GREMLIN Database
HFLC - Modulator of FtsH protease HflC
UniProt: P0ABC3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10435
Length: 334 (310)
Sequences: 374 (252)
Seq/√Len: 14.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_R60_E7.1091.00
245_E248_K5.2381.00
298_R302_A4.3331.00
281_K285_D3.5890.99
181_R189_K3.2690.99
263_E267_Q3.1300.98
8_I15_V3.0880.98
6_I9_I2.8920.97
235_A239_R2.7400.96
259_R263_E2.6780.95
119_L205_V2.5590.94
92_Y201_L2.4560.92
246_A250_R2.4410.92
278_E281_K2.4160.92
266_R272_R2.3680.91
30_I325_Y2.3660.91
267_Q270_I2.3340.90
230_E242_G2.2860.89
96_R204_E2.2140.87
103_Y250_R2.1400.85
6_I14_V2.0200.82
37_V222_A1.9920.81
222_A229_A1.9560.80
29_G63_K1.9540.80
21_F25_E1.9390.79
68_R209_R1.9330.79
126_R132_G1.9200.78
293_F303_Y1.9130.78
8_I12_V1.8670.76
184_A188_G1.8570.76
39_R60_E1.8400.75
145_G275_G1.8340.75
5_V14_V1.8100.74
243_Q246_A1.8040.74
92_Y246_A1.7970.73
79_F125_D1.7930.73
50_P246_A1.7490.71
295_A325_Y1.7380.71
195_P205_V1.7380.71
36_K263_E1.7200.70
198_M201_L1.7110.70
9_I192_V1.6760.68
280_A302_A1.6650.67
152_R155_L1.6560.67
245_E249_L1.6550.67
6_I10_I1.6300.66
33_R36_K1.6270.66
106_A132_G1.6270.66
66_D209_R1.6220.65
211_K229_A1.6210.65
256_E259_R1.6170.65
32_L35_G1.5980.64
7_A15_V1.5980.64
276_D283_F1.5900.64
9_I280_A1.5880.64
8_I30_I1.5840.63
231_R242_G1.5770.63
140_V259_R1.5770.63
9_I204_E1.5560.62
13_L56_I1.5500.62
23_V29_G1.5490.62
37_V101_S1.5460.61
14_V18_M1.5450.61
20_V26_G1.5280.61
224_Y227_M1.5210.60
96_R272_R1.5040.59
179_A182_V1.4980.59
145_G148_T1.4940.59
5_V8_I1.4900.59
50_P185_E1.4850.58
10_I22_V1.4730.58
52_L213_I1.4560.57
273_G279_A1.4560.57
273_G283_F1.4460.56
104_Y129_S1.4430.56
29_G62_V1.4220.55
127_L250_R1.4210.55
227_M231_R1.4190.55
88_I139_I1.3890.53
9_I180_E1.3870.53
25_E35_G1.3860.53
29_G132_G1.3720.52
77_D100_F1.3680.52
33_R238_H1.3580.51
74_N275_G1.3540.51
190_V294_Y1.3530.51
276_D288_S1.3470.51
187_K190_V1.3260.50
72_M93_I1.3080.49
236_R243_Q1.3040.48
235_A242_G1.2960.48
273_G277_A1.2930.48
103_Y258_T1.2870.47
150_E158_G1.2860.47
28_R32_L1.2790.47
79_F129_S1.2670.46
220_S224_Y1.2640.46
189_K278_E1.2510.46
21_F30_I1.2460.45
145_G149_L1.2410.45
25_E32_L1.1950.43
15_V20_V1.1940.42
8_I23_V1.1910.42
183_T190_V1.1910.42
233_A265_E1.1840.42
9_I14_V1.1760.41
9_I12_V1.1600.41
50_P218_E1.1530.40
107_T132_G1.1510.40
135_D233_A1.1480.40
99_D324_R1.1470.40
132_G216_P1.1450.40
127_L253_A1.1440.40
104_Y107_T1.1430.40
