GREMLIN Database
ATPG - ATP synthase gamma chain
UniProt: P0ABA6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10104
Length: 287 (283)
Sequences: 3886 (2418)
Seq/√Len: 143.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_S122_G6.0551.00
211_D214_A5.0241.00
91_L235_N4.1771.00
239_E243_R3.7001.00
75_R112_Q3.4031.00
174_K184_T3.3971.00
248_K252_D3.3951.00
18_Q255_G3.1511.00
79_L156_M2.9611.00
28_A240_Q2.9591.00
75_R114_D2.9271.00
169_Y187_Q2.7931.00
77_G165_L2.7751.00
159_A164_R2.7611.00
98_K101_A2.6831.00
103_M115_L2.6271.00
78_Y102_E2.5171.00
158_Q162_E2.4661.00
135_A155_V2.4371.00
170_I231_G2.4291.00
114_D134_V2.4151.00
167_K187_Q2.3541.00
176_I182_V2.2021.00
71_R166_D2.1661.00
123_V136_Q2.1191.00
80_V99_L2.1011.00
99_L126_F2.0951.00
256_S260_E2.0911.00
240_Q243_R2.0701.00
36_Q40_A2.0181.00
102_E105_T1.9931.00
82_S96_F1.9881.00
48_T51_K1.9161.00
155_V159_A1.9081.00
154_K158_Q1.8431.00
25_E248_K1.8401.00
105_T109_K1.8341.00
96_F125_F1.8051.00
91_L173_N1.8041.00
165_L168_L1.8011.00
117_M122_G1.7851.00
277_L281_V1.7791.00
100_L125_F1.7661.00
171_V185_I1.7591.00
176_I180_S1.7511.00
102_E171_V1.7411.00
15_Q262_Q1.7271.00
174_K182_V1.6701.00
177_N180_S1.6551.00
99_L171_V1.6511.00
117_M133_V1.6481.00
169_Y185_I1.6371.00
73_V166_D1.6241.00
114_D132_N1.5991.00
149_L232_V1.5961.00
74_K166_D1.5931.00
10_K261_L1.5811.00
98_K102_E1.5751.00
15_Q18_Q1.5691.00
159_A165_L1.5511.00
43_R234_E1.5481.00
173_N238_S1.5261.00
275_Q279_E1.5221.00
88_C243_R1.5201.00
76_V169_Y1.5101.00
153_V225_E1.5021.00
115_L131_G1.4731.00
79_L228_V1.4711.00
98_K183_P1.3991.00
10_K267_K1.3971.00
102_E169_Y1.3761.00
99_L103_M1.3731.00
275_Q278_T1.3651.00
264_V268_A1.3401.00
98_K185_I1.3391.00
114_D165_L1.3361.00
95_L171_V1.3151.00
95_L99_L1.3141.00
66_P69_E1.2981.00
155_V158_Q1.2891.00
17_T20_I1.2821.00
279_E282_S1.2771.00
17_T21_T1.2741.00
268_A272_S1.2721.00
123_V138_T1.2721.00
255_G259_K1.2701.00
14_V17_T1.2551.00
18_Q25_E1.2521.00
77_G116_A1.2451.00
33_R37_D1.2321.00
36_Q175_F1.2241.00
88_C92_N1.2241.00
5_K9_S1.2051.00
8_R12_A1.1981.00
100_L129_V1.1921.00
261_L264_V1.1881.00
80_V95_L1.1671.00
236_L240_Q1.1651.00
278_T282_S1.1571.00
77_G168_L1.1561.00
114_D164_R1.1450.99
115_L126_F1.1390.99
78_Y113_C1.1350.99
96_F126_F1.1340.99
99_L115_L1.1310.99
83_T92_N1.1310.99
77_G156_M1.1300.99
25_E244_M1.1280.99
64_K69_E1.1270.99
80_V122_G1.1200.99
187_Q192_P1.1110.99
223_Y227_Q1.1110.99
173_N235_N1.1090.99
117_M123_V1.0990.99
281_V284_A1.0940.99
186_S227_Q1.0930.99
27_V31_K1.0870.99
39_M237_A1.0710.99
65_H68_L1.0660.99
7_I265_Y1.0650.99
3_G6_E1.0580.99
114_D159_A1.0470.99
101_A105_T1.0430.99
100_L126_F1.0370.99
100_L104_K1.0360.99
11_I258_I1.0270.99
159_A162_E1.0190.99
116_A134_V1.0160.99
24_M87_L1.0110.99
178_T241_A1.0090.99
6_E9_S1.0040.99
76_V167_K1.0030.99
78_Y99_L0.9930.98
259_K263_L0.9850.98
32_M241_A0.9850.98
66_P161_D0.9800.98
77_G134_V0.9780.98
75_R164_R0.9770.98
2_A275_Q0.9760.98
256_S259_K0.9670.98
84_D139_G0.9660.98
16_N42_S0.9640.98
