GREMLIN Database
ATPZ - ATP synthase protein I
UniProt: P0ABC0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10106
Length: 126 (115)
Sequences: 312 (222)
Seq/√Len: 20.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_A104_L2.7230.99
46_A93_A2.6620.98
53_L81_F2.6560.98
108_W112_L2.6350.98
17_V111_V2.4650.97
59_W65_T2.4360.97
16_L20_L2.3740.97
94_L105_I2.3650.97
27_L34_P2.1990.95
41_I44_G2.1650.94
78_G102_L2.1140.94
47_V112_L1.9190.90
22_V48_F1.9060.89
55_M68_K1.8930.89
59_W63_A1.7790.86
58_A74_T1.7720.86
22_V111_V1.7660.85
28_L32_K1.7630.85
63_A74_T1.6600.82
77_F83_V1.6040.79
33_D72_A1.5080.75
9_N90_L1.5050.75
58_A61_H1.4890.74
75_F79_E1.4370.71
17_V28_L1.3750.68
98_K109_V1.3280.65
66_P69_G1.3260.65
40_A107_T1.3200.64
84_L108_W1.3180.64
35_F38_V1.3070.64
45_L50_P1.2940.63
14_L119_P1.2730.61
25_S110_L1.2720.61
91_V95_A1.2670.61
41_I84_L1.2660.61
38_V99_A1.2600.61
27_L31_L1.2510.60
93_A104_L1.2310.59
22_V44_G1.2280.59
99_A103_P1.2240.58
72_A76_A1.2220.58
12_R15_L1.2040.57
42_S97_L1.1630.54
58_A65_T1.1620.54
29_F103_P1.1600.54
20_L25_S1.1510.54
87_L108_W1.1490.53
14_L104_L1.1430.53
78_G84_L1.1430.53
90_L105_I1.1350.53
46_A89_L1.1320.52
65_T90_L1.0950.50
62_Q65_T1.0770.49
37_G41_I1.0750.49
116_I120_A1.0730.48
76_A80_A1.0670.48
17_V106_V1.0640.48
13_K121_V1.0600.48
14_L18_Q1.0580.47
34_P37_G1.0470.47
57_F112_L1.0430.47
54_F118_A1.0400.46
19_L29_F1.0260.45
49_L52_V1.0170.45
15_L89_L0.9980.44
61_H74_T0.9900.43
44_G112_L0.9880.43
11_A14_L0.9720.42
25_S35_F0.9700.42
83_V108_W0.9650.41
21_V108_W0.9620.41
72_A99_A0.9560.41
33_D111_V0.9410.40
53_L57_F0.9290.39
15_L48_F0.9190.39
49_L95_A0.9100.38
51_N61_H0.9100.38
42_S99_A0.9060.38
29_F40_A0.9020.37
25_S33_D0.8910.37
70_R92_V0.8850.36
61_H65_T0.8810.36
109_V118_A0.8690.35
20_L34_P0.8690.35
15_L52_V0.8490.34
67_A119_P0.8440.34
44_G115_Q0.8430.34
27_L108_W0.8180.32
38_V62_Q0.8110.32
71_V112_L0.8090.32
74_T94_L0.8090.32
25_S69_G0.8050.32
26_G41_I0.8050.32
78_G103_P0.7940.31
57_F76_A0.7910.31
88_V102_L0.7850.31
45_L74_T0.7840.31
62_Q78_G0.7780.30
68_K76_A0.7740.30
95_A108_W0.7720.30
52_V61_H0.7680.30
61_H80_A0.7650.29
66_P103_P0.7550.29
26_G111_V0.7530.29
43_G82_K0.7490.29
102_L109_V0.7410.28
12_R123_N0.7330.28
37_G63_A0.7210.27
57_F78_G0.7190.27
68_K79_E0.7150.27
94_L101_F0.7120.27
28_L68_K0.7080.26
62_Q66_P0.7070.26
53_L71_V0.7030.26
83_V86_M0.6950.26
40_A103_P0.6860.25
58_A104_L0.6830.25
65_T71_V0.6780.25
62_Q68_K0.6750.25
98_K103_P0.6740.25
39_S60_R0.6720.25
38_V97_L0.6610.24
74_T92_V0.6570.24
58_A71_V0.6550.24
99_A116_I0.6540.24
80_A119_P0.6500.24
75_F86_M0.6440.23
42_S118_A0.6400.23
76_A116_I0.6350.23
14_L98_K0.6340.23
52_V56_I0.6270.22
58_A86_M0.6260.22
75_F89_L0.6180.22
47_V89_L0.6140.22
8_R17_V0.6120.22
36_W40_A0.6070.22
50_P85_A0.6070.22
23_I91_V0.6030.21
111_V119_P0.6010.21
14_L54_F0.5980.21
99_A102_L0.5980.21
91_V94_L0.5910.21
84_L103_P0.5900.21
27_L45_L0.5900.21
49_L87_L0.5890.21
19_L75_F0.5890.21
44_G92_V0.5880.21
65_T68_K0.5830.21
38_V111_V0.5820.20
26_G87_L0.5820.20
47_V69_G0.5680.20
18_Q37_G0.5660.20
60_R63_A0.5650.20
19_L62_Q0.5630.20
26_G101_F0.5610.20
57_F61_H0.5600.20
30_S34_P0.5500.19
91_V104_L0.5490.19
34_P38_V0.5470.19
32_K115_Q0.5450.19
47_V117_L0.5450.19
55_M108_W0.5400.19
62_Q71_V0.5340.19
13_K30_S0.5320.18
38_V42_S0.5320.18
95_A104_L0.5250.18
46_A90_L0.5240.18
19_L41_I0.5120.18
86_M108_W0.5090.18
75_F106_V0.5080.17
66_P72_A0.5010.17
11_A53_L0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j01B 1 0.3889 1.3 0.959 Contact Map
4czbA 2 0.9603 1.2 0.96 Contact Map
3w4tA 1 0.5159 1.2 0.96 Contact Map
3j1zP 8 0.9841 1.1 0.961 Contact Map
2zy9A 2 0.9206 1.1 0.961 Contact Map
2khfA 1 0.1984 1 0.962 Contact Map
4humA 1 0.5794 0.8 0.964 Contact Map
3j45G 1 0.5079 0.8 0.965 Contact Map
4tq3A 1 0.7143 0.7 0.966 Contact Map
4lz6A 1 0.5159 0.7 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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