230_E235_A1.1420.40
249_L255_Y1.1400.40
182_V251_A1.1380.39
5_V12_V1.1380.39
83_E212_Q1.1290.39
29_G256_E1.1230.39
74_N93_I1.1170.38
85_K216_P1.1160.38
303_Y322_F1.1140.38
50_P69_I1.1130.38
66_D108_G1.1130.38
153_D309_G1.1100.38
50_P92_Y1.1000.38
132_G291_P1.0990.37
66_D77_D1.0940.37
131_I139_I1.0900.37
233_A236_R1.0890.37
130_E134_L1.0780.36
11_I19_S1.0770.36
85_K131_I1.0730.36
73_D90_D1.0720.36
9_I309_G1.0660.36
275_G319_D1.0640.36
28_R251_A1.0600.35
140_V226_R1.0600.35
257_V261_L1.0490.35
320_S327_K1.0470.35
32_L298_R1.0470.35
12_V324_R1.0450.35
231_R235_A1.0430.35
140_V218_E1.0350.34
25_E34_F1.0300.34
254_D259_R1.0270.34
55_K207_D1.0220.34
256_E268_G1.0200.33
50_P241_Q1.0160.33
118_L121_R1.0150.33
227_M242_G1.0150.33
28_R67_A1.0060.33
256_E285_D1.0030.33
10_I14_V1.0000.33
215_L251_A0.9960.32
123_F208_V0.9950.32
75_Q139_I0.9940.32
304_E321_D0.9940.32
105_L223_I0.9910.32
306_S322_F0.9900.32
273_G287_F0.9890.32
218_E284_A0.9850.32
67_A72_M0.9760.31
94_K251_A0.9760.31
98_S256_E0.9740.31
127_L131_I0.9730.31
65_L216_P0.9710.31
7_A188_G0.9700.31
53_H131_I0.9680.31
62_V66_D0.9670.31
13_L193_I0.9660.31
14_V309_G0.9650.31
93_I251_A0.9640.31
55_K242_G0.9640.31
197_S233_A0.9640.31
202_G208_V0.9640.31
242_G249_L0.9580.31
54_F131_I0.9570.30
84_K190_V0.9570.30
157_S160_A0.9540.30
301_R326_M0.9530.30
88_I236_R0.9490.30
251_A262_A0.9480.30
202_G205_V0.9460.30
102_R139_I0.9460.30
46_L271_M0.9450.30
270_I274_E0.9450.30
184_A187_K0.9380.30
83_E101_S0.9350.29
77_D233_A0.9320.29
13_L16_L0.9270.29
265_E269_R0.9250.29
30_I144_R0.9240.29
140_V264_A0.9240.29
26_G35_G0.9180.29
114_Q238_H0.9160.29
196_N199_A0.9130.28
81_T87_L0.9090.28
103_Y124_S0.9080.28
124_S223_I0.9070.28
89_V186_T0.9060.28
312_D321_D0.9050.28
103_Y127_L0.9040.28
126_R139_I0.8950.28
211_K273_G0.8910.28
293_F300_L0.8910.28
136_V194_N0.8860.27
241_Q257_V0.8850.27
37_V112_I0.8850.27
8_I13_L0.8800.27
211_K214_N0.8790.27
232_E243_Q0.8780.27
240_S283_F0.8750.27
203_I267_Q0.8750.27
227_M230_E0.8740.27
82_K127_L0.8720.27
177_E186_T0.8690.27
115_A242_G0.8620.26
12_V16_L0.8610.26
69_I206_V0.8520.26
263_E266_R0.8420.25
228_R262_A0.8410.25
89_V129_S0.8380.25
85_K298_R0.8310.25
155_L159_S0.8270.25
188_G192_V0.8260.25
5_V15_V0.8230.25
197_S210_I0.8200.25
8_I16_L0.8180.24
79_F105_L0.8160.24
83_E229_A0.8160.24
217_T254_D0.8080.24
10_I27_E0.8060.24
155_L162_T0.8050.24
101_S222_A0.8020.24
104_Y213_I0.8000.24
114_Q118_L0.7970.24
64_M274_E0.7950.24
