GREMLIN Database
BOLA - Protein BolA
UniProt: P0ABE2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10125
Length: 105 (85)
Sequences: 1431 (984)
Seq/√Len: 106.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_E59_M2.8421.00
10_K67_E2.6161.00
4_R8_E2.5461.00
4_R24_D2.4691.00
25_E40_K2.3441.00
8_E12_R2.3071.00
68_L72_V2.2631.00
7_I64_L2.1281.00
9_E13_A2.0441.00
49_T83_K2.0371.00
56_R84_E1.9551.00
65_A69_S1.8811.00
43_L79_T1.8511.00
22_V41_V1.8361.00
58_R61_Y1.8111.00
23_V40_K1.7531.00
51_E55_N1.5961.00
15_F59_M1.5241.00
15_F63_T1.5181.00
6_R10_K1.4621.00
31_V35_S1.4151.00
54_L58_R1.4111.00
24_D35_S1.3841.00
61_Y68_L1.3801.00
15_F43_L1.3441.00
14_A63_T1.2990.99
6_R67_E1.2990.99
3_I72_V1.2730.99
21_E42_V1.2440.99
47_R51_E1.2320.99
46_D82_I1.2200.99
54_L61_Y1.2100.99
25_E28_R1.2050.99
17_P47_R1.1680.99
34_G37_S1.1580.98
46_D49_T1.1490.98
19_F42_V1.1290.98
10_K66_E1.1060.98
32_P35_S1.0690.97
25_E76_A1.0650.97
59_M63_T1.0570.97
55_N58_R1.0530.97
42_V78_H1.0450.97
52_R55_N1.0380.97
11_L41_V1.0320.97
5_E8_E1.0160.97
3_I71_T1.0100.96
53_F61_Y0.9950.96
27_Y30_N0.9930.96
7_I22_V0.9820.96
28_R40_K0.9610.95
40_K76_A0.9510.95
19_F85_W0.9430.95
53_F57_H0.9210.94
36_E39_F0.9140.94
24_D36_E0.9050.94
5_E9_E0.8910.93
40_K78_H0.8900.93
17_P20_L0.8780.92
18_V46_D0.8750.92
6_R71_T0.8720.92
18_V86_E0.8580.92
37_S72_V0.8550.91
3_I6_R0.8480.91
30_N33_A0.8340.90
24_D37_S0.8130.89
18_V82_I0.7920.88
57_H61_Y0.7840.87
42_V85_W0.7790.87
54_L76_A0.7750.87
41_V75_L0.7700.87
6_R9_E0.7600.86
66_E69_S0.7540.85
42_V80_Y0.7340.84
37_S71_T0.7160.82
52_R84_E0.7160.82
56_R79_T0.7090.82
47_R59_M0.7000.81
57_H77_L0.6990.81
53_F81_T0.6940.80
31_V34_G0.6930.80
65_A68_L0.6900.80
80_Y85_W0.6870.80
64_L67_E0.6830.79
16_Q46_D0.6820.79
20_L41_V0.6760.79
66_E70_T0.6570.77
67_E71_T0.6530.76
14_A47_R0.6520.76
62_S65_A0.6370.74
80_Y84_E0.6230.73
3_I24_D0.6230.73
55_N61_Y0.6220.73
24_D33_A0.6210.72
11_L60_I0.6150.72
24_D32_P0.6110.71
83_K86_E0.6070.71
10_K68_L0.5960.69
59_M62_S0.5960.69
16_Q47_R0.5890.68
41_V77_L0.5870.68
49_T82_I0.5790.67
49_T81_T0.5750.67
83_K87_G0.5720.66
11_L15_F0.5590.64
43_L77_L0.5560.64
12_R16_Q0.5490.63
46_D60_I0.5460.63
11_L43_L0.5440.62
17_P46_D0.5350.61
6_R72_V0.5330.61
41_V58_R0.5310.61
10_K64_L0.5260.60
57_H78_H0.5240.60
57_H80_Y0.5210.59
11_L20_L0.5140.58
36_E67_E0.5120.58
28_R33_A0.5120.58
39_F68_L0.5110.58
23_V42_V0.5100.58
30_N35_S0.5090.57
44_V56_R0.5070.57
61_Y77_L0.5060.57
48_F56_R0.5040.57
4_R12_R0.5030.56
8_E21_E0.5020.56
30_N34_G0.5010.56
18_V44_V0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2dhmA 1 0.9524 100 0.171 Contact Map
1v60A 1 0.9429 100 0.192 Contact Map
2ma0A 1 0.8095 100 0.274 Contact Map
4pugA 1 0.819 100 0.276 Contact Map
4puiA 1 0.8 100 0.29 Contact Map
3o2eA 2 0.7905 100 0.346 Contact Map
2kdnA 1 0.819 100 0.35 Contact Map
1v9jA 1 0.8095 100 0.358 Contact Map
2mm9A 1 0.8762 100 0.372 Contact Map
3tr3A 2 0.7524 99.9 0.394 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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