GREMLIN Database
ATPA - ATP synthase subunit alpha
UniProt: P0ABB0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10098
Length: 513 (427)
Sequences: 7753 (2618)
Seq/√Len: 126.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_N113_A7.9441.00
161_R255_D4.6211.00
196_V242_G4.4551.00
356_E369_N4.1391.00
41_I73_A3.7801.00
440_S443_Q3.7141.00
51_E90_C3.2911.00
152_A368_V3.2481.00
393_I427_V3.1001.00
385_I449_F3.0281.00
53_I73_A2.9761.00
93_R96_E2.8881.00
106_R116_D2.7581.00
53_I88_V2.6441.00
61_A73_A2.5921.00
47_C63_A2.5731.00
194_I246_G2.5631.00
101_R254_E2.5241.00
144_Q161_R2.4831.00
243_C328_P2.4681.00
54_S89_K2.4561.00
102_G124_D2.4441.00
96_E126_F2.4351.00
246_G324_L2.3751.00
151_K439_M2.3721.00
382_Q387_K2.2941.00
159_I327_L2.2881.00
392_G395_T2.2761.00
177_A435_Q2.2671.00
215_H219_A2.2251.00
41_I88_V2.2241.00
155_S444_Q2.1731.00
108_V245_M2.1431.00
127_S131_A2.1211.00
359_L364_I2.1101.00
210_R213_E2.1081.00
40_R70_S2.1081.00
224_V245_M2.0971.00
118_K213_E2.0561.00
337_V354_F2.0361.00
216_G219_A2.0171.00
401_R404_A1.9881.00
210_R214_E1.9751.00
392_G419_K1.9711.00
384_K388_K1.9611.00
48_M51_E1.9571.00
206_S210_R1.9511.00
156_M393_I1.9491.00
31_I82_L1.9301.00
33_S40_R1.9291.00
209_V223_V1.9021.00
389_L449_F1.8811.00
424_G428_T1.8711.00
28_E87_K1.8061.00
159_I353_I1.7981.00
247_E300_R1.7861.00
460_E463_K1.7851.00
56_P87_K1.7671.00
407_S421_L1.7621.00
32_V42_H1.7471.00
364_I428_T1.7431.00
222_I245_M1.7361.00
147_Q154_D1.7291.00
364_I432_K1.7031.00
127_S244_A1.7021.00
127_S248_Y1.6951.00
404_A408_Q1.6921.00
155_S430_L1.6891.00
454_G457_A1.6811.00
466_S470_A1.6781.00
144_Q303_R1.6731.00
362_A428_T1.6671.00
106_R118_K1.6641.00
330_I345_V1.6411.00
450_A455_Y1.6361.00
51_E92_G1.6251.00
125_G252_R1.6191.00
170_D173_T1.6091.00
429_E432_K1.6081.00
108_V224_V1.6071.00
27_N90_C1.6061.00
97_V245_M1.5941.00
463_K466_S1.5931.00
459_V463_K1.5911.00
363_G391_G1.5651.00
194_I245_M1.5651.00
106_R119_G1.5451.00
98_P126_F1.5371.00
103_L245_M1.5341.00
389_L445_S1.5071.00
102_G122_D1.5011.00
158_P378_G1.4931.00
55_L61_A1.4931.00
31_I86_M1.4851.00
422_D425_Q1.4761.00
450_A456_L1.4631.00
166_L349_T1.4601.00
102_G123_H1.4571.00
95_L129_V1.4521.00
101_R248_Y1.4511.00
32_V70_S1.4461.00
255_D323_S1.4451.00
434_K437_A1.4171.00
411_S422_D1.4121.00
146_V191_I1.4071.00
248_Y252_R1.3981.00
378_G390_S1.3931.00
264_S268_V1.3921.00
399_Q417_T1.3921.00
148_T159_I1.3891.00
399_Q402_E1.3851.00
198_I238_A1.3851.00
30_T87_K1.3821.00
127_S251_D1.3821.00
47_C71_V1.3811.00
196_V260_Y1.3791.00
26_H89_K1.3771.00
93_R126_F1.3641.00
41_I44_L1.3551.00
243_C301_A1.3531.00
56_P89_K1.3511.00
109_N230_E1.3461.00
256_A324_L1.3421.00
395_T416_A1.3371.00
47_C53_I1.3371.00