12_V173_N0.7940.23
285_D288_S0.7920.23
132_G210_I0.7910.23
6_I175_I0.7890.23
10_I309_G0.7880.23
185_E189_K0.7880.23
10_I155_L0.7860.23
183_T187_K0.7830.23
28_R100_F0.7830.23
187_K206_V0.7810.23
16_L29_G0.7800.23
47_V266_R0.7760.23
276_D279_A0.7760.23
229_A258_T0.7760.23
290_D293_F0.7670.22
119_L260_T0.7650.22
227_M283_F0.7630.22
5_V11_I0.7620.22
206_V291_P0.7590.22
125_D205_V0.7520.22
100_F104_Y0.7510.22
15_V157_S0.7510.22
78_R107_T0.7510.22
82_K118_L0.7470.22
16_L289_K0.7440.22
152_R157_S0.7440.22
5_V319_D0.7430.22
28_R72_M0.7380.21
92_Y132_G0.7380.21
173_N324_R0.7380.21
119_L308_S0.7370.21
93_I141_T0.7340.21
242_G296_F0.7330.21
95_W242_G0.7330.21
5_V16_L0.7320.21
53_H107_T0.7310.21
65_L104_Y0.7290.21
34_F207_D0.7280.21
21_F32_L0.7260.21
188_G292_D0.7260.21
94_K215_L0.7250.21
130_E216_P0.7230.21
8_I162_T0.7230.21
174_A191_P0.7220.21
10_I15_V0.7210.21
266_R316_M0.7190.21
244_E248_K0.7170.21
191_P252_T0.7140.20
61_T254_D0.7120.20
31_T54_F0.7110.20
182_V186_T0.7110.20
207_D227_M0.7100.20
321_D327_K0.7100.20
32_L36_K0.7070.20
245_E255_Y0.7060.20
24_K326_M0.7060.20
59_I123_F0.7060.20
22_V25_E0.7050.20
238_H252_T0.7050.20
78_R223_I0.7010.20
227_M276_D0.6990.20
94_K136_V0.6940.20
160_A163_E0.6940.20
65_L129_S0.6930.20
17_Y208_V0.6920.20
309_G316_M0.6890.20
31_T119_L0.6840.19
11_I192_V0.6820.19
83_E100_F0.6790.19
72_M80_V0.6750.19
221_E232_E0.6750.19
82_K278_E0.6720.19
16_L254_D0.6690.19
26_G308_S0.6680.19
100_F266_R0.6680.19
283_F288_S0.6660.19
321_D325_Y0.6650.19
261_L312_D0.6650.19
106_A126_R0.6650.19
142_D234_V0.6650.19
142_D292_D0.6630.19
312_D327_K0.6620.19
12_V224_Y0.6610.19
74_N80_V0.6590.19
72_M214_N0.6580.19
253_A262_A0.6560.18
14_V113_S0.6550.18
181_R185_E0.6540.18
123_F134_L0.6530.18
182_V215_L0.6520.18
68_R96_R0.6520.18
82_K194_N0.6490.18
243_Q254_D0.6400.18
65_L186_T0.6400.18
58_F247_E0.6380.18
12_V45_P0.6370.18
201_L233_A0.6370.18
26_G89_V0.6360.18
64_M133_R0.6350.18
107_T127_L0.6350.18
21_F34_F0.6330.18
294_Y298_R0.6330.18
53_H102_R0.6330.18
223_I227_M0.6300.18
27_E280_A0.6290.18
162_T172_D0.6280.18
279_A286_A0.6280.18
61_T89_V0.6270.18
7_A17_Y0.6250.17
232_E261_L0.6250.17
176_A206_V0.6240.17
242_G293_F0.6240.17
19_S85_K0.6230.17
55_K294_Y0.6220.17
238_H241_Q0.6210.17
114_Q127_L0.6210.17
100_F200_A0.6200.17
28_R138_D0.6180.17
9_I289_K0.6180.17
273_G296_F0.6140.17
275_G283_F0.6140.17
102_R208_V0.6110.17
127_L300_L0.6100.17
66_D312_D0.6090.17
124_S217_T0.6090.17
