GREMLIN Database
HFLK - Modulator of FtsH protease HflK
UniProt: P0ABC7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10436
Length: 419 (343)
Sequences: 1259 (776)
Seq/√Len: 41.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_N172_K7.2681.00
114_F117_L6.8041.00
110_R130_D6.8031.00
172_K228_D4.6991.00
173_Y181_D4.4621.00
296_Q300_E4.0791.00
274_E278_R3.8741.00
187_A220_L3.7801.00
96_G124_W3.5281.00
92_W96_G3.2731.00
184_L231_I3.0781.00
357_Q360_K3.0511.00
116_H130_D2.9901.00
260_N263_Q2.8421.00
99_T122_L2.8271.00
106_G132_V2.7471.00
314_E317_A2.5731.00
125_K130_D2.5371.00
98_Y118_V2.4971.00
107_V174_L2.4761.00
166_R232_T2.4721.00
306_A310_K2.4261.00
110_R115_S2.4071.00
312_L316_K2.3381.00
329_E332_E2.2931.00
135_V170_P2.2691.00
140_V143_L2.1240.99
94_A124_W2.0950.99
288_E291_R2.0900.99
33_G36_Q2.0870.99
96_G125_K1.9600.99
115_S130_D1.9570.99
83_I87_A1.9490.99
218_R222_E1.9420.99
291_R295_A1.9320.99
161_M188_T1.9240.99
90_I94_A1.9160.99
211_V215_D1.8890.99
100_I106_G1.8800.99
47_K50_K1.8540.98
161_M192_L1.8190.98
179_S182_D1.7970.98
248_K252_D1.7880.98
242_R248_K1.7530.98
108_V130_D1.7250.97
216_T220_L1.7170.97
196_I204_I1.7030.97
139_A142_E1.6940.97
109_T133_K1.6710.97
97_F123_N1.6690.97
320_E324_E1.6650.97
46_R49_S1.6520.97
195_V216_T1.6510.97
215_D218_R1.6510.97
187_A223_T1.6460.97
84_A88_I1.6400.97
126_P130_D1.6380.97
105_R170_P1.6360.96
299_L302_Q1.6040.96
92_W124_W1.5940.96
37_G42_D1.5870.96
92_W125_K1.5800.96
109_T131_E1.5610.95
105_R120_P1.5350.95
263_Q267_E1.5290.95
135_V167_V1.5200.95
126_P129_I1.5180.95
55_L59_K1.5140.95
300_E304_E1.5010.94
172_K176_S1.4980.94
103_A136_N1.4970.94
38_P43_D1.4530.93
194_G198_K1.4520.93
194_G219_E1.4380.93
262_Q265_I1.4370.93
33_G38_P1.4370.93
38_P41_L1.4130.92
216_T238_F1.4100.92
82_T90_I1.4000.92
177_V229_M1.3990.92
52_L56_G1.3870.92
203_R207_E1.3800.91
255_I259_E1.3680.91
125_K128_F1.3680.91
39_P43_D1.3680.91
176_S228_D1.3610.91
201_M241_A1.3480.90
177_V184_L1.3480.90
146_S185_R1.3470.90
269_E280_N1.3290.90
253_D260_N1.3100.89
203_R208_G1.2980.89
221_E225_R1.2780.88
102_E166_R1.2760.88
184_L224_I1.2690.87
173_Y231_I1.2670.87
364_A368_K1.2580.87
183_S187_A1.2550.87
259_E262_Q1.2520.87
32_G38_P1.2490.87
191_A219_E1.2370.86
261_E296_Q1.2210.85
109_T113_K1.2130.85
285_R289_E1.2060.85
366_A371_N1.1980.84
80_V84_A1.1940.84
318_A322_T1.1890.84
78_G82_T1.1870.84
38_P44_I1.1810.83
138_E142_E1.1800.83
175_Y194_G1.1740.83
242_R252_D1.1740.83
85_A89_V1.1730.83
52_L55_L1.1700.83
106_G118_V1.1680.83
366_A375_N1.1670.82
95_S124_W1.1590.82
106_G136_N1.1560.82
367_A373_A1.1470.81
37_G46_R1.1300.80
212_I243_P1.1250.80
206_T251_F1.1210.80
111_F129_I1.1210.80
367_A371_N1.1060.79
111_F115_S1.0970.78
