GREMLIN Database
EUTM - Ethanolamine utilization protein EutM
UniProt: P0ABF4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14187
Length: 97 (86)
Sequences: 1348 (757)
Seq/√Len: 81.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_M45_V4.6581.00
60_A72_V3.1731.00
53_K57_D2.9441.00
56_T74_V2.9301.00
40_L70_V2.4031.00
49_V76_P2.2581.00
15_L43_A1.9941.00
63_A69_L1.9031.00
56_T72_V1.8651.00
59_G63_A1.8441.00
7_I56_T1.6691.00
69_L72_V1.6471.00
21_A25_A1.6431.00
6_M42_T1.6211.00
12_L16_I1.6021.00
57_D61_A1.5781.00
10_R70_V1.5581.00
4_L44_M1.5320.99
45_V56_T1.5200.99
10_R68_E1.5190.99
46_R83_E1.4650.99
61_A64_Q1.4400.99
22_M59_G1.4080.99
80_G84_E1.4050.99
48_D51_A1.3650.99
3_A78_P1.3590.99
4_L74_V1.2750.98
21_A59_G1.2060.97
28_V55_A1.1940.97
9_T18_A1.1880.97
9_T63_A1.1720.97
35_Q38_G1.1550.96
61_A65_R1.1550.96
17_E65_R1.1500.96
57_D60_A1.1310.96
27_R50_A1.1030.95
2_E46_R1.0890.95
32_G44_M1.0790.95
7_I18_A1.0780.95
50_A54_A1.0400.94
19_S30_L1.0130.93
8_E40_L1.0100.93
5_G56_T1.0080.92
15_L33_V1.0040.92
37_G77_R0.9960.92
29_K46_R0.9850.92
21_A62_A0.9450.90
19_S39_G0.9370.89
17_E21_A0.9230.89
4_L86_F0.9220.89
6_M44_M0.9060.88
28_V45_V0.8960.87
15_L41_C0.8950.87
12_L15_L0.8930.87
37_G71_S0.8720.86
56_T60_A0.8710.86
3_A76_P0.8680.85
60_A69_L0.8660.85
6_M73_H0.8500.84
12_L44_M0.8480.84
10_R40_L0.8470.84
54_A58_A0.8370.83
3_A28_V0.8360.83
22_M37_G0.8240.82
58_A62_A0.8160.82
6_M75_I0.7980.80
30_L45_V0.7950.80
21_A58_A0.7870.79
52_C76_P0.7550.77
78_P82_L0.7530.76
10_R86_F0.7500.76
52_C81_D0.7480.76
42_T77_R0.7440.75
4_L78_P0.7430.75
57_D62_A0.7430.75
25_A58_A0.7320.74
75_I79_H0.7260.74
37_G41_C0.7160.73
6_M36_I0.7150.73
31_V46_R0.7120.72
3_A49_V0.6990.71
73_H82_L0.6950.70
18_A58_A0.6860.69
81_D84_E0.6780.69
26_A54_A0.6760.68
3_A31_V0.6720.68
64_Q80_G0.6710.68
3_A77_R0.6490.65
26_A58_A0.6460.65
2_E29_K0.6460.65
39_G70_V0.6450.65
18_A62_A0.6400.64
41_C82_L0.6350.63
35_Q41_C0.6290.63
6_M56_T0.6240.62
53_K78_P0.6230.62
6_M86_F0.6100.60
46_R87_P0.6100.60
37_G40_L0.6090.60
11_G17_E0.6040.60
18_A63_A0.5940.58
3_A60_A0.5870.57
18_A49_V0.5850.57
60_A64_Q0.5800.57
11_G59_G0.5780.56
38_G73_H0.5780.56
11_G68_E0.5740.56
15_L50_A0.5710.55
12_L37_G0.5690.55
34_K44_M0.5640.54
51_A58_A0.5580.54
27_R48_D0.5580.54
81_D85_V0.5550.53
29_K80_G0.5510.53
14_A17_E0.5500.53
48_D58_A0.5440.52
25_A30_L0.5440.52
14_A62_A0.5300.50
71_S85_V0.5300.50
32_G82_L0.5290.50
23_V28_V0.5260.50
53_K60_A0.5240.49
58_A69_L0.5240.49
13_V51_A0.5220.49
9_T33_V0.5100.47
51_A54_A0.5070.47
71_S76_P0.5060.47
33_V38_G0.5020.46
50_A67_G0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mpyA 5 0.9897 100 0.115 Contact Map
4qifA 5 0.9381 100 0.158 Contact Map
4ox7A 3 1 100 0.159 Contact Map
4ox6A 3 1 99.9 0.165 Contact Map
2a10A 3 1 99.9 0.181 Contact Map
3gv2A 3 0 99.9 0.181 Contact Map
3ssrB 4 1 99.9 0.182 Contact Map
2a1bA 3 1 99.9 0.182 Contact Map
3ssqA 6 1 99.9 0.183 Contact Map
3bn4A 3 0.9278 99.9 0.186 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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