GREMLIN Database
ACCA - Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
UniProt: P0ABD5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11647
Length: 319 (252)
Sequences: 4604 (2161)
Seq/√Len: 136.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_F106_A4.6051.00
103_G146_L4.1571.00
197_C214_G3.6781.00
243_K246_L3.3381.00
109_D287_K2.6991.00
114_M146_L2.6311.00
179_E183_R2.6141.00
234_A240_S2.5671.00
114_M155_M2.5401.00
144_L184_N2.4931.00
161_I197_C2.4521.00
151_E192_G2.4281.00
218_N289_Q2.3961.00
147_M188_M2.3821.00
161_I212_G2.3591.00
148_Q187_E2.3211.00
278_N281_A2.2971.00
218_N266_S2.2631.00
81_L283_A2.2051.00
63_I222_Y2.1991.00
72_R201_G2.1451.00
75_T117_G2.1381.00
83_F115_I2.1201.00
266_S292_A2.1141.00
113_V158_I2.0981.00
228_I232_G2.0781.00
108_L291_L2.0421.00
81_L280_E2.0371.00
220_L282_M2.0301.00
252_G257_R2.0161.00
76_L102_V1.9631.00
158_I198_T1.9461.00
76_L119_Q1.8951.00
88_E104_G1.8411.00
221_Q269_P1.8281.00
87_D107_R1.8151.00
109_D291_L1.7941.00
107_R112_P1.7641.00
83_F108_L1.7311.00
151_E188_M1.7151.00
266_S293_D1.7081.00
160_F198_T1.6931.00
103_G114_M1.6561.00
149_M153_F1.6411.00
75_T118_H1.5921.00
100_A139_G1.5551.00
228_I233_C1.5261.00
82_A108_L1.5021.00
136_A171_G1.4971.00
63_I256_P1.4861.00
116_I159_T1.4821.00
148_Q184_N1.4821.00
82_A287_K1.4751.00
233_C251_M1.4681.00
218_N293_D1.4631.00
216_K293_D1.4551.00
154_K193_V1.4411.00
108_L287_K1.4341.00
204_G224_T1.4281.00
230_P251_M1.4151.00
95_Y175_R1.4131.00
144_L187_E1.4071.00
95_Y138_E1.3991.00
120_K132_F1.3961.00
114_M149_M1.3921.00
79_V115_I1.3811.00
75_T79_V1.3771.00
264_I267_I1.3701.00
149_M155_M1.3691.00
74_Y119_Q1.3561.00
105_I155_M1.3551.00
106_A115_I1.3401.00
266_S289_Q1.3371.00
219_M223_S1.3371.00
105_I114_M1.3321.00
109_D280_E1.3151.00
134_M164_P1.2861.00
105_I153_F1.2841.00
92_D103_G1.2791.00
92_D145_R1.2701.00
151_E191_L1.2611.00
212_G217_V1.2481.00
171_G174_E1.2371.00
38_E42_R1.2191.00
90_A97_D1.2121.00
112_P155_M1.2061.00
49_E53_K1.2021.00
196_V293_D1.2021.00
75_T102_V1.1901.00
218_N268_I1.1810.99
242_D245_P1.1810.99
101_I116_I1.1690.99
90_A102_V1.1650.99
195_V214_G1.1500.99
287_K291_L1.1420.99
147_M191_L1.1320.99
89_L105_I1.1320.99
217_V264_I1.1250.99
219_M264_I1.1250.99
96_A99_K1.1220.99
64_A253_I1.1030.99
158_I290_L1.1000.99
259_K264_I1.0880.99
281_A285_S1.0870.99
157_I193_V1.0800.99
151_E193_V1.0750.99
84_D107_R1.0680.99
90_A93_R1.0670.99
45_E56_A1.0440.99
84_D110_G1.0430.99
241_A244_A1.0430.99
214_G217_V1.0410.99
75_T119_Q1.0400.99
108_L290_L1.0380.99
62_Q65_Q1.0360.99
251_M254_I1.0350.99
108_L113_V1.0330.99
108_L158_I1.0240.99
183_R187_E1.0230.99
167_Y171_G1.0220.98
254_I257_R1.0220.98
283_A286_L1.0210.98
68_R269_P1.0170.98
188_M193_V1.0160.98
149_M152_R1.0030.98
