GREMLIN Database
YEAV - Uncharacterized transporter YeaV
UniProt: P0ABD1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13508
Length: 481 (439)
Sequences: 3288 (1918)
Seq/√Len: 91.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_R26_K4.6051.00
139_L376_S4.0181.00
316_F322_N3.4591.00
214_L218_V3.4221.00
214_L349_F3.4111.00
25_G282_R3.1571.00
175_A403_L2.9461.00
70_S73_A2.8411.00
314_H318_N2.7161.00
188_S366_D2.6571.00
311_Y343_L2.5991.00
118_I134_V2.5871.00
228_I306_G2.5651.00
172_T176_F2.5311.00
322_N325_Q2.5051.00
59_Y317_I2.4881.00
216_L307_V2.4731.00
212_P307_V2.4391.00
216_L225_T2.4331.00
122_T126_P2.4301.00
286_I441_L2.3831.00
215_V343_L2.3791.00
13_A290_I2.3721.00
8_L434_V2.3601.00
33_S202_K2.3521.00
29_Y194_N2.3311.00
82_F302_W2.2951.00
358_I362_A2.2941.00
191_I199_R2.2581.00
158_T169_D2.2261.00
4_L431_L2.1971.00
182_G399_T2.1971.00
13_A291_W2.1581.00
187_L191_I2.1471.00
338_Q341_M2.1461.00
11_Y438_I2.1321.00
8_L438_I2.1051.00
365_M398_I2.0941.00
124_V127_Q2.0891.00
190_W392_L2.0881.00
67_A70_S2.0871.00
424_L428_V2.0811.00
227_S310_S2.0381.00
30_S33_S2.0311.00
186_C190_W2.0091.00
158_T177_V1.9811.00
268_S419_V1.9681.00
110_K119_A1.9151.00
208_A360_F1.9131.00
122_T130_W1.9001.00
17_Y442_K1.8921.00
129_P133_L1.8911.00
228_I303_F1.8761.00
16_K19_N1.8751.00
119_A127_Q1.8651.00
56_A316_F1.8541.00
340_L353_Y1.8541.00
230_N248_P1.8541.00
186_C395_C1.8491.00
128_G131_G1.8411.00
363_S367_A1.8401.00
15_S18_G1.8271.00
206_W210_L1.8191.00
5_A430_L1.7951.00
340_L349_F1.7841.00
158_T173_V1.7811.00
176_F180_L1.7811.00
117_I433_K1.7771.00
220_P224_I1.7721.00
237_Q241_Q1.7711.00
171_F407_F1.7661.00
7_G11_Y1.7571.00
25_G107_R1.7561.00
369_A395_C1.7401.00
162_S169_D1.7381.00
428_V432_V1.7361.00
365_M369_A1.7221.00
36_F40_C1.7201.00
50_W53_A1.6781.00
253_S257_N1.6761.00
89_A266_W1.6571.00
373_A390_L1.6531.00
158_T174_Q1.6481.00
21_R24_E1.6461.00
315_Q342_S1.6321.00
115_S132_K1.6211.00
216_L221_T1.6201.00
238_N241_Q1.6171.00
40_C359_I1.6051.00
31_T288_E1.5981.00
18_G287_K1.5811.00
56_A323_V1.5781.00
319_G322_N1.5651.00
199_R203_M1.5581.00
228_I302_W1.5491.00
137_M429_I1.5451.00
179_L403_L1.5371.00
50_W332_G1.5271.00
4_L434_V1.5251.00
86_G298_T1.5221.00
183_G187_L1.5201.00
431_L435_G1.5091.00
167_L173_V1.4971.00
190_W388_R1.4901.00
11_Y15_S1.4861.00
6_M10_I1.4741.00
345_A348_L1.4621.00
171_F174_Q1.4601.00
336_V353_Y1.4520.99
5_A434_V1.4520.99
12_L286_I1.4520.99
122_T432_V1.4430.99
162_S168_P1.4340.99
119_A124_V1.4230.99
209_F213_L1.4100.99
203_M206_W1.4080.99
98_L286_I1.4080.99
3_L244_L1.4060.99
186_C392_L1.4040.99
59_Y69_R1.4030.99
74_L317_I1.3940.99
356_V359_I1.3900.99
79_P238_N1.3880.99
33_S198_Q1.3740.99
179_L183_G1.3700.99
6_M239_F1.3680.99
170_N173_V1.3660.99
