CDSA - ECOLI - GREMLIN Contacts

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CDSA - Phosphatidate cytidylyltransferase

UniProt:	P0ABG1	Sequences: MLKYRLISAFVLIPVVIAALFLLPPVGFAIVTLVVCMLAAWEWGQLSGFTTRSQRVWLAVLCGLLLALMLFLLPEYHRNIHQPLVEISLWASLGWWIVALLLVLFYPGSAAIWRNSKTLRLIFGVLTIVPFFWGMLALRAWHYDENHYSGAIWLLYVMILVWGADSGAYMFGKLFGKHKLAPKVSPGKTWQGFIGGLATAAVISWGYGMWANLDVAPVTLLICSIVAALASVLGDLTESMFKREAGIKDSGHLIPGHGGILDRIDSLTAAVPVFACLLLLVFRTL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10139
Length:	285 (259)
Sequences:	4744 (3675)
Seq/√Len:	228.3

ECOLI - CDSA YNBB
BACSU - CDSA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
8_S	254_I	6.114	1.00
167_G	199_T	5.080	1.00
178_H	191_Q	4.181	1.00
171_F	195_G	4.124	1.00
193_F	232_V	3.814	1.00
238_E	250_S	3.329	1.00
163_G	203_I	3.229	1.00
177_K	191_Q	3.152	1.00
171_F	199_T	2.916	1.00
173_K	189_T	2.803	1.00
39_A	260_I	2.757	1.00
158_M	162_W	2.677	1.00
43_W	124_G	2.602	1.00
9_A	14_P	2.544	1.00
171_F	175_F	2.477	1.00
6_L	170_M	2.311	1.00
164_A	232_V	2.286	1.00
204_S	224_S	2.137	1.00
157_V	271_V	2.097	1.00
180_L	193_F	2.082	1.00
46_L	247_I	2.052	1.00
257_H	263_R	2.026	1.00
19_A	31_V	2.018	1.00
164_A	228_A	1.974	1.00
156_Y	224_S	1.959	1.00
46_L	250_S	1.928	1.00
180_L	190_W	1.910	1.00
170_M	174_L	1.867	1.00
194_I	198_A	1.863	1.00
9_A	13_I	1.859	1.00
168_A	196_G	1.840	1.00
164_A	231_S	1.821	1.00
38_L	260_I	1.806	1.00
178_H	190_W	1.802	1.00
22_L	27_G	1.768	1.00
10_F	14_P	1.752	1.00
190_W	194_I	1.751	1.00
171_F	174_L	1.737	1.00
35_V	260_I	1.659	1.00
41_W	45_Q	1.627	1.00
40_A	44_G	1.603	1.00
230_A	273_V	1.594	1.00
223_C	277_L	1.578	1.00
180_L	236_L	1.571	1.00
102_L	107_P	1.570	1.00
220_L	224_S	1.569	1.00
34_V	38_L	1.548	1.00
201_A	221_L	1.538	1.00
41_W	251_G	1.458	1.00
119_L	123_F	1.457	1.00
264_I	267_L	1.456	1.00
7_I	11_V	1.448	1.00
219_T	277_L	1.445	1.00
160_L	204_S	1.436	1.00
134_G	271_V	1.436	1.00
163_G	199_T	1.427	1.00
161_V	270_A	1.424	1.00
159_I	203_I	1.379	1.00
197_L	228_A	1.367	1.00
127_T	131_F	1.361	1.00
157_V	274_F	1.357	1.00
179_K	189_T	1.351	1.00
206_G	210_W	1.345	1.00
197_L	225_I	1.343	1.00
134_G	276_C	1.341	1.00
124_G	127_T	1.336	1.00
171_F	198_A	1.323	1.00
202_V	206_G	1.319	1.00
131_F	134_G	1.306	1.00
30_I	34_V	1.304	1.00
237_T	269_A	1.302	1.00
18_A	22_L	1.288	1.00
101_L	104_L	1.282	1.00
231_S	266_S	1.274	1.00
237_T	241_F	1.271	1.00
179_K	187_G	1.268	1.00
134_G	137_A	1.265	1.00
127_T	130_P	1.265	1.00
201_A	225_I	1.263	1.00
230_A	270_A	1.259	1.00
