GREMLIN Database
CDD - Cytidine deaminase
UniProt: P0ABF6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10137
Length: 294 (268)
Sequences: 322 (209)
Seq/√Len: 12.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
215_L260_A6.5611.00
90_M101_V4.9651.00
81_S116_E3.8890.99
183_G200_N3.7780.99
48_D51_A3.2440.98
33_L86_F3.1830.98
113_L226_S3.1740.97
109_S242_G3.1640.97
101_V106_S3.1420.97
66_T72_N3.0470.97
106_S245_I2.6310.93
112_W228_A2.6060.92
240_L276_T2.5730.92
217_C247_L2.5730.92
79_G116_E2.5500.91
195_A212_G2.4860.90
219_D252_Y2.4360.89
216_E258_Q2.4130.89
110_H160_Y2.3310.87
111_A115_G2.2990.86
245_I249_L2.2820.86
80_V118_A2.2100.84
35_G83_T2.0880.80
184_Y196_I2.0460.79
186_L196_I2.0420.79
196_I263_A2.0130.78
42_K49_E1.9850.77
198_A212_G1.8460.71
31_A53_A1.8100.69
114_S203_H1.7960.69
77_A107_A1.7660.67
21_E25_A1.7650.67
119_L268_A1.7450.66
195_A199_A1.7330.66
239_P262_L1.6740.63
272_Q278_A1.6710.63
200_N257_I1.6670.63
218_K256_D1.6560.62
145_L251_G1.6380.61
122_I136_M1.6180.60
65_R210_P1.6110.60
65_R248_N1.5950.59
169_D231_A1.5880.59
201_R226_S1.5850.59
177_M199_A1.5660.58
198_A214_A1.5510.57
223_F252_Y1.5420.57
32_L83_T1.5420.57
49_E78_R1.5410.57
24_L27_K1.5230.56
131_H234_N1.5190.55
180_Q203_H1.4780.53
158_R164_A1.4560.52
189_D259_R1.4420.51
167_P170_L1.4370.51
33_L40_S1.4240.50
38_V42_K1.4150.50
119_L244_L1.4100.50
227_Y236_T1.4050.50
188_G196_I1.4020.49
66_T93_I1.4000.49
50_D146_R1.3930.49
139_L145_L1.3900.49
96_T223_F1.3860.49
96_T242_G1.3860.49
203_H242_G1.3840.48
178_D251_G1.3780.48
78_R123_T1.3770.48
115_G279_T1.3750.48
18_S21_E1.3730.48
177_M184_Y1.3670.48
109_S272_Q1.3610.47
39_S247_L1.3510.47
41_L277_S1.3510.47
25_A184_Y1.3500.47
200_N212_G1.3410.46
20_L177_M1.3370.46
177_M211_S1.3270.45
140_N178_D1.3220.45
71_F139_L1.3140.45
110_H125_N1.3040.44
123_T148_H1.3000.44
31_A94_G1.2980.44
90_M248_N1.2970.44
226_S248_N1.2930.44
18_S25_A1.2860.43
130_G134_Q1.2860.43
226_S246_L1.2770.43
211_S239_P1.2630.42
264_E271_I1.2530.42
191_L198_A1.2440.41
242_G272_Q1.2180.40
32_L114_S1.2090.39
24_L101_V1.2000.39
152_R203_H1.1820.38
125_N160_Y1.1790.38
191_L214_A1.1670.37
71_F133_R1.1650.37
273_W277_S1.1550.37
32_L53_A1.1540.37
68_L207_S1.1420.36
83_T258_Q1.1360.36
179_E221_R1.1340.36
62_A90_M1.1290.36
236_T239_P1.1180.35
66_T101_V1.1160.35
73_V133_R1.1030.34
147_I227_Y1.1020.34
159_D163_D1.1020.34
38_V49_E1.0920.34
127_T160_Y1.0910.34
133_R167_P1.0830.33
41_L45_T1.0760.33
97_M100_T1.0610.32
273_W285_C1.0600.32
92_F279_T1.0560.32
88_A108_I1.0490.32
34_T191_L1.0410.32
117_K179_E1.0360.31
82_G116_E1.0360.31
68_L203_H1.0340.31
37_Q115_G1.0320.31
195_A214_A1.0300.31
237_L241_Q1.0280.31
23_I33_L1.0230.31
214_A222_I1.0220.31
208_K244_L1.0080.30
92_F244_L1.0040.30
44_A282_A1.0040.30
137_N230_N1.0030.30
88_A112_W1.0020.30
139_L228_A0.9950.30
262_L276_T0.9940.29
176_L244_L0.9910.29
107_A149_L0.9870.29