316_F321_I1.3610.99
154_A177_V1.3500.99
324_P328_E1.3460.99
14_T291_W1.3390.99
152_V261_F1.3380.99
323_V327_L1.3360.99
79_P234_L1.3330.99
198_Q202_K1.3270.99
298_T302_W1.3260.99
231_A306_G1.3140.99
96_A433_K1.3100.99
229_I233_G1.3080.99
396_V400_L1.3060.99
79_P242_M1.3000.99
348_L351_A1.2900.99
388_R391_R1.2900.99
129_P132_K1.2890.99
121_I435_G1.2870.99
93_Y266_W1.2810.99
311_Y339_V1.2760.99
88_S243_S1.2750.99
14_T287_K1.2690.99
168_P173_V1.2600.99
32_L205_G1.2560.99
161_L173_V1.2540.99
369_A398_I1.2530.99
5_A95_L1.2510.98
423_A427_L1.2370.98
158_T170_N1.2340.98
413_E416_K1.2330.98
364_H367_A1.2330.98
6_M91_A1.2330.98
29_Y279_R1.2310.98
119_A126_P1.2290.98
191_I195_N1.2250.98
99_I433_K1.2170.98
123_G128_G1.2130.98
236_T240_L1.2100.98
158_T168_P1.2070.98
181_S358_I1.1820.98
68_P73_A1.1810.98
405_I418_T1.1750.98
338_Q342_S1.1740.98
220_P314_H1.1690.98
299_V303_F1.1620.98
21_R285_K1.1580.97
173_V176_F1.1510.97
224_I307_V1.1490.97
163_A341_M1.1490.97
203_M359_I1.1440.97
28_E194_N1.1390.97
240_L243_S1.1380.97
43_L89_A1.1360.97
200_L366_D1.1260.97
438_I442_K1.1250.97
49_Y333_E1.1190.97
171_F175_A1.1160.97
105_H112_L1.1120.97
88_S235_T1.1120.97
32_L36_F1.1060.97
43_L301_C1.1050.97
116_G119_A1.1040.97
20_I441_L1.1020.97
75_E230_N1.0990.97
17_Y438_I1.0980.97
130_W133_L1.0960.96
108_K440_W1.0960.96
347_K351_A1.0960.96
316_F319_G1.0940.96
99_I437_F1.0940.96
189_S395_C1.0880.96
6_M87_I1.0850.96
94_T293_L1.0830.96
110_K126_P1.0790.96
52_V335_A1.0720.96
10_I14_T1.0680.96
393_F397_V1.0660.96
6_M88_S1.0660.96
115_S185_F1.0650.96
225_T229_I1.0640.96
232_I302_W1.0500.96
189_S193_I1.0460.95
269_Y364_H1.0460.95
62_P68_P1.0450.95
35_L296_G1.0420.95
184_I362_A1.0410.95
72_Q75_E1.0390.95
295_L299_V1.0370.95
137_M422_T1.0340.95
15_S20_I1.0340.95
160_G337_Q1.0330.95
213_L217_I1.0210.95
29_Y37_M1.0200.95
87_I91_A1.0200.95
125_R128_G1.0200.95
426_F429_I1.0170.95
270_T430_L1.0170.95
179_L396_V1.0040.94
97_S289_V1.0020.94
3_L88_S1.0000.94
110_K116_G1.0000.94
227_S231_A0.9990.94
72_Q76_F0.9970.94
146_L197_L0.9970.94
123_G131_G0.9970.94
175_A179_L0.9960.94
120_A123_G0.9930.94
323_V335_A0.9910.94
185_F395_C0.9910.94
223_F317_I0.9890.94
69_R73_A0.9840.94
351_A355_G0.9800.94
325_Q328_E0.9720.93
237_Q240_L0.9630.93
78_V231_A0.9630.93
178_I402_P0.9620.93
161_L165_T0.9590.93
316_F324_P0.9590.93
277_V293_L0.9590.93
104_F440_W0.9570.93
180_L184_I0.9490.92
43_L47_T0.9420.92
231_A234_L0.9410.92
226_N246_T0.9390.92
437_F441_L0.9380.92
148_I416_K0.9330.92
13_A18_G0.9320.92
87_I294_I0.9320.92
343_L348_L0.9310.92
31_T35_L0.9270.92
53_A254_F0.9270.92
334_T338_Q0.9200.91
80_Y242_M0.9190.91
360_F364_H0.9100.91
148_I415_M0.9070.91
163_A334_T0.9050.91
58_Y254_F0.9030.90
392_L396_V0.9010.90
323_V328_E0.9010.90
8_L95_L0.8990.90