370_D375_N1.0940.78
98_Y122_L1.0930.78
191_A216_T1.0830.77
44_I89_V1.0810.77
238_F268_A1.0760.77
31_K37_G1.0700.77
147_G189_D1.0650.76
213_R235_D1.0570.76
49_S52_L1.0560.76
214_S217_Q1.0560.76
125_K132_V1.0490.75
197_G281_G1.0470.75
172_K286_I1.0440.75
105_R119_E1.0430.75
138_E141_R1.0420.75
43_D56_G1.0410.75
280_N287_L1.0380.74
36_Q39_P1.0280.74
365_P374_S1.0270.74
105_R166_R1.0250.73
367_A372_G1.0210.73
30_N33_G1.0180.73
37_G41_L1.0130.73
164_Q202_D1.0100.72
265_I274_E1.0030.72
79_R96_G1.0020.72
123_N239_Q1.0020.72
39_P44_I1.0000.72
278_R282_Q0.9980.71
86_A131_E0.9970.71
314_E318_A0.9830.70
106_G135_V0.9820.70
209_R252_D0.9730.69
372_G375_N0.9720.69
273_N276_Q0.9720.69
114_F171_E0.9690.69
162_N239_Q0.9690.69
43_D46_R0.9670.69
305_V309_A0.9610.69
366_A369_S0.9600.68
154_E259_E0.9570.68
194_G220_L0.9520.68
187_A252_D0.9520.68
46_R51_K0.9500.68
206_T268_A0.9470.67
367_A374_S0.9460.67
371_N374_S0.9420.67
255_I258_R0.9420.67
46_R332_E0.9380.67
47_K51_K0.9330.66
87_A91_I0.9320.66
188_T192_L0.9250.66
264_Y267_E0.9250.66
309_A313_P0.9230.65
45_F48_L0.9210.65
218_R365_P0.9200.65
85_A320_E0.9190.65
108_V132_V0.9160.65
135_V174_L0.9150.65
272_T299_L0.9140.65
371_N375_N0.9120.64
320_E342_L0.9110.64
294_K298_I0.9110.64
31_K35_D0.9010.63
265_I269_E0.8990.63
369_S374_S0.8980.63
261_E265_I0.8950.63
139_A143_L0.8930.63
140_V165_Y0.8890.62
46_R50_K0.8880.62
210_T214_S0.8850.62
81_V85_A0.8840.62
37_G43_D0.8810.62
170_P210_T0.8770.61
252_D255_I0.8770.61
367_A375_N0.8760.61
138_E143_L0.8750.61
317_A347_G0.8720.61
204_I272_T0.8720.61
162_N234_L0.8710.61
312_L315_Y0.8710.61
78_G90_I0.8710.61
348_G351_M0.8640.60
224_I326_L0.8630.60
106_G238_F0.8590.60
287_L304_E0.8590.60
50_K53_G0.8530.59
45_F49_S0.8520.59
198_K215_D0.8520.59
147_G266_R0.8500.59
191_A223_T0.8480.59
223_T227_Y0.8430.58
175_Y284_Q0.8420.58
251_F259_E0.8420.58
173_Y326_L0.8400.58
116_H123_N0.8400.58
320_E334_V0.8370.58
369_S373_A0.8360.58
318_A321_I0.8330.57
315_Y323_R0.8320.57
33_G58_G0.8280.57
366_A370_D0.8270.57
222_E363_N0.8250.57
269_E272_T0.8220.56
92_W128_F0.8200.56
182_D186_Q0.8190.56
34_R42_D0.8160.56
60_G85_A0.8120.55
359_L362_G0.8070.55
85_A374_S0.8060.55
258_R266_R0.8000.54
158_R221_E0.7990.54
92_W126_P0.7980.54
15_P18_S0.7960.54
280_N321_I0.7960.54
175_Y223_T0.7950.54
219_E223_T0.7940.54
100_I134_P0.7930.54
194_G307_R0.7920.54
260_N277_P0.7900.53
150_L271_Y0.7880.53
90_I306_A0.7870.53
106_G170_P0.7840.53
258_R276_Q0.7780.52
96_G253_D0.7760.52
109_T210_T0.7760.52
323_R354_P0.7760.52
143_L255_I0.7700.51
367_A370_D0.7670.51
365_P369_S0.7670.51
368_K373_A0.7650.51
165_Y186_Q0.7600.51
204_I212_I0.7600.51
318_A323_R0.7560.50
205_L241_A0.7530.50
110_R126_P0.7520.50
15_P31_K0.7510.50