150_I154_K0.9630.98
152_P228_V0.9610.98
74_K112_Q0.9580.98
103_M113_C0.9580.98
50_R227_Q0.9390.98
79_L170_I0.9290.98
66_P70_D0.9280.98
79_L116_A0.9270.98
83_T91_L0.9260.98
102_E185_I0.9250.98
181_Q242_A0.9250.98
53_I216_L0.9230.98
79_L168_L0.9210.98
149_L153_V0.9210.98
80_V126_F0.9190.97
19_K88_C0.9180.97
37_D41_A0.9180.97
156_M168_L0.9150.97
22_K25_E0.9110.97
116_A159_A0.9090.97
213_K217_D0.9090.97
88_C239_E0.9060.97
253_N257_L0.8920.97
71_R74_K0.8900.97
110_G113_C0.8770.97
271_A279_E0.8740.97
188_L224_V0.8710.97
172_S238_S0.8700.97
146_L229_Y0.8680.96
123_V127_N0.8670.96
282_S285_A0.8660.96
46_A227_Q0.8600.96
252_D256_S0.8600.96
35_S237_A0.8600.96
80_V96_F0.8590.96
29_A173_N0.8560.96
116_A156_M0.8550.96
175_F238_S0.8540.96
145_S148_E0.8530.96
118_I152_P0.8410.96
127_N136_Q0.8350.96
192_P195_D0.8350.96
230_Q234_E0.8330.96
226_S230_Q0.8320.96
70_D192_P0.8280.95
28_A121_K0.8280.95
43_R47_E0.8250.95
75_R166_D0.8250.95
88_C278_T0.8240.95
154_K225_E0.8180.95
83_T173_N0.8110.95
63_Y68_L0.8110.95
78_Y171_V0.8080.95
81_V232_V0.8070.95
4_A8_R0.8050.95
42_S230_Q0.8010.94
148_E151_G0.7980.94
96_F129_V0.7980.94
10_K254_G0.7950.94
73_V76_V0.7950.94
7_I264_V0.7940.94
181_Q241_A0.7930.94
202_K205_D0.7910.94
45_Y49_M0.7860.94
76_V111_V0.7820.94
14_V261_L0.7800.94
130_G133_V0.7780.94
101_A104_K0.7780.94
51_K120_S0.7760.94
73_V167_K0.7750.93
85_R268_A0.7750.93
171_V183_P0.7730.93
7_I242_A0.7550.93
116_A135_A0.7550.93
67_Y157_L0.7490.92
153_V228_V0.7470.92
275_Q285_A0.7440.92
245_V249_A0.7390.92
84_D173_N0.7370.92
21_T251_T0.7360.92
141_G144_P0.7290.91
97_K101_A0.7270.91
200_K203_S0.7250.91
282_S287_V0.7220.91
20_I24_M0.7200.91
28_A40_A0.7190.91
120_S138_T0.7170.91
26_M36_Q0.7170.91
84_D142_D0.7170.91
74_K111_V0.7170.91
78_Y103_M0.7150.90
75_R165_L0.7150.90
53_I191_L0.7140.90
158_Q161_D0.7130.90
137_V152_P0.7100.90
151_G155_V0.7080.90
126_F131_G0.7080.90
71_R160_Y0.7070.90
12_A16_N0.7050.90
10_K221_R0.7020.90
174_K238_S0.7020.90
127_N133_V0.7020.90
26_M30_S0.7010.90
39_M234_E0.6960.89
95_L235_N0.6960.89
120_S124_S0.6950.89
81_V91_L0.6950.89
142_D236_L0.6920.89
277_L282_S0.6910.89
15_Q258_I0.6880.89
247_M250_A0.6850.88
11_I14_V0.6850.88
96_F99_L0.6840.88
66_P71_R0.6830.88
91_L190_P0.6810.88
91_L238_S0.6800.88
29_A35_S0.6780.88
238_S243_R0.6780.88
153_V156_M0.6750.88
10_K14_V0.6720.87
83_T239_E0.6710.87
109_K112_Q0.6700.87
76_V113_C0.6700.87
83_T236_L0.6650.87
222_R226_S0.6640.87
16_N19_K0.6640.87
7_I267_K0.6610.87
124_S277_L0.6600.87
29_A244_M0.6600.87
93_I97_K0.6560.86
257_L260_E0.6550.86
21_T254_G0.6540.86
12_A15_Q0.6530.86
65_H70_D0.6530.86
70_D167_K0.6520.86
90_G93_I0.6480.86
252_D257_L0.6470.85
78_Y169_Y0.6470.85
112_Q132_N0.6450.85
149_L228_V0.6420.85
22_K251_T0.6420.85
175_F241_A0.6380.85
59_G206_Y0.6330.84
25_E32_M0.6320.84
201_H204_W0.6310.84
20_I87_L0.6310.84
153_V224_V0.6310.84
215_L227_Q0.6300.84
24_M28_A0.6290.84
100_L131_G0.6270.84
105_T108_D0.6260.84
146_L150_I0.6260.84
17_T92_N0.6240.83
76_V110_G0.6210.83
