GREMLIN Database
PGSA - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
UniProt: P0ABF8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10706
Length: 182 (170)
Sequences: 4380 (2889)
Seq/√Len: 221.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_L56_W3.3081.00
62_F66_L3.2211.00
83_T95_A3.0081.00
124_S170_Q2.9201.00
9_L45_T2.8171.00
21_V81_L2.4701.00
133_A163_L2.4571.00
126_I166_W2.2481.00
40_C139_A2.2181.00
20_F78_A2.1981.00
4_N60_T2.1631.00
21_V77_I2.1601.00
104_I172_L2.1221.00
23_V38_I2.0731.00
17_I73_V2.0501.00
125_W129_V2.0131.00
137_A160_A1.9731.00
43_A135_M1.9311.00
169_L173_S1.9081.00
30_W34_A1.8841.00
61_R64_A1.8771.00
173_S176_R1.8641.00
4_N58_Q1.8381.00
24_F81_L1.7821.00
59_S64_A1.7691.00
44_V47_W1.7601.00
51_F55_R1.7501.00
23_V34_A1.7221.00
3_F8_L1.7041.00
16_L38_I1.6761.00
129_V132_T1.6271.00
10_T66_L1.6081.00
133_A159_V1.6041.00
42_A74_L1.5821.00
92_T161_A1.5621.00
33_F37_L1.5601.00
134_Q164_T1.5311.00
141_L153_G1.4881.00
36_A139_A1.4881.00
24_F85_H1.4871.00
170_Q174_A1.4821.00
140_W156_L1.4681.00
44_V48_F1.4441.00
98_M164_T1.4311.00
151_Y155_A1.4271.00
52_L58_Q1.4271.00
14_V70_A1.4211.00
9_L48_F1.4041.00
36_A143_W1.3981.00
6_P58_Q1.3901.00
132_T136_V1.3791.00
11_L15_I1.3761.00
92_T158_F1.3511.00
47_W51_F1.3211.00
140_W153_G1.3161.00
141_L157_F1.3121.00
105_I172_L1.3081.00
19_F23_V1.3081.00
16_L41_V1.2901.00
14_V73_V1.2781.00
112_M175_A1.2781.00
165_L169_L1.2651.00
131_T135_M1.2441.00
37_L41_V1.2401.00
137_A157_F1.2201.00
9_L44_V1.2151.00
112_M121_V1.2121.00
8_L12_F1.1901.00
88_S157_F1.1881.00
19_F38_I1.1821.00
5_I8_L1.1771.00
32_P87_H1.1551.00
126_I170_Q1.1521.00
23_V35_A1.1511.00
78_A138_L1.1391.00
109_R130_K1.1321.00
20_F38_I1.1301.00
16_L19_F1.1041.00
6_P52_L1.1021.00
25_Y81_L1.0881.00
3_F11_L1.0761.00
97_T165_L1.0721.00
155_A159_V1.0201.00
97_T161_A1.0071.00
23_V31_S1.0001.00
83_T90_W0.9971.00
132_T135_M0.9951.00
15_I18_P0.9911.00
6_P9_L0.9881.00
75_V138_L0.9851.00
40_C136_V0.9831.00
76_A80_V0.9791.00
79_M138_L0.9751.00
76_A99_I0.9731.00
144_R153_G0.9641.00
124_S174_A0.9621.00
39_F74_L0.9431.00
106_S109_R0.9361.00
15_I19_F0.9331.00
33_F143_W0.9311.00
48_F52_L0.9261.00
96_A100_A0.9261.00
55_R59_S0.9190.99
92_T157_F0.9130.99
164_T168_M0.9090.99
105_I168_M0.9010.99
127_G130_K0.9010.99
124_S127_G0.8970.99
77_I81_L0.8940.99
129_V163_L0.8890.99
137_A156_L0.8880.99
24_F142_L0.8880.99
22_L26_L0.8840.99
166_W170_Q0.8820.99
75_V79_M0.8810.99
68_P131_T0.8770.99
12_F45_T0.8650.99
127_G167_S0.8640.99
101_R167_S0.8640.99
17_I77_I0.8630.99
34_A38_I0.8600.99
8_L11_L0.8560.99
40_C44_V0.8460.99
154_I158_F0.8450.99
12_F41_V0.8440.99
162_V166_W0.8340.99
151_Y154_I0.8340.99
137_A153_G0.8320.99
64_A120_S0.8310.99
79_M98_M0.8270.99
82_V87_H0.8230.99
64_A122_A0.8180.99
89_W92_T0.8080.99
90_W96_A0.7940.98
