GREMLIN Database
CDSA - Phosphatidate cytidylyltransferase
UniProt: P0ABG1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10139
Length: 285 (259)
Sequences: 4744 (3675)
Seq/√Len: 228.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_S254_I6.1141.00
167_G199_T5.0801.00
178_H191_Q4.1811.00
171_F195_G4.1241.00
193_F232_V3.8141.00
238_E250_S3.3291.00
163_G203_I3.2291.00
177_K191_Q3.1521.00
171_F199_T2.9161.00
173_K189_T2.8031.00
39_A260_I2.7571.00
158_M162_W2.6771.00
43_W124_G2.6021.00
9_A14_P2.5441.00
171_F175_F2.4771.00
6_L170_M2.3111.00
164_A232_V2.2861.00
204_S224_S2.1371.00
157_V271_V2.0971.00
180_L193_F2.0821.00
46_L247_I2.0521.00
257_H263_R2.0261.00
19_A31_V2.0181.00
164_A228_A1.9741.00
156_Y224_S1.9591.00
46_L250_S1.9281.00
180_L190_W1.9101.00
170_M174_L1.8671.00
194_I198_A1.8631.00
9_A13_I1.8591.00
168_A196_G1.8401.00
164_A231_S1.8211.00
38_L260_I1.8061.00
178_H190_W1.8021.00
22_L27_G1.7681.00
10_F14_P1.7521.00
190_W194_I1.7511.00
171_F174_L1.7371.00
35_V260_I1.6591.00
41_W45_Q1.6271.00
40_A44_G1.6031.00
230_A273_V1.5941.00
223_C277_L1.5781.00
180_L236_L1.5711.00
102_L107_P1.5701.00
220_L224_S1.5691.00
34_V38_L1.5481.00
201_A221_L1.5381.00
41_W251_G1.4581.00
119_L123_F1.4571.00
264_I267_L1.4561.00
7_I11_V1.4481.00
219_T277_L1.4451.00
160_L204_S1.4361.00
134_G271_V1.4361.00
163_G199_T1.4271.00
161_V270_A1.4241.00
159_I203_I1.3791.00
197_L228_A1.3671.00
127_T131_F1.3611.00
157_V274_F1.3571.00
179_K189_T1.3511.00
206_G210_W1.3451.00
197_L225_I1.3431.00
134_G276_C1.3411.00
124_G127_T1.3361.00
171_F198_A1.3231.00
202_V206_G1.3191.00
131_F134_G1.3061.00
30_I34_V1.3041.00
237_T269_A1.3021.00
18_A22_L1.2881.00
101_L104_L1.2821.00
231_S266_S1.2741.00
237_T241_F1.2711.00
179_K187_G1.2681.00
134_G137_A1.2651.00
127_T130_P1.2651.00
201_A225_I1.2631.00
230_A270_A1.2591.00
39_A261_L1.2531.00
14_P18_A1.2491.00
8_S255_P1.2261.00
161_V267_L1.2231.00
200_A228_A1.2151.00
205_W221_L1.2111.00
134_G275_A1.2101.00
206_G209_M1.2061.00
17_I21_F1.2031.00
92_S96_W1.2011.00
8_S11_V1.1881.00
67_A70_L1.1861.00
196_G228_A1.1831.00
167_G195_G1.1811.00
3_K7_I1.1801.00
72_L76_Y1.1781.00
32_T136_L1.1601.00
160_L200_A1.1581.00
156_Y207_Y1.1541.00
46_L245_A1.1521.00
176_G191_Q1.1431.00
190_W193_F1.1311.00
131_F135_M1.1251.00
24_P27_G1.1231.00
181_A184_V1.1161.00
9_A170_M1.1011.00
39_A264_I1.0921.00
227_A274_F1.0901.00
218_V222_I1.0851.00
173_K187_G1.0841.00
193_F229_L1.0771.00
228_A232_V1.0721.00
102_L105_F1.0701.00
161_V231_S1.0611.00
6_L10_F1.0611.00
43_W47_S1.0581.00
103_V107_P1.0551.00
158_M267_L1.0541.00
135_M154_L1.0541.00
254_I260_I1.0481.00
251_G254_I1.0411.00
29_A136_L1.0391.00
127_T238_E1.0361.00
128_I261_L1.0301.00
12_L264_I1.0301.00
216_A219_T1.0271.00
180_L194_I1.0241.00
227_A270_A1.0191.00
