GREMLIN Database
ATPD - ATP synthase subunit delta
UniProt: P0ABA4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10105
Length: 177 (169)
Sequences: 4174 (3207)
Seq/√Len: 246.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_V103_S3.8111.00
80_M92_V3.0531.00
110_D142_K2.7271.00
122_L141_C2.5881.00
130_E136_K2.5771.00
112_I144_D2.4601.00
152_I163_S2.3551.00
110_D140_N2.3191.00
31_M70_D2.2841.00
119_E123_A2.2441.00
119_E122_L2.1971.00
62_I78_R2.1201.00
58_A82_E2.0051.00
123_A127_A1.9911.00
123_A126_S1.9881.00
118_S121_Q1.9711.00
32_L93_L1.9571.00
24_S70_D1.8501.00
31_M73_G1.7951.00
110_D154_R1.7701.00
95_Q98_H1.7651.00
26_E104_E1.6571.00
108_E138_K1.6411.00
59_E63_A1.6261.00
112_I142_K1.6051.00
100_R104_E1.5961.00
113_S141_C1.5881.00
56_T59_E1.5591.00
122_L126_S1.5451.00
147_V163_S1.5301.00
62_I66_G1.5281.00
166_G170_R1.5211.00
113_S151_V1.4701.00
109_V155_A1.4551.00
113_S117_L1.4431.00
19_A28_W1.4271.00
114_A143_I1.4241.00
107_A135_R1.4101.00
24_S27_R1.4031.00
149_A164_V1.3911.00
127_A131_K1.3871.00
36_A94_E1.3841.00
16_F103_S1.3791.00
81_A86_L1.3781.00
33_A97_I1.3771.00
55_E59_E1.3421.00
44_M64_V1.3381.00
53_A56_T1.3321.00
29_Q97_I1.3281.00
111_V139_L1.3261.00
29_Q100_R1.3211.00
76_L92_V1.3181.00
112_I152_I1.3041.00
126_S130_E1.2901.00
108_E140_N1.2901.00
133_L155_A1.2891.00
147_V152_I1.2871.00
58_A78_R1.2801.00
112_I147_V1.2691.00
74_Q78_R1.2501.00
47_L60_S1.2441.00
151_V162_G1.2381.00
101_A108_E1.2271.00
128_A131_K1.2141.00
111_V117_L1.1921.00
65_C77_I1.1911.00
65_C69_L1.1911.00
62_I74_Q1.1791.00
45_A49_S1.1501.00
124_K128_A1.1491.00
29_Q104_E1.1481.00
127_A130_E1.1451.00
128_A132_R1.1271.00
111_V153_I1.1191.00
106_T136_K1.1041.00
107_A137_V1.0981.00
126_S139_L1.0941.00
28_W73_G1.0891.00
125_I151_V1.0881.00
101_A106_T1.0791.00
116_A122_L1.0731.00
18_F72_N1.0661.00
69_L74_Q1.0661.00
120_Q123_A1.0611.00
29_Q33_A1.0601.00
109_V139_L1.0541.00
165_R169_E1.0541.00
36_A93_L1.0501.00
48_L57_L1.0501.00
66_G74_Q1.0451.00
16_F20_V1.0431.00
116_A143_I1.0401.00
25_V96_F1.0311.00
26_E30_D1.0261.00
13_K17_D1.0261.00
30_D33_A1.0241.00
27_R31_M1.0081.00
43_Q46_E0.9941.00
79_V83_N0.9921.00
36_A97_I0.9891.00
58_A62_I0.9891.00
16_F99_L0.9881.00
15_A76_L0.9831.00
27_R70_D0.9811.00
59_E62_I0.9731.00
120_Q124_K0.9711.00
71_E74_Q0.9691.00
15_A18_F0.9671.00
35_A65_C0.9641.00
80_M86_L0.9621.00
54_P84_G0.9591.00
97_I101_A0.9581.00
133_L158_M0.9431.00
30_D34_F0.9411.00
18_F22_H0.9321.00
76_L80_M0.9311.00
24_S28_W0.9291.00
101_A138_K0.9101.00
32_L73_G0.9061.00
27_R30_D0.9011.00
116_A119_E0.8921.00
105_A135_R0.8861.00
11_Y85_R0.8821.00
22_H72_N0.8720.99
112_I154_R0.8690.99
36_A40_K0.8650.99
24_S72_N0.8640.99
152_I159_V0.8600.99
75_N78_R0.8590.99
35_A69_L0.8380.99
7_V88_A0.8340.99
96_F100_R0.8280.99
45_A90_P0.8250.99
12_A99_L0.8200.99