39_A	261_L	1.253	1.00
14_P	18_A	1.249	1.00
8_S	255_P	1.226	1.00
161_V	267_L	1.223	1.00
200_A	228_A	1.215	1.00
205_W	221_L	1.211	1.00
134_G	275_A	1.210	1.00
206_G	209_M	1.206	1.00
17_I	21_F	1.203	1.00
92_S	96_W	1.201	1.00
8_S	11_V	1.188	1.00
67_A	70_L	1.186	1.00
196_G	228_A	1.183	1.00
167_G	195_G	1.181	1.00
3_K	7_I	1.180	1.00
72_L	76_Y	1.178	1.00
32_T	136_L	1.160	1.00
160_L	200_A	1.158	1.00
156_Y	207_Y	1.154	1.00
46_L	245_A	1.152	1.00
176_G	191_Q	1.143	1.00
190_W	193_F	1.131	1.00
131_F	135_M	1.125	1.00
24_P	27_G	1.123	1.00
181_A	184_V	1.116	1.00
9_A	170_M	1.101	1.00
39_A	264_I	1.092	1.00
227_A	274_F	1.090	1.00
218_V	222_I	1.085	1.00
173_K	187_G	1.084	1.00
193_F	229_L	1.077	1.00
228_A	232_V	1.072	1.00
102_L	105_F	1.070	1.00
161_V	231_S	1.061	1.00
6_L	10_F	1.061	1.00
43_W	47_S	1.058	1.00
103_V	107_P	1.055	1.00
158_M	267_L	1.054	1.00
135_M	154_L	1.054	1.00
254_I	260_I	1.048	1.00
251_G	254_I	1.041	1.00
29_A	136_L	1.039	1.00
127_T	238_E	1.036	1.00
128_I	261_L	1.030	1.00
12_L	264_I	1.030	1.00
216_A	219_T	1.027	1.00
180_L	194_I	1.024	1.00
227_A	270_A	1.019	1.00
73_L	77_H	1.016	1.00
73_L	76_Y	1.011	1.00
127_T	132_F	1.004	1.00
12_L	254_I	0.996	1.00
8_S	256_G	0.988	1.00
4_Y	8_S	0.972	1.00
38_L	41_W	0.968	1.00
6_L	166_S	0.966	1.00
180_L	232_V	0.966	1.00
156_Y	274_F	0.963	1.00
96_W	99_A	0.963	1.00
205_W	209_M	0.963	1.00
36_C	132_F	0.961	1.00
270_A	274_F	0.960	1.00
200_A	203_I	0.954	1.00
101_L	105_F	0.953	1.00
106_Y	109_S	0.949	1.00
27_G	30_I	0.934	1.00
162_W	257_H	0.933	1.00
35_V	264_I	0.929	1.00
207_Y	211_A	0.929	1.00
14_P	162_W	0.928	1.00
103_V	106_Y	0.923	1.00
167_G	171_F	0.911	1.00
164_A	196_G	0.909	0.99
68_L	71_F	0.908	0.99
135_M	271_V	0.903	0.99
28_F	154_L	0.900	0.99
215_V	219_T	0.899	0.99
13_I	17_I	0.899	0.99
204_S	220_L	0.898	0.99
205_W	217_P	0.882	0.99
4_Y	7_I	0.880	0.99
156_Y	204_S	0.874	0.99
182_P	193_F	0.873	0.99
11_V	14_P	0.868	0.99
123_F	127_T	0.866	0.99
27_G	31_V	0.863	0.99
40_A	63_G	0.860	0.99
208_G	220_L	0.859	0.99
96_W	105_F	0.851	0.99
219_T	223_C	0.850	0.99
138_L	275_A	0.846	0.99
167_G	196_G	0.840	0.99
12_L	15_V	0.837	0.99
128_I	268_T	0.835	0.99
160_L	224_S	0.835	0.99
137_A	275_A	0.833	0.99
26_V	30_I	0.832	0.99
37_M	41_W	0.829	0.99
172_G	248_K	0.827	0.99
128_I	131_F	0.820	0.99
175_F	191_Q	0.820	0.99
139_R	151_A	0.818	0.99
162_W	263_R	0.813	0.99
66_L	70_L	0.811	0.99
184_V	240_M	0.810	0.99
115_N	119_L	0.799	0.99
187_G	190_W	0.796	0.99
199_T	203_I	0.794	0.99
69_M	73_L	0.794	0.99
105_F	109_S	0.793	0.99