73_L77_H1.0161.00
73_L76_Y1.0111.00
127_T132_F1.0041.00
12_L254_I0.9961.00
8_S256_G0.9881.00
4_Y8_S0.9721.00
38_L41_W0.9681.00
6_L166_S0.9661.00
180_L232_V0.9661.00
156_Y274_F0.9631.00
96_W99_A0.9631.00
205_W209_M0.9631.00
36_C132_F0.9611.00
270_A274_F0.9601.00
200_A203_I0.9541.00
101_L105_F0.9531.00
106_Y109_S0.9491.00
27_G30_I0.9341.00
162_W257_H0.9331.00
35_V264_I0.9291.00
207_Y211_A0.9291.00
14_P162_W0.9281.00
103_V106_Y0.9231.00
167_G171_F0.9111.00
164_A196_G0.9090.99
68_L71_F0.9080.99
135_M271_V0.9030.99
28_F154_L0.9000.99
215_V219_T0.8990.99
13_I17_I0.8990.99
204_S220_L0.8980.99
205_W217_P0.8820.99
4_Y7_I0.8800.99
156_Y204_S0.8740.99
182_P193_F0.8730.99
11_V14_P0.8680.99
123_F127_T0.8660.99
27_G31_V0.8630.99
40_A63_G0.8600.99
208_G220_L0.8590.99
96_W105_F0.8510.99
219_T223_C0.8500.99
138_L275_A0.8460.99
167_G196_G0.8400.99
12_L15_V0.8370.99
128_I268_T0.8350.99
160_L224_S0.8350.99
137_A275_A0.8330.99
26_V30_I0.8320.99
37_M41_W0.8290.99
172_G248_K0.8270.99
128_I131_F0.8200.99
175_F191_Q0.8200.99
139_R151_A0.8180.99
162_W263_R0.8130.99
66_L70_L0.8110.99
184_V240_M0.8100.99
115_N119_L0.7990.99
187_G190_W0.7960.99
199_T203_I0.7940.99
69_M73_L0.7940.99
105_F109_S0.7930.99
70_L74_P0.7920.99
104_L107_P0.7900.99
99_A107_P0.7890.99
226_V277_L0.7880.99
96_W100_L0.7830.98
135_M139_R0.7810.98
237_T240_M0.7810.98
39_A128_I0.7770.98
21_F163_G0.7770.98
179_K182_P0.7760.98
40_A124_G0.7750.98
238_E261_L0.7750.98
105_F108_G0.7730.98
229_L232_V0.7720.98
21_F151_A0.7700.98
235_D248_K0.7690.98
103_V108_G0.7630.98
15_V19_A0.7630.98
161_V266_S0.7530.98
176_G189_T0.7490.98
43_W261_L0.7480.98
9_A162_W0.7440.98
107_P110_A0.7350.98
3_K6_L0.7320.98
238_E241_F0.7300.98
37_M64_L0.7290.98
221_L225_I0.7280.98
19_A27_G0.7230.97
164_A200_A0.7230.97
15_V18_A0.7210.97
171_F189_T0.7200.97
28_F136_L0.7190.97
20_L154_L0.7190.97
134_G138_L0.7170.97
219_T222_I0.7170.97
102_L106_Y0.7160.97
44_G121_L0.7160.97
6_L174_L0.7150.97
94_G98_V0.7140.97
12_L162_W0.7130.97
37_M60_V0.7080.97
185_S248_K0.7000.97
104_L109_S0.7000.97
188_K248_K0.6980.97
247_I250_S0.6960.97
38_L251_G0.6950.97
70_L73_L0.6940.97
167_G170_M0.6920.97
93_L108_G0.6920.97
69_M75_E0.6900.97
203_I207_Y0.6900.97
267_L271_V0.6900.97
229_L233_L0.6870.97
163_G167_G0.6860.97
28_F139_R0.6860.97
224_S228_A0.6800.96
109_S112_I0.6750.96
160_L227_A0.6750.96
69_M72_L0.6710.96
161_V250_S0.6700.96
98_V102_L0.6670.96
178_H194_I0.6660.96
181_A187_G0.6650.96
6_L9_A0.6630.96
139_R150_G0.6630.96
172_G186_P0.6600.96
217_P221_L0.6600.96
123_F139_R0.6580.96
162_W166_S0.6570.96
24_P139_R0.6550.95
16_V162_W0.6540.95
260_I264_I0.6540.95
16_V264_I0.6500.95
95_W102_L0.6490.95
136_L140_A0.6490.95
46_L238_E0.6480.95
194_I197_L0.6440.95
119_L133_W0.6420.95
64_L67_A0.6400.95
29_A33_L0.6380.95
