HFLC - ECOLI - GREMLIN Contacts

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HFLC - Modulator of FtsH protease HflC

UniProt:	P0ABC3	Sequences: MRKSVIAIIIIVLVVLYMSVFVVKEGERGITLRFGKVLRDDDNKPLVYEPGLHFKIPFIETVKMLDARIQTMDNQADRFVTKEKKDLIVDSYIKWRISDFSRYYLATGGGDISQAEVLLKRKFSDRLRSEIGRLDVKDIVTDSRGRLTLEVRDALNSGSAGTEDEVTTPAADNAIAEAAERVTAETKGKVPVINPNSMAALGIEVVDVRIKQINLPTEVSEAIYNRMRAEREAVARRHRSQGQEEAEKLRATADYEVTRTLAEAERQGRIMRGEGDAEAAKLFADAFSKDPDFYAFIRSLRAYENSFSGNQDVMVMSPDSDFFRYMKTPTSATR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10435
Length:	334 (310)
Sequences:	374 (252)
Seq/√Len:	14.3

ECOLI - HFLC HFLK QMCA
HALSA - Q9HSA8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
33_R	60_E	7.109	1.00
245_E	248_K	5.238	1.00
298_R	302_A	4.333	1.00
281_K	285_D	3.589	0.99
181_R	189_K	3.269	0.99
263_E	267_Q	3.130	0.98
8_I	15_V	3.088	0.98
6_I	9_I	2.892	0.97
235_A	239_R	2.740	0.96
259_R	263_E	2.678	0.95
119_L	205_V	2.559	0.94
92_Y	201_L	2.456	0.92
246_A	250_R	2.441	0.92
278_E	281_K	2.416	0.92
266_R	272_R	2.368	0.91
30_I	325_Y	2.366	0.91
267_Q	270_I	2.334	0.90
230_E	242_G	2.286	0.89
96_R	204_E	2.214	0.87
103_Y	250_R	2.140	0.85
6_I	14_V	2.020	0.82
37_V	222_A	1.992	0.81
222_A	229_A	1.956	0.80
29_G	63_K	1.954	0.80
21_F	25_E	1.939	0.79
68_R	209_R	1.933	0.79
126_R	132_G	1.920	0.78
293_F	303_Y	1.913	0.78
8_I	12_V	1.867	0.76
184_A	188_G	1.857	0.76
39_R	60_E	1.840	0.75
145_G	275_G	1.834	0.75
5_V	14_V	1.810	0.74
243_Q	246_A	1.804	0.74
92_Y	246_A	1.797	0.73
79_F	125_D	1.793	0.73
50_P	246_A	1.749	0.71
295_A	325_Y	1.738	0.71
195_P	205_V	1.738	0.71
36_K	263_E	1.720	0.70
198_M	201_L	1.711	0.70
9_I	192_V	1.676	0.68
280_A	302_A	1.665	0.67
152_R	155_L	1.656	0.67
245_E	249_L	1.655	0.67
6_I	10_I	1.630	0.66
33_R	36_K	1.627	0.66
106_A	132_G	1.627	0.66
66_D	209_R	1.622	0.65
211_K	229_A	1.621	0.65
256_E	259_R	1.617	0.65
32_L	35_G	1.598	0.64
7_A	15_V	1.598	0.64
276_D	283_F	1.590	0.64
9_I	280_A	1.588	0.64
8_I	30_I	1.584	0.63
231_R	242_G	1.577	0.63
140_V	259_R	1.577	0.63
9_I	204_E	1.556	0.62
13_L	56_I	1.550	0.62
23_V	29_G	1.549	0.62
37_V	101_S	1.546	0.61
14_V	18_M	1.545	0.61
20_V	26_G	1.528	0.61
224_Y	227_M	1.521	0.60
96_R	272_R	1.504	0.59
179_A	182_V	1.498	0.59
145_G	148_T	1.494	0.59
5_V	8_I	1.490	0.59
50_P	185_E	1.485	0.58
10_I	22_V	1.473	0.58
52_L	213_I	1.456	0.57
273_G	279_A	1.456	0.57
