GREMLIN Database
BCCP - Biotin carboxyl carrier protein of acetyl-CoA carboxylase
UniProt: P0ABD8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10275
Length: 156 (147)
Sequences: 3214 (2478)
Seq/√Len: 204.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_S29_S4.2721.00
111_V132_S3.2591.00
84_R149_D3.2271.00
104_E107_Q3.1931.00
108_K134_T3.0041.00
22_E31_R2.8241.00
93_R104_E2.7831.00
137_A154_V2.7431.00
20_E33_S2.7201.00
141_E144_Q2.6571.00
117_I124_M2.5921.00
110_N132_S2.5711.00
96_S99_A2.5561.00
81_H131_K2.4291.00
82_I154_V2.3501.00
110_N113_D2.2471.00
100_K104_E2.1981.00
82_I151_P2.1691.00
19_S35_A2.1591.00
81_H130_D2.0801.00
2_D5_K2.0361.00
94_T142_S2.0231.00
105_V137_A1.9231.00
13_V21_L1.8791.00
147_E150_E1.8461.00
14_E17_G1.8261.00
13_V32_I1.7671.00
139_L151_P1.7591.00
80_G154_V1.6761.00
103_I153_V1.6371.00
138_I153_V1.6331.00
22_E29_S1.5801.00
135_V153_V1.5791.00
107_Q113_D1.5611.00
85_S118_V1.5531.00
4_R8_K1.4991.00
133_G155_I1.4941.00
88_V148_F1.4781.00
18_I32_I1.4121.00
139_L154_V1.3921.00
83_V155_I1.3801.00
136_K154_V1.3771.00
94_T101_A1.3591.00
83_V115_L1.3421.00
91_F116_C1.3301.00
115_L153_V1.3121.00
93_R142_S1.3071.00
7_K12_L1.2541.00
20_E31_R1.2531.00
95_P102_F1.2191.00
93_R141_E1.2181.00
77_E80_G1.2041.00
14_E34_R1.1941.00
19_S36_A1.1761.00
105_V138_I1.1351.00
8_K11_E1.1341.00
116_C153_V1.1311.00
42_P45_Q1.1121.00
129_A133_G1.1081.00
13_V16_S1.1051.00
123_M149_D1.0981.00
103_I113_D1.0801.00
123_M128_E1.0661.00
25_E28_E1.0491.00
140_V150_E1.0231.00
11_E15_E1.0061.00
10_I18_I0.9941.00
11_E14_E0.9841.00
10_I32_I0.9761.00
80_G136_K0.9681.00
43_V46_Q0.9681.00
7_K11_E0.9500.99
12_L30_V0.9250.99
4_R7_K0.9140.99
95_P99_A0.9090.99
10_I16_S0.8880.99
7_K15_E0.8780.99
61_A66_T0.8780.99
103_I135_V0.8740.99
94_T98_D0.8610.99
144_Q150_E0.8500.99
85_S125_N0.8470.99
10_I13_V0.8420.99
108_K132_S0.8390.99
3_I8_K0.8340.99
112_G130_D0.8310.99
103_I138_I0.8300.98
117_I125_N0.8220.98
19_S33_S0.8180.98
97_P102_F0.8150.98
102_F114_T0.8110.98
114_T126_Q0.8020.98
24_S27_E0.7960.98
124_M142_S0.7880.98
120_A125_N0.7820.98
69_S72_A0.7820.98
16_S32_I0.7750.98
6_I21_L0.7680.98
102_F117_I0.7670.97
123_M126_Q0.7650.97
81_H155_I0.7590.97
13_V34_R0.7590.97
5_K8_K0.7540.97
17_G34_R0.7500.97
57_A60_N0.7500.97
79_S154_V0.7470.97
120_A126_Q0.7440.97
43_V75_A0.7360.97
111_V131_K0.7280.97
35_A39_A0.7260.97
116_C152_L0.7170.96
92_Y97_P0.7130.96
57_A62_A0.7120.96
44_M47_A0.7090.96
111_V129_A0.7070.96
92_Y124_M0.7050.96
