GREMLIN Database
BFR - Bacterioferritin
UniProt: P0ABD3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10113
Length: 158 (147)
Sequences: 1674 (886)
Seq/√Len: 73.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_E88_R3.9311.00
57_R122_E3.5461.00
37_L150_L3.0681.00
4_D111_V2.9511.00
107_Y111_V2.7951.00
82_D85_E2.5981.00
88_R92_A2.5301.00
32_F86_M2.4791.00
6_K9_N2.3261.00
98_A102_R2.2891.00
78_N92_A2.1381.00
6_K111_V2.0061.00
139_D143_K1.9951.00
98_A131_I1.9671.00
30_R56_D1.9191.00
84_E142_Q1.9161.00
16_G20_V1.8611.00
141_I146_L1.8421.00
10_Y107_Y1.7771.00
91_L135_E1.7761.00
50_D53_K1.7251.00
49_I52_M1.6751.00
33_K60_E1.6571.00
42_D46_H1.6250.99
118_D121_I1.6040.99
84_E146_L1.5720.99
12_N67_G1.5540.99
106_G110_S1.5290.99
99_K103_E1.5290.99
15_L62_I1.5260.99
104_A120_M1.4910.99
144_M150_L1.4580.99
14_L101_L1.4460.99
78_N96_D1.4430.99
51_E130_H1.4330.99
98_A127_E1.4280.99
62_I67_G1.4130.99
109_D117_R1.4010.98
50_D126_D1.3850.98
59_I71_L1.3830.98
43_V46_H1.3800.98
84_E138_L1.3660.98
25_Y94_E1.3640.98
22_I52_M1.3270.98
6_K107_Y1.3070.98
34_N66_E1.2950.97
5_T9_N1.2880.97
26_F29_A1.2870.97
96_D100_N1.2760.97
37_L143_K1.2570.97
109_D114_Y1.2420.97
105_I121_I1.2170.96
13_K100_N1.2150.96
7_V108_A1.2030.96
48_S52_M1.1970.96
54_H130_H1.1410.95
10_Y104_A1.1400.95
32_F41_N1.1360.95
17_N100_N1.1240.94
83_V150_L1.1180.94
18_E94_E1.1120.94
34_N64_F1.1090.94
58_Y116_S1.0980.93
18_E54_H1.0950.93
18_E127_E1.0870.93
31_M80_G1.0860.93
58_Y123_I1.0860.93
21_A51_E1.0740.93
140_L144_M1.0560.92
18_E25_Y1.0540.92
10_Y103_E1.0520.92
31_M35_W1.0480.92
7_V111_V1.0440.92
14_L100_N1.0340.91
47_E51_E1.0290.91
91_L95_L1.0220.91
16_G73_D1.0170.91
132_D136_T1.0000.90
133_W137_E0.9870.89
7_V107_Y0.9850.89
54_H94_E0.9810.89
51_E54_H0.9670.88
115_V125_R0.9670.88
43_V133_W0.9640.88
58_Y119_M0.9570.88
103_E112_H0.9570.88
31_M63_L0.9550.88
10_Y100_N0.9510.87
45_Y49_I0.9390.87
127_E130_H0.9160.85
148_N151_Q0.9030.84
16_G75_G0.9000.84
4_D107_Y0.8990.84
50_D127_E0.8980.84
51_E94_E0.8970.84
125_R128_E0.8940.84
61_R116_S0.8910.84
97_G127_E0.8850.83
144_M148_N0.8810.83
57_R123_I0.8790.83
80_G90_D0.8770.83
107_Y110_S0.8760.83
28_H90_D0.8740.82
21_A54_H0.8680.82
26_F56_D0.8620.82
13_K103_E0.8530.81
95_L131_I0.8500.81
21_A24_Q0.8350.80
88_R138_L0.8300.79
41_N45_Y0.8270.79
54_H127_E0.8200.78
103_E107_Y0.8190.78
29_A45_Y0.8180.78
44_E50_D0.8180.78
14_L58_Y0.8080.77
33_K41_N0.8080.77
92_A95_L0.8030.77