273_G	283_F	1.446	0.56
104_Y	129_S	1.443	0.56
29_G	62_V	1.422	0.55
127_L	250_R	1.421	0.55
227_M	231_R	1.419	0.55
88_I	139_I	1.389	0.53
9_I	180_E	1.387	0.53
25_E	35_G	1.386	0.53
29_G	132_G	1.372	0.52
77_D	100_F	1.368	0.52
33_R	238_H	1.358	0.51
74_N	275_G	1.354	0.51
190_V	294_Y	1.353	0.51
276_D	288_S	1.347	0.51
187_K	190_V	1.326	0.50
72_M	93_I	1.308	0.49
236_R	243_Q	1.304	0.48
235_A	242_G	1.296	0.48
273_G	277_A	1.293	0.48
103_Y	258_T	1.287	0.47
150_E	158_G	1.286	0.47
28_R	32_L	1.279	0.47
79_F	129_S	1.267	0.46
220_S	224_Y	1.264	0.46
189_K	278_E	1.251	0.46
21_F	30_I	1.246	0.45
145_G	149_L	1.241	0.45
25_E	32_L	1.195	0.43
15_V	20_V	1.194	0.42
8_I	23_V	1.191	0.42
183_T	190_V	1.191	0.42
233_A	265_E	1.184	0.42
9_I	14_V	1.176	0.41
9_I	12_V	1.160	0.41
50_P	218_E	1.153	0.40
107_T	132_G	1.151	0.40
135_D	233_A	1.148	0.40
99_D	324_R	1.147	0.40
132_G	216_P	1.145	0.40
127_L	253_A	1.144	0.40
104_Y	107_T	1.143	0.40
230_E	235_A	1.142	0.40
249_L	255_Y	1.140	0.40
182_V	251_A	1.138	0.39
5_V	12_V	1.138	0.39
83_E	212_Q	1.129	0.39
29_G	256_E	1.123	0.39
74_N	93_I	1.117	0.38
85_K	216_P	1.116	0.38
303_Y	322_F	1.114	0.38
50_P	69_I	1.113	0.38
66_D	108_G	1.113	0.38
153_D	309_G	1.110	0.38
50_P	92_Y	1.100	0.38
132_G	291_P	1.099	0.37
66_D	77_D	1.094	0.37
131_I	139_I	1.090	0.37
233_A	236_R	1.089	0.37
130_E	134_L	1.078	0.36
11_I	19_S	1.077	0.36
85_K	131_I	1.073	0.36
73_D	90_D	1.072	0.36
9_I	309_G	1.066	0.36
275_G	319_D	1.064	0.36
28_R	251_A	1.060	0.35
140_V	226_R	1.060	0.35
257_V	261_L	1.049	0.35
320_S	327_K	1.047	0.35
32_L	298_R	1.047	0.35
12_V	324_R	1.045	0.35
231_R	235_A	1.043	0.35
140_V	218_E	1.035	0.34
25_E	34_F	1.030	0.34
254_D	259_R	1.027	0.34
55_K	207_D	1.022	0.34
256_E	268_G	1.020	0.33
50_P	241_Q	1.016	0.33
118_L	121_R	1.015	0.33
227_M	242_G	1.015	0.33
28_R	67_A	1.006	0.33
256_E	285_D	1.003	0.33
10_I	14_V	1.000	0.33
215_L	251_A	0.996	0.32
123_F	208_V	0.995	0.32
75_Q	139_I	0.994	0.32
304_E	321_D	0.994	0.32
105_L	223_I	0.991	0.32
306_S	322_F	0.990	0.32
273_G	287_F	0.989	0.32
218_E	284_A	0.985	0.32
67_A	72_M	0.976	0.31
94_K	251_A	0.976	0.31
98_S	256_E	0.974	0.31
127_L	131_I	0.973	0.31
65_L	216_P	0.971	0.31
7_A	188_G	0.970	0.31
53_H	131_I	0.968	0.31
62_V	66_D	0.967	0.31
13_L	193_I	0.966	0.31
14_V	309_G	0.965	0.31
93_I	251_A	0.964	0.31
55_K	242_G	0.964	0.31
197_S	233_A	0.964	0.31
202_G	208_V	0.964	0.31