386_M445_S1.3311.00
197_A205_I1.3301.00
239_P297_L1.3281.00
339_A342_P1.3191.00
211_K380_A1.3131.00
213_E218_L1.3131.00
114_P119_G1.3091.00
177_A436_Y1.3081.00
106_R114_P1.3061.00
79_Y82_L1.3051.00
97_V241_A1.3011.00
362_A404_A1.2951.00
383_T441_V1.2911.00
459_V467_F1.2901.00
131_A251_D1.2901.00
54_S91_T1.2891.00
253_G321_T1.2721.00
446_L450_A1.2611.00
298_L348_I1.2541.00
60_Y113_A1.2491.00
391_G394_R1.2371.00
107_V209_V1.2331.00
403_L417_T1.2300.99
142_V160_G1.2290.99
270_Y293_L1.2270.99
147_Q441_V1.2250.99
190_G254_E1.2240.99
140_Q143_D1.2150.99
214_E217_A1.2100.99
42_H69_D1.1970.99
294_H345_V1.1950.99
34_V82_L1.1900.99
118_K121_L1.1890.99
379_G387_K1.1850.99
415_D419_K1.1800.99
159_I325_T1.1800.99
274_S282_G1.1770.99
358_N361_N1.1640.99
243_C324_L1.1630.99
372_I401_R1.1550.99
449_F453_R1.1520.99
157_I353_I1.1480.99
104_L222_I1.1450.99
123_H126_F1.1450.99
153_V183_I1.1390.99
30_T42_H1.1380.99
423_H457_A1.1310.99
392_G396_A1.1300.99
56_P86_M1.1270.99
153_V353_I1.1240.99
138_E320_K1.1190.99
419_K423_H1.1090.99
145_P381_A1.1080.99
298_L345_V1.1070.99
53_I61_A1.1050.99
75_V79_Y1.0990.99
443_Q447_V1.0980.99
377_V381_A1.0970.99
42_H70_S1.0940.99
427_V451_A1.0900.99
364_I431_L1.0900.99
110_T241_A1.0890.99
101_R252_R1.0780.99
125_G248_Y1.0750.99
191_I249_F1.0680.99
408_Q414_D1.0650.99
202_A227_T1.0620.99
222_I249_F1.0610.99
196_V258_I1.0600.98
263_L345_V1.0600.98
116_D119_G1.0580.98
170_D357_T1.0560.98
150_Y178_L1.0540.98
54_S60_Y1.0520.98
184_I221_T1.0490.98
150_Y153_V1.0460.98
332_T339_A1.0410.98
170_D335_G1.0370.98
138_E319_G1.0340.98
456_L459_V1.0320.98
332_T342_P1.0320.98
148_T327_L1.0250.98
98_P123_H1.0190.98
77_G234_L1.0140.98
230_E234_L1.0130.98
40_R67_E1.0080.98
263_L298_L1.0060.98
403_L407_S1.0030.98
240_Y293_L1.0000.98
148_T154_D0.9980.98
191_I254_E0.9910.98
52_M91_T0.9890.98
165_E327_L0.9860.98
106_R121_L0.9860.98
358_N401_R0.9860.98
100_G103_L0.9820.98
127_S252_R0.9800.97
252_R256_A0.9790.97
387_K391_G0.9750.97
110_T234_L0.9700.97
41_I53_I0.9690.97
378_G382_Q0.9680.97
103_L222_I0.9680.97
456_L467_F0.9580.97
335_G338_S0.9570.97
415_D418_R0.9570.97
439_M447_V0.9550.97
294_H348_I0.9490.97
359_L432_K0.9470.97
55_L86_M0.9440.97
110_T115_I0.9430.97
198_I260_Y0.9400.97
369_N372_I0.9350.97
395_T399_Q0.9350.97
335_G357_T0.9330.97
103_L108_V0.9300.97
190_G255_D0.9220.96
113_A120_P0.9120.96
337_V372_I0.9100.96
235_Q272_Q0.9090.96
414_D417_T0.9080.96
422_D426_K0.9030.96
242_G258_I0.8970.96
28_E89_K0.8960.96
354_F357_T0.8960.96
268_V286_F0.8950.96
152_A431_L0.8910.96
250_R256_A0.8910.96
243_C258_I0.8870.95
159_I165_E0.8850.95
155_S448_L0.8780.95
101_R249_F0.8770.95
419_K422_D0.8760.95
400_Y424_G0.8750.95
463_K467_F0.8680.95
