FTSW - ECOLI - GREMLIN Contacts

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FTSW - Lipid II flippase FtsW

UniProt:	P0ABG4	Sequences: MRLSLPRLKMPRLPGFSILVWISTALKGWVMGSREKDTDSLIMYDRTLLWLTFGLAAIGFIMVTSASMPIGQRLTNDPFFFAKRDGVYLILAFILAIITLRLPMEFWQRYSATMLLGSIILLMIVLVVGSSVKGASRWIDLGLLRIQPAELTKLSLFCYIANYLVRKGDEVRNNLRGFLKPMGVILVLAVLLLAQPDLGTVVVLFVTTLAMLFLAGAKLWQFIAIIGMGISAVVLLILAEPYRIRRVTAFWNPWEDPFGSGYQLTQSLMAFGRGELWGQGLGNSVQKLEYLPEAHTDFIFAIIGEELGYVGVVLALLMVFFVAFRAMSIGRKALEIDHRFSGFLACSIGIWFSFQALVNVGAAAGMLPTKGLTLPLISYGGSSLLIMSTAIMMLLRIDYETRLEKAQAFVRGSR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10344
Length:	414 (355)
Sequences:	8072 (5556)
Seq/√Len:	294.9

ECOLI - FTSW RODA
BACSU - FTSW SP5E RODA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
326_A	349_G	3.831	1.00
45_D	325_R	3.729	1.00
326_A	394_L	3.571	1.00
140_D	143_L	3.246	1.00
210_A	350_I	3.164	1.00
131_S	136_S	2.820	1.00
56_A	89_L	2.751	1.00
51_L	321_F	2.742	1.00
304_G	312_V	2.695	1.00
104_M	341_S	2.691	1.00
252_N	255_E	2.669	1.00
271_F	304_G	2.653	1.00
256_D	259_G	2.606	1.00
345_A	394_L	2.558	1.00
118_S	155_S	2.526	1.00
114_M	155_S	2.452	1.00
92_A	388_S	2.427	1.00
99_T	389_T	2.393	1.00
52_T	391_I	2.383	1.00
77_D	83_K	2.282	1.00
51_L	322_V	2.239	1.00
348_I	394_L	2.153	1.00
303_I	315_A	2.148	1.00
118_S	152_T	2.105	1.00
300_F	312_V	2.064	1.00
189_A	201_V	2.063	1.00
376_L	391_I	2.055	1.00
96_A	395_L	2.046	1.00
214_L	346_C	2.040	1.00
293_E	296_T	2.022	1.00
323_A	353_S	1.977	1.00
62_M	303_I	1.950	1.00
376_L	387_M	1.911	1.00
254_W	265_T	1.886	1.00
60_F	82_A	1.886	1.00
133_K	293_E	1.883	1.00
80_F	84_R	1.878	1.00
124_I	139_I	1.833	1.00
328_S	332_K	1.818	1.00
62_M	307_L	1.809	1.00
108_Q	340_F	1.808	1.00
140_D	145_R	1.805	1.00
234_V	237_I	1.803	1.00
211_M	347_S	1.797	1.00
185_I	208_T	1.752	1.00
362_A	369_T	1.750	1.00
361_G	367_L	1.747	1.00
264_L	369_T	1.741	1.00
281_L	307_L	1.726	1.00
124_I	128_V	1.715	1.00
333_A	397_I	1.714	1.00
326_A	345_A	1.673	1.00
356_A	360_V	1.667	1.00
348_I	390_A	1.638	1.00
257_P	265_T	1.637	1.00
190_V	194_A	1.626	1.00
86_G	90_I	1.618	1.00
313_V	317_L	1.607	1.00
158_C	344_L	1.580	1.00
245_R	260_S	1.580	1.00
58_I	303_I	1.577	1.00
122_L	152_T	1.561	1.00
60_F	85_D	1.554	1.00
116_L	120_I	1.546	1.00