242_G	249_L	0.958	0.31
54_F	131_I	0.957	0.30
84_K	190_V	0.957	0.30
157_S	160_A	0.954	0.30
301_R	326_M	0.953	0.30
88_I	236_R	0.949	0.30
251_A	262_A	0.948	0.30
202_G	205_V	0.946	0.30
102_R	139_I	0.946	0.30
46_L	271_M	0.945	0.30
270_I	274_E	0.945	0.30
184_A	187_K	0.938	0.30
83_E	101_S	0.935	0.29
77_D	233_A	0.932	0.29
13_L	16_L	0.927	0.29
265_E	269_R	0.925	0.29
30_I	144_R	0.924	0.29
140_V	264_A	0.924	0.29
26_G	35_G	0.918	0.29
114_Q	238_H	0.916	0.29
196_N	199_A	0.913	0.28
81_T	87_L	0.909	0.28
103_Y	124_S	0.908	0.28
124_S	223_I	0.907	0.28
89_V	186_T	0.906	0.28
312_D	321_D	0.905	0.28
103_Y	127_L	0.904	0.28
126_R	139_I	0.895	0.28
211_K	273_G	0.891	0.28
293_F	300_L	0.891	0.28
136_V	194_N	0.886	0.27
241_Q	257_V	0.885	0.27
37_V	112_I	0.885	0.27
8_I	13_L	0.880	0.27
211_K	214_N	0.879	0.27
232_E	243_Q	0.878	0.27
240_S	283_F	0.875	0.27
203_I	267_Q	0.875	0.27
227_M	230_E	0.874	0.27
82_K	127_L	0.872	0.27
177_E	186_T	0.869	0.27
115_A	242_G	0.862	0.26
12_V	16_L	0.861	0.26
69_I	206_V	0.852	0.26
263_E	266_R	0.842	0.25
228_R	262_A	0.841	0.25
89_V	129_S	0.838	0.25
85_K	298_R	0.831	0.25
155_L	159_S	0.827	0.25
188_G	192_V	0.826	0.25
5_V	15_V	0.823	0.25
197_S	210_I	0.820	0.25
8_I	16_L	0.818	0.24
79_F	105_L	0.816	0.24
83_E	229_A	0.816	0.24
217_T	254_D	0.808	0.24
10_I	27_E	0.806	0.24
155_L	162_T	0.805	0.24
101_S	222_A	0.802	0.24
104_Y	213_I	0.800	0.24
114_Q	118_L	0.797	0.24
64_M	274_E	0.795	0.24
12_V	173_N	0.794	0.23
285_D	288_S	0.792	0.23
132_G	210_I	0.791	0.23
6_I	175_I	0.789	0.23
10_I	309_G	0.788	0.23
185_E	189_K	0.788	0.23
10_I	155_L	0.786	0.23
183_T	187_K	0.783	0.23
28_R	100_F	0.783	0.23
187_K	206_V	0.781	0.23
16_L	29_G	0.780	0.23
47_V	266_R	0.776	0.23
276_D	279_A	0.776	0.23
229_A	258_T	0.776	0.23
290_D	293_F	0.767	0.22
119_L	260_T	0.765	0.22
227_M	283_F	0.763	0.22
5_V	11_I	0.762	0.22
206_V	291_P	0.759	0.22
125_D	205_V	0.752	0.22
100_F	104_Y	0.751	0.22
15_V	157_S	0.751	0.22
78_R	107_T	0.751	0.22
82_K	118_L	0.747	0.22
16_L	289_K	0.744	0.22
152_R	157_S	0.744	0.22
5_V	319_D	0.743	0.22
28_R	72_M	0.738	0.21
92_Y	132_G	0.738	0.21
173_N	324_R	0.738	0.21
119_L	308_S	0.737	0.21
93_I	141_T	0.734	0.21
242_G	296_F	0.733	0.21
95_W	242_G	0.733	0.21
5_V	16_L	0.732	0.21
53_H	107_T	0.731	0.21
65_L	104_Y	0.729	0.21
34_F	207_D	0.728	0.21
21_F	32_L	0.726	0.21
188_G	292_D	0.726	0.21
94_K	215_L	0.725	0.21
