GREMLIN Database
C561 - Cytochrome b561
UniProt: P0ABE5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10172
Length: 176 (170)
Sequences: 2657 (1966)
Seq/√Len: 150.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_A162_W5.4341.00
156_L160_Y3.3921.00
102_L106_Y3.1231.00
16_V56_M2.9141.00
20_V94_F2.7171.00
9_Q62_L2.6291.00
47_S115_F2.5991.00
6_S66_Y2.4211.00
76_K79_M2.3971.00
159_H168_L2.2971.00
10_I172_P2.2951.00
8_L62_L2.2091.00
16_V94_F2.2041.00
81_G84_H2.1911.00
159_H166_T2.1441.00
86_G150_L2.1401.00
6_S62_L2.0911.00
88_L92_L2.0651.00
16_V55_L2.0271.00
27_M30_R1.9111.00
11_S15_L1.7891.00
6_S9_Q1.7801.00
51_S114_A1.7211.00
56_M94_F1.7201.00
159_H167_L1.6931.00
135_S138_E1.6621.00
85_L88_L1.6441.00
103_V133_L1.6411.00
77_P81_G1.6171.00
56_M95_I1.5971.00
9_Q66_Y1.5931.00
96_A140_L1.5881.00
23_A52_I1.5641.00
149_G153_A1.5491.00
148_I152_A1.5461.00
12_I58_V1.5431.00
46_V105_M1.5381.00
159_H165_N1.4751.00
4_K10_I1.4361.00
53_L98_P1.4331.00
81_G85_L1.4331.00
142_N146_F1.4071.00
106_Y122_A1.3981.00
165_N168_L1.3961.00
136_W140_L1.3921.00
146_F150_L1.3681.00
21_I25_C1.3191.00
79_M157_A1.3141.00
62_L66_Y1.3111.00
97_L141_A1.3091.00
129_R132_S1.3031.00
86_G154_A1.2831.00
77_P80_T1.2711.00
102_L107_N1.2331.00
35_R38_R1.2241.00
29_F33_F1.2151.00
30_R42_N1.2121.00
97_L140_L1.1951.00
44_I48_C1.1921.00
24_Y148_I1.1911.00
80_T84_H1.1781.00
107_N123_S1.1751.00
104_M134_K1.1691.00
44_I47_S1.1591.00
89_V147_V1.1591.00
114_A117_L1.1431.00
42_N46_V1.1421.00
166_T169_R1.1391.00
50_I114_A1.1291.00
97_L100_I1.1220.99
100_I141_A1.1200.99
85_L89_V1.1150.99
100_I133_L1.1120.99
107_N130_V1.1050.99
150_L154_A1.0970.99
53_L57_V1.0940.99
100_I136_W1.0930.99
8_L11_S1.0810.99
91_Y94_F1.0770.99
150_L153_A1.0760.99
4_K172_P1.0670.99
7_R10_I1.0550.99
113_F118_T1.0490.99
102_L122_A1.0450.99
72_I75_P1.0130.99
138_E142_N1.0070.99
94_F98_P1.0030.99
155_A159_H1.0010.99
63_R68_T1.0000.99
72_I166_T0.9980.99
27_M141_A0.9930.99
78_M81_G0.9920.99
139_T143_L0.9870.99
144_G148_I0.9810.99
152_A155_A0.9720.99
12_I62_L0.9690.98
25_C29_F0.9670.98
53_L102_L0.9600.98
39_P42_N0.9580.98
40_L44_I0.9470.98
92_L96_A0.9450.98
57_V61_L0.9430.98
60_L95_I0.9350.98
106_Y121_Y0.9340.98
71_I84_H0.9290.98
7_R11_S0.9240.98
60_L88_L0.9180.98
139_T142_N0.9150.98
131_D135_S0.8980.98
39_P43_M0.8910.97
72_I165_N0.8900.97
126_N129_R0.8870.97
161_F164_D0.8820.97
56_M98_P0.8810.97
109_G121_Y0.8790.97
99_V103_V0.8760.97
90_I148_I0.8650.97
20_V144_G0.8580.97
71_I75_P0.8570.97
52_I56_M0.8520.97
128_E132_S0.8440.96
19_L52_I0.8430.96
146_F149_G0.8430.96
17_F21_I0.8390.96
27_M145_Y0.8390.96
140_L143_L0.8280.96
20_V56_M0.8230.96
26_A41_I0.8210.96
105_M112_W0.8180.96
112_W119_M0.8170.96
9_Q68_T0.8090.95
50_I54_V0.7930.95
102_L120_P0.7900.95
22_A48_C0.7880.95
74_K80_T0.7850.95