199_R202_K0.8970.90
148_I405_I0.8940.90
50_W152_V0.8940.90
67_A73_A0.8900.90
84_H259_T0.8890.90
376_S390_L0.8870.90
112_L115_S0.8860.90
231_A310_S0.8850.90
29_Y33_S0.8830.89
184_I187_L0.8810.89
149_S153_T0.8780.89
126_P131_G0.8760.89
326_V338_Q0.8760.89
218_V349_F0.8720.89
182_G185_F0.8720.89
146_L368_V0.8710.89
372_M398_I0.8670.89
200_L359_I0.8670.89
3_L243_S0.8660.88
233_G244_L0.8650.88
439_R443_Q0.8630.88
91_A94_T0.8620.88
102_Y444_D0.8590.88
193_I370_Y0.8570.88
195_N199_R0.8570.88
119_A125_R0.8550.88
45_S153_T0.8510.88
51_G305_F0.8500.88
36_F205_G0.8470.87
108_K444_D0.8450.87
346_G350_L0.8420.87
59_Y70_S0.8420.87
71_Q317_I0.8400.87
38_F364_H0.8390.87
374_A386_P0.8350.87
45_S149_S0.8310.86
230_N234_L0.8300.86
52_V339_V0.8300.86
263_W266_W0.8300.86
295_L298_T0.8280.86
175_A407_F0.8260.86
189_S391_R0.8250.86
316_F320_V0.8200.86
345_A349_F0.8190.86
233_G246_T0.8160.85
150_L361_L0.8150.85
111_G116_G0.8140.85
57_Y61_T0.8130.85
340_L350_L0.8020.84
33_S36_F0.8010.84
69_R72_Q0.7990.84
74_L249_L0.7990.84
162_S167_L0.7980.84
82_F231_A0.7960.84
218_V343_L0.7960.84
327_L331_G0.7950.84
45_S361_L0.7940.84
398_I402_P0.7940.84
40_C201_S0.7920.84
191_I194_N0.7910.84
345_A351_A0.7900.83
188_S201_S0.7880.83
202_K366_D0.7880.83
293_L296_G0.7860.83
239_F243_S0.7710.82
64_L76_F0.7700.82
46_S85_W0.7670.82
221_T224_I0.7660.82
223_F310_S0.7640.81
204_V363_S0.7640.81
318_N322_N0.7630.81
65_N68_P0.7620.81
238_N242_M0.7620.81
215_V311_Y0.7620.81
113_S379_N0.7620.81
306_G311_Y0.7610.81
223_F314_H0.7600.81
53_A332_G0.7600.81
118_I432_V0.7590.81
37_M280_V0.7590.81
122_T436_G0.7580.81
369_A373_A0.7570.81
20_I107_R0.7570.81
8_L12_L0.7550.81
316_F323_V0.7540.81
21_R288_E0.7540.81
12_L98_L0.7530.80
326_V330_L0.7520.80
182_G361_L0.7500.80
121_I130_W0.7490.80
224_I303_F0.7490.80
209_F300_G0.7480.80
86_G302_W0.7460.80
86_G89_A0.7460.80
47_T149_S0.7450.80
210_L348_L0.7440.80
51_G304_F0.7420.79
194_N199_R0.7410.79
373_A386_P0.7410.79
151_V261_F0.7410.79
188_S200_L0.7410.79
164_L351_A0.7410.79
172_T179_L0.7390.79
331_G334_T0.7390.79
81_S305_F0.7380.79
107_R444_D0.7380.79
161_L167_L0.7370.79
3_L240_L0.7360.79
388_R392_L0.7310.78
210_L214_L0.7300.78
214_L345_A0.7300.78
408_T412_L0.7290.78
60_Q324_P0.7290.78
178_I361_L0.7270.78
420_V423_A0.7270.78
118_I141_A0.7260.78
37_M40_C0.7250.78
201_S366_D0.7230.78
167_L176_F0.7220.78
185_F368_V0.7220.78
214_L340_L0.7210.77
172_T175_A0.7200.77
189_S369_A0.7200.77
267_I429_I0.7190.77
137_M421_L0.7180.77
143_V372_M0.7180.77
233_G236_T0.7160.77
259_T263_W0.7150.77
52_V56_A0.7150.77
162_S165_T0.7140.77
150_L153_T0.7130.77
16_K307_V0.7110.76
90_W281_S0.7100.76
20_I102_Y0.7100.76
104_F110_K0.7090.76
65_N76_F0.7080.76
223_F227_S0.7080.76
272_G368_V0.7080.76
7_G239_F0.7080.76
