GREMLIN Database
ATP6 - ATP synthase subunit a
UniProt: P0AB98 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10099
Length: 271 (215)
Sequences: 5417 (2823)
Seq/√Len: 192.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_S149_V3.6511.00
104_L157_V3.6331.00
113_F250_T3.3361.00
179_T193_L3.0311.00
105_A257_M2.7321.00
162_L200_L2.6281.00
74_K77_T2.5461.00
108_I112_V2.4981.00
196_E199_S2.4311.00
51_V54_L2.4001.00
151_L208_G2.2891.00
115_M143_P2.1401.00
187_A190_P2.0801.00
58_V62_S2.0591.00
142_V215_M2.0471.00
173_G176_K1.9841.00
109_F253_A1.9001.00
193_L197_G1.8551.00
119_D142_V1.8531.00
190_P194_I1.8341.00
53_G115_M1.8001.00
157_V260_T1.7841.00
37_T40_T1.7801.00
51_V55_L1.7761.00
163_F167_K1.7761.00
67_A70_G1.7341.00
198_V202_S1.7281.00
113_F117_L1.7201.00
105_A261_I1.7121.00
186_W189_I1.7051.00
88_G92_D1.6751.00
162_L174_F1.6721.00
191_V194_I1.6591.00
253_A257_M1.6111.00
209_L213_G1.6031.00
151_L155_L1.5951.00
84_G88_G1.5831.00
101_I164_Y1.5831.00
76_Q80_E1.5621.00
45_S149_V1.5541.00
151_L154_A1.5391.00
36_A40_T1.5361.00
60_F64_A1.5351.00
147_V208_G1.5311.00
77_T81_L1.5231.00
82_V110_V1.5021.00
150_T212_F1.4961.00
205_V208_G1.4881.00
87_N102_A1.4751.00
72_P76_Q1.4541.00
39_W42_N1.4491.00
169_K177_E1.4451.00
65_K68_T1.4401.00
50_V53_G1.4361.00
161_I264_L1.4321.00
218_G245_H1.4301.00
61_R65_K1.4291.00
184_N192_N1.4121.00
50_V54_L1.4071.00
56_F114_L1.3961.00
219_E245_H1.3751.00
43_I47_F1.3701.00
161_I263_Y1.3671.00
179_T189_I1.3611.00
53_G118_M1.3591.00
190_P193_L1.3551.00
147_V151_L1.3431.00
125_L146_D1.3421.00
75_F79_I1.3421.00
91_K99_K1.3351.00
117_L246_I1.3151.00
184_N189_I1.3141.00
117_L249_I1.3081.00
77_T84_G1.2871.00
175_T179_T1.2831.00
225_I241_W1.2781.00
159_I163_F1.2711.00
176_K181_Q1.2621.00
206_S263_Y1.2361.00
171_I175_T1.2171.00
150_T208_G1.2111.00
112_V256_F1.2051.00
251_L255_I1.1981.00
42_N45_S1.1901.00
221_I241_W1.1831.00
91_K98_S1.1751.00
72_P80_E1.1701.00
120_L246_I1.1661.00
166_I175_T1.1521.00
188_F192_N1.1521.00
189_I193_L1.1511.00
54_L58_V1.1511.00
104_L260_T1.1471.00
59_L63_V1.1461.00
91_K96_G1.1401.00
196_E200_L1.1201.00
84_G87_N1.1181.00
147_V209_L1.1131.00
78_A82_V1.1111.00
241_W244_F1.1061.00
62_S65_K1.1021.00
45_S49_S1.0891.00
216_Y220_L1.0881.00
155_L159_I1.0861.00
102_A106_L1.0821.00
112_V153_M1.0701.00
117_L250_T1.0591.00
158_F204_P1.0421.00
85_F88_G1.0381.00
87_N91_K1.0341.00
36_A39_W1.0231.00
57_L61_R1.0181.00
55_L59_L1.0181.00
104_L156_G1.0171.00
91_K102_A1.0161.00
186_W190_P1.0141.00
48_F52_L1.0131.00
205_V209_L1.0121.00
62_S66_K1.0061.00
149_V152_S1.0061.00
182_P194_I0.9920.99
93_M258_V0.9890.99
63_V75_F0.9880.99
145_A219_E0.9680.99
154_A208_G0.9660.99
203_K266_M0.9560.99
43_I48_F0.9440.99
183_F190_P0.9330.99
142_V219_E0.9330.99
66_K69_S0.9300.99
61_R64_A0.9260.99
169_K173_G0.9210.99
90_V93_M0.9190.99
111_W115_M0.9160.99
74_K78_A0.9150.99
41_I46_M0.9120.99
46_M50_V0.9110.99
153_M211_L0.9100.99
87_N99_K0.9090.99
145_A215_M0.9090.99
105_A260_T0.9090.99
186_W194_I0.9010.99
46_M146_D0.8970.99
112_V211_L0.8920.99
81_L84_G0.8880.99
201_L204_P0.8880.99
64_A79_I0.8860.99
199_S203_K0.8810.99
120_L242_A0.8790.99
69_S73_G0.8760.99
94_Y261_I0.8740.99
223_I228_L0.8740.99
194_I197_G0.8740.99
166_I174_F0.8730.99
63_V66_K0.8720.99
240_P243_I0.8710.99
57_L114_L0.8660.99
38_F43_I0.8610.99
218_G248_I0.8600.99
52_L56_F0.8580.99
158_F200_L0.8570.99
86_V109_F0.8540.98
197_G201_L0.8530.98
89_S258_V0.8510.98
162_L166_I0.8340.98
108_I157_V0.8300.98
240_P244_F0.8220.98
67_A71_V0.8160.98
214_N248_I0.8140.98
