GREMLIN Database
ARSB - Arsenical pump membrane protein
UniProt: P0AB93 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12236
Length: 429 (400)
Sequences: 5717 (3958)
Seq/√Len: 197.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
228_W232_L3.7431.00
90_R93_L3.7221.00
82_H86_W3.3371.00
8_F12_I3.3301.00
401_Y404_R3.2561.00
122_V143_A2.9941.00
377_P387_L2.7721.00
303_E307_G2.6581.00
221_P225_K2.5931.00
12_I16_I2.5761.00
14_L17_W2.5011.00
115_A147_A2.4671.00
13_V17_W2.4121.00
12_I15_V2.4091.00
45_D298_N2.3921.00
171_G174_E2.3811.00
42_H45_D2.3781.00
225_K228_W2.3771.00
72_E273_K2.3711.00
226_T262_V2.2461.00
364_A368_G2.2311.00
227_G230_V2.2171.00
78_W82_H2.2091.00
406_G410_T2.1921.00
12_I17_W2.1571.00
233_L237_G2.1521.00
82_H85_R2.1071.00
10_L14_L2.1071.00
132_S136_T2.1061.00
102_G118_L2.1051.00
43_P47_P2.0591.00
46_I49_V2.0141.00
8_F15_V1.9531.00
21_G24_I1.9441.00
403_F407_I1.9281.00
6_A10_L1.8921.00
150_A187_I1.8911.00
192_V196_L1.8861.00
230_V234_L1.8781.00
213_S216_E1.8771.00
10_L17_W1.8681.00
225_K229_V1.8571.00
115_A386_W1.8521.00
140_V386_W1.8451.00
287_L290_Y1.8391.00
8_F17_W1.8201.00
231_L235_L1.8081.00
252_A259_L1.7741.00
163_V345_A1.7671.00
228_W231_L1.7651.00
227_G231_L1.7511.00
232_L236_V1.7481.00
44_G48_V1.7461.00
229_V233_L1.7461.00
226_T230_V1.7311.00
61_I283_V1.7211.00
415_F419_A1.7101.00
326_F418_L1.7071.00
32_A36_L1.7021.00
99_V142_A1.6811.00
96_T195_H1.6801.00
333_S375_I1.6561.00
87_G97_W1.6431.00
224_F227_G1.6351.00
230_V233_L1.6341.00
70_L75_F1.6331.00
383_T386_W1.6191.00
222_A225_K1.6061.00
110_A113_G1.6041.00
8_F11_T1.6001.00
174_E177_S1.5931.00
234_L238_F1.5901.00
8_F14_L1.5881.00
185_A420_A1.5751.00
72_E277_G1.5651.00
92_R195_H1.5641.00
177_S181_P1.5501.00
8_F16_I1.5471.00
31_G36_L1.5431.00
224_F228_W1.5431.00
380_S383_T1.5391.00
238_F242_E1.5381.00
230_V238_F1.5361.00
151_S158_N1.5351.00
196_L200_K1.5291.00
32_A35_A1.5231.00
413_V417_T1.5131.00
329_A414_L1.5061.00
123_I395_M1.5051.00
286_S290_Y1.4981.00
223_T227_G1.4841.00
27_S32_A1.4841.00
259_L263_A1.4771.00
24_I27_S1.4721.00
155_I165_A1.4621.00
270_N273_K1.4611.00
100_L187_I1.4611.00
222_A226_T1.4541.00
6_A12_I1.4441.00
221_P224_F1.4271.00
231_L234_L1.4151.00
398_S401_Y1.4071.00
49_V53_V1.4001.00
11_T14_L1.3911.00
402_Y406_G1.3821.00
236_V239_F1.3711.00
260_F264_K1.3681.00
400_G404_R1.3671.00
261_V265_R1.3641.00
391_S396_T1.3641.00
239_F242_E1.3561.00
7_I11_T1.3501.00
248_V251_I1.3491.00
227_G238_F1.3471.00
285_F288_G1.3461.00
220_D223_T1.3411.00
10_L15_V1.3351.00
308_V311_V1.3241.00
66_I234_L1.3221.00
377_P384_L1.3191.00
