GREMLIN Database
ARSC - Arsenate reductase
UniProt: P0AB96 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12237
Length: 141 (113)
Sequences: 3373 (2075)
Seq/√Len: 195.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_H36_E3.8031.00
41_R83_D3.0241.00
23_R29_P2.7771.00
77_T80_R2.3471.00
46_K50_D2.3431.00
85_M92_I2.3031.00
40_T43_E2.2121.00
48_I82_I2.1701.00
64_E68_E2.0281.00
20_E24_N1.8951.00
55_V78_D1.8581.00
83_D87_Q1.8191.00
6_I97_V1.7681.00
65_P88_H1.7191.00
111_V114_E1.7051.00
41_R82_I1.6981.00
8_H31_I1.6971.00
41_R45_V1.6951.00
99_T102_G1.6131.00
45_V79_D1.6061.00
32_I43_E1.6011.00
50_D103_T1.5671.00
76_F84_F1.5621.00
23_R28_E1.5501.00
48_I55_V1.5041.00
47_L98_V1.4931.00
6_I19_L1.4721.00
5_T30_T1.4641.00
70_G73_E1.4281.00
54_S57_A1.4161.00
14_T17_N1.4041.00
54_S78_D1.3791.00
39_P92_I1.3561.00
32_I37_T1.3551.00
19_L31_I1.3041.00
65_P90_I1.2761.00
8_H15_S1.2681.00
65_P68_E1.2371.00
51_M58_L1.2371.00
65_P69_L1.2291.00
45_V82_I1.2071.00
58_L96_I1.2021.00
53_I58_L1.1971.00
59_L81_L1.1961.00
10_P33_H1.1901.00
7_Y47_L1.1671.00
38_P92_I1.1641.00
17_N20_E1.1541.00
5_T32_I1.1481.00
48_I58_L1.1381.00
41_R86_L1.1161.00
21_M113_L1.1041.00
61_K67_E1.1031.00
19_L23_R1.0951.00
69_L88_H1.0921.00
41_R79_D1.0921.00
18_T112_V1.0791.00
44_L82_I1.0781.00
99_T115_I1.0601.00
7_Y32_I1.0561.00
51_M96_I1.0541.00
56_R66_Y1.0491.00
62_N93_N1.0301.00
8_H19_L1.0211.00
4_I27_T1.0071.00
7_Y98_V1.0011.00
50_D101_L0.9941.00
104_R114_E0.9820.99
53_I57_A0.9810.99
45_V78_D0.9670.99
35_L90_I0.9590.99
47_L96_I0.9460.99
104_R111_V0.9380.99
56_R73_E0.9180.99
110_E113_L0.9120.99
17_N109_S0.9040.99
80_R83_D0.8910.99
55_V81_L0.8860.99
20_E23_R0.8860.99
97_V112_V0.8850.99
104_R115_I0.8830.99
43_E46_K0.8770.99
21_M25_S0.8730.99
61_K93_N0.8630.99
14_T109_S0.8570.99
64_E67_E0.8560.99
17_N62_N0.8460.98
11_A63_V0.8350.98
76_F81_L0.8340.98
106_C111_V0.8320.98
21_M109_S0.8300.98
7_Y43_E0.8110.98
76_F80_R0.7840.97
6_I18_T0.7820.97
4_I97_V0.7520.97
25_S113_L0.7490.97
109_S113_L0.7420.96
96_I105_L0.7380.96
55_V82_I0.7360.96
22_I25_S0.7310.96
16_R19_L0.7300.96
56_R59_L0.7260.96
48_I52_G0.7210.96
56_R81_L0.7110.96
66_Y71_L0.7060.95
21_M107_R0.6850.95
72_A76_F0.6830.94
93_N106_C0.6720.94
30_T37_T0.6690.94
24_N27_T0.6640.94
54_S81_L0.6600.93
47_L103_T0.6600.93
18_T111_V0.6570.93
48_I78_D0.6520.93
11_A16_R0.6520.93
39_P43_E0.6490.93
59_L85_M0.6470.93
66_Y72_A0.6450.93
112_V116_L0.6440.93
61_K66_Y0.6430.92
5_T43_E0.6430.92
63_V90_I0.6330.92
42_D45_V0.6270.92
50_D98_V0.6260.91
59_L66_Y0.6190.91
6_I31_I0.6170.91
13_G17_N0.6150.91
45_V49_A0.6130.91
7_Y39_P0.6130.91
111_V115_I0.6110.90
69_L91_L0.6050.90
66_Y81_L0.6020.90
67_E106_C0.6020.90
80_R84_F0.5990.90
19_L29_P0.5940.89
18_T109_S0.5910.89
78_D81_L0.5870.89
59_L78_D0.5860.89
9_N35_L0.5840.88
18_T97_V0.5840.88
73_E76_F0.5840.88
82_I86_L0.5810.88
18_T104_R0.5780.88
55_V85_M0.5760.88
4_I99_T0.5750.88
17_N24_N0.5740.88
58_L85_M0.5610.86
50_D99_T0.5590.86
49_A78_D0.5560.86
18_T106_C0.5530.86
44_L92_I0.5530.86
4_I22_I0.5530.86
81_L84_F0.5380.84
57_A93_N0.5350.84
13_G109_S0.5340.84
39_P47_L0.5310.83
11_A33_H0.5300.83
14_T62_N0.5270.83
104_R112_V0.5240.82
104_R116_L0.5190.82
27_T99_T0.5180.82
108_P111_V0.5180.82
97_V104_R0.5120.81
61_K72_A0.5110.81
75_K84_F0.5100.81
24_N101_L0.5050.80
79_D83_D0.5040.80
109_S112_V0.5040.80
9_N15_S0.5000.79
51_M103_T0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s3cA 2 0.9787 100 0.237 Contact Map
2mu0A 1 0.8227 100 0.355 Contact Map
1z3eA 1 0.844 100 0.364 Contact Map
3rdwA 1 0.8085 100 0.366 Contact Map
3f0iA 1 0.8156 100 0.371 Contact Map
3gkxA 2 0.8227 100 0.378 Contact Map
3l78A 1 0.8298 100 0.385 Contact Map
3fz4A 1 0.8156 100 0.386 Contact Map
2kokA 1 0.8227 100 0.395 Contact Map
2m46A 1 0.8156 100 0.41 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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