135_V155_I0.6990.96
56_P59_S0.6980.96
74_A77_E0.6980.96
3_I6_I0.6950.96
90_T117_I0.6940.95
3_I11_E0.6930.95
114_T128_E0.6910.95
62_A65_A0.6900.95
36_A39_A0.6900.95
131_K155_I0.6900.95
119_E122_K0.6860.95
64_P67_V0.6810.95
116_C126_Q0.6790.95
13_V123_M0.6740.95
112_G115_L0.6670.94
9_L16_S0.6660.94
85_S88_V0.6650.94
121_M125_N0.6590.94
69_S73_P0.6590.94
40_S44_M0.6540.94
87_M120_A0.6450.93
19_S37_P0.6420.93
65_A68_P0.6420.93
116_C123_M0.6380.93
6_I126_Q0.6370.93
78_I82_I0.6290.93
60_N64_P0.6290.93
6_I123_M0.6290.93
23_I28_E0.6220.92
9_L25_E0.6210.92
139_L150_E0.6170.92
44_M48_Y0.6160.92
109_V155_I0.6160.92
102_F139_L0.6100.91
68_P71_E0.6080.91
48_Y56_P0.6040.91
24_S28_E0.6020.91
31_R34_R0.6020.91
34_R126_Q0.5980.91
12_L28_E0.5950.90
68_P73_P0.5920.90
70_M74_A0.5890.90
16_S21_L0.5870.90
91_F103_I0.5850.90
60_N63_A0.5840.89
59_S65_A0.5830.89
118_V148_F0.5810.89
8_K14_E0.5780.89
12_L21_L0.5680.88
9_L32_I0.5660.88
41_F46_Q0.5660.88
58_Q62_A0.5660.88
75_A78_I0.5650.88
91_F130_D0.5630.88
36_A40_S0.5620.88
87_M123_M0.5610.88
68_P72_A0.5600.87
43_V47_A0.5600.87
67_V70_M0.5590.87
91_F123_M0.5580.87
101_A104_E0.5580.87
101_A143_G0.5550.87
93_R101_A0.5550.87
37_P41_F0.5510.87
129_A135_V0.5500.87
97_P122_K0.5470.86
33_S37_P0.5460.86
129_A132_S0.5450.86
85_S91_F0.5450.86
66_T72_A0.5400.86
87_M125_N0.5380.85
88_V147_E0.5360.85
75_A137_A0.5340.85
88_V120_A0.5340.85
41_F44_M0.5310.85
83_V130_D0.5310.85
91_F140_V0.5300.84
23_I87_M0.5260.84
84_R151_P0.5260.84
94_T117_I0.5260.84
87_M90_T0.5250.84
63_A69_S0.5250.84
16_S25_E0.5240.84
48_Y62_A0.5240.84
79_S82_I0.5200.83
13_V18_I0.5200.83
94_T124_M0.5190.83
69_S74_A0.5190.83
38_A42_P0.5180.83
117_I127_I0.5160.83
111_V130_D0.5150.83
57_A68_P0.5150.83
87_M121_M0.5120.82
73_P76_A0.5110.82
116_C130_D0.5100.82
65_A69_S0.5100.82
4_R15_E0.5080.82
115_L138_I0.5060.82
66_T74_A0.5060.82
131_K134_T0.5060.82
40_S63_A0.5040.81
87_M145_P0.5040.81
15_E19_S0.5040.81
21_L32_I0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hr7B 1 0.5128 100 0.28 Contact Map
3va7A 1 0.8974 99.9 0.554 Contact Map
2qf7A 4 0.75 99.8 0.589 Contact Map
3hblA 4 0.7885 99.8 0.594 Contact Map
4qshA 4 0.7628 99.8 0.594 Contact Map
3bg3A 4 0.7564 99.8 0.598 Contact Map
4rcnA 6 0.8462 99.7 0.62 Contact Map
3n6rA 1 0.9423 99.7 0.627 Contact Map
5a35A 1 0.5256 99.7 0.632 Contact Map
3u9tA 3 0.3846 99.7 0.638 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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