11_T15_V1.3161.00
96_T191_L1.3151.00
173_R177_S1.3121.00
220_D224_F1.2971.00
43_P46_I1.2941.00
322_L418_L1.2921.00
5_G9_V1.2841.00
304_Y307_G1.2821.00
23_G27_S1.2751.00
260_F263_A1.2711.00
144_G386_W1.2651.00
228_W235_L1.2651.00
137_L401_Y1.2651.00
248_V252_A1.2591.00
280_W283_V1.2581.00
330_F334_I1.2521.00
341_V369_C1.2501.00
62_A256_A1.2401.00
132_S201_D1.2261.00
207_D210_L1.2231.00
45_D48_V1.2171.00
235_L239_F1.2141.00
232_L238_F1.2081.00
26_W30_L1.2061.00
192_V195_H1.2051.00
98_I122_V1.2051.00
204_Q207_D1.2051.00
218_I221_P1.1951.00
407_I410_T1.1861.00
185_A416_V1.1841.00
225_K235_L1.1831.00
104_A108_L1.1821.00
235_L238_F1.1821.00
34_L37_V1.1761.00
262_V265_R1.1751.00
71_D277_G1.1721.00
234_L255_G1.1651.00
220_D225_K1.1561.00
180_V184_I1.1471.00
405_T408_I1.1461.00
229_V232_L1.1421.00
44_G47_P1.1341.00
33_V37_V1.1331.00
31_G34_L1.1331.00
327_L331_L1.1321.00
364_A421_L1.1281.00
9_V13_V1.1261.00
45_D49_V1.1201.00
101_L105_V1.1201.00
223_T226_T1.1191.00
49_V52_I1.1071.00
152_L183_D1.1051.00
207_D211_L1.0981.00
332_S369_C1.0931.00
231_L239_F1.0891.00
27_S31_G1.0811.00
43_P49_V1.0801.00
127_L393_K1.0791.00
256_A263_A1.0761.00
88_N93_L1.0751.00
273_K276_R1.0751.00
193_M412_P1.0731.00
208_M211_L1.0711.00
238_F241_L1.0711.00
7_I16_I1.0701.00
186_A413_V1.0681.00
10_L13_V1.0631.00
227_G234_L1.0561.00
132_S137_L1.0511.00
232_L235_L1.0511.00
326_F330_F1.0481.00
119_T140_V1.0461.00
228_W239_F1.0461.00
249_S252_A1.0421.00
159_L290_Y1.0411.00
28_A32_A1.0411.00
300_G303_E1.0401.00
61_I65_I1.0391.00
236_V240_V1.0381.00
410_T414_L1.0361.00
272_G276_R1.0321.00
411_L415_F1.0321.00
252_A263_A1.0321.00
410_T413_V1.0311.00
163_V338_M1.0311.00
398_S404_R1.0301.00
336_N339_P1.0261.00
407_I411_L1.0221.00
228_W238_F1.0221.00
189_A193_M1.0181.00
198_F201_D1.0161.00
37_V40_V1.0131.00
228_W236_V1.0121.00
10_L16_I1.0121.00
57_T287_L1.0121.00
6_A14_L1.0041.00
227_G235_L1.0011.00
25_G28_A1.0011.00
6_A13_V0.9951.00
399_W410_T0.9951.00
22_L26_W0.9951.00
77_E81_L0.9901.00
141_M145_F0.9901.00
404_R408_I0.9891.00
205_N208_M0.9891.00
225_K239_F0.9871.00
237_G241_L0.9871.00
85_R214_P0.9821.00
226_T233_L0.9780.99
28_A31_G0.9740.99
24_I36_L0.9730.99
7_I17_W0.9710.99
294_Y298_N0.9690.99
240_V244_L0.9670.99
227_G233_L0.9660.99
226_T229_V0.9660.99
251_I256_A0.9650.99
380_S384_L0.9640.99
271_T275_L0.9600.99
252_A255_G0.9570.99
394_N397_I0.9550.99
280_W284_I0.9550.99
231_L241_L0.9520.99
39_G42_H0.9440.99
176_A179_M0.9420.99
230_V241_L0.9400.99
11_T17_W0.9390.99
225_K231_L0.9370.99
239_F243_P0.9370.99
232_L239_F0.9370.99
227_G241_L0.9320.99
102_G143_A0.9310.99