119_G123_H0.8620.95
108_V121_L0.8620.95
351_G376_R0.8610.95
106_R115_I0.8600.95
201_K204_T0.8600.95
193_C196_V0.8590.95
337_V342_P0.8570.95
158_P441_V0.8560.95
170_D343_T0.8550.94
463_K470_A0.8530.94
83_A86_M0.8490.94
38_V277_L0.8470.94
207_N380_A0.8470.94
292_Y295_S0.8460.94
268_V333_Q0.8460.94
51_E154_D0.8440.94
342_P354_F0.8400.94
135_G138_E0.8400.94
140_Q303_R0.8400.94
110_T230_E0.8390.94
303_R323_S0.8380.94
95_L237_L0.8370.94
200_Q204_T0.8370.94
184_I220_N0.8330.94
267_A294_H0.8280.94
184_I187_R0.8270.93
255_D303_R0.8260.93
217_A221_T0.8240.93
160_G377_V0.8220.93
209_V213_E0.8200.93
393_I452_E0.8190.93
50_G63_A0.8190.93
219_A222_I0.8170.93
266_Q297_L0.8170.93
379_G394_R0.8170.93
147_Q438_P0.8160.93
144_Q255_D0.8150.93
57_G81_D0.8140.93
294_H344_N0.8130.93
301_A326_A0.8110.93
462_S465_G0.8080.93
262_D329_I0.8080.93
38_V72_G0.8080.93
378_G386_M0.8050.93
96_E128_A0.8010.92
140_Q319_G0.7940.92
439_M444_Q0.7900.92
198_I239_P0.7870.92
51_E91_T0.7860.92
248_Y251_D0.7860.92
361_N372_I0.7850.92
393_I448_L0.7850.92
51_E94_I0.7850.92
170_D336_D0.7810.91
388_K392_G0.7810.91
154_D444_Q0.7780.91
77_G113_A0.7770.91
148_T153_V0.7770.91
145_P158_P0.7750.91
102_G125_G0.7750.91
290_V293_L0.7720.91
62_I76_M0.7720.91
194_I222_I0.7710.91
396_A427_V0.7710.91
168_I342_P0.7700.91
99_V244_A0.7700.91
217_A220_N0.7690.91
156_M390_S0.7640.90
39_I55_L0.7600.90
395_T432_K0.7600.90
399_Q403_L0.7590.90
389_L448_L0.7570.90
129_V241_A0.7560.90
256_A272_Q0.7510.90
397_L427_V0.7500.90
74_V273_I0.7480.90
147_Q440_S0.7470.89
400_Y404_A0.7460.89
153_V157_I0.7460.89
31_I39_I0.7450.89
286_F336_D0.7440.89
334_A339_A0.7430.89
35_S409_F0.7390.89
400_Y428_T0.7390.89
141_S380_A0.7380.89
146_V187_R0.7380.89
170_D285_A0.7380.89
241_A244_A0.7370.89
384_K466_S0.7360.89
238_A242_G0.7360.89
94_I128_A0.7340.89
184_I259_I0.7330.89
336_D343_T0.7310.88
430_L447_V0.7310.88
140_Q321_T0.7300.88
157_I368_V0.7280.88
53_I71_V0.7280.88
413_L421_L0.7240.88
115_I120_P0.7220.88
240_Y266_Q0.7210.88
158_P382_Q0.7210.88
461_L465_G0.7210.88
386_M441_V0.7210.88
121_L124_D0.7200.88
104_L218_L0.7200.88
423_H454_G0.7180.88
396_A419_K0.7180.88
416_A425_Q0.7170.87
52_M60_Y0.7160.87
412_D418_R0.7150.87
382_Q445_S0.7110.87
443_Q446_L0.7110.87
266_Q293_L0.7100.87
388_K391_G0.7090.87
109_N115_I0.7080.87
184_I195_Y0.7060.87
231_S234_L0.7050.87
157_I374_V0.7040.86
467_F470_A0.7040.86
183_I327_L0.7040.86
158_P386_M0.7030.86
259_I329_I0.7020.86
76_M234_L0.7020.86
383_T445_S0.7010.86
111_L114_P0.7000.86
247_E250_R0.6990.86
260_Y297_L0.6990.86
161_R323_S0.6950.86
77_G231_S0.6920.86
283_R344_N0.6910.85
354_F372_I0.6890.85
171_R348_I0.6890.85
145_P377_V0.6880.85
370_P397_L0.6880.85
113_A126_F0.6870.85