90_M126_Y0.9830.29
58_P149_L0.9820.29
127_T155_H0.9790.29
75_A103_A0.9780.29
118_A271_I0.9720.29
117_K223_F0.9710.28
51_A248_N0.9580.28
21_E27_K0.9550.28
49_E120_A0.9530.28
106_S249_L0.9490.28
20_L49_E0.9490.28
72_N244_L0.9480.28
185_A218_K0.9480.28
223_F250_K0.9440.27
62_A216_E0.9430.27
46_G49_E0.9330.27
78_R119_L0.9280.27
147_I163_D0.9270.27
118_A141_S0.9270.27
124_V261_V0.9260.27
25_A268_A0.9250.27
39_S44_A0.9180.26
54_F171_E0.9150.26
33_L50_D0.9120.26
136_M157_L0.9110.26
28_Y196_I0.9100.26
64_A142_G0.9100.26
19_A186_L0.9080.26
19_A23_I0.9020.26
80_V117_K0.9010.26
218_K258_Q0.8980.26
61_A139_L0.8940.25
223_F263_A0.8900.25
33_L263_A0.8890.25
43_S266_A0.8860.25
194_A222_I0.8800.25
20_L146_R0.8780.25
189_D261_V0.8770.25
266_A283_L0.8760.25
24_L106_S0.8740.25
182_H210_P0.8690.24
274_D277_S0.8680.24
47_L136_M0.8610.24
99_Q110_H0.8590.24
52_L279_T0.8570.24
216_E222_I0.8490.24
67_P196_I0.8470.24
183_G222_I0.8450.23
213_V272_Q0.8430.23
69_S134_Q0.8420.23
37_Q182_H0.8420.23
133_R170_L0.8330.23
131_H207_S0.8320.23
130_G161_L0.8290.23
210_P248_N0.8230.23
51_A272_Q0.8220.23
98_Q131_H0.8090.22
237_L272_Q0.8090.22
135_F138_E0.8080.22
146_R250_K0.8080.22
125_N149_L0.8080.22
112_W149_L0.8070.22
215_L263_A0.8070.22
118_A207_S0.8050.22
260_A263_A0.7980.22
221_R252_Y0.7980.22
161_L169_D0.7960.22
112_W150_P0.7930.22
73_V104_E0.7920.22
36_E187_T0.7900.21
216_E259_R0.7860.21
74_G160_Y0.7850.21
213_V224_S0.7830.21
175_L178_D0.7790.21
90_M151_G0.7780.21
277_S281_K0.7770.21
227_Y231_A0.7760.21
100_T110_H0.7750.21
253_D256_D0.7720.21
22_P215_L0.7700.21
101_V279_T0.7690.21
58_P61_A0.7690.21
144_D263_A0.7650.21
96_T272_Q0.7650.21
71_F233_F0.7640.21
109_S245_I0.7620.21
31_A83_T0.7600.20
152_R160_Y0.7590.20
39_S49_E0.7590.20
133_R206_Y0.7560.20
138_E206_Y0.7530.20
174_T184_Y0.7460.20
199_A210_P0.7400.20
88_A107_A0.7360.20
110_H114_S0.7300.19
140_N147_I0.7290.19
34_T95_A0.7240.19
256_D266_A0.7220.19
49_E68_L0.7200.19
266_A269_P0.7150.19
125_N230_N0.7130.19
25_A43_S0.7080.19
281_K286_H0.7080.19
168_K175_L0.7050.19
128_P132_C0.7030.19
129_C132_C0.7030.19
95_A110_H0.7030.19
195_A198_A0.7000.19
136_M166_G0.7000.19
240_L283_L0.6960.18
19_A24_L0.6930.18
184_Y210_P0.6910.18
19_A22_P0.6910.18
113_L261_V0.6900.18
130_G133_R0.6840.18
133_R235_P0.6830.18
18_S40_S0.6830.18
100_T209_S0.6830.18
104_E165_F0.6800.18
74_G133_R0.6790.18
33_L38_V0.6790.18
72_N141_S0.6760.18
40_S185_A0.6740.18
203_H261_V0.6720.18
203_H238_P0.6710.18
134_Q235_P0.6680.18
144_D187_T0.6680.18
273_W284_G0.6670.18
184_Y199_A0.6650.17
108_I269_P0.6650.17
152_R219_D0.6640.17
157_L227_Y0.6640.17
254_Y271_I0.6570.17
203_H226_S0.6560.17
212_G245_I0.6550.17
195_A204_M0.6540.17
34_T197_A0.6500.17
101_V253_D0.6480.17
18_S28_Y0.6470.17
68_L96_T0.6460.17
219_D253_D0.6440.17
212_G240_L0.6430.17
131_H134_Q0.6430.17
130_G135_F0.6400.17
238_P276_T0.6400.17
76_I86_F0.6390.17
