GREMLIN Database
CYNT - Carbonic anhydrase 1
UniProt: P0ABE9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10176
Length: 219 (188)
Sequences: 4065 (2473)
Seq/√Len: 180.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_V179_G4.7241.00
161_Q170_L4.1041.00
33_R91_S4.0801.00
157_L179_G3.1131.00
64_G103_A2.9811.00
167_R171_E2.7011.00
157_L177_L2.6411.00
2_K6_D2.6161.00
35_L81_V2.4381.00
92_D178_H2.3721.00
105_T109_S2.2541.00
82_E86_A2.2481.00
168_L172_E2.1961.00
99_S181_V2.1931.00
150_R190_A2.1781.00
105_T145_A2.1691.00
149_V181_V2.1571.00
63_A80_S2.1191.00
30_Q42_S2.0471.00
5_I191_A2.0111.00
40_S58_F1.8951.00
180_W189_I1.8861.00
6_D10_K1.8721.00
10_K51_Q1.8441.00
169_A174_R1.8211.00
85_V169_A1.8131.00
78_S163_H1.7911.00
84_A90_V1.7741.00
85_V166_V1.7611.00
183_D190_A1.7541.00
50_T57_L1.7091.00
9_L13_R1.7011.00
83_Y87_A1.6831.00
89_R169_A1.6611.00
9_L188_S1.6461.00
22_L25_Q1.5851.00
150_R181_V1.5741.00
35_L80_S1.5531.00
35_L90_V1.5491.00
136_R139_S1.5371.00
30_Q102_G1.5301.00
183_D186_S1.5021.00
81_V160_L1.4801.00
161_Q177_L1.4791.00
66_I126_A1.4741.00
100_N185_E1.4651.00
6_D9_L1.4611.00
108_A148_M1.4381.00
60_I80_S1.4281.00
153_V157_L1.3931.00
7_G51_Q1.3901.00
133_N151_E1.3621.00
151_E154_I1.3381.00
107_I126_A1.3321.00
19_R22_L1.3171.00
129_A155_A1.3141.00
92_D176_A1.3111.00
62_N65_N1.3031.00
65_N152_N1.2851.00
89_R174_R1.2771.00
10_K14_E1.2741.00
140_D143_S1.2451.00
35_L93_I1.2281.00
159_N162_T1.2181.00
169_A175_I1.2161.00
68_P76_G1.2071.00
99_S183_D1.2041.00
166_V175_I1.1881.00
104_M126_A1.1771.00
8_F12_Q1.1601.00
124_R127_D1.1561.00
146_A150_R1.1491.00
67_V77_V1.1331.00
85_V90_V1.1271.00
127_D130_R1.1101.00
96_C180_W1.0951.00
19_R25_Q1.0931.00
91_S174_R1.0921.00
94_V180_W1.0881.00
180_W191_A1.0881.00
83_Y102_G1.0851.00
100_N105_T1.0841.00
36_F96_C1.0701.00
87_A116_M1.0571.00
132_V151_E1.0441.00
86_A168_L1.0391.00
21_A24_K1.0361.00
37_I81_V1.0331.00
142_P146_A1.0291.00
108_A145_A1.0220.99
154_I192_F0.9880.99
50_T180_W0.9780.99
40_S88_L0.9730.99
38_S44_L0.9700.99
38_S96_C0.9610.99
63_A103_A0.9590.99
109_S141_L0.9570.99
40_S60_I0.9410.99
191_A194_G0.9350.99
77_V81_V0.9340.99
52_R57_L0.9320.99
186_S190_A0.9310.99
125_Y128_S0.9270.99
27_A100_N0.9210.99
21_A25_Q0.9210.99
31_S89_R0.9080.99
138_H141_L0.9040.99
155_A158_A0.8980.99
110_C127_D0.8950.99
7_G10_K0.8940.99
36_F50_T0.8890.99
47_E52_R0.8890.99
104_M148_M0.8790.98
116_M119_V0.8760.98
7_G11_F0.8740.98
42_S102_G0.8710.98
116_M120_S0.8530.98
141_L144_K0.8510.98
145_A149_V0.8480.98
45_V49_V0.8450.98
47_E57_L0.8440.98
104_M149_V0.8420.98
14_E51_Q0.8390.98
5_I189_I0.8390.98
67_V156_Q0.8390.98
141_L145_A0.8380.98
4_I50_T0.8370.98
85_V93_I0.8220.98
3_E7_G0.8200.98
152_N156_Q0.8170.97
151_E155_A0.8170.97
68_P77_V0.8130.97
97_G153_V0.8100.97
65_N156_Q0.8090.97
29_Q100_N0.8040.97
12_Q188_S0.7980.97
30_Q58_F0.7850.97
126_A129_A0.7830.97
102_G119_V0.7820.97
147_A151_E0.7780.97
154_I179_G0.7770.97
143_S147_A0.7770.97
69_S118_A0.7760.97
60_I77_V0.7730.96
86_A165_S0.7730.96
34_T91_S0.7730.96
24_K27_A0.7700.96
67_V78_S0.7660.96
132_V155_A0.7640.96