200_Q265_K0.6870.85
257_L327_L0.6860.85
458_D465_G0.6850.85
55_L88_V0.6850.85
174_G261_D0.6850.85
453_R464_I0.6850.85
214_E218_L0.6830.85
405_A408_Q0.6800.85
34_V129_V0.6790.84
142_V377_V0.6760.84
383_T386_M0.6720.84
205_I225_V0.6700.84
67_E72_G0.6690.84
404_A428_T0.6670.83
397_L401_R0.6670.83
95_L154_D0.6660.83
66_L84_E0.6640.83
98_P124_D0.6640.83
397_L424_G0.6640.83
399_Q416_A0.6630.83
236_Y270_Y0.6630.83
95_L241_A0.6630.83
146_V159_I0.6610.83
41_I71_V0.6590.83
213_E219_A0.6580.83
150_Y435_Q0.6580.83
392_G452_E0.6580.83
226_A230_E0.6540.82
116_D121_L0.6530.82
148_T301_A0.6520.82
74_V277_L0.6510.82
122_D125_G0.6480.82
382_Q390_S0.6480.82
343_T346_I0.6460.81
417_T421_L0.6450.81
173_T357_T0.6440.81
118_K218_L0.6380.81
97_V100_G0.6370.81
386_M390_S0.6370.81
183_I257_L0.6370.81
396_A452_E0.6360.80
371_G397_L0.6360.80
114_P121_L0.6330.80
458_D467_F0.6310.80
396_A420_Q0.6310.80
462_S466_S0.6310.80
188_D255_D0.6310.80
268_V344_N0.6310.80
180_I208_V0.6290.80
338_S345_V0.6280.80
152_A370_P0.6280.80
377_V382_Q0.6270.79
356_E372_I0.6270.79
104_L191_I0.6260.79
25_A89_K0.6260.79
267_A341_V0.6260.79
459_V462_S0.6260.79
108_V111_L0.6250.79
235_Q247_E0.6250.79
167_I353_I0.6250.79
114_P120_P0.6250.79
423_H426_K0.6240.79
40_R72_G0.6220.79
175_K261_D0.6210.79
460_E466_S0.6210.79
201_K265_K0.6200.79
188_D191_I0.6190.79
155_S158_P0.6190.79
92_G95_L0.6190.79
465_G470_A0.6180.79
193_C221_T0.6180.79
47_C90_C0.6170.78
184_I193_C0.6160.78
258_I301_A0.6160.78
243_C246_G0.6150.78
239_P260_Y0.6140.78
143_D303_R0.6140.78
115_I225_V0.6130.78
60_Y63_A0.6130.78
385_I389_L0.6120.78
189_S220_N0.6110.78
143_D321_T0.6110.78
52_M95_L0.6090.78
132_I296_R0.6090.78
193_C259_I0.6090.78
114_P118_K0.6080.77
106_R120_P0.6080.77
243_C260_Y0.6060.77
128_A131_A0.6050.77
160_G381_A0.6050.77
245_M249_F0.6050.77
35_S38_V0.6040.77
453_R465_G0.6030.77
441_V445_S0.6030.77
150_Y182_A0.6020.77
147_Q442_A0.6010.77
147_Q444_Q0.5990.76
165_E351_G0.5990.76
120_P123_H0.5980.76
426_K461_L0.5970.76
72_G277_L0.5970.76
426_K429_E0.5950.76
182_A185_N0.5930.76
43_G47_C0.5920.76
460_E470_A0.5910.75
66_L72_G0.5910.75
279_R302_A0.5890.75
160_G376_R0.5890.75
126_F419_K0.5880.75
271_R341_V0.5880.75
266_Q270_Y0.5870.75
182_A186_Q0.5870.75
425_Q428_T0.5870.75
128_A244_A0.5860.75
107_V115_I0.5850.75
78_P81_D0.5840.75
104_L254_E0.5840.75
180_I225_V0.5810.74
65_N72_G0.5800.74
392_G460_E0.5790.74
102_G119_G0.5790.74
211_K214_E0.5790.74
453_R456_L0.5770.74
407_S417_T0.5770.74
403_L408_Q0.5730.73
39_I79_Y0.5710.73
102_G121_L0.5710.73
429_E465_G0.5700.73
171_R347_S0.5700.73
110_T114_P0.5700.73
91_T94_I0.5690.73
213_E221_T0.5690.73
171_R268_V0.5670.72
115_I230_E0.5660.72
195_Y205_I0.5660.72