164_L	211_M	1.546	1.00
341_S	397_I	1.544	1.00
345_A	397_I	1.540	1.00
65_S	306_E	1.536	1.00
110_Y	113_T	1.533	1.00
125_V	139_I	1.531	1.00
284_S	302_I	1.524	1.00
277_W	310_V	1.489	1.00
316_L	360_V	1.485	1.00
149_A	200_T	1.482	1.00
300_F	360_V	1.467	1.00
83_K	86_G	1.453	1.00
203_V	372_L	1.441	1.00
115_L	188_L	1.429	1.00
303_I	377_I	1.429	1.00
266_Q	286_Q	1.428	1.00
146_I	151_L	1.427	1.00
66_A	302_I	1.423	1.00
123_M	127_V	1.420	1.00
330_G	345_A	1.417	1.00
279_Q	285_V	1.416	1.00
56_A	388_S	1.408	1.00
130_S	140_D	1.402	1.00
157_F	347_S	1.399	1.00
88_Y	381_G	1.398	1.00
319_V	356_A	1.391	1.00
211_M	343_F	1.383	1.00
113_T	117_G	1.375	1.00
207_T	351_W	1.368	1.00
240_E	243_R	1.358	1.00
276_L	309_Y	1.355	1.00
51_L	318_M	1.349	1.00
96_A	392_M	1.347	1.00
373_T	383_S	1.339	1.00
352_F	387_M	1.336	1.00
62_M	299_I	1.335	1.00
130_S	145_R	1.334	1.00
338_H	341_S	1.331	1.00
156_L	204_L	1.329	1.00
95_L	389_T	1.328	1.00
323_A	356_A	1.326	1.00
241_P	244_I	1.325	1.00
120_I	124_I	1.323	1.00
52_T	388_S	1.312	1.00
58_I	315_A	1.296	1.00
323_A	349_G	1.295	1.00
396_R	400_E	1.294	1.00
192_L	204_L	1.293	1.00
119_I	187_V	1.288	1.00
162_N	166_R	1.263	1.00
206_V	354_F	1.262	1.00
137_R	149_A	1.259	1.00
104_M	396_R	1.258	1.00
174_N	177_G	1.251	1.00
89_L	384_L	1.249	1.00
90_I	94_I	1.249	1.00
264_L	365_G	1.248	1.00
256_D	260_S	1.246	1.00
298_F	369_T	1.245	1.00
60_F	86_G	1.244	1.00
261_G	265_T	1.236	1.00
284_S	306_E	1.228	1.00
64_T	82_A	1.228	1.00
267_S	363_A	1.218	1.00
223_I	227_G	1.203	1.00
218_K	221_Q	1.201	1.00
94_I	98_I	1.194	1.00
152_T	188_L	1.192	1.00
48_L	322_V	1.180	1.00
55_L	377_I	1.179	1.00
239_A	243_R	1.177	1.00
269_M	286_Q	1.169	1.00
244_I	248_T	1.165	1.00
309_Y	313_V	1.163	1.00
83_K	87_V	1.159	1.00
241_P	245_R	1.159	1.00
329_I	345_A	1.157	1.00
61_I	281_L	1.150	1.00
160_I	208_T	1.140	1.00
124_I	127_V	1.137	1.00
106_F	109_R	1.137	1.00
327_M	349_G	1.131	1.00
107_W	393_M	1.125	1.00
174_N	180_K	1.115	1.00
322_V	391_I	1.115	1.00
111_S	162_N	1.114	1.00
125_V	148_P	1.114	1.00
157_F	207_T	1.102	1.00
64_T	79_F	1.098	1.00
108_Q	162_N	1.096	1.00
262_Y	292_P	1.089	1.00
316_L	356_A	1.088	1.00
186_L	190_V	1.087	1.00
183_G	187_V	1.082	1.00
104_M	338_H	1.082	1.00
108_Q	165_V	1.080	1.00
273_R	279_Q	1.080	1.00
112_A	116_L	1.074	1.00
