ACCA - ECOLI - GREMLIN Contacts

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ACCA - Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

UniProt:	P0ABD5	Sequences: MSLNFLDFEQPIAELEAKIDSLTAVSRQDEKLDINIDEEVHRLREKSVELTRKIFADLGAWQIAQLARHPQRPYTLDYVRLAFDEFDELAGDRAYADDKAIVGGIARLDGRPVMIIGHQKGRETKEKIRRNFGMPAPEGYRKALRLMQMAERFKMPIITFIDTPGAYPGVGAEERGQSEAIARNLREMSRLGVPVVCTVIGEGGSGGALAIGVGDKVNMLQYSTYSVISPEGCASILWKSADKAPLAAEAMGIIAPRLKELKLIDSIIPEPLGGAHRNPEAMAASLKAQLLADLADLDVLSTEDLKNRRYQRLMSYGYA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11647
Length:	319 (252)
Sequences:	4604 (2161)
Seq/√Len:	136.1

ECOLI - ACCA ACCD
BACSU - ACCA ACCD PCCB YNGE
HALSA - Q9HRN1 Q9HPQ0
SULSO - Q97VY8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
83_F	106_A	4.605	1.00
103_G	146_L	4.157	1.00
197_C	214_G	3.678	1.00
243_K	246_L	3.338	1.00
109_D	287_K	2.699	1.00
114_M	146_L	2.631	1.00
179_E	183_R	2.614	1.00
234_A	240_S	2.567	1.00
114_M	155_M	2.540	1.00
144_L	184_N	2.493	1.00
161_I	197_C	2.452	1.00
151_E	192_G	2.428	1.00
218_N	289_Q	2.396	1.00
147_M	188_M	2.382	1.00
161_I	212_G	2.359	1.00
148_Q	187_E	2.321	1.00
278_N	281_A	2.297	1.00
218_N	266_S	2.263	1.00
81_L	283_A	2.205	1.00
63_I	222_Y	2.199	1.00
72_R	201_G	2.145	1.00
75_T	117_G	2.138	1.00
83_F	115_I	2.120	1.00
266_S	292_A	2.114	1.00
113_V	158_I	2.098	1.00
228_I	232_G	2.078	1.00
108_L	291_L	2.042	1.00
81_L	280_E	2.037	1.00
220_L	282_M	2.030	1.00
252_G	257_R	2.016	1.00
76_L	102_V	1.963	1.00
158_I	198_T	1.946	1.00
76_L	119_Q	1.895	1.00
88_E	104_G	1.841	1.00
221_Q	269_P	1.828	1.00
87_D	107_R	1.815	1.00
109_D	291_L	1.794	1.00
107_R	112_P	1.764	1.00
83_F	108_L	1.731	1.00
151_E	188_M	1.715	1.00
266_S	293_D	1.708	1.00
160_F	198_T	1.693	1.00
103_G	114_M	1.656	1.00
149_M	153_F	1.641	1.00
75_T	118_H	1.592	1.00
100_A	139_G	1.555	1.00
228_I	233_C	1.526	1.00
82_A	108_L	1.502	1.00
136_A	171_G	1.497	1.00
63_I	256_P	1.486	1.00
116_I	159_T	1.482	1.00
148_Q	184_N	1.482	1.00
82_A	287_K	1.475	1.00
233_C	251_M	1.468	1.00
218_N	293_D	1.463	1.00
216_K	293_D	1.455	1.00
154_K	193_V	1.441	1.00
108_L	287_K	1.434	1.00
204_G	224_T	1.428	1.00
230_P	251_M	1.415	1.00
95_Y	175_R	1.413	1.00
144_L	187_E	1.407	1.00
95_Y	138_E	1.399	1.00
120_K	132_F	1.396	1.00
114_M	149_M	1.392	1.00
79_V	115_I	1.381	1.00
75_T	79_V	1.377	1.00
264_I	267_I	1.370	1.00
149_M	155_M	1.369	1.00
74_Y	119_Q	1.356	1.00
105_I	155_M	1.355	1.00
106_A	115_I	1.340	1.00
266_S	289_Q	1.337	1.00
219_M	223_S	1.337	1.00