36_Q44_I0.7480.49
283_A287_L0.7480.49
83_I216_T0.7470.49
192_L220_L0.7430.49
49_S77_G0.7420.49
148_V189_D0.7410.49
105_R241_A0.7390.49
76_L101_K0.7390.49
275_V351_M0.7380.48
330_T334_V0.7380.48
147_G246_E0.7380.48
148_V158_R0.7370.48
165_Y311_L0.7370.48
242_R256_A0.7340.48
137_V268_A0.7330.48
46_R342_L0.7310.48
252_D259_E0.7310.48
188_T220_L0.7300.48
309_A312_L0.7280.48
48_L53_G0.7280.48
14_D18_S0.7280.48
292_A307_R0.7270.47
32_G36_Q0.7260.47
45_F50_K0.7250.47
36_Q41_L0.7230.47
31_K61_T0.7180.47
71_G74_P0.7160.46
168_T232_T0.7160.46
30_N34_R0.7160.46
154_E201_M0.7160.46
84_A366_A0.7140.46
187_A190_S0.7130.46
14_D42_D0.7120.46
289_E343_V0.7080.46
87_A364_A0.7070.46
190_S311_L0.7060.46
188_T259_E0.7040.45
155_N325_R0.7020.45
35_D335_L0.7020.45
136_N317_A0.7010.45
273_N288_E0.7000.45
52_L59_K0.6980.45
180_P183_S0.6960.45
186_Q252_D0.6930.44
33_G46_R0.6930.44
90_I326_L0.6920.44
165_Y240_A0.6900.44
136_N252_D0.6900.44
73_R76_L0.6890.44
79_R83_I0.6890.44
295_A299_L0.6830.43
216_T219_E0.6830.43
286_I350_L0.6830.43
90_I367_A0.6810.43
341_V350_L0.6800.43
308_F315_Y0.6800.43
104_E134_P0.6790.43
304_E309_A0.6780.43
363_N373_A0.6750.43
143_L224_I0.6730.42
41_L47_K0.6720.42
162_N235_D0.6720.42
119_E328_I0.6710.42
77_G80_V0.6700.42
74_P87_A0.6680.42
350_L358_M0.6660.42
168_T225_R0.6650.42
109_T170_P0.6630.42
273_N283_A0.6630.42
82_T339_R0.6590.41
292_A347_G0.6590.41
210_T252_D0.6580.41
118_V126_P0.6570.41
50_K54_G0.6550.41
132_V210_T0.6550.41
38_P51_K0.6540.41
15_P30_N0.6540.41
221_E305_V0.6500.40
207_E273_N0.6500.40
165_Y242_R0.6490.40
366_A373_A0.6490.40
122_L159_V0.6490.40
287_L291_R0.6470.40
224_I229_M0.6420.40
110_R179_S0.6420.40
339_R351_M0.6420.40
325_R354_P0.6410.40
219_E238_F0.6400.39
279_A290_A0.6390.39
139_A238_F0.6360.39
330_T333_K0.6360.39
79_R91_I0.6350.39
292_A313_P0.6350.39
98_Y241_A0.6340.39
258_R326_L0.6340.39
43_D47_K0.6320.39
370_D373_A0.6300.39
368_K372_G0.6300.39
56_G60_G0.6290.38
247_V303_G0.6270.38
84_A297_T0.6260.38
191_A222_E0.6260.38
85_A370_D0.6250.38
261_E270_A0.6220.38
183_S227_Y0.6220.38
49_S55_L0.6180.38
81_V123_N0.6170.37
61_T73_R0.6150.37
162_N237_N0.6140.37
154_E253_D0.6130.37
286_I363_N0.6130.37
18_S59_K0.6120.37
98_Y273_N0.6080.37
292_A295_A0.6080.37
195_V212_I0.6080.37
165_Y201_M0.6060.36
251_F325_R0.6060.36
222_E225_R0.6050.36
98_Y116_H0.6040.36
359_L366_A0.6030.36
110_R125_K0.6030.36
364_A369_S0.6010.36
52_L233_L0.5990.36
88_I366_A0.5990.36
92_W95_S0.5980.36
137_V183_S0.5980.36
103_A166_R0.5980.36
83_I360_K0.5970.36
286_I364_A0.5960.36
57_G180_P0.5960.36
158_R229_M0.5940.35
238_F269_E0.5940.35
210_T216_T0.5930.35
50_K58_G0.5910.35
33_G60_G0.5890.35
48_L51_K0.5890.35
81_V88_I0.5880.35
53_G56_G0.5880.35