91_L	385_L	1.073	1.00
110_Y	114_M	1.069	1.00
161_A	211_M	1.069	1.00
150_E	153_K	1.068	1.00
81_F	295_H	1.064	1.00
47_T	321_F	1.062	1.00
92_A	384_L	1.062	1.00
224_A	228_M	1.059	1.00
291_L	301_A	1.055	1.00
245_R	248_T	1.050	1.00
81_F	379_Y	1.050	1.00
344_L	397_I	1.050	1.00
119_I	188_L	1.049	1.00
315_A	377_I	1.048	1.00
355_Q	383_S	1.046	1.00
157_F	351_W	1.045	1.00
49_L	395_L	1.044	1.00
238_L	241_P	1.043	1.00
100_L	392_M	1.037	1.00
395_L	398_D	1.035	1.00
132_V	145_R	1.033	1.00
351_W	390_A	1.032	1.00
113_T	116_L	1.029	1.00
93_F	97_I	1.016	1.00
349_G	394_L	1.015	1.00
158_C	340_F	1.012	1.00
160_I	181_P	1.011	1.00
266_Q	269_M	1.011	1.00
44_Y	49_L	1.010	1.00
96_A	99_T	1.006	1.00
225_I	229_G	0.998	1.00
276_L	310_V	0.991	1.00
48_L	329_I	0.990	1.00
296_T	379_Y	0.989	1.00
50_W	54_G	0.988	1.00
199_G	370_K	0.985	1.00
329_I	398_D	0.979	1.00
249_A	260_S	0.973	1.00
229_G	233_V	0.972	1.00
63_V	66_A	0.970	1.00
262_Y	266_Q	0.965	1.00
104_M	397_I	0.965	1.00
112_A	159_Y	0.956	1.00
115_L	119_I	0.955	1.00
151_L	386_I	0.950	1.00
254_W	268_L	0.948	1.00
137_R	199_G	0.946	1.00
179_L	183_G	0.942	1.00
268_L	365_G	0.940	1.00
355_Q	373_T	0.939	1.00
100_L	396_R	0.939	1.00
55_L	322_V	0.937	1.00
47_T	325_R	0.936	1.00
80_F	83_K	0.935	1.00
200_T	373_T	0.933	1.00
202_V	206_V	0.930	1.00
362_A	370_K	0.927	1.00
330_G	349_G	0.926	1.00
303_I	307_L	0.922	1.00
84_R	88_Y	0.922	1.00
58_I	318_M	0.921	1.00
189_A	205_F	0.920	1.00
111_S	340_F	0.914	1.00
324_F	328_S	0.913	1.00
344_L	393_M	0.913	1.00
199_G	362_A	0.910	1.00
163_Y	181_P	0.910	1.00
256_D	261_G	0.909	1.00
54_G	318_M	0.906	1.00
267_S	301_A	0.902	1.00
126_L	194_A	0.902	1.00
84_R	87_V	0.901	1.00
352_F	356_A	0.898	1.00
85_D	88_Y	0.898	1.00
154_L	389_T	0.897	1.00
222_F	226_I	0.897	1.00
339_R	342_G	0.897	1.00
106_F	110_Y	0.888	1.00
154_L	393_M	0.887	1.00
100_L	399_Y	0.887	1.00
103_P	106_F	0.884	1.00
213_F	219_L	0.882	1.00
154_L	386_I	0.881	1.00
374_L	377_I	0.878	1.00
98_I	102_L	0.874	1.00
157_F	348_I	0.867	1.00
232_A	236_L	0.865	1.00
394_L	397_I	0.864	1.00
63_V	299_I	0.859	1.00
253_P	265_T	0.858	1.00
330_G	346_C	0.856	1.00
119_I	123_M	0.855	1.00
197_D	200_T	0.854	1.00
176_R	180_K	0.853	1.00
198_L	243_R	0.853	1.00
383_S	387_M	0.851	1.00
219_L	223_I	0.850	1.00
125_V	136_S	0.845	1.00
96_A	391_I	0.845	1.00
