
249_A260_S0.9731.00
229_G233_V0.9721.00
63_V66_A0.9701.00
262_Y266_Q0.9651.00
104_M397_I0.9651.00
112_A159_Y0.9561.00
115_L119_I0.9551.00
151_L386_I0.9501.00
254_W268_L0.9481.00
137_R199_G0.9461.00
179_L183_G0.9421.00
268_L365_G0.9401.00
355_Q373_T0.9391.00
100_L396_R0.9391.00
55_L322_V0.9371.00
47_T325_R0.9361.00
80_F83_K0.9351.00
200_T373_T0.9331.00
202_V206_V0.9301.00
362_A370_K0.9271.00
330_G349_G0.9261.00
303_I307_L0.9221.00
84_R88_Y0.9221.00
58_I318_M0.9211.00
189_A205_F0.9201.00
111_S340_F0.9141.00
324_F328_S0.9131.00
344_L393_M0.9131.00
199_G362_A0.9101.00
163_Y181_P0.9101.00
256_D261_G0.9091.00
54_G318_M0.9061.00
267_S301_A0.9021.00
126_L194_A0.9021.00
84_R87_V0.9011.00
352_F356_A0.8981.00
85_D88_Y0.8981.00
154_L389_T0.8971.00
222_F226_I0.8971.00
339_R342_G0.8971.00
106_F110_Y0.8881.00
154_L393_M0.8871.00
100_L399_Y0.8871.00
103_P106_F0.8841.00
213_F219_L0.8821.00
154_L386_I0.8811.00
374_L377_I0.8781.00
98_I102_L0.8741.00
157_F348_I0.8671.00
232_A236_L0.8651.00
394_L397_I0.8641.00
63_V299_I0.8591.00
253_P265_T0.8581.00
330_G346_C0.8561.00
119_I123_M0.8551.00
197_D200_T0.8541.00
176_R180_K0.8531.00
198_L243_R0.8531.00
383_S387_M0.8511.00
219_L223_I0.8501.00
125_V136_S0.8451.00
96_A391_I0.8451.00
95_L385_L0.8441.00
205_F209_L0.8411.00
53_F57_A0.8401.00
99_T107_W0.8391.00
84_R379_Y0.8381.00
177_G180_K0.8341.00
346_C350_I0.8331.00
264_L267_S0.8331.00
291_L294_A0.8321.00
312_V364_A0.8311.00
295_H379_Y0.8301.00
92_A385_L0.8291.00
164_L215_A0.8291.00
58_I62_M0.8281.00
228_M232_A0.8281.00
361_G366_M0.8281.00
154_L390_A0.8281.00
320_F324_F0.8241.00
65_S280_G0.8221.00
140_D144_L0.8221.00
193_L201_V0.8131.00
280_G306_E0.8131.00
52_T322_V0.8131.00
156_L185_I0.8101.00
111_S155_S0.8091.00
57_A61_I0.8071.00
357_L366_M0.8071.00
237_I244_I0.8071.00
249_A255_E0.8061.00
79_F82_A0.8061.00
317_L321_F0.8041.00
284_S287_K0.7990.99
92_A392_M0.7940.99
157_F211_M0.7940.99
159_Y184_V0.7910.99
198_L202_V0.7910.99
253_P261_G0.7900.99
392_M396_R0.7890.99
214_L350_I0.7830.99
263_Q267_S0.7800.99
294_A302_I0.7790.99
319_V374_L0.7770.99
340_F344_L0.7750.99
88_Y385_L0.7740.99
82_A86_G0.7740.99
245_R249_A0.7730.99
267_S298_F0.7730.99
115_L159_Y0.7710.99
102_L107_W0.7690.99
207_T210_A0.7680.99
146_I386_I0.7670.99
55_L315_A0.7660.99
312_V316_L0.7640.99
122_L191_L0.7630.99
129_G136_S0.7620.99
300_F315_A0.7580.99
96_A388_S0.7540.99
271_F364_A0.7530.99