108_V116_H0.5870.35
201_M213_R0.5860.35
298_I340_K0.5860.35
155_N251_F0.5860.35
98_Y132_V0.5860.35
41_L46_R0.5850.35
277_P325_R0.5850.35
253_D277_P0.5850.35
93_A97_F0.5840.35
365_P371_N0.5830.34
87_A360_K0.5810.34
165_Y265_I0.5800.34
95_S208_G0.5800.34
136_N282_Q0.5800.34
311_L326_L0.5790.34
347_G356_D0.5770.34
154_E266_R0.5770.34
240_A252_D0.5770.34
106_G124_W0.5760.34
43_D90_I0.5760.34
82_T289_E0.5740.34
176_S212_I0.5730.34
123_N240_A0.5730.34
14_D17_G0.5720.34
103_A248_K0.5710.33
311_L334_V0.5710.33
233_L262_Q0.5670.33
313_P317_A0.5650.33
85_A90_I0.5650.33
167_V268_A0.5640.33
73_R85_A0.5640.33
91_I95_S0.5630.33
50_K364_A0.5610.33
179_S211_V0.5610.33
82_T85_A0.5600.33
265_I272_T0.5590.32
51_K58_G0.5570.32
362_G374_S0.5560.32
201_M246_E0.5560.32
238_F264_Y0.5560.32
242_R262_Q0.5550.32
200_T203_R0.5550.32
321_I352_V0.5550.32
31_K173_Y0.5530.32
41_L45_F0.5510.32
146_S219_E0.5500.32
194_G258_R0.5490.32
88_I226_P0.5480.32
365_P370_D0.5470.31
85_A363_N0.5470.31
153_D250_A0.5460.31
30_N59_K0.5460.31
95_S127_T0.5450.31
59_K132_V0.5440.31
361_G375_N0.5440.31
88_I92_W0.5410.31
272_T280_N0.5410.31
284_Q288_E0.5400.31
170_P174_L0.5400.31
160_E215_D0.5390.31
254_A273_N0.5380.31
73_R83_I0.5380.31
41_L44_I0.5370.31
335_L370_D0.5350.31
271_Y340_K0.5340.30
132_V167_V0.5340.30
248_K256_A0.5320.30
38_P56_G0.5320.30
345_D348_G0.5300.30
103_A235_D0.5300.30
111_F198_K0.5290.30
255_I262_Q0.5280.30
323_R334_V0.5280.30
108_V127_T0.5270.30
102_E122_L0.5270.30
233_L375_N0.5260.30
88_I328_I0.5260.30
105_R237_N0.5250.30
282_Q360_K0.5240.30
243_P251_F0.5220.30
293_Y307_R0.5220.30
220_L223_T0.5210.29
97_F122_L0.5210.29
192_L216_T0.5210.29
272_T336_G0.5210.29
315_Y322_T0.5210.29
240_A248_K0.5200.29
105_R267_E0.5180.29
88_I270_A0.5170.29
84_A218_R0.5170.29
190_S205_L0.5150.29
158_R343_V0.5150.29
83_I371_N0.5140.29
364_A371_N0.5140.29
141_R167_V0.5130.29
103_A138_E0.5130.29
191_A326_L0.5130.29
110_R260_N0.5130.29
97_F306_A0.5120.29
82_T86_A0.5120.29
217_Q238_F0.5110.29
89_V345_D0.5110.29
362_G365_P0.5110.29
191_A215_D0.5110.29
102_E225_R0.5100.29
302_Q305_V0.5090.28
153_D325_R0.5090.28
141_R144_A0.5080.28
306_A336_G0.5070.28
176_S291_R0.5050.28
287_L324_E0.5050.28
221_E266_R0.5040.28
163_V188_T0.5000.28
45_F54_G0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bk6A 3 0.4057 100 0.725 Contact Map
4fvgA 2 0.2601 100 0.776 Contact Map
1winA 1 0.3198 99.9 0.786 Contact Map
2rpbA 1 0.2697 99.9 0.814 Contact Map
4efaG 1 0.2172 76.3 0.964 Contact Map
2zuoA 7 0.7733 56 0.969 Contact Map
2kk7A 1 0.1241 25.5 0.974 Contact Map
2kogA 1 0.2267 21.1 0.975 Contact Map
3v6iB 1 0.222 21 0.975 Contact Map
2pk2A 3 0 20.7 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0108 seconds.