179_M183_D0.9300.99
174_E178_V0.9300.99
256_A259_L0.9280.99
304_Y308_V0.9280.99
225_K240_V0.9270.99
35_A295_G0.9230.99
168_F362_V0.9230.99
24_I31_G0.9220.99
230_V235_L0.9180.99
77_E128_A0.9110.99
409_M413_V0.9110.99
404_R407_I0.9080.99
249_S259_L0.9070.99
196_L199_R0.9070.99
270_N274_V0.9070.99
36_L41_V0.9070.99
6_A17_W0.9020.99
188_V192_V0.9020.99
203_P207_D0.9010.99
182_V367_I0.9010.99
198_F405_T0.9000.99
225_K236_V0.8990.99
379_G384_L0.8970.99
27_S30_L0.8970.99
249_S256_A0.8950.99
83_V97_W0.8880.99
36_L40_V0.8870.99
182_V186_A0.8870.99
112_D151_S0.8860.99
384_L389_V0.8850.99
206_Y210_L0.8820.99
189_A416_V0.8810.99
140_V390_L0.8800.99
203_P206_Y0.8790.99
191_L195_H0.8790.99
225_K232_L0.8790.99
318_W422_A0.8770.99
383_T387_L0.8750.99
370_D373_P0.8740.99
36_L39_G0.8690.99
7_I15_V0.8690.99
7_I12_I0.8650.99
406_G409_M0.8640.99
328_T344_G0.8630.99
406_G417_T0.8630.99
176_A183_D0.8620.99
256_A260_F0.8570.99
270_N275_L0.8530.99
399_W406_G0.8510.99
408_I411_L0.8470.99
110_A120_P0.8460.99
379_G383_T0.8440.98
160_V338_M0.8440.98
126_L139_F0.8410.98
331_L340_T0.8390.98
100_L104_A0.8390.98
332_S373_P0.8310.98
9_V16_I0.8310.98
32_A40_V0.8240.98
215_A220_D0.8230.98
204_Q210_L0.8210.98
401_Y405_T0.8210.98
100_L191_L0.8200.98
332_S379_G0.8190.98
328_T365_N0.8180.98
6_A15_V0.8140.98
13_V16_I0.8120.98
382_A385_L0.8100.98
172_F176_A0.8090.98
228_W242_E0.8060.98
403_F406_G0.8040.98
288_G292_V0.8020.98
255_G259_L0.7990.98
229_V240_V0.7960.98
222_A229_V0.7950.98
195_H199_R0.7940.98
9_V17_W0.7920.98
233_L236_V0.7890.98
31_G35_A0.7870.98
251_I255_G0.7810.98
403_F410_T0.7770.97
307_G311_V0.7750.97
29_T37_V0.7710.97
119_T386_W0.7690.97
138_A194_L0.7690.97
24_I32_A0.7670.97
400_G403_F0.7660.97
181_P420_A0.7640.97
153_P183_D0.7590.97
32_A288_G0.7590.97
26_W29_T0.7570.97
218_I222_A0.7530.97
42_H46_I0.7520.97
65_I256_A0.7510.97
65_I275_L0.7500.97
215_A221_P0.7470.97
95_F139_F0.7450.97
189_A412_P0.7450.97
338_M341_V0.7440.97
28_A36_L0.7430.97
224_F230_V0.7390.97
226_T231_L0.7380.97
228_W233_L0.7380.97
140_V146_I0.7370.96
286_S373_P0.7370.96
398_S402_Y0.7330.96
282_I380_S0.7330.96
140_V143_A0.7300.96
6_A16_I0.7290.96
258_I263_A0.7290.96
206_Y211_L0.7280.96
97_W101_L0.7280.96
255_G263_A0.7270.96
158_N161_N0.7250.96
6_A9_V0.7250.96
401_Y417_T0.7250.96
211_L215_A0.7240.96
230_V237_G0.7240.96
366_V369_C0.7230.96
149_T152_L0.7220.96
325_G418_L0.7220.96
160_V370_D0.7190.96
234_L242_E0.7180.96
14_L20_K0.7140.96
199_R202_I0.7140.96
147_A382_A0.7130.96
382_A388_H0.7130.96
308_V312_L0.7130.96
286_S289_M0.7130.96
333_S336_N0.7120.96
87_G94_L0.7110.96
227_G237_G0.7100.96