164_L357_M0.7060.76
9_V93_Y0.7060.76
62_P65_N0.7060.76
3_L239_F0.7030.76
97_S239_F0.7020.76
182_G398_I0.7020.76
152_V413_E0.7010.75
224_I311_Y0.7000.75
78_V82_F0.6940.75
88_S239_F0.6940.75
108_K443_Q0.6930.75
29_Y193_I0.6920.75
111_G119_A0.6880.74
225_T307_V0.6820.73
25_G28_E0.6810.73
397_V400_L0.6790.73
43_L88_S0.6790.73
315_Q339_V0.6760.73
41_A273_V0.6750.73
185_F373_A0.6730.72
28_E282_R0.6720.72
443_Q446_A0.6690.72
97_S102_Y0.6690.72
370_Y391_R0.6690.72
169_D174_Q0.6680.72
50_W335_A0.6680.72
15_S290_I0.6670.72
121_I436_G0.6660.72
373_A387_D0.6660.72
9_V95_L0.6660.72
311_Y362_A0.6660.72
186_C396_V0.6640.71
9_V294_I0.6620.71
89_A419_V0.6580.71
84_H263_W0.6550.70
96_A270_T0.6540.70
288_E291_W0.6540.70
61_T68_P0.6540.70
30_S36_F0.6540.70
346_G351_A0.6540.70
120_A135_D0.6520.70
91_A294_I0.6520.70
197_L386_P0.6520.70
346_G349_F0.6520.70
188_S204_V0.6500.70
272_G364_H0.6500.70
432_V435_G0.6490.70
153_T156_T0.6490.70
115_S368_V0.6470.70
439_R442_K0.6450.69
78_V227_S0.6440.69
340_L344_P0.6440.69
101_A289_V0.6440.69
53_A56_A0.6440.69
254_F304_F0.6420.69
102_Y107_R0.6420.69
60_Q69_R0.6420.69
107_R150_L0.6400.69
324_P327_L0.6390.69
226_N229_I0.6390.69
229_I244_L0.6380.68
132_K136_L0.6380.68
164_L350_L0.6370.68
32_L295_L0.6370.68
158_T162_S0.6360.68
42_G274_A0.6360.68
11_Y14_T0.6360.68
377_T390_L0.6350.68
38_F42_G0.6340.68
189_S365_M0.6340.68
80_Y264_L0.6330.68
383_G386_P0.6330.68
289_V297_S0.6300.67
155_A174_Q0.6300.67
217_I397_V0.6290.67
148_I419_V0.6270.67
34_W292_G0.6260.67
204_V360_F0.6250.67
52_V312_A0.6190.66
212_P300_G0.6190.66
139_L372_M0.6180.66
55_W402_P0.6160.66
88_S92_T0.6130.65
339_V343_L0.6120.65
110_K127_Q0.6110.65
62_P73_A0.6080.65
142_T263_W0.6070.65
202_K206_W0.6070.65
341_M346_G0.6070.65
197_L367_A0.6050.64
44_G47_T0.6050.64
141_A268_S0.6050.64
143_V398_I0.6040.64
216_L224_I0.6020.64
178_I406_L0.6020.64
214_L344_P0.5980.63
35_L300_G0.5950.63
90_W360_F0.5940.63
102_Y437_F0.5940.63
106_V384_D0.5930.63
91_A95_L0.5920.63
95_L434_V0.5920.63
285_K288_E0.5920.63
217_I225_T0.5910.63
43_L266_W0.5910.63
75_E234_L0.5900.62
236_T239_F0.5890.62
215_V308_M0.5890.62
100_M275_M0.5880.62
118_I131_G0.5880.62
54_E258_W0.5870.62
57_Y332_G0.5860.62
247_D253_S0.5860.62
280_V433_K0.5840.62
379_N384_D0.5830.62
312_A339_V0.5810.61
310_S314_H0.5810.61
231_A249_L0.5800.61
133_L136_L0.5800.61
74_L223_F0.5790.61
10_I294_I0.5790.61
25_G29_Y0.5790.61
405_I412_L0.5770.61
86_G90_W0.5760.61
50_W245_F0.5750.60
311_Y314_H0.5750.60
192_G366_D0.5740.60
398_I419_V0.5730.60
267_I430_L0.5730.60
56_A335_A0.5720.60
442_K445_Y0.5720.60
222_E225_T0.5720.60
46_S266_W0.5690.60
36_F202_K0.5680.60
178_I403_L0.5680.60
215_V315_Q0.5680.60
21_R25_G0.5660.59
120_A131_G0.5650.59
159_R169_D0.5650.59