70_L	74_P	0.792	0.99
104_L	107_P	0.790	0.99
99_A	107_P	0.789	0.99
226_V	277_L	0.788	0.99
96_W	100_L	0.783	0.98
135_M	139_R	0.781	0.98
237_T	240_M	0.781	0.98
39_A	128_I	0.777	0.98
21_F	163_G	0.777	0.98
179_K	182_P	0.776	0.98
40_A	124_G	0.775	0.98
238_E	261_L	0.775	0.98
105_F	108_G	0.773	0.98
229_L	232_V	0.772	0.98
21_F	151_A	0.770	0.98
235_D	248_K	0.769	0.98
103_V	108_G	0.763	0.98
15_V	19_A	0.763	0.98
161_V	266_S	0.753	0.98
176_G	189_T	0.749	0.98
43_W	261_L	0.748	0.98
9_A	162_W	0.744	0.98
107_P	110_A	0.735	0.98
3_K	6_L	0.732	0.98
238_E	241_F	0.730	0.98
37_M	64_L	0.729	0.98
221_L	225_I	0.728	0.98
19_A	27_G	0.723	0.97
164_A	200_A	0.723	0.97
15_V	18_A	0.721	0.97
171_F	189_T	0.720	0.97
28_F	136_L	0.719	0.97
20_L	154_L	0.719	0.97
134_G	138_L	0.717	0.97
219_T	222_I	0.717	0.97
102_L	106_Y	0.716	0.97
44_G	121_L	0.716	0.97
6_L	174_L	0.715	0.97
94_G	98_V	0.714	0.97
12_L	162_W	0.713	0.97
37_M	60_V	0.708	0.97
185_S	248_K	0.700	0.97
104_L	109_S	0.700	0.97
188_K	248_K	0.698	0.97
247_I	250_S	0.696	0.97
38_L	251_G	0.695	0.97
70_L	73_L	0.694	0.97
167_G	170_M	0.692	0.97
93_L	108_G	0.692	0.97
69_M	75_E	0.690	0.97
203_I	207_Y	0.690	0.97
267_L	271_V	0.690	0.97
229_L	233_L	0.687	0.97
163_G	167_G	0.686	0.97
28_F	139_R	0.686	0.97
224_S	228_A	0.680	0.96
109_S	112_I	0.675	0.96
160_L	227_A	0.675	0.96
69_M	72_L	0.671	0.96
161_V	250_S	0.670	0.96
98_V	102_L	0.667	0.96
178_H	194_I	0.666	0.96
181_A	187_G	0.665	0.96
6_L	9_A	0.663	0.96
139_R	150_G	0.663	0.96
172_G	186_P	0.660	0.96
217_P	221_L	0.660	0.96
123_F	139_R	0.658	0.96
162_W	166_S	0.657	0.96
24_P	139_R	0.655	0.95
16_V	162_W	0.654	0.95
260_I	264_I	0.654	0.95
16_V	264_I	0.650	0.95
95_W	102_L	0.649	0.95
136_L	140_A	0.649	0.95
46_L	238_E	0.648	0.95
194_I	197_L	0.644	0.95
119_L	133_W	0.642	0.95
64_L	67_A	0.640	0.95
29_A	33_L	0.638	0.95
188_K	192_G	0.636	0.95
185_S	188_K	0.635	0.95
54_Q	117_K	0.632	0.95
107_P	113_W	0.632	0.95
129_V	132_F	0.631	0.94
96_W	107_P	0.629	0.94
8_S	12_L	0.624	0.94
127_T	268_T	0.623	0.94
20_L	28_F	0.621	0.94
172_G	185_S	0.620	0.94
9_A	257_H	0.620	0.94
103_V	109_S	0.618	0.94
22_L	25_P	0.618	0.94
9_A	12_L	0.614	0.94
40_A	43_W	0.612	0.94
68_L	76_Y	0.612	0.94
249_D	257_H	0.610	0.93
200_A	207_Y	0.607	0.93
115_N	118_T	0.606	0.93
98_V	104_L	0.606	0.93
193_F	228_A	0.603	0.93
181_A	236_L	0.603	0.93
90_W	97_I	0.602	0.93
172_G	188_K	0.602	0.93
104_L	108_G	0.600	0.93
41_W	253_L	0.599	0.93
99_A	102_L	0.599	0.93
35_V	132_F	0.599	0.93
110_A	113_W	0.598	0.93
43_W	241_F	0.598	0.93