223_Y226_S0.6210.83
245_V248_K0.6210.83
121_K175_F0.6200.83
56_L219_L0.6190.83
116_A137_V0.6180.83
146_L222_R0.6180.83
49_M223_Y0.6170.83
125_F129_V0.6150.82
104_K108_D0.6150.82
150_I225_E0.6120.82
6_E242_A0.6110.82
133_V136_Q0.6100.82
33_R84_D0.6090.82
198_D202_K0.6090.82
47_E51_K0.6060.82
14_V21_T0.6030.81
27_V36_Q0.6020.81
58_H203_S0.6010.81
81_V231_G0.5980.81
23_A209_E0.5970.81
67_Y161_D0.5950.80
95_L183_P0.5940.80
14_V33_R0.5920.80
233_V236_L0.5910.80
181_Q238_S0.5910.80
63_Y217_D0.5900.80
186_S230_Q0.5890.80
157_L161_D0.5870.79
17_T31_K0.5850.79
153_V157_L0.5840.79
91_L181_Q0.5840.79
245_V277_L0.5830.79
271_A275_Q0.5830.79
46_A230_Q0.5820.79
210_P215_L0.5820.79
263_L266_N0.5820.79
26_M206_Y0.5810.79
255_G258_I0.5810.79
70_D199_L0.5780.78
151_G154_K0.5760.78
5_K85_R0.5760.78
118_I122_G0.5740.78
198_D201_H0.5740.78
179_M245_V0.5730.78
43_R174_K0.5720.78
174_K186_S0.5710.78
260_E264_V0.5700.77
159_A163_G0.5690.77
258_I262_Q0.5680.77
74_K167_K0.5680.77
181_Q224_V0.5670.77
229_Y233_V0.5640.77
18_Q258_I0.5640.77
199_L203_S0.5640.77
122_G126_F0.5600.76
249_A258_I0.5590.76
36_Q39_M0.5580.76
211_D215_L0.5570.76
50_R54_G0.5570.76
99_L102_E0.5560.76
160_Y267_K0.5550.76
269_R273_I0.5550.76
24_M243_R0.5550.76
7_I27_V0.5540.75
109_K202_K0.5540.75
19_K124_S0.5530.75
31_K92_N0.5520.75
98_K171_V0.5520.75
25_E30_S0.5510.75
122_G279_E0.5500.75
172_S186_S0.5500.75
60_N203_S0.5500.75
79_L118_I0.5500.75
202_K213_K0.5490.75
179_M287_V0.5460.74
284_A287_V0.5420.74
81_V235_N0.5420.74
222_R229_Y0.5410.74
161_D168_L0.5400.74
58_H199_L0.5400.74
51_K55_H0.5390.73
87_L118_I0.5390.73
214_A217_D0.5370.73
251_T276_E0.5350.73
173_N183_P0.5330.73
147_S150_I0.5320.73
67_Y71_R0.5300.72
246_A253_N0.5280.72
30_S61_L0.5280.72
224_V231_G0.5280.72
19_K27_V0.5270.72
56_L220_L0.5260.72
19_K141_G0.5260.72
2_A6_E0.5250.72
50_R230_Q0.5240.71
28_A108_D0.5240.71
152_P156_M0.5230.71
27_V30_S0.5230.71
23_A263_L0.5230.71
168_L189_L0.5220.71
97_K166_D0.5220.71
10_K256_S0.5200.71
64_K68_L0.5190.71
156_M165_L0.5180.71
33_R240_Q0.5170.70
251_T254_G0.5160.70
32_M230_Q0.5140.70
75_R110_G0.5140.70
16_N244_M0.5120.70
161_D164_R0.5120.70
32_M36_Q0.5090.69
58_H200_K0.5090.69
101_A199_L0.5090.69
81_V118_I0.5070.69
13_S17_T0.5070.69
8_R275_Q0.5070.69
28_A260_E0.5060.69
59_G212_P0.5050.69
148_E160_Y0.5050.69
93_I125_F0.5040.68
108_D111_V0.5040.68
206_Y233_V0.5030.68
69_E72_D0.5030.68
267_K272_S0.5020.68
283_G287_V0.5010.68
117_M126_F0.5010.68
64_K70_D0.5010.68
96_F115_L0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qe7G 1 0.7909 100 -0.018 Contact Map
3oaaG 2 0.9895 100 -0.013 Contact Map
2xokG 1 0.9164 100 0.039 Contact Map
3ziaG 1 0.9164 100 0.055 Contact Map
2ck3G 1 0.6272 100 0.065 Contact Map
1fs0G 2 0.7631 100 0.28 Contact Map
1qw2A 3 0.3449 12.6 0.965 Contact Map
2ec4A 1 0.4634 8.2 0.968 Contact Map
2xusA 5 0.1463 6.3 0.97 Contact Map
2x31A 2 0.4774 5.7 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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