188_K192_G0.6360.95
185_S188_K0.6350.95
54_Q117_K0.6320.95
107_P113_W0.6320.95
129_V132_F0.6310.94
96_W107_P0.6290.94
8_S12_L0.6240.94
127_T268_T0.6230.94
20_L28_F0.6210.94
172_G185_S0.6200.94
9_A257_H0.6200.94
103_V109_S0.6180.94
22_L25_P0.6180.94
9_A12_L0.6140.94
40_A43_W0.6120.94
68_L76_Y0.6120.94
249_D257_H0.6100.93
200_A207_Y0.6070.93
115_N118_T0.6060.93
98_V104_L0.6060.93
193_F228_A0.6030.93
181_A236_L0.6030.93
90_W97_I0.6020.93
172_G188_K0.6020.93
104_L108_G0.6000.93
41_W253_L0.5990.93
99_A102_L0.5990.93
35_V132_F0.5990.93
110_A113_W0.5980.93
43_W241_F0.5980.93
178_H183_K0.5980.93
44_G59_A0.5980.93
66_L69_M0.5970.93
63_G129_V0.5960.93
99_A103_V0.5940.93
253_L260_I0.5880.92
138_L154_L0.5870.92
243_R248_K0.5870.92
91_A94_G0.5850.92
185_S258_G0.5850.92
12_L16_V0.5820.92
88_S92_S0.5810.92
248_K258_G0.5810.92
65_L69_M0.5800.92
62_C66_L0.5780.91
7_I14_P0.5780.91
95_W101_L0.5780.91
89_L93_L0.5770.91
181_A240_M0.5770.91
92_S95_W0.5760.91
71_F75_E0.5760.91
241_F250_S0.5740.91
11_V15_V0.5730.91
127_T139_R0.5730.91
200_A224_S0.5710.91
46_L241_F0.5700.91
272_P276_C0.5690.91
60_V64_L0.5680.91
93_L112_I0.5680.91
45_Q49_F0.5640.90
159_I163_G0.5630.90
63_G67_A0.5630.90
208_G217_P0.5620.90
258_G262_D0.5610.90
16_V19_A0.5580.90
31_V35_V0.5570.90
157_V161_V0.5570.90
90_W93_L0.5560.90
251_G272_P0.5550.90
166_S199_T0.5540.90
188_K235_D0.5520.90
67_A71_F0.5480.89
157_V267_L0.5480.89
177_K266_S0.5470.89
155_L159_I0.5470.89
93_L99_A0.5440.89
162_W272_P0.5430.89
14_P17_I0.5430.89
259_G262_D0.5430.89
92_S97_I0.5400.89
161_V238_E0.5380.88
150_G153_W0.5380.88
164_A167_G0.5380.88
251_G256_G0.5380.88
162_W267_L0.5360.88
151_A155_L0.5360.88
32_T273_V0.5350.88
13_I170_M0.5350.88
59_A121_L0.5300.88
67_A75_E0.5290.87
100_L104_L0.5280.87
93_L103_V0.5280.87
12_L35_V0.5240.87
60_V63_G0.5230.87
59_A66_L0.5220.87
239_S249_D0.5220.87
92_S106_Y0.5210.87
41_W252_H0.5210.87
152_I211_A0.5210.87
116_S120_R0.5190.87
96_W103_V0.5190.87
181_A233_L0.5180.86
239_S248_K0.5170.86
132_F268_T0.5160.86
62_C77_H0.5150.86
181_A193_F0.5100.86
74_P77_H0.5050.85
132_F264_I0.5050.85
201_A224_S0.5050.85
186_P248_K0.5040.85
162_W168_A0.5040.85
47_S245_A0.5030.85
58_L62_C0.5030.85
13_I158_M0.5030.85
187_G250_S0.5030.85
63_G66_L0.5020.85
179_K190_W0.5010.85
242_K262_D0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q2eA 2 0.9088 100 0.162 Contact Map
1oisA 1 0.2105 2.9 0.971 Contact Map
4c48C 1 0.1544 2.1 0.973 Contact Map
3b9wA 3 0.9088 1.8 0.974 Contact Map
2k1kA 2 0.1333 1.6 0.975 Contact Map
4us3A 1 0.5719 1.6 0.975 Contact Map
1qleD 1 0.1439 1.6 0.975 Contact Map
1m56D 1 0.1193 1.3 0.976 Contact Map
3mk7C 2 0.2421 1.3 0.976 Contact Map
1skhA 1 0.1053 1.2 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0089 seconds.