130_E	216_P	0.723	0.21
8_I	162_T	0.723	0.21
174_A	191_P	0.722	0.21
10_I	15_V	0.721	0.21
266_R	316_M	0.719	0.21
244_E	248_K	0.717	0.21
191_P	252_T	0.714	0.20
61_T	254_D	0.712	0.20
31_T	54_F	0.711	0.20
182_V	186_T	0.711	0.20
207_D	227_M	0.710	0.20
321_D	327_K	0.710	0.20
32_L	36_K	0.707	0.20
245_E	255_Y	0.706	0.20
24_K	326_M	0.706	0.20
59_I	123_F	0.706	0.20
22_V	25_E	0.705	0.20
238_H	252_T	0.705	0.20
78_R	223_I	0.701	0.20
227_M	276_D	0.699	0.20
94_K	136_V	0.694	0.20
160_A	163_E	0.694	0.20
65_L	129_S	0.693	0.20
17_Y	208_V	0.692	0.20
309_G	316_M	0.689	0.20
31_T	119_L	0.684	0.19
11_I	192_V	0.682	0.19
83_E	100_F	0.679	0.19
72_M	80_V	0.675	0.19
221_E	232_E	0.675	0.19
82_K	278_E	0.672	0.19
16_L	254_D	0.669	0.19
26_G	308_S	0.668	0.19
100_F	266_R	0.668	0.19
283_F	288_S	0.666	0.19
321_D	325_Y	0.665	0.19
261_L	312_D	0.665	0.19
106_A	126_R	0.665	0.19
142_D	234_V	0.665	0.19
142_D	292_D	0.663	0.19
312_D	327_K	0.662	0.19
12_V	224_Y	0.661	0.19
74_N	80_V	0.659	0.19
72_M	214_N	0.658	0.19
253_A	262_A	0.656	0.18
14_V	113_S	0.655	0.18
181_R	185_E	0.654	0.18
123_F	134_L	0.653	0.18
182_V	215_L	0.652	0.18
68_R	96_R	0.652	0.18
82_K	194_N	0.649	0.18
243_Q	254_D	0.640	0.18
65_L	186_T	0.640	0.18
58_F	247_E	0.638	0.18
12_V	45_P	0.637	0.18
201_L	233_A	0.637	0.18
26_G	89_V	0.636	0.18
64_M	133_R	0.635	0.18
107_T	127_L	0.635	0.18
21_F	34_F	0.633	0.18
294_Y	298_R	0.633	0.18
53_H	102_R	0.633	0.18
223_I	227_M	0.630	0.18
27_E	280_A	0.629	0.18
162_T	172_D	0.628	0.18
279_A	286_A	0.628	0.18
61_T	89_V	0.627	0.18
7_A	17_Y	0.625	0.17
232_E	261_L	0.625	0.17
176_A	206_V	0.624	0.17
242_G	293_F	0.624	0.17
19_S	85_K	0.623	0.17
55_K	294_Y	0.622	0.17
238_H	241_Q	0.621	0.17
114_Q	127_L	0.621	0.17
100_F	200_A	0.620	0.17
28_R	138_D	0.618	0.17
9_I	289_K	0.618	0.17
273_G	296_F	0.614	0.17
275_G	283_F	0.614	0.17
102_R	208_V	0.611	0.17
127_L	300_L	0.610	0.17
66_D	312_D	0.609	0.17
124_S	217_T	0.609	0.17
6_I	12_V	0.607	0.17
64_M	96_R	0.605	0.17
50_P	65_L	0.604	0.17
19_S	219_V	0.604	0.17
95_W	294_Y	0.603	0.17
160_A	164_D	0.599	0.17
275_G	292_D	0.598	0.17
16_L	220_S	0.597	0.17
249_L	252_T	0.595	0.17
7_A	192_V	0.594	0.17
57_P	264_A	0.589	0.16
12_V	149_L	0.585	0.16
6_I	309_G	0.584	0.16
77_D	101_S	0.579	0.16
79_F	216_P	0.579	0.16
69_I	203_I	0.578	0.16
265_E	286_A	0.578	0.16
286_A	318_P	0.578	0.16
144_R	148_T	0.576	0.16
102_R	105_L	0.573	0.16