77_D122_R1.0010.98
257_R261_L0.9980.98
186_R190_R0.9890.98
172_A177_Q0.9880.98
233_C250_A0.9880.98
288_A292_A0.9840.98
48_V52_R0.9820.98
101_I135_P0.9810.98
171_G175_R0.9710.98
39_E42_R0.9700.98
199_V212_G0.9660.98
196_V290_L0.9620.98
61_W65_Q0.9570.98
259_K266_S0.9560.98
235_S241_A0.9560.98
61_W64_A0.9420.97
188_M195_V0.9390.97
135_P210_A0.9390.97
204_G210_A0.9390.97
249_E262_K0.9370.97
64_A67_A0.9350.97
49_E52_R0.9340.97
137_P173_E0.9320.97
282_M286_L0.9260.97
118_H211_I0.9240.97
74_Y77_D0.9240.97
238_W247_A0.9230.97
216_K266_S0.9190.97
116_I147_M0.9110.97
115_I160_F0.9090.97
109_D277_R0.9080.97
138_E175_R0.9070.97
34_I37_D0.9040.97
159_T197_C0.8950.97
268_I286_L0.8930.96
289_Q292_A0.8910.96
154_K191_L0.8900.96
59_G62_Q0.8900.96
229_S232_G0.8890.96
289_Q293_D0.8880.96
116_I146_L0.8820.96
89_L146_L0.8790.96
147_M185_L0.8720.96
167_Y170_V0.8710.96
79_V102_V0.8690.96
92_D142_K0.8690.96
82_A283_A0.8630.96
41_H45_E0.8600.96
102_V119_Q0.8480.95
90_A142_K0.8470.95
118_H135_P0.8470.95
248_A252_G0.8460.95
91_G149_M0.8450.95
64_A68_R0.8400.95
44_R48_V0.8380.95
105_I149_M0.8320.95
268_I278_N0.8320.95
83_F87_D0.8320.95
217_V225_Y0.8310.95
157_I191_L0.8300.95
151_E215_D0.8290.95
101_I211_I0.8280.95
224_T253_I0.8270.95
96_A138_E0.8240.94
198_T286_L0.8240.94
155_M193_V0.8150.94
79_V83_F0.8140.94
135_P139_G0.8110.94
144_L148_Q0.8080.94
82_A279_P0.8080.94
36_I42_R0.8060.94
116_I157_I0.8040.94
101_I143_A0.8020.94
271_P274_G0.8010.94
82_A160_F0.8010.94
227_V233_C0.7910.93
147_M157_I0.7900.93
81_L279_P0.7890.93
38_E41_H0.7890.93
279_P283_A0.7830.93
78_Y200_I0.7790.93
79_V104_G0.7780.93
46_K50_L0.7780.93
136_A175_R0.7780.93
143_A181_I0.7740.92
280_E284_A0.7730.92
192_G215_D0.7720.92
245_P249_E0.7640.92
85_E107_R0.7610.92
230_P254_I0.7610.92
184_N187_E0.7580.92
270_E273_G0.7570.92
86_F104_G0.7570.92
74_Y122_R0.7560.92
61_W245_P0.7560.92
185_L189_S0.7530.91
198_T279_P0.7430.91
249_E252_G0.7420.91
136_A167_Y0.7400.91
77_D80_R0.7380.91
50_L67_A0.7360.90
60_A249_E0.7340.90
204_G226_S0.7310.90
256_P260_E0.7300.90
76_L90_A0.7240.90
188_M191_L0.7190.89
40_V44_R0.7190.89
146_L157_I0.7170.89
44_R55_F0.7140.89
105_I112_P0.7080.89
36_I40_V0.7080.89
83_F113_V0.7050.88
152_R155_M0.7040.88
50_L53_K0.6980.88
44_R47_S0.6920.88
169_G172_A0.6900.87
55_F66_L0.6890.87
47_S50_L0.6860.87
215_D263_L0.6840.87
195_V215_D0.6840.87
257_R260_E0.6790.87
64_A224_T0.6780.86
58_L62_Q0.6780.86
101_I118_H0.6760.86
91_G114_M0.6710.86
73_P81_L0.6710.86
41_H44_R0.6710.86
191_L195_V0.6680.86
220_L286_L0.6680.86
32_L36_I0.6660.85
75_T200_I0.6660.85
59_G249_E0.6650.85
273_G278_N0.6640.85
91_G153_F0.6600.85
159_T211_I0.6590.85
184_N195_V0.6530.84
104_G142_K0.6520.84
63_I221_Q0.6500.84
47_S51_T0.6490.84