105_I	114_M	1.332	1.00
109_D	280_E	1.315	1.00
134_M	164_P	1.286	1.00
105_I	153_F	1.284	1.00
92_D	103_G	1.279	1.00
92_D	145_R	1.270	1.00
151_E	191_L	1.261	1.00
212_G	217_V	1.248	1.00
171_G	174_E	1.237	1.00
38_E	42_R	1.219	1.00
90_A	97_D	1.212	1.00
112_P	155_M	1.206	1.00
49_E	53_K	1.202	1.00
196_V	293_D	1.202	1.00
75_T	102_V	1.190	1.00
218_N	268_I	1.181	0.99
242_D	245_P	1.181	0.99
101_I	116_I	1.169	0.99
90_A	102_V	1.165	0.99
195_V	214_G	1.150	0.99
287_K	291_L	1.142	0.99
147_M	191_L	1.132	0.99
89_L	105_I	1.132	0.99
217_V	264_I	1.125	0.99
219_M	264_I	1.125	0.99
96_A	99_K	1.122	0.99
64_A	253_I	1.103	0.99
158_I	290_L	1.100	0.99
259_K	264_I	1.088	0.99
281_A	285_S	1.087	0.99
157_I	193_V	1.080	0.99
151_E	193_V	1.075	0.99
84_D	107_R	1.068	0.99
90_A	93_R	1.067	0.99
45_E	56_A	1.044	0.99
84_D	110_G	1.043	0.99
241_A	244_A	1.043	0.99
214_G	217_V	1.041	0.99
75_T	119_Q	1.040	0.99
108_L	290_L	1.038	0.99
62_Q	65_Q	1.036	0.99
251_M	254_I	1.035	0.99
108_L	113_V	1.033	0.99
108_L	158_I	1.024	0.99
183_R	187_E	1.023	0.99
167_Y	171_G	1.022	0.98
254_I	257_R	1.022	0.98
283_A	286_L	1.021	0.98
68_R	269_P	1.017	0.98
188_M	193_V	1.016	0.98
149_M	152_R	1.003	0.98
77_D	122_R	1.001	0.98
257_R	261_L	0.998	0.98
186_R	190_R	0.989	0.98
172_A	177_Q	0.988	0.98
233_C	250_A	0.988	0.98
288_A	292_A	0.984	0.98
48_V	52_R	0.982	0.98
101_I	135_P	0.981	0.98
171_G	175_R	0.971	0.98
39_E	42_R	0.970	0.98
199_V	212_G	0.966	0.98
196_V	290_L	0.962	0.98
61_W	65_Q	0.957	0.98
259_K	266_S	0.956	0.98
235_S	241_A	0.956	0.98
61_W	64_A	0.942	0.97
188_M	195_V	0.939	0.97
135_P	210_A	0.939	0.97
204_G	210_A	0.939	0.97
249_E	262_K	0.937	0.97
64_A	67_A	0.935	0.97
49_E	52_R	0.934	0.97
137_P	173_E	0.932	0.97
282_M	286_L	0.926	0.97
118_H	211_I	0.924	0.97
74_Y	77_D	0.924	0.97
238_W	247_A	0.923	0.97
216_K	266_S	0.919	0.97
116_I	147_M	0.911	0.97
115_I	160_F	0.909	0.97
109_D	277_R	0.908	0.97
138_E	175_R	0.907	0.97
34_I	37_D	0.904	0.97
159_T	197_C	0.895	0.97
268_I	286_L	0.893	0.96
289_Q	292_A	0.891	0.96
154_K	191_L	0.890	0.96
59_G	62_Q	0.890	0.96
229_S	232_G	0.889	0.96
289_Q	293_D	0.888	0.96
116_I	146_L	0.882	0.96
89_L	146_L	0.879	0.96
147_M	185_L	0.872	0.96
167_Y	170_V	0.871	0.96
79_V	102_V	0.869	0.96
92_D	142_K	0.869	0.96
82_A	283_A	0.863	0.96
41_H	45_E	0.860	0.96
102_V	119_Q	0.848	0.95
90_A	142_K	0.847	0.95
118_H	135_P	0.847	0.95
248_A	252_G	0.846	0.95
91_G	149_M	0.845	0.95
64_A	68_R	0.840	0.95
44_R	48_V	0.838	0.95
105_I	149_M	0.832	0.95
268_I	278_N	0.832	0.95
83_F	87_D	0.832	0.95