6_I12_V0.6070.17
64_M96_R0.6050.17
50_P65_L0.6040.17
19_S219_V0.6040.17
95_W294_Y0.6030.17
160_A164_D0.5990.17
275_G292_D0.5980.17
16_L220_S0.5970.17
249_L252_T0.5950.17
7_A192_V0.5940.17
57_P264_A0.5890.16
12_V149_L0.5850.16
6_I309_G0.5840.16
77_D101_S0.5790.16
79_F216_P0.5790.16
69_I203_I0.5780.16
265_E286_A0.5780.16
286_A318_P0.5780.16
144_R148_T0.5760.16
102_R105_L0.5730.16
11_I159_S0.5730.16
207_D231_R0.5730.16
78_R222_A0.5720.16
9_I15_V0.5700.16
31_T280_A0.5680.16
8_I184_A0.5670.16
211_K294_Y0.5650.16
200_A267_Q0.5640.16
91_S301_R0.5620.16
37_V83_E0.5610.16
83_E120_K0.5610.16
82_K305_N0.5600.16
9_I176_A0.5590.15
81_T95_W0.5560.15
6_I170_A0.5550.15
5_V285_D0.5550.15
245_E284_A0.5550.15
106_A206_V0.5520.15
35_G81_T0.5500.15
49_E204_E0.5480.15
29_G272_R0.5480.15
203_I288_S0.5470.15
201_L247_E0.5470.15
169_P172_D0.5470.15
207_D283_F0.5450.15
153_D206_V0.5450.15
254_D309_G0.5440.15
230_E257_V0.5420.15
299_S302_A0.5420.15
291_P295_A0.5400.15
99_D204_E0.5380.15
66_D302_A0.5380.15
241_Q246_A0.5370.15
103_Y216_P0.5370.15
6_I17_Y0.5370.15
213_I245_E0.5360.15
228_R244_E0.5350.15
100_F286_A0.5350.15
122_K125_D0.5340.15
6_I13_L0.5330.15
90_D231_R0.5320.15
53_H127_L0.5320.15
72_M251_A0.5310.15
154_A263_E0.5310.15
22_V178_A0.5300.15
66_D255_Y0.5300.15
201_L248_K0.5280.15
10_I30_I0.5280.15
89_V205_V0.5270.15
84_K93_I0.5270.15
97_I102_R0.5270.15
183_T186_T0.5260.15
234_V262_A0.5250.15
140_V161_G0.5240.15
12_V200_A0.5220.14
81_T136_V0.5220.14
27_E178_A0.5210.14
207_D296_F0.5200.14
219_V320_S0.5170.14
293_F296_F0.5160.14
141_T251_A0.5150.14
37_V68_R0.5150.14
221_E259_R0.5140.14
78_R216_P0.5140.14
90_D128_R0.5140.14
21_F266_R0.5130.14
60_E114_Q0.5120.14
83_E222_A0.5120.14
16_L288_S0.5120.14
254_D274_E0.5110.14
45_P142_D0.5090.14
36_K172_D0.5080.14
47_V67_A0.5070.14
111_D130_E0.5060.14
15_V319_D0.5060.14
94_K122_K0.5060.14
93_I182_V0.5050.14
65_L97_I0.5030.14
141_T182_V0.5010.14
11_I15_V0.5010.14
77_D323_F0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bk6A 3 0.509 100 0.694 Contact Map
1winA 1 0.4162 99.9 0.756 Contact Map
4fvgA 2 0.3263 99.9 0.761 Contact Map
2rpbA 1 0.3383 99.7 0.803 Contact Map
2zuoA 7 0.8263 89.4 0.944 Contact Map
3v6iA 1 0.3383 38.7 0.963 Contact Map
2dm9A 2 0.1587 35.7 0.963 Contact Map
2kk7A 1 0.1557 23.8 0.966 Contact Map
1dceA 1 0.3084 13.3 0.97 Contact Map
5ajiA 3 0.5449 10.5 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0101 seconds.