178_H	183_K	0.598	0.93
44_G	59_A	0.598	0.93
66_L	69_M	0.597	0.93
63_G	129_V	0.596	0.93
99_A	103_V	0.594	0.93
253_L	260_I	0.588	0.92
138_L	154_L	0.587	0.92
243_R	248_K	0.587	0.92
91_A	94_G	0.585	0.92
185_S	258_G	0.585	0.92
12_L	16_V	0.582	0.92
88_S	92_S	0.581	0.92
248_K	258_G	0.581	0.92
65_L	69_M	0.580	0.92
62_C	66_L	0.578	0.91
7_I	14_P	0.578	0.91
95_W	101_L	0.578	0.91
89_L	93_L	0.577	0.91
181_A	240_M	0.577	0.91
92_S	95_W	0.576	0.91
71_F	75_E	0.576	0.91
241_F	250_S	0.574	0.91
11_V	15_V	0.573	0.91
127_T	139_R	0.573	0.91
200_A	224_S	0.571	0.91
46_L	241_F	0.570	0.91
272_P	276_C	0.569	0.91
60_V	64_L	0.568	0.91
93_L	112_I	0.568	0.91
45_Q	49_F	0.564	0.90
159_I	163_G	0.563	0.90
63_G	67_A	0.563	0.90
208_G	217_P	0.562	0.90
258_G	262_D	0.561	0.90
16_V	19_A	0.558	0.90
31_V	35_V	0.557	0.90
157_V	161_V	0.557	0.90
90_W	93_L	0.556	0.90
251_G	272_P	0.555	0.90
166_S	199_T	0.554	0.90
188_K	235_D	0.552	0.90
67_A	71_F	0.548	0.89
157_V	267_L	0.548	0.89
177_K	266_S	0.547	0.89
155_L	159_I	0.547	0.89
93_L	99_A	0.544	0.89
162_W	272_P	0.543	0.89
14_P	17_I	0.543	0.89
259_G	262_D	0.543	0.89
92_S	97_I	0.540	0.89
161_V	238_E	0.538	0.88
150_G	153_W	0.538	0.88
164_A	167_G	0.538	0.88
251_G	256_G	0.538	0.88
162_W	267_L	0.536	0.88
151_A	155_L	0.536	0.88
32_T	273_V	0.535	0.88
13_I	170_M	0.535	0.88
59_A	121_L	0.530	0.88
67_A	75_E	0.529	0.87
100_L	104_L	0.528	0.87
93_L	103_V	0.528	0.87
12_L	35_V	0.524	0.87
60_V	63_G	0.523	0.87
59_A	66_L	0.522	0.87
239_S	249_D	0.522	0.87
92_S	106_Y	0.521	0.87
41_W	252_H	0.521	0.87
152_I	211_A	0.521	0.87
116_S	120_R	0.519	0.87
96_W	103_V	0.519	0.87
181_A	233_L	0.518	0.86
239_S	248_K	0.517	0.86
132_F	268_T	0.516	0.86
62_C	77_H	0.515	0.86
181_A	193_F	0.510	0.86
74_P	77_H	0.505	0.85
132_F	264_I	0.505	0.85
201_A	224_S	0.505	0.85
186_P	248_K	0.504	0.85
162_W	168_A	0.504	0.85
47_S	245_A	0.503	0.85
58_L	62_C	0.503	0.85
13_I	158_M	0.503	0.85
187_G	250_S	0.503	0.85
63_G	66_L	0.502	0.85
179_K	190_W	0.501	0.85
242_K	262_D	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4q2eA	2	0.9088	100	0.162	Contact Map
1oisA	1	0.2105	2.9	0.971	Contact Map
4c48C	1	0.1544	2.1	0.973	Contact Map
3b9wA	3	0.9088	1.8	0.974	Contact Map
2k1kA	2	0.1333	1.6	0.975	Contact Map
4us3A	1	0.5719	1.6	0.975	Contact Map
1qleD	1	0.1439	1.6	0.975	Contact Map
1m56D	1	0.1193	1.3	0.976	Contact Map
3mk7C	2	0.2421	1.3	0.976	Contact Map
1skhA	1	0.1053	1.2	0.977	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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