95_L	385_L	0.844	1.00
205_F	209_L	0.841	1.00
53_F	57_A	0.840	1.00
99_T	107_W	0.839	1.00
84_R	379_Y	0.838	1.00
177_G	180_K	0.834	1.00
346_C	350_I	0.833	1.00
264_L	267_S	0.833	1.00
291_L	294_A	0.832	1.00
312_V	364_A	0.831	1.00
295_H	379_Y	0.830	1.00
92_A	385_L	0.829	1.00
164_L	215_A	0.829	1.00
58_I	62_M	0.828	1.00
228_M	232_A	0.828	1.00
361_G	366_M	0.828	1.00
154_L	390_A	0.828	1.00
320_F	324_F	0.824	1.00
65_S	280_G	0.822	1.00
140_D	144_L	0.822	1.00
193_L	201_V	0.813	1.00
280_G	306_E	0.813	1.00
52_T	322_V	0.813	1.00
156_L	185_I	0.810	1.00
111_S	155_S	0.809	1.00
57_A	61_I	0.807	1.00
357_L	366_M	0.807	1.00
237_I	244_I	0.807	1.00
249_A	255_E	0.806	1.00
79_F	82_A	0.806	1.00
317_L	321_F	0.804	1.00
284_S	287_K	0.799	0.99
92_A	392_M	0.794	0.99
157_F	211_M	0.794	0.99
159_Y	184_V	0.791	0.99
198_L	202_V	0.791	0.99
253_P	261_G	0.790	0.99
392_M	396_R	0.789	0.99
214_L	350_I	0.783	0.99
263_Q	267_S	0.780	0.99
294_A	302_I	0.779	0.99
319_V	374_L	0.777	0.99
340_F	344_L	0.775	0.99
88_Y	385_L	0.774	0.99
82_A	86_G	0.774	0.99
245_R	249_A	0.773	0.99
267_S	298_F	0.773	0.99
115_L	159_Y	0.771	0.99
102_L	107_W	0.769	0.99
207_T	210_A	0.768	0.99
146_I	386_I	0.767	0.99
55_L	315_A	0.766	0.99
312_V	316_L	0.764	0.99
122_L	191_L	0.763	0.99
129_G	136_S	0.762	0.99
300_F	315_A	0.758	0.99
96_A	388_S	0.754	0.99
271_F	364_A	0.753	0.99
325_R	328_S	0.752	0.99
192_L	200_T	0.744	0.99
396_R	399_Y	0.742	0.99
87_V	90_I	0.741	0.99
161_A	165_V	0.737	0.99
252_N	261_G	0.736	0.99
121_L	146_I	0.736	0.99
298_F	363_A	0.735	0.99
362_A	367_L	0.732	0.99
47_T	51_L	0.732	0.99
105_E	338_H	0.730	0.99
97_I	101_R	0.730	0.99
93_F	96_A	0.727	0.99
198_L	240_E	0.725	0.99
231_S	234_V	0.723	0.99
302_I	306_E	0.722	0.99
152_T	155_S	0.715	0.99
210_A	354_F	0.713	0.99
345_A	349_G	0.712	0.99
360_V	364_A	0.710	0.99
68_M	287_K	0.709	0.99
185_I	189_A	0.708	0.99
64_T	282_G	0.705	0.99
56_A	93_F	0.704	0.99
161_A	340_F	0.704	0.99
181_P	208_T	0.703	0.99
63_V	85_D	0.701	0.99
104_M	344_L	0.700	0.99
300_F	374_L	0.698	0.99
221_Q	225_I	0.697	0.99
164_L	181_P	0.696	0.99
264_L	298_F	0.696	0.99
79_F	83_K	0.693	0.99
387_M	390_A	0.692	0.99
121_L	151_L	0.692	0.99
223_I	226_I	0.691	0.99
206_V	210_A	0.689	0.99
360_V	374_L	0.688	0.98
322_V	352_F	0.685	0.98
112_A	162_N	0.682	0.98