325_R328_S0.7520.99
192_L200_T0.7440.99
396_R399_Y0.7420.99
87_V90_I0.7410.99
161_A165_V0.7370.99
252_N261_G0.7360.99
121_L146_I0.7360.99
298_F363_A0.7350.99
362_A367_L0.7320.99
47_T51_L0.7320.99
105_E338_H0.7300.99
97_I101_R0.7300.99
93_F96_A0.7270.99
198_L240_E0.7250.99
231_S234_V0.7230.99
302_I306_E0.7220.99
152_T155_S0.7150.99
210_A354_F0.7130.99
345_A349_G0.7120.99
360_V364_A0.7100.99
68_M287_K0.7090.99
185_I189_A0.7080.99
64_T282_G0.7050.99
56_A93_F0.7040.99
161_A340_F0.7040.99
181_P208_T0.7030.99
63_V85_D0.7010.99
104_M344_L0.7000.99
300_F374_L0.6980.99
221_Q225_I0.6970.99
164_L181_P0.6960.99
264_L298_F0.6960.99
79_F83_K0.6930.99
387_M390_A0.6920.99
121_L151_L0.6920.99
223_I226_I0.6910.99
206_V210_A0.6890.99
360_V374_L0.6880.98
322_V352_F0.6850.98
112_A162_N0.6820.98
135_A195_Q0.6820.98
333_A338_H0.6800.98
249_A261_G0.6800.98
51_L325_R0.6790.98
358_V367_L0.6780.98
317_L320_F0.6760.98
393_M397_I0.6760.98
121_L125_V0.6730.98
151_L389_T0.6730.98
341_S344_L0.6720.98
157_F344_L0.6720.98
299_I377_I0.6700.98
160_I185_I0.6690.98
333_A341_S0.6690.98
178_F182_M0.6650.98
339_R343_F0.6630.98
327_M350_I0.6590.98
137_R196_P0.6570.98
269_M272_G0.6550.98
167_K180_K0.6530.98
164_L212_L0.6510.98
217_A222_F0.6500.98
232_A235_L0.6470.98
249_A253_P0.6470.98
141_L145_R0.6460.98
237_I247_V0.6450.98
231_S235_L0.6450.98
322_V326_A0.6430.98
167_K170_E0.6420.98
180_K183_G0.6380.98
287_K306_E0.6350.97
299_I303_I0.6350.97
227_G231_S0.6340.97
350_I354_F0.6330.97
135_A196_P0.6320.97
268_L272_G0.6320.97
359_N363_A0.6310.97
307_L311_G0.6300.97
122_L196_P0.6290.97
77_D80_F0.6280.97
126_L136_S0.6260.97
242_Y245_R0.6250.97
103_P341_S0.6220.97
178_F212_L0.6220.97
95_L98_I0.6210.97
85_D89_L0.6200.97
167_K177_G0.6200.97
215_A343_F0.6190.97
123_M191_L0.6190.97
159_Y163_Y0.6180.97
125_V195_Q0.6170.97
162_N340_F0.6160.97
265_T269_M0.6130.97
220_W224_A0.6130.97
123_M126_L0.6100.97
221_Q224_A0.6100.97
54_G57_A0.6080.97
327_M331_R0.6060.97
332_K398_D0.6050.97
108_Q338_H0.6050.97
230_I234_V0.6040.97
254_W261_G0.6010.96
43_M399_Y0.6000.96
284_S305_E0.5990.96
321_F325_R0.5990.96
163_Y184_V0.5990.96
300_F316_L0.5990.96
168_G171_V0.5980.96
266_Q292_P0.5970.96
130_S136_S0.5970.96
133_K136_S0.5950.96
164_L343_F0.5940.96
247_V251_W0.5930.96
46_R50_W0.5920.96
326_A391_I0.5890.96
98_I101_R0.5870.96
333_A345_A0.5870.96
146_I382_S0.5870.96
101_R399_Y0.5860.96