61_L65_K0.7840.95
54_V61_L0.7830.95
10_I171_M0.7830.95
95_I99_V0.7770.94
167_L170_M0.7740.94
33_F41_I0.7730.94
107_N133_L0.7680.94
45_H49_G0.7660.94
123_S126_N0.7450.93
84_H88_L0.7430.93
99_V102_L0.7420.93
108_R130_V0.7390.93
33_F36_S0.7370.93
136_W139_T0.7340.92
19_L48_C0.7340.92
43_M116_G0.7230.92
71_I74_K0.7190.92
23_A48_C0.7150.91
156_L164_D0.7080.91
153_A157_A0.6980.90
9_Q12_I0.6950.90
7_R172_P0.6950.90
113_F116_G0.6910.90
5_Y9_Q0.6880.90
81_G163_K0.6880.90
39_P110_N0.6850.90
78_M82_L0.6730.89
97_L144_G0.6690.88
131_D134_K0.6680.88
118_T121_Y0.6670.88
42_N134_K0.6620.88
127_F131_D0.6610.88
53_L56_M0.6570.88
83_A86_G0.6540.87
100_I103_V0.6520.87
24_Y28_E0.6520.87
75_P79_M0.6480.87
22_A26_A0.6450.87
43_M105_M0.6430.86
38_R42_N0.6400.86
103_V124_E0.6380.86
51_S115_F0.6340.86
34_P38_R0.6310.85
57_V95_I0.6290.85
28_E145_Y0.6290.85
59_R91_Y0.6280.85
143_L147_V0.6270.85
145_Y149_G0.6240.85
43_M47_S0.6240.85
103_V123_S0.6210.85
160_Y163_K0.6150.84
93_L144_G0.6100.83
50_I112_W0.6090.83
93_L143_L0.6070.83
82_L154_A0.6050.83
145_Y148_I0.6040.83
26_A48_C0.6010.83
82_L85_L0.5910.82
31_G142_N0.5900.81
54_V58_V0.5880.81
103_V107_N0.5880.81
16_V91_Y0.5860.81
8_L58_V0.5850.81
28_E32_F0.5850.81
89_V93_L0.5830.81
100_I104_M0.5810.80
105_M109_G0.5810.80
17_F24_Y0.5770.80
73_P76_K0.5750.80
142_N149_G0.5720.79
27_M42_N0.5720.79
29_F41_I0.5720.79
75_P166_T0.5710.79
61_L64_L0.5710.79
29_F32_F0.5680.79
108_R134_K0.5680.79
68_T84_H0.5640.78
8_L66_Y0.5590.78
39_P108_R0.5580.78
74_K162_W0.5560.77
163_K168_L0.5520.77
72_I169_R0.5510.77
155_A170_M0.5460.76
129_R133_L0.5450.76
160_Y164_D0.5430.76
100_I140_L0.5430.76
93_L147_V0.5410.76
111_P118_T0.5390.75
113_F121_Y0.5380.75
43_M46_V0.5370.75
166_T171_M0.5360.75
168_L171_M0.5350.75
167_L171_M0.5330.74
114_A119_M0.5310.74
9_Q170_M0.5310.74
104_M108_R0.5310.74
157_A161_F0.5290.74
50_I119_M0.5280.74
16_V23_A0.5280.74
26_A32_F0.5270.74
148_I153_A0.5240.73
45_H137_H0.5230.73
126_N130_V0.5210.73
6_S68_T0.5200.73
24_Y30_R0.5190.73
86_G147_V0.5180.72
47_S113_F0.5140.72
82_L86_G0.5120.72
130_V134_K0.5110.71
42_N104_M0.5080.71
96_A143_L0.5080.71
19_L23_A0.5080.71
104_M130_V0.5070.71
79_M83_A0.5060.71
94_F103_V0.5040.70
90_I94_F0.5030.70
142_N145_Y0.5030.70
103_V141_A0.5030.70
93_L140_L0.5010.70
59_R90_I0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gd3A 2 0.8409 100 0.472 Contact Map
1kqfC 3 0.8977 99.9 0.49 Contact Map
4o6yA 2 0.8011 52.5 0.926 Contact Map
1q16C 2 0.8977 44.8 0.929 Contact Map
3cx5C 2 0.6875 35.6 0.933 Contact Map
2qjyA 2 0.7386 23 0.939 Contact Map
1pp9C 2 0.6193 17.8 0.942 Contact Map
4ogqA 2 0.7045 7.5 0.951 Contact Map
4i0uA 4 0.375 6.1 0.953 Contact Map
4ev6A 3 0.3864 5.8 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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