135_A	195_Q	0.682	0.98
333_A	338_H	0.680	0.98
249_A	261_G	0.680	0.98
51_L	325_R	0.679	0.98
358_V	367_L	0.678	0.98
317_L	320_F	0.676	0.98
393_M	397_I	0.676	0.98
121_L	125_V	0.673	0.98
151_L	389_T	0.673	0.98
341_S	344_L	0.672	0.98
157_F	344_L	0.672	0.98
299_I	377_I	0.670	0.98
160_I	185_I	0.669	0.98
333_A	341_S	0.669	0.98
178_F	182_M	0.665	0.98
339_R	343_F	0.663	0.98
327_M	350_I	0.659	0.98
137_R	196_P	0.657	0.98
269_M	272_G	0.655	0.98
167_K	180_K	0.653	0.98
164_L	212_L	0.651	0.98
217_A	222_F	0.650	0.98
232_A	235_L	0.647	0.98
249_A	253_P	0.647	0.98
141_L	145_R	0.646	0.98
237_I	247_V	0.645	0.98
231_S	235_L	0.645	0.98
322_V	326_A	0.643	0.98
167_K	170_E	0.642	0.98
180_K	183_G	0.638	0.98
287_K	306_E	0.635	0.97
299_I	303_I	0.635	0.97
227_G	231_S	0.634	0.97
350_I	354_F	0.633	0.97
135_A	196_P	0.632	0.97
268_L	272_G	0.632	0.97
359_N	363_A	0.631	0.97
307_L	311_G	0.630	0.97
122_L	196_P	0.629	0.97
77_D	80_F	0.628	0.97
126_L	136_S	0.626	0.97
242_Y	245_R	0.625	0.97
103_P	341_S	0.622	0.97
178_F	212_L	0.622	0.97
95_L	98_I	0.621	0.97
85_D	89_L	0.620	0.97
167_K	177_G	0.620	0.97
215_A	343_F	0.619	0.97
123_M	191_L	0.619	0.97
159_Y	163_Y	0.618	0.97
125_V	195_Q	0.617	0.97
162_N	340_F	0.616	0.97
265_T	269_M	0.613	0.97
220_W	224_A	0.613	0.97
123_M	126_L	0.610	0.97
221_Q	224_A	0.610	0.97
54_G	57_A	0.608	0.97
327_M	331_R	0.606	0.97
332_K	398_D	0.605	0.97
108_Q	338_H	0.605	0.97
230_I	234_V	0.604	0.97
254_W	261_G	0.601	0.96
43_M	399_Y	0.600	0.96
284_S	305_E	0.599	0.96
321_F	325_R	0.599	0.96
163_Y	184_V	0.599	0.96
300_F	316_L	0.599	0.96
168_G	171_V	0.598	0.96
266_Q	292_P	0.597	0.96
130_S	136_S	0.597	0.96
133_K	136_S	0.595	0.96
164_L	343_F	0.594	0.96
247_V	251_W	0.593	0.96
46_R	50_W	0.592	0.96
326_A	391_I	0.589	0.96
98_I	101_R	0.587	0.96
333_A	345_A	0.587	0.96
146_I	382_S	0.587	0.96
101_R	399_Y	0.586	0.96
91_L	95_L	0.586	0.96
255_E	261_G	0.585	0.96
45_D	398_D	0.582	0.96
348_I	397_I	0.580	0.96
116_L	119_I	0.579	0.96
248_T	256_D	0.577	0.96
161_A	347_S	0.576	0.96
115_L	184_V	0.575	0.96
175_L	180_K	0.575	0.96
161_A	344_L	0.574	0.95
155_S	159_Y	0.571	0.95
280_G	305_E	0.571	0.95
387_M	391_I	0.570	0.95
105_E	108_Q	0.569	0.95
315_A	319_V	0.567	0.95
333_A	337_D	0.567	0.95
319_V	376_L	0.564	0.95
60_F	89_L	0.564	0.95
386_I	390_A	0.563	0.95