89_S92_A0.8010.77
26_F48_S0.7990.76
19_L22_I0.7950.76
47_E54_H0.7890.76
20_V75_G0.7800.75
9_N13_K0.7790.75
26_F45_Y0.7580.73
113_D116_S0.7550.72
105_I124_L0.7520.72
49_I53_K0.7510.72
51_E97_G0.7480.72
24_Q90_D0.7440.71
106_G112_H0.7410.71
91_L131_I0.7360.70
97_G126_D0.7330.70
143_K150_L0.7330.70
22_I48_S0.7330.70
82_D146_L0.7190.69
117_R121_I0.7150.68
16_G86_M0.7140.68
88_R142_Q0.7070.67
56_D60_E0.7020.67
102_R114_Y0.6940.66
29_A41_N0.6930.66
50_D54_H0.6900.65
105_I117_R0.6830.65
38_K42_D0.6770.64
40_L83_V0.6700.63
58_Y120_M0.6680.63
32_F44_E0.6650.63
109_D151_Q0.6650.63
17_N97_G0.6640.62
68_L81_E0.6630.62
52_M56_D0.6600.62
30_R60_E0.6480.61
26_F52_M0.6460.60
84_E141_I0.6420.60
93_L131_I0.6400.60
45_Y56_D0.6340.59
136_T139_D0.6290.58
46_H50_D0.6270.58
108_A120_M0.6260.58
25_Y54_H0.6210.57
18_E97_G0.6130.56
94_E130_H0.6070.56
33_K45_Y0.6040.55
49_I56_D0.6020.55
105_I120_M0.6010.55
64_F132_D0.5960.54
85_E88_R0.5940.54
18_E130_H0.5930.54
93_L101_L0.5930.54
30_R59_I0.5930.54
71_L76_K0.5850.53
54_H126_D0.5800.52
70_N81_E0.5790.52
70_N74_L0.5790.52
17_N47_E0.5770.52
47_E134_L0.5750.52
115_V128_E0.5730.51
83_V146_L0.5730.51
114_Y151_Q0.5720.51
19_L113_D0.5690.51
96_D99_K0.5660.51
6_K110_S0.5660.51
27_L68_L0.5640.50
71_L77_L0.5640.50
21_A47_E0.5610.50
79_I89_S0.5610.50
17_N101_L0.5610.50
15_L134_L0.5570.49
45_Y48_S0.5490.48
32_F83_V0.5470.48
137_E149_Y0.5470.48
27_L79_I0.5460.48
101_L127_E0.5440.48
51_E127_E0.5420.48
33_K38_K0.5390.47
115_V121_I0.5360.47
114_Y117_R0.5350.47
61_R113_D0.5340.47
21_A93_L0.5330.46
24_Q28_H0.5320.46
81_E85_E0.5310.46
12_N62_I0.5300.46
63_L132_D0.5300.46
8_I62_I0.5290.46
80_G85_E0.5280.46
25_Y130_H0.5260.46
23_N132_D0.5250.45
102_R151_Q0.5210.45
72_Q81_E0.5140.44
84_E150_L0.5130.44
78_N89_S0.5120.44
43_V47_E0.5110.44
6_K99_K0.5090.44
31_M68_L0.5080.43
138_L142_Q0.5030.43
100_N104_A0.5030.43
128_E132_D0.5030.43
70_N75_G0.5020.43
118_D122_E0.5010.43
53_K57_R0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cvrA 2 0.9873 100 0.407 Contact Map
2v8tA 5 0.981 100 0.412 Contact Map
3r2kA 6 0.9684 100 0.42 Contact Map
3fvbA 6 1 100 0.422 Contact Map
4tofA 6 0.9937 100 0.423 Contact Map
1o9iA 6 0.9557 100 0.423 Contact Map
3gvyA 5 1 100 0.424 Contact Map
1jgcA 6 1 100 0.433 Contact Map
3uoiA 7 0.9937 100 0.435 Contact Map
1nfvA 7 0.9937 100 0.441 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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