11_I	159_S	0.573	0.16
207_D	231_R	0.573	0.16
78_R	222_A	0.572	0.16
9_I	15_V	0.570	0.16
31_T	280_A	0.568	0.16
8_I	184_A	0.567	0.16
211_K	294_Y	0.565	0.16
200_A	267_Q	0.564	0.16
91_S	301_R	0.562	0.16
37_V	83_E	0.561	0.16
83_E	120_K	0.561	0.16
82_K	305_N	0.560	0.16
9_I	176_A	0.559	0.15
81_T	95_W	0.556	0.15
6_I	170_A	0.555	0.15
5_V	285_D	0.555	0.15
245_E	284_A	0.555	0.15
106_A	206_V	0.552	0.15
35_G	81_T	0.550	0.15
49_E	204_E	0.548	0.15
29_G	272_R	0.548	0.15
203_I	288_S	0.547	0.15
201_L	247_E	0.547	0.15
169_P	172_D	0.547	0.15
207_D	283_F	0.545	0.15
153_D	206_V	0.545	0.15
254_D	309_G	0.544	0.15
230_E	257_V	0.542	0.15
299_S	302_A	0.542	0.15
291_P	295_A	0.540	0.15
99_D	204_E	0.538	0.15
66_D	302_A	0.538	0.15
241_Q	246_A	0.537	0.15
103_Y	216_P	0.537	0.15
6_I	17_Y	0.537	0.15
213_I	245_E	0.536	0.15
228_R	244_E	0.535	0.15
100_F	286_A	0.535	0.15
122_K	125_D	0.534	0.15
6_I	13_L	0.533	0.15
90_D	231_R	0.532	0.15
53_H	127_L	0.532	0.15
72_M	251_A	0.531	0.15
154_A	263_E	0.531	0.15
22_V	178_A	0.530	0.15
66_D	255_Y	0.530	0.15
201_L	248_K	0.528	0.15
10_I	30_I	0.528	0.15
89_V	205_V	0.527	0.15
84_K	93_I	0.527	0.15
97_I	102_R	0.527	0.15
183_T	186_T	0.526	0.15
234_V	262_A	0.525	0.15
140_V	161_G	0.524	0.15
12_V	200_A	0.522	0.14
81_T	136_V	0.522	0.14
27_E	178_A	0.521	0.14
207_D	296_F	0.520	0.14
219_V	320_S	0.517	0.14
293_F	296_F	0.516	0.14
141_T	251_A	0.515	0.14
37_V	68_R	0.515	0.14
221_E	259_R	0.514	0.14
78_R	216_P	0.514	0.14
90_D	128_R	0.514	0.14
21_F	266_R	0.513	0.14
60_E	114_Q	0.512	0.14
83_E	222_A	0.512	0.14
16_L	288_S	0.512	0.14
254_D	274_E	0.511	0.14
45_P	142_D	0.509	0.14
36_K	172_D	0.508	0.14
47_V	67_A	0.507	0.14
111_D	130_E	0.506	0.14
15_V	319_D	0.506	0.14
94_K	122_K	0.506	0.14
93_I	182_V	0.505	0.14
65_L	97_I	0.503	0.14
141_T	182_V	0.501	0.14
11_I	15_V	0.501	0.14
77_D	323_F	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bk6A	3	0.509	100	0.694	Contact Map
1winA	1	0.4162	99.9	0.756	Contact Map
4fvgA	2	0.3263	99.9	0.761	Contact Map
2rpbA	1	0.3383	99.7	0.803	Contact Map
2zuoA	7	0.8263	89.4	0.944	Contact Map
3v6iA	1	0.3383	38.7	0.963	Contact Map
2dm9A	2	0.1587	35.7	0.963	Contact Map
2kk7A	1	0.1557	23.8	0.966	Contact Map
1dceA	1	0.3084	13.3	0.97	Contact Map
5ajiA	3	0.5449	10.5	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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