65_R223_F0.6380.17
124_V227_Y0.6360.17
39_S213_V0.6360.17
151_G155_H0.6360.17
42_K259_R0.6350.17
100_T279_T0.6320.16
211_S255_P0.6290.16
28_Y258_Q0.6270.16
245_I283_L0.6240.16
186_L197_A0.6220.16
253_D258_Q0.6190.16
53_A209_S0.6170.16
123_T238_P0.6170.16
38_V93_I0.6170.16
38_V207_S0.6130.16
107_A111_A0.6120.16
96_T212_G0.6090.16
196_I260_A0.6090.16
188_G193_Q0.6070.16
80_V213_V0.6030.16
95_A203_H0.6010.16
90_M119_L0.6000.16
142_G274_D0.5990.16
31_A182_H0.5990.16
125_N137_N0.5990.16
125_N238_P0.5950.15
98_Q272_Q0.5950.15
101_V258_Q0.5910.15
119_L201_R0.5890.15
73_V130_G0.5870.15
64_A93_I0.5850.15
49_E196_I0.5850.15
88_A106_S0.5850.15
193_Q197_A0.5840.15
65_R254_Y0.5810.15
84_W124_V0.5800.15
229_E232_A0.5790.15
35_G46_G0.5770.15
147_I278_A0.5760.15
248_N254_Y0.5750.15
96_T252_Y0.5740.15
74_G150_P0.5730.15
35_G267_D0.5720.15
181_D197_A0.5720.15
126_Y203_H0.5700.15
211_S240_L0.5690.15
18_S43_S0.5680.15
98_Q270_L0.5660.15
66_T122_I0.5650.15
95_A245_I0.5650.15
28_Y283_L0.5650.15
187_T218_K0.5630.15
29_F123_T0.5620.15
73_V170_L0.5620.15
42_K274_D0.5610.15
200_N203_H0.5600.15
69_S235_P0.5580.14
32_L38_V0.5580.14
69_S130_G0.5550.14
196_I223_F0.5540.14
73_V89_N0.5520.14
67_P205_P0.5510.14
91_E133_R0.5500.14
64_A239_P0.5490.14
165_F169_D0.5490.14
204_M207_S0.5480.14
41_L49_E0.5480.14
159_D179_E0.5480.14
19_A77_A0.5470.14
144_D221_R0.5450.14
67_P133_R0.5450.14
123_T127_T0.5410.14
133_R233_F0.5380.14
18_S83_T0.5380.14
125_N211_S0.5360.14
133_R169_D0.5340.14
176_L260_A0.5340.14
61_A125_N0.5320.14
28_Y101_V0.5310.14
223_F255_P0.5310.14
127_T163_D0.5310.14
50_D154_A0.5300.14
179_E191_L0.5300.14
76_I171_E0.5300.14
191_L284_G0.5290.14
33_L188_G0.5290.14
46_G224_S0.5280.14
23_I41_L0.5260.14
150_P228_A0.5260.14
146_R217_C0.5260.14
99_Q163_D0.5240.14
71_F74_G0.5230.14
106_S109_S0.5210.14
95_A282_A0.5210.14
99_Q160_Y0.5200.14
71_F165_F0.5190.14
119_L272_Q0.5180.13
22_P25_A0.5170.13
76_I255_P0.5170.13
108_I237_L0.5150.13
107_A230_N0.5150.13
67_P97_M0.5140.13
32_L261_V0.5140.13
108_I115_G0.5130.13
207_S254_Y0.5120.13
34_T83_T0.5110.13
98_Q246_L0.5110.13
66_T148_H0.5110.13
142_G279_T0.5100.13
186_L266_A0.5090.13
201_R213_V0.5080.13
259_R286_H0.5070.13
64_A254_Y0.5050.13
101_V115_G0.5050.13
23_I210_P0.5050.13
164_A259_R0.5040.13
20_L51_A0.5020.13
122_I202_S0.5020.13
99_Q122_I0.5020.13
204_M234_N0.5020.13
186_L215_L0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1cttA 2 0.9966 100 0.367 Contact Map
4eg2A 4 1 100 0.425 Contact Map
2d30A 4 0.3878 100 0.746 Contact Map
3dmoA 4 0.415 100 0.756 Contact Map
3b8fA 4 0.4354 100 0.772 Contact Map
1r5tA 4 0.432 99.9 0.784 Contact Map
1uwzA 4 0.4082 99.9 0.785 Contact Map
2fr5A 6 0.4286 99.9 0.786 Contact Map
3mpzA 4 0.4082 99.9 0.79 Contact Map
3r2nA 4 0.3946 99.9 0.796 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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