217_V	225_Y	0.831	0.95
157_I	191_L	0.830	0.95
151_E	215_D	0.829	0.95
101_I	211_I	0.828	0.95
224_T	253_I	0.827	0.95
96_A	138_E	0.824	0.94
198_T	286_L	0.824	0.94
155_M	193_V	0.815	0.94
79_V	83_F	0.814	0.94
135_P	139_G	0.811	0.94
144_L	148_Q	0.808	0.94
82_A	279_P	0.808	0.94
36_I	42_R	0.806	0.94
116_I	157_I	0.804	0.94
101_I	143_A	0.802	0.94
271_P	274_G	0.801	0.94
82_A	160_F	0.801	0.94
227_V	233_C	0.791	0.93
147_M	157_I	0.790	0.93
81_L	279_P	0.789	0.93
38_E	41_H	0.789	0.93
279_P	283_A	0.783	0.93
78_Y	200_I	0.779	0.93
79_V	104_G	0.778	0.93
46_K	50_L	0.778	0.93
136_A	175_R	0.778	0.93
143_A	181_I	0.774	0.92
280_E	284_A	0.773	0.92
192_G	215_D	0.772	0.92
245_P	249_E	0.764	0.92
85_E	107_R	0.761	0.92
230_P	254_I	0.761	0.92
184_N	187_E	0.758	0.92
270_E	273_G	0.757	0.92
86_F	104_G	0.757	0.92
74_Y	122_R	0.756	0.92
61_W	245_P	0.756	0.92
185_L	189_S	0.753	0.91
198_T	279_P	0.743	0.91
249_E	252_G	0.742	0.91
136_A	167_Y	0.740	0.91
77_D	80_R	0.738	0.91
50_L	67_A	0.736	0.90
60_A	249_E	0.734	0.90
204_G	226_S	0.731	0.90
256_P	260_E	0.730	0.90
76_L	90_A	0.724	0.90
188_M	191_L	0.719	0.89
40_V	44_R	0.719	0.89
146_L	157_I	0.717	0.89
44_R	55_F	0.714	0.89
105_I	112_P	0.708	0.89
36_I	40_V	0.708	0.89
83_F	113_V	0.705	0.88
152_R	155_M	0.704	0.88
50_L	53_K	0.698	0.88
44_R	47_S	0.692	0.88
169_G	172_A	0.690	0.87
55_F	66_L	0.689	0.87
47_S	50_L	0.686	0.87
215_D	263_L	0.684	0.87
195_V	215_D	0.684	0.87
257_R	260_E	0.679	0.87
64_A	224_T	0.678	0.86
58_L	62_Q	0.678	0.86
101_I	118_H	0.676	0.86
91_G	114_M	0.671	0.86
73_P	81_L	0.671	0.86
41_H	44_R	0.671	0.86
191_L	195_V	0.668	0.86
220_L	286_L	0.668	0.86
32_L	36_I	0.666	0.85
75_T	200_I	0.666	0.85
59_G	249_E	0.665	0.85
273_G	278_N	0.664	0.85
91_G	153_F	0.660	0.85
159_T	211_I	0.659	0.85
184_N	195_V	0.653	0.84
104_G	142_K	0.652	0.84
63_I	221_Q	0.650	0.84
47_S	51_T	0.649	0.84
143_A	147_M	0.648	0.84
121_G	133_G	0.648	0.84
183_R	186_R	0.647	0.84
120_K	164_P	0.646	0.84
37_D	40_V	0.645	0.84
91_G	105_I	0.644	0.84
185_L	213_V	0.643	0.83
157_I	188_M	0.641	0.83
252_G	260_E	0.635	0.83
100_A	135_P	0.635	0.83
246_L	249_E	0.634	0.83
54_I	93_R	0.632	0.82
65_Q	69_H	0.629	0.82
82_A	291_L	0.627	0.82
45_E	49_E	0.626	0.82
148_Q	190_R	0.624	0.82
34_I	38_E	0.623	0.82
36_I	39_E	0.623	0.82
114_M	150_A	0.619	0.81
88_E	97_D	0.618	0.81
214_G	264_I	0.618	0.81
266_S	278_N	0.617	0.81
138_E	141_R	0.615	0.81
197_C	217_V	0.615	0.81
269_P	272_L	0.614	0.81
274_G	280_E	0.609	0.80
184_N	188_M	0.608	0.80
262_K	265_D	0.606	0.80