383_T449_F0.5650.72
101_R124_D0.5630.72
389_L452_E0.5630.72
461_L464_I0.5620.72
154_D186_Q0.5620.72
103_L123_H0.5600.71
44_L47_C0.5590.71
27_N45_A0.5590.71
143_D440_S0.5590.71
125_G128_A0.5580.71
440_S446_L0.5580.71
64_L277_L0.5570.71
263_L297_L0.5560.71
158_P374_V0.5550.71
244_A248_Y0.5550.71
445_S449_F0.5540.71
145_P441_V0.5540.71
99_V103_L0.5530.71
57_G89_K0.5530.71
384_K434_K0.5510.70
130_E240_Y0.5510.70
171_R346_I0.5510.70
120_P124_D0.5510.70
303_R319_G0.5500.70
461_L466_S0.5490.70
250_R324_L0.5480.70
107_V225_V0.5480.70
165_E353_I0.5460.70
243_C247_E0.5460.70
411_S421_L0.5450.69
430_L444_Q0.5450.69
236_Y273_I0.5430.69
347_S374_V0.5430.69
108_V112_G0.5430.69
418_R422_D0.5420.69
111_L409_F0.5420.69
212_L217_A0.5420.69
410_A418_R0.5400.69
153_V178_L0.5390.69
31_I34_V0.5380.68
240_Y277_L0.5380.68
55_L60_Y0.5380.68
170_D332_T0.5370.68
110_T113_A0.5360.68
464_I467_F0.5360.68
224_V241_A0.5350.68
184_I215_H0.5340.68
76_M240_Y0.5340.68
458_D464_I0.5340.68
167_I402_E0.5330.68
130_E296_R0.5330.68
159_I187_R0.5320.68
447_V450_A0.5320.68
168_I349_T0.5320.68
161_R292_Y0.5310.67
460_E464_I0.5310.67
38_V240_Y0.5290.67
151_K447_V0.5270.67
74_V405_A0.5260.67
205_I227_T0.5260.67
286_F405_A0.5260.67
176_T261_D0.5250.67
27_N46_D0.5240.66
441_V444_Q0.5240.66
336_D339_A0.5240.66
197_A200_Q0.5240.66
143_D380_A0.5220.66
383_T388_K0.5220.66
62_I95_L0.5200.66
442_A446_L0.5190.66
118_K123_H0.5190.66
48_M83_A0.5180.66
137_I369_N0.5170.65
140_Q320_K0.5170.65
101_R120_P0.5160.65
38_V276_L0.5160.65
144_Q321_T0.5150.65
104_L107_V0.5150.65
379_G382_Q0.5150.65
35_S277_L0.5140.65
218_L223_V0.5130.65
363_G395_T0.5130.65
231_S235_Q0.5120.65
25_A28_E0.5120.65
235_Q250_R0.5110.65
283_R287_P0.5100.64
298_L328_P0.5100.64
350_D376_R0.5100.64
48_M66_L0.5100.64
333_Q338_S0.5090.64
216_G221_T0.5080.64
458_D463_K0.5060.64
379_G435_Q0.5060.64
235_Q326_A0.5060.64
359_L362_A0.5060.64
233_A273_I0.5060.64
235_Q268_V0.5050.64
76_M111_L0.5050.64
383_T442_A0.5040.63
53_I63_A0.5040.63
75_V82_L0.5040.63
230_E287_P0.5020.63
334_A343_T0.5010.63
270_Y273_I0.5010.63
186_Q438_P0.5010.63
272_Q286_F0.5010.63
148_T168_I0.5010.63
413_L417_T0.5000.63
123_H248_Y0.5000.63
188_D219_A0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oaaA 2 0.9513 100 0.065 Contact Map
2qe7A 1 0.924 100 0.073 Contact Map
1fx0A 1 0.9298 100 0.088 Contact Map
2ck3A 1 0.9337 100 0.091 Contact Map
2r9vA 1 0.9474 100 0.097 Contact Map
3j9tA 1 0.9259 100 0.173 Contact Map
3mfyA 1 0.7778 100 0.175 Contact Map
3vr4A 1 0.9318 100 0.184 Contact Map
3gqbA 1 0.922 100 0.186 Contact Map
3vr4D 1 0.8441 100 0.19 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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