143_A147_M0.6480.84
121_G133_G0.6480.84
183_R186_R0.6470.84
120_K164_P0.6460.84
37_D40_V0.6450.84
91_G105_I0.6440.84
185_L213_V0.6430.83
157_I188_M0.6410.83
252_G260_E0.6350.83
100_A135_P0.6350.83
246_L249_E0.6340.83
54_I93_R0.6320.82
65_Q69_H0.6290.82
82_A291_L0.6270.82
45_E49_E0.6260.82
148_Q190_R0.6240.82
34_I38_E0.6230.82
36_I39_E0.6230.82
114_M150_A0.6190.81
88_E97_D0.6180.81
214_G264_I0.6180.81
266_S278_N0.6170.81
138_E141_R0.6150.81
197_C217_V0.6150.81
269_P272_L0.6140.81
274_G280_E0.6090.80
184_N188_M0.6080.80
262_K265_D0.6060.80
33_D36_I0.6050.80
83_F290_L0.6030.79
254_I258_L0.6030.79
109_D274_G0.6010.79
141_R180_A0.6010.79
210_A224_T0.5960.79
284_A287_K0.5920.78
252_G261_L0.5920.78
62_Q77_D0.5910.78
226_S232_G0.5900.78
143_A159_T0.5890.78
272_L277_R0.5870.78
281_A284_A0.5860.77
257_R262_K0.5820.77
262_K266_S0.5820.77
256_P259_K0.5800.77
68_R77_D0.5770.76
45_E53_K0.5750.76
234_A238_W0.5730.76
162_D230_P0.5700.75
269_P285_S0.5700.75
94_A183_R0.5680.75
91_G103_G0.5680.75
109_D284_A0.5650.75
96_A136_A0.5620.74
218_N279_P0.5600.74
52_R56_A0.5600.74
38_E43_L0.5600.74
98_D139_G0.5540.73
252_G258_L0.5500.73
156_P193_V0.5480.73
32_L38_E0.5480.73
167_Y228_I0.5480.73
109_D288_A0.5470.72
228_I251_M0.5470.72
235_S246_L0.5450.72
259_K262_K0.5450.72
146_L149_M0.5440.72
132_F194_P0.5420.72
104_G146_L0.5400.72
163_T202_E0.5390.71
148_Q186_R0.5390.71
159_T195_V0.5380.71
97_D138_E0.5360.71
199_V217_V0.5360.71
187_E190_R0.5360.71
50_L54_I0.5350.71
32_L56_A0.5320.70
33_D48_V0.5320.70
34_I56_A0.5320.70
251_M257_R0.5300.70
284_A288_A0.5290.70
78_Y220_L0.5290.70
53_K57_D0.5280.70
84_D87_D0.5280.70
60_A63_I0.5260.70
78_Y283_A0.5260.70
200_I220_L0.5250.69
115_I158_I0.5250.69
87_D104_G0.5240.69
39_E46_K0.5240.69
234_A243_K0.5230.69
204_G211_I0.5220.69
185_L188_M0.5200.69
82_A158_I0.5180.68
84_D108_L0.5180.68
34_I39_E0.5150.68
37_D41_H0.5150.68
246_L252_G0.5130.68
57_D60_A0.5130.68
50_L64_A0.5120.68
282_M285_S0.5120.68
47_S67_A0.5120.68
95_Y171_G0.5110.67
107_R110_G0.5080.67
40_V43_L0.5080.67
233_C253_I0.5070.67
99_K138_E0.5050.66
193_V215_D0.5050.66
288_A291_L0.5050.66
33_D37_D0.5050.66
148_Q152_R0.5050.66
242_D246_L0.5030.66
268_I285_S0.5010.66
271_P278_N0.5000.66
148_Q151_E0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f9yA 2 0.9436 100 0.318 Contact Map
2f9iA 2 0.9561 100 0.328 Contact Map
3u9rB 5 0.8903 100 0.394 Contact Map
1vrgA 4 0.8245 100 0.398 Contact Map
4rcnA 6 0.8683 100 0.4 Contact Map
1pixA 4 0.9122 100 0.407 Contact Map
3gf3A 4 0.8997 100 0.413 Contact Map
2f9iB 1 0.7367 100 0.439 Contact Map
3n6rB 4 0.8056 100 0.447 Contact Map
1x0uA 5 0.8652 100 0.449 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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