33_D	36_I	0.605	0.80
83_F	290_L	0.603	0.79
254_I	258_L	0.603	0.79
109_D	274_G	0.601	0.79
141_R	180_A	0.601	0.79
210_A	224_T	0.596	0.79
284_A	287_K	0.592	0.78
252_G	261_L	0.592	0.78
62_Q	77_D	0.591	0.78
226_S	232_G	0.590	0.78
143_A	159_T	0.589	0.78
272_L	277_R	0.587	0.78
281_A	284_A	0.586	0.77
257_R	262_K	0.582	0.77
262_K	266_S	0.582	0.77
256_P	259_K	0.580	0.77
68_R	77_D	0.577	0.76
45_E	53_K	0.575	0.76
234_A	238_W	0.573	0.76
162_D	230_P	0.570	0.75
269_P	285_S	0.570	0.75
94_A	183_R	0.568	0.75
91_G	103_G	0.568	0.75
109_D	284_A	0.565	0.75
96_A	136_A	0.562	0.74
218_N	279_P	0.560	0.74
52_R	56_A	0.560	0.74
38_E	43_L	0.560	0.74
98_D	139_G	0.554	0.73
252_G	258_L	0.550	0.73
156_P	193_V	0.548	0.73
32_L	38_E	0.548	0.73
167_Y	228_I	0.548	0.73
109_D	288_A	0.547	0.72
228_I	251_M	0.547	0.72
235_S	246_L	0.545	0.72
259_K	262_K	0.545	0.72
146_L	149_M	0.544	0.72
132_F	194_P	0.542	0.72
104_G	146_L	0.540	0.72
163_T	202_E	0.539	0.71
148_Q	186_R	0.539	0.71
159_T	195_V	0.538	0.71
97_D	138_E	0.536	0.71
199_V	217_V	0.536	0.71
187_E	190_R	0.536	0.71
50_L	54_I	0.535	0.71
32_L	56_A	0.532	0.70
33_D	48_V	0.532	0.70
34_I	56_A	0.532	0.70
251_M	257_R	0.530	0.70
284_A	288_A	0.529	0.70
78_Y	220_L	0.529	0.70
53_K	57_D	0.528	0.70
84_D	87_D	0.528	0.70
60_A	63_I	0.526	0.70
78_Y	283_A	0.526	0.70
200_I	220_L	0.525	0.69
115_I	158_I	0.525	0.69
87_D	104_G	0.524	0.69
39_E	46_K	0.524	0.69
234_A	243_K	0.523	0.69
204_G	211_I	0.522	0.69
185_L	188_M	0.520	0.69
82_A	158_I	0.518	0.68
84_D	108_L	0.518	0.68
34_I	39_E	0.515	0.68
37_D	41_H	0.515	0.68
246_L	252_G	0.513	0.68
57_D	60_A	0.513	0.68
50_L	64_A	0.512	0.68
282_M	285_S	0.512	0.68
47_S	67_A	0.512	0.68
95_Y	171_G	0.511	0.67
107_R	110_G	0.508	0.67
40_V	43_L	0.508	0.67
233_C	253_I	0.507	0.67
99_K	138_E	0.505	0.66
193_V	215_D	0.505	0.66
288_A	291_L	0.505	0.66
33_D	37_D	0.505	0.66
148_Q	152_R	0.505	0.66
242_D	246_L	0.503	0.66
268_I	285_S	0.501	0.66
271_P	278_N	0.500	0.66
148_Q	151_E	0.500	0.66

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2f9yA	2	0.9436	100	0.318	Contact Map
2f9iA	2	0.9561	100	0.328	Contact Map
3u9rB	5	0.8903	100	0.394	Contact Map
1vrgA	4	0.8245	100	0.398	Contact Map
4rcnA	6	0.8683	100	0.4	Contact Map
1pixA	4	0.9122	100	0.407	Contact Map
3gf3A	4	0.8997	100	0.413	Contact Map
2f9iB	1	0.7367	100	0.439	Contact Map
3n6rB	4	0.8056	100	0.447	Contact Map
1x0uA	5	0.8652	100	0.449	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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