249_A	264_L	0.562	0.95
248_T	255_E	0.561	0.95
118_S	151_L	0.560	0.95
357_L	367_L	0.559	0.95
358_V	362_A	0.558	0.95
267_S	291_L	0.557	0.95
252_N	256_D	0.557	0.95
226_I	230_I	0.556	0.95
248_T	252_N	0.556	0.95
391_I	394_L	0.556	0.95
291_L	302_I	0.555	0.95
51_L	317_L	0.555	0.95
329_I	333_A	0.555	0.95
213_F	222_F	0.554	0.95
64_T	68_M	0.554	0.95
167_K	171_V	0.553	0.94
326_A	329_I	0.553	0.94
133_K	295_H	0.552	0.94
99_T	392_M	0.552	0.94
92_A	95_L	0.551	0.94
58_I	377_I	0.550	0.94
158_C	393_M	0.549	0.94
204_L	208_T	0.548	0.94
137_R	370_K	0.548	0.94
187_V	190_V	0.547	0.94
81_F	84_R	0.545	0.94
382_S	386_I	0.544	0.94
147_Q	150_E	0.544	0.94
88_Y	92_A	0.543	0.94
192_L	201_V	0.542	0.94
100_L	395_L	0.542	0.94
137_R	372_L	0.541	0.94
85_D	384_L	0.541	0.94
264_L	268_L	0.540	0.94
170_E	176_R	0.538	0.94
388_S	392_M	0.537	0.94
109_R	113_T	0.535	0.93
357_L	361_G	0.533	0.93
272_G	309_Y	0.533	0.93
122_L	192_L	0.532	0.93
91_L	94_I	0.532	0.93
285_V	288_L	0.530	0.93
48_L	325_R	0.529	0.93
51_L	54_G	0.527	0.93
48_L	326_A	0.526	0.93
314_L	318_M	0.525	0.93
309_Y	312_V	0.524	0.93
104_M	400_E	0.524	0.93
44_Y	100_L	0.524	0.93
88_Y	91_L	0.523	0.93
314_L	317_L	0.523	0.93
175_L	179_L	0.523	0.93
267_S	364_A	0.522	0.93
256_D	262_Y	0.520	0.92
196_P	242_Y	0.520	0.92
89_L	388_S	0.519	0.92
236_L	239_A	0.518	0.92
133_K	137_R	0.517	0.92
348_I	393_M	0.517	0.92
234_V	238_L	0.517	0.92
48_L	391_I	0.517	0.92
122_L	125_V	0.516	0.92
88_Y	379_Y	0.515	0.92
265_T	268_L	0.511	0.92
108_Q	166_R	0.510	0.92
115_L	187_V	0.508	0.92
191_L	196_P	0.506	0.91
132_V	140_D	0.505	0.91
326_A	330_G	0.505	0.91
137_R	195_Q	0.504	0.91
105_E	333_A	0.502	0.91
245_R	255_E	0.501	0.91
322_V	394_L	0.500	0.91
199_G	296_T	0.500	0.91
209_L	226_I	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2hl7A	1	0.0845	45.4	0.966	Contact Map
2kogA	1	0.1618	44.7	0.966	Contact Map
3ne5A	3	0.1932	36.7	0.967	Contact Map
2kw0A	1	0.0797	32.3	0.968	Contact Map
4mt1A	3	0.2029	31.8	0.968	Contact Map
2oo9A	2	0.1039	23.9	0.97	Contact Map
3e35A	3	0.0556	20.7	0.971	Contact Map
3hd7A	1	0.1618	19.6	0.971	Contact Map
2ooaA	1	0.1014	18.2	0.972	Contact Map
2dahA	1	0.1111	18.2	0.972	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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