144_K148_M0.7580.96
78_S118_A0.7550.96
136_R140_D0.7540.96
86_A169_A0.7510.96
153_V181_V0.7510.96
19_R53_E0.7500.96
87_A119_V0.7420.96
20_E23_F0.7410.96
52_R56_D0.7380.95
14_E18_K0.7280.95
58_F102_G0.7230.95
50_T96_C0.7230.95
142_P147_A0.7230.95
16_F21_A0.7150.95
160_L166_V0.7140.95
108_A144_K0.7120.94
69_S125_Y0.7100.94
45_V59_V0.7090.94
19_R23_F0.7080.94
76_G79_A0.7070.94
158_A161_Q0.7060.94
143_S146_A0.7020.94
75_G79_A0.7010.94
15_A48_L0.6980.94
160_L177_L0.6970.94
127_D131_V0.6960.94
102_G106_A0.6870.93
146_A149_V0.6840.93
34_T92_D0.6840.93
46_P59_V0.6800.93
134_E144_K0.6790.93
12_Q16_F0.6770.93
147_A150_R0.6770.93
83_Y88_L0.6740.93
146_A183_D0.6700.92
131_V134_E0.6660.92
146_A181_V0.6660.92
23_F54_P0.6660.92
69_S121_H0.6650.92
25_Q53_E0.6640.92
117_P120_S0.6610.92
4_I36_F0.6590.92
130_R148_M0.6580.92
47_E59_V0.6570.92
46_P54_P0.6560.92
65_N97_G0.6520.91
125_Y129_A0.6510.91
125_Y159_N0.6510.91
62_N76_G0.6510.91
132_V158_A0.6500.91
105_T108_A0.6470.91
25_Q29_Q0.6470.91
104_M107_I0.6460.91
94_V178_H0.6450.91
3_E33_R0.6410.91
76_G122_W0.6370.90
181_V190_A0.6360.90
37_I67_V0.6330.90
38_S81_V0.6330.90
15_A53_E0.6260.90
99_S184_I0.6250.90
177_L194_G0.6240.90
126_A130_R0.6160.89
82_E118_A0.6160.89
24_K28_T0.6150.89
118_A121_H0.6140.89
100_N142_P0.6090.88
133_N147_A0.6090.88
58_F84_A0.6080.88
34_T94_V0.6020.88
34_T82_E0.6020.88
121_H125_Y0.6010.88
94_V191_A0.5990.88
15_A18_K0.5970.87
40_S83_Y0.5940.87
83_Y105_T0.5920.87
62_N122_W0.5910.87
146_A185_E0.5910.87
170_L176_A0.5890.87
169_A172_E0.5860.86
157_L161_Q0.5840.86
164_P168_L0.5820.86
82_E187_G0.5780.86
22_L53_E0.5780.86
166_V169_A0.5780.86
16_F23_F0.5750.85
121_H124_R0.5750.85
46_P57_L0.5730.85
76_G90_V0.5720.85
78_S160_L0.5680.85
27_A184_I0.5650.84
48_L54_P0.5640.84
138_H144_K0.5630.84
129_A151_E0.5630.84
33_R52_R0.5590.84
118_A163_H0.5550.83
5_I94_V0.5550.83
119_V164_P0.5510.83
180_W192_F0.5500.83
106_A119_V0.5470.83
107_I130_R0.5460.82
164_P167_R0.5440.82
112_C168_L0.5440.82
3_E52_R0.5430.82
39_C101_C0.5430.82
165_S168_L0.5410.82
93_I166_V0.5400.82
62_N77_V0.5380.81
38_S46_P0.5380.81
178_H191_A0.5360.81
59_V62_N0.5360.81
83_Y119_V0.5330.81
108_A130_R0.5330.81
85_V175_I0.5320.81
35_L84_A0.5300.81
107_I127_D0.5290.80
36_F46_P0.5260.80
121_H164_P0.5260.80
131_V155_A0.5250.80
104_M152_N0.5250.80
36_F57_L0.5240.80
7_G194_G0.5220.80
63_A79_A0.5170.79
118_A164_P0.5160.79
8_F189_I0.5150.79
96_C182_Y0.5120.78
37_I46_P0.5090.78
16_F20_E0.5090.78
98_H101_C0.5070.78
67_V159_N0.5050.77
38_S45_V0.5050.77
39_C98_H0.5020.77
136_R144_K0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ddzA 2 0.9726 100 0.169 Contact Map
3qy1A 4 0.9543 100 0.17 Contact Map
4rxyA 4 0.9361 100 0.171 Contact Map
3e3iA 6 0.9361 100 0.175 Contact Map
2w3qA 2 0.8584 100 0.176 Contact Map
4o1kA 4 0.9269 100 0.183 Contact Map
1ekjA 5 0.9315 100 0.187 Contact Map
4o1jA 4 0.8767 100 0.187 Contact Map
3eyxA 2 0.8676 100 0.201 Contact Map
3ucjA 4 0.968 100 0.202 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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