161_D166_G0.8180.99
9_R95_Q0.8150.99
125_I129_M0.8150.99
36_A90_P0.8120.99
129_M133_L0.8080.99
71_E75_N0.8080.99
109_V129_M0.8040.99
54_P58_A0.8030.99
106_T138_K0.7990.99
107_A133_L0.7960.99
38_V65_C0.7940.99
34_F37_E0.7900.99
154_R159_V0.7780.99
99_L102_V0.7740.99
35_A77_I0.7700.99
22_H71_E0.7700.99
129_M137_V0.7690.99
146_S165_R0.7660.99
63_A66_G0.7640.99
34_F38_V0.7630.99
88_A91_D0.7580.99
124_K127_A0.7550.99
57_L84_G0.7490.98
25_V103_S0.7420.98
113_S147_V0.7290.98
126_S136_K0.7270.98
131_K134_S0.7230.98
69_L73_G0.7110.98
49_S87_N0.7100.98
25_V104_E0.7050.98
33_A37_E0.7050.98
169_E173_D0.7040.98
116_A141_C0.7020.98
19_A25_V0.6980.98
95_Q99_L0.6970.98
8_A95_Q0.6890.97
148_M164_V0.6850.97
152_I165_R0.6830.97
129_M160_I0.6810.97
159_V162_G0.6780.97
18_F21_E0.6720.97
50_G57_L0.6710.97
114_A147_V0.6680.97
99_L103_S0.6620.97
18_F28_W0.6620.97
28_W70_D0.6560.96
52_L56_T0.6530.96
170_R173_D0.6510.96
42_E45_A0.6500.96
42_E46_E0.6470.96
40_K90_P0.6440.96
61_F81_A0.6420.96
72_N75_N0.6390.96
118_S122_L0.6380.96
67_E74_Q0.6380.96
35_A73_G0.6380.96
39_T44_M0.6340.96
44_M60_S0.6140.95
113_S143_I0.6130.95
94_E98_H0.6130.95
126_S138_K0.6070.95
107_A129_M0.6060.94
125_I153_I0.6060.94
56_T63_A0.6040.94
31_M34_F0.6010.94
77_I89_L0.6010.94
68_Q74_Q0.5990.94
107_A156_G0.5980.94
132_R158_M0.5950.94
91_D95_Q0.5950.94
15_A28_W0.5890.94
20_V25_V0.5880.94
100_R106_T0.5880.94
38_V41_N0.5880.94
83_N163_S0.5860.93
125_I160_I0.5800.93
149_A161_D0.5800.93
105_A136_K0.5750.93
47_L52_L0.5750.93
28_W72_N0.5750.93
170_R174_V0.5710.93
134_S137_V0.5660.92
144_D165_R0.5600.92
87_N90_P0.5580.92
44_M47_L0.5550.91
39_T48_L0.5510.91
141_C147_V0.5500.91
16_F25_V0.5500.91
169_E172_A0.5490.91
105_A134_S0.5490.91
10_P172_A0.5480.91
164_V168_L0.5460.91
126_S141_C0.5430.91
132_R160_I0.5420.90
122_L139_L0.5390.90
93_L97_I0.5370.90
10_P85_R0.5360.90
113_S121_Q0.5310.90
50_G163_S0.5300.90
19_A96_F0.5300.90
111_V141_C0.5290.89
15_A31_M0.5290.89
111_V125_I0.5250.89
48_L156_G0.5240.89
97_I108_E0.5210.89
142_K147_V0.5210.89
25_V100_R0.5200.89
15_A73_G0.5200.89
29_Q96_F0.5200.89
109_V133_L0.5170.88
114_A141_C0.5170.88
7_V76_L0.5130.88
9_R102_V0.5120.88
157_D165_R0.5120.88
8_A91_D0.5060.87
48_L61_F0.5040.87
164_V173_D0.5030.87
161_D165_R0.5010.87
91_D94_E0.5000.87
51_A149_A0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wssS 1 0.8757 100 0.116 Contact Map
1abvA 1 0.5932 100 0.383 Contact Map
3lg8A 1 0.5254 94.8 0.865 Contact Map
3v6iA 1 0.8588 91.3 0.881 Contact Map
4efaE 1 0.9379 83.1 0.895 Contact Map
2dm9A 2 0.6045 80.5 0.898 Contact Map
1pjhA 4 0.2825 16.3 0.936 Contact Map
4uera 1 0.791 14.1 0.938 Contact Map
1repC 1 0.5028 10.3 0.941 Contact Map
4l7mA 1 0.8079 6.7 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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