9_L12_F0.7930.98
3_F7_T0.7840.98
32_P85_H0.7830.98
150_E154_I0.7680.98
16_L20_F0.7630.98
134_Q160_A0.7620.98
26_L31_S0.7570.98
43_A74_L0.7570.98
76_A102_E0.7380.98
126_I167_S0.7370.98
72_K134_Q0.7260.97
149_V153_G0.7250.97
65_F110_E0.7230.97
102_E164_T0.7230.97
108_L130_K0.7200.97
51_F56_W0.7170.97
5_I56_W0.7170.97
21_V96_A0.7100.97
110_E113_A0.7040.97
9_L52_L0.6990.97
136_V156_L0.6970.97
126_I129_V0.6950.96
102_E106_S0.6950.96
101_R130_K0.6900.96
36_A40_C0.6880.96
34_A37_L0.6870.96
18_P70_A0.6860.96
24_F32_P0.6860.96
20_F35_A0.6820.96
145_P148_W0.6810.96
77_I96_A0.6780.96
73_V100_A0.6770.96
59_S123_V0.6750.96
35_A42_A0.6690.96
173_S177_A0.6650.95
147_I150_E0.6640.95
104_I107_A0.6620.95
14_V66_L0.6540.95
18_P68_P0.6530.95
101_R105_I0.6530.95
75_V135_M0.6480.95
5_I52_L0.6470.95
36_A142_L0.6460.95
130_K167_S0.6430.95
84_E90_W0.6430.95
145_P150_E0.6390.94
151_Y156_L0.6340.94
160_A164_T0.6320.94
12_F16_L0.6310.94
106_S113_A0.6300.94
112_M116_G0.6230.94
72_K123_V0.6180.93
80_V95_A0.6170.93
129_V133_A0.6160.93
21_V25_Y0.6140.93
95_A99_I0.6130.93
88_S91_V0.6080.93
172_L176_R0.6080.93
80_V83_T0.6070.93
136_V140_W0.6070.93
112_M115_L0.6060.93
20_F81_L0.6050.93
140_W152_A0.6050.93
107_A111_W0.6020.92
99_I103_I0.6000.92
123_V126_I0.5990.92
69_V107_A0.5970.92
159_V163_L0.5940.92
92_T154_I0.5920.92
79_M160_A0.5880.92
6_P56_W0.5880.92
133_A156_L0.5880.92
76_A103_I0.5860.91
31_S34_A0.5830.91
25_Y85_H0.5810.91
102_E130_K0.5790.91
32_P144_R0.5780.91
75_V106_S0.5690.90
124_S131_T0.5690.90
125_W132_T0.5680.90
75_V134_Q0.5640.90
80_V99_I0.5620.90
4_N8_L0.5560.89
54_R127_G0.5540.89
64_A123_V0.5520.89
175_A178_D0.5490.89
112_M119_S0.5470.88
141_L154_I0.5450.88
16_L42_A0.5450.88
130_K163_L0.5450.88
10_T14_V0.5440.88
9_L47_W0.5400.88
160_A163_L0.5370.87
56_W60_T0.5360.87
162_V165_L0.5340.87
8_L60_T0.5330.87
87_H145_P0.5330.87
6_P10_T0.5310.87
123_V130_K0.5260.86
39_F43_A0.5260.86
35_A81_L0.5260.86
72_K131_T0.5230.86
81_L85_H0.5230.86
52_L55_R0.5220.86
5_I58_Q0.5220.86
3_F60_T0.5200.86
145_P153_G0.5200.86
91_V158_F0.5190.86
72_K164_T0.5190.86
9_L66_L0.5160.85
25_Y84_E0.5160.85
157_F160_A0.5130.85
174_A178_D0.5120.85
24_F35_A0.5110.85
47_W132_T0.5110.85
174_A177_A0.5060.84
149_V152_A0.5050.84
5_I9_L0.5030.84
43_A47_W0.5020.84
107_A110_E0.5000.84
72_K102_E0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mndA 2 0.9231 100 0.382 Contact Map
4o6mA 2 0.9341 99.9 0.441 Contact Map
3j08A 2 0.3407 5.8 0.95 Contact Map
3tx3A 2 0.8352 4.1 0.953 Contact Map
3m73A 3 0.3626 4 0.954 Contact Map
2kesA 1 0.1264 3.5 0.955 Contact Map
1vryA 1 0.3242 1.9 0.961 Contact Map
3wu2J 1 0.2143 1.8 0.961 Contact Map
2yzcA 4 0.3022 1.7 0.962 Contact Map
2nrgA 1 0.4505 1.3 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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