189_I194_I0.8130.98
165_S174_F0.8070.98
94_Y98_S0.8050.98
113_F253_A0.8030.98
168_M268_S0.7990.98
148_N152_S0.7990.98
49_S53_G0.7990.98
209_L254_F0.7910.97
38_F42_N0.7860.97
207_L214_N0.7780.97
179_T190_P0.7690.97
117_L121_L0.7660.97
202_S206_S0.7630.97
245_H248_I0.7620.97
64_A75_F0.7580.97
97_K100_L0.7530.97
181_Q193_L0.7450.96
164_Y168_M0.7450.96
142_V245_H0.7450.96
110_V114_L0.7430.96
230_P235_W0.7430.96
78_A81_L0.7430.96
104_L108_I0.7420.96
202_S205_V0.7400.96
225_I237_L0.7310.96
121_L124_D0.7300.96
183_F191_V0.7290.96
43_I51_V0.7270.96
96_G99_K0.7200.96
206_S242_A0.7190.96
100_L168_M0.7190.96
115_M144_S0.7190.96
207_L260_T0.7160.96
212_F216_Y0.7150.95
86_V106_L0.7150.95
181_Q196_E0.7120.95
206_S222_F0.7070.95
142_V249_I0.7040.95
228_L232_W0.7020.95
161_I207_L0.7010.95
241_W245_H0.7000.95
158_F199_S0.6970.95
40_T43_I0.6940.95
52_L55_L0.6940.95
65_K69_S0.6900.95
109_F113_F0.6900.95
160_L264_L0.6750.94
40_T44_D0.6750.94
203_K207_L0.6710.94
211_L214_N0.6700.94
56_F59_L0.6700.94
178_L181_Q0.6680.94
117_L120_L0.6650.93
101_I160_L0.6640.93
95_H258_V0.6630.93
122_P245_H0.6620.93
224_L228_L0.6600.93
160_L164_Y0.6600.93
101_I264_L0.6560.93
225_I238_N0.6560.93
207_L263_Y0.6550.93
51_V65_K0.6550.93
64_A67_A0.6540.93
232_W239_V0.6530.93
222_F226_A0.6480.92
95_H98_S0.6460.92
99_K121_L0.6400.92
83_I106_L0.6370.92
181_Q188_F0.6370.92
178_L200_L0.6350.92
262_V266_M0.6340.92
54_L61_R0.6320.92
157_V161_I0.6280.91
234_Q237_L0.6210.91
148_N217_A0.6170.91
215_M245_H0.6160.90
154_A207_L0.6140.90
185_H189_I0.6120.90
120_L249_I0.6120.90
60_F79_I0.6100.90
235_W238_N0.6030.90
37_T41_I0.5990.89
73_G76_Q0.5990.89
116_N119_D0.5970.89
76_Q263_Y0.5950.89
221_I238_N0.5940.89
195_L198_V0.5920.89
41_I45_S0.5920.89
177_E196_E0.5910.89
65_K70_G0.5910.89
58_V65_K0.5870.88
44_D47_F0.5850.88
109_F218_G0.5800.88
192_N195_L0.5800.88
154_A204_P0.5800.88
258_V261_I0.5780.88
48_F51_V0.5760.87
111_W149_V0.5750.87
237_L240_P0.5740.87
229_L235_W0.5740.87
187_A194_I0.5690.87
169_K267_A0.5690.87
185_H190_P0.5650.86
148_N206_S0.5650.86
228_L233_S0.5640.86
158_F162_L0.5620.86
89_S92_D0.5600.86
250_T253_A0.5560.85
198_V258_V0.5550.85
217_A248_I0.5500.85
244_F251_L0.5460.84
142_V145_A0.5440.84
46_M53_G0.5440.84
234_Q238_N0.5430.84
63_V195_L0.5420.84
54_L68_T0.5400.84
101_I254_F0.5400.84
215_M218_G0.5400.84
83_I102_A0.5400.84
66_K80_E0.5360.83
158_F207_L0.5350.83
231_W235_W0.5330.83
120_L215_M0.5330.83
223_I227_G0.5320.83
185_H188_F0.5310.83
112_V116_N0.5300.83
47_F51_V0.5290.83
109_F112_V0.5290.83
86_V90_V0.5270.82
170_G173_G0.5260.82
119_D219_E0.5250.82
219_E248_I0.5240.82
201_L205_V0.5240.82
213_G217_A0.5230.82
88_G91_K0.5220.82
244_F255_I0.5220.82
53_G143_P0.5220.82
162_L165_S0.5210.82
248_I255_I0.5200.81
49_S52_L0.5160.81
158_F161_I0.5160.81
60_F65_K0.5140.81
244_F247_L0.5140.81
255_I266_M0.5110.80
224_L244_F0.5110.80
214_N249_I0.5080.80
108_I260_T0.5070.80
120_L150_T0.5050.80
229_L234_Q0.5030.79
214_N251_L0.5030.79
247_L251_L0.5020.79
125_L195_L0.5020.79
165_S267_A0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1c17M 1 0.524 100 0.391 Contact Map
1oedC 1 0.1292 6.6 0.967 Contact Map
3vsqA 3 0.214 5.8 0.968 Contact Map
1oedE 1 0.1292 4.9 0.969 Contact Map
1oedB 1 0.1292 4.9 0.969 Contact Map
2bg9C 1 0.2472 4.6 0.97 Contact Map
2bg9E 1 0.2435 2.7 0.973 Contact Map
4ev6A 3 0.5166 2.6 0.973 Contact Map
2rddB 1 0.1365 2.4 0.974 Contact Map
4ioxA 1 0.1882 2.2 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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