59_Y74_L0.5640.59
319_G324_P0.5640.59
408_T411_S0.5630.59
370_Y374_A0.5630.59
397_V401_I0.5620.59
102_Y286_I0.5600.58
269_Y273_V0.5600.58
441_L445_Y0.5590.58
104_F437_F0.5580.58
154_A178_I0.5580.58
417_T420_V0.5560.58
89_A93_Y0.5560.58
336_V357_M0.5560.58
13_A16_K0.5560.58
186_C399_T0.5560.58
94_T290_I0.5560.58
99_I267_I0.5550.58
442_K446_A0.5530.58
212_P216_L0.5520.57
163_A346_G0.5510.57
35_L111_G0.5510.57
332_G339_V0.5490.57
205_G359_I0.5490.57
121_I128_G0.5490.57
28_E279_R0.5490.57
63_G68_P0.5480.57
279_R391_R0.5470.57
55_W138_F0.5470.57
400_L404_S0.5470.57
221_T225_T0.5470.57
269_Y272_G0.5470.57
22_L282_R0.5460.57
120_A128_G0.5460.57
249_L411_S0.5460.57
373_A376_S0.5460.57
224_I310_S0.5450.56
180_L183_G0.5440.56
261_F264_L0.5440.56
114_L138_F0.5430.56
165_T351_A0.5430.56
428_V431_L0.5430.56
38_F277_V0.5430.56
124_V128_G0.5430.56
43_L262_Y0.5430.56
12_L441_L0.5430.56
384_D389_G0.5420.56
99_I104_F0.5410.56
50_W254_F0.5400.56
191_I365_M0.5400.56
181_S184_I0.5400.56
172_T348_L0.5380.55
107_R282_R0.5380.55
247_D250_G0.5380.55
54_E85_W0.5360.55
233_G248_P0.5360.55
179_L351_A0.5350.55
193_I388_R0.5340.55
157_F358_I0.5330.55
424_L427_L0.5330.55
298_T301_C0.5320.55
51_G436_G0.5320.55
92_T430_L0.5310.55
441_L444_D0.5310.55
45_S51_G0.5300.54
89_A301_C0.5300.54
133_L443_Q0.5290.54
311_Y315_Q0.5280.54
38_F367_A0.5280.54
185_F398_I0.5280.54
114_L426_F0.5270.54
185_F189_S0.5270.54
164_L277_V0.5250.54
327_L330_L0.5250.54
323_V339_V0.5240.54
336_V340_L0.5220.53
434_V438_I0.5220.53
11_Y19_N0.5200.53
120_A439_R0.5200.53
6_M294_I0.5190.53
48_L419_V0.5190.53
47_T208_A0.5190.53
157_F181_S0.5190.53
320_V323_V0.5180.53
149_S305_F0.5180.53
270_T373_A0.5180.53
413_E421_L0.5170.53
143_V365_M0.5160.52
303_F307_V0.5150.52
50_W258_W0.5150.52
413_E417_T0.5150.52
211_L353_Y0.5140.52
4_L69_R0.5140.52
331_G338_Q0.5130.52
51_G441_L0.5130.52
216_L354_L0.5120.52
141_A395_C0.5120.52
148_I152_V0.5120.52
261_F268_S0.5120.52
246_T255_T0.5090.51
443_Q447_D0.5080.51
12_L17_Y0.5080.51
6_M48_L0.5070.51
7_G240_L0.5070.51
87_I232_I0.5070.51
315_Q320_V0.5060.51
264_L424_L0.5060.51
76_F79_P0.5040.51
275_M374_A0.5040.51
232_I288_E0.5030.51
195_N198_Q0.5030.51
144_G371_T0.5020.51
244_L247_D0.5010.50
22_L102_Y0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c7rA 3 0.9751 100 0.066 Contact Map
2wswA 3 0.9231 100 0.069 Contact Map
2xq2A 2 0.8773 97.7 0.949 Contact Map
3dh4A 3 0.8337 97.4 0.953 Contact Map
3giaA 1 0.763 95.7 0.961 Contact Map
3l1lA 2 0.7734 94.2 0.964 Contact Map
4djkA 2 0.7214 88.9 0.969 Contact Map
2jlnA 1 0.738 74.3 0.974 Contact Map
4us3A 1 0.7173 59.5 0.976 Contact Map
4h33A 3 0.1705 37.1 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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