91_L95_L0.5860.96
255_E261_G0.5850.96
45_D398_D0.5820.96
348_I397_I0.5800.96
116_L119_I0.5790.96
248_T256_D0.5770.96
161_A347_S0.5760.96
115_L184_V0.5750.96
175_L180_K0.5750.96
161_A344_L0.5740.95
155_S159_Y0.5710.95
280_G305_E0.5710.95
387_M391_I0.5700.95
105_E108_Q0.5690.95
315_A319_V0.5670.95
333_A337_D0.5670.95
319_V376_L0.5640.95
60_F89_L0.5640.95
386_I390_A0.5630.95
249_A264_L0.5620.95
248_T255_E0.5610.95
118_S151_L0.5600.95
357_L367_L0.5590.95
358_V362_A0.5580.95
267_S291_L0.5570.95
252_N256_D0.5570.95
226_I230_I0.5560.95
248_T252_N0.5560.95
391_I394_L0.5560.95
291_L302_I0.5550.95
51_L317_L0.5550.95
329_I333_A0.5550.95
213_F222_F0.5540.95
64_T68_M0.5540.95
167_K171_V0.5530.94
326_A329_I0.5530.94
133_K295_H0.5520.94
99_T392_M0.5520.94
92_A95_L0.5510.94
58_I377_I0.5500.94
158_C393_M0.5490.94
204_L208_T0.5480.94
137_R370_K0.5480.94
187_V190_V0.5470.94
81_F84_R0.5450.94
382_S386_I0.5440.94
147_Q150_E0.5440.94
88_Y92_A0.5430.94
192_L201_V0.5420.94
100_L395_L0.5420.94
137_R372_L0.5410.94
85_D384_L0.5410.94
264_L268_L0.5400.94
170_E176_R0.5380.94
388_S392_M0.5370.94
109_R113_T0.5350.93
357_L361_G0.5330.93
272_G309_Y0.5330.93
122_L192_L0.5320.93
91_L94_I0.5320.93
285_V288_L0.5300.93
48_L325_R0.5290.93
51_L54_G0.5270.93
48_L326_A0.5260.93
314_L318_M0.5250.93
309_Y312_V0.5240.93
104_M400_E0.5240.93
44_Y100_L0.5240.93
88_Y91_L0.5230.93
314_L317_L0.5230.93
175_L179_L0.5230.93
267_S364_A0.5220.93
256_D262_Y0.5200.92
196_P242_Y0.5200.92
89_L388_S0.5190.92
236_L239_A0.5180.92
133_K137_R0.5170.92
348_I393_M0.5170.92
234_V238_L0.5170.92
48_L391_I0.5170.92
122_L125_V0.5160.92
88_Y379_Y0.5150.92
265_T268_L0.5110.92
108_Q166_R0.5100.92
115_L187_V0.5080.92
191_L196_P0.5060.91
132_V140_D0.5050.91
326_A330_G0.5050.91
137_R195_Q0.5040.91
105_E333_A0.5020.91
245_R255_E0.5010.91
322_V394_L0.5000.91
199_G296_T0.5000.91
209_L226_I0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hl7A 1 0.0845 45.4 0.966 Contact Map
2kogA 1 0.1618 44.7 0.966 Contact Map
3ne5A 3 0.1932 36.7 0.967 Contact Map
2kw0A 1 0.0797 32.3 0.968 Contact Map
4mt1A 3 0.2029 31.8 0.968 Contact Map
2oo9A 2 0.1039 23.9 0.97 Contact Map
3e35A 3 0.0556 20.7 0.971 Contact Map
3hd7A 1 0.1618 19.6 0.971 Contact Map
2ooaA 1 0.1014 18.2 0.972 Contact Map
2dahA 1 0.1111 18.2 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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