112_D158_N0.7100.96
215_A218_I0.7080.96
249_S260_F0.7070.96
176_A180_V0.7060.96
278_A290_Y0.7050.95
24_I28_A0.7010.95
28_A35_A0.6960.95
164_S366_V0.6960.95
235_L240_V0.6960.95
127_L136_T0.6930.95
372_G375_I0.6930.95
328_T369_C0.6910.95
380_S387_L0.6900.95
379_G382_A0.6890.95
8_F13_V0.6890.95
331_L334_I0.6860.95
7_I13_V0.6860.95
220_D226_T0.6830.95
324_T365_N0.6830.95
248_V256_A0.6780.94
252_A262_V0.6770.94
139_F143_A0.6760.94
179_M366_V0.6760.94
46_I53_V0.6730.94
156_V172_F0.6730.94
194_L198_F0.6700.94
21_G29_T0.6690.94
398_S406_G0.6680.94
235_L242_E0.6670.94
259_L265_R0.6670.94
249_S262_V0.6670.94
154_L157_S0.6650.94
399_W403_F0.6650.94
30_L34_L0.6650.94
381_L384_L0.6650.94
234_L251_I0.6640.94
214_P217_A0.6630.94
179_M182_V0.6630.94
145_F190_T0.6630.94
46_I52_I0.6610.94
122_V139_F0.6590.94
396_T400_G0.6560.93
38_T41_V0.6560.93
41_V45_D0.6560.93
414_L417_T0.6550.93
62_A252_A0.6510.93
407_I417_T0.6500.93
49_V294_Y0.6500.93
373_P379_G0.6500.93
103_A187_I0.6480.93
213_S217_A0.6480.93
396_T404_R0.6480.93
375_I379_G0.6470.93
175_Y179_M0.6470.93
248_V264_K0.6440.93
249_S255_G0.6430.93
206_Y209_A0.6420.93
205_N211_L0.6410.93
226_T232_L0.6400.93
102_G146_I0.6380.92
157_S160_V0.6380.92
241_L244_L0.6380.92
228_W234_L0.6370.92
271_T274_V0.6370.92
285_F289_M0.6350.92
165_A172_F0.6350.92
204_Q208_M0.6340.92
202_I205_N0.6340.92
328_T368_G0.6300.92
257_L260_F0.6290.92
214_P218_I0.6290.92
111_N158_N0.6290.92
282_I387_L0.6280.92
106_A160_V0.6280.92
25_G32_A0.6270.92
234_L239_F0.6240.92
131_F139_F0.6220.91
256_A262_V0.6190.91
111_N382_A0.6190.91
236_V241_L0.6190.91
152_L179_M0.6180.91
329_A410_T0.6160.91
9_V14_L0.6160.91
221_P226_T0.6140.91
106_A157_S0.6130.91
57_T283_V0.6120.91
237_G242_E0.6110.91
99_V190_T0.6100.91
34_L38_T0.6090.91
332_S336_N0.6080.91
20_K23_G0.6080.91
408_I412_P0.6070.90
223_T229_V0.6060.90
7_I31_G0.6040.90
203_P211_L0.6040.90
219_K222_A0.6040.90
384_L387_L0.6040.90
257_L261_V0.6030.90
35_A40_V0.6030.90
25_G36_L0.6010.90
76_F113_G0.6000.90
68_L277_G0.5990.90
228_W241_L0.5990.90
215_A219_K0.5990.90
23_G29_T0.5990.90
272_G275_L0.5980.90
122_V126_L0.5980.90
101_L147_A0.5970.90
21_G27_S0.5950.90
250_A254_V0.5950.90
35_A39_G0.5930.89
398_S410_T0.5930.89
32_A39_G0.5920.89
419_A422_A0.5910.89
281_Q284_I0.5900.89
349_D352_T0.5890.89
224_F235_L0.5880.89
179_M367_I0.5880.89
85_R127_L0.5860.89
381_L386_W0.5860.89
381_L385_L0.5860.89
384_L388_H0.5860.89
145_F149_T0.5850.89
119_T389_V0.5850.89
307_G310_N0.5830.89
321_T364_A0.5820.89
231_L238_F0.5780.88
44_G49_V0.5760.88
373_P383_T0.5760.88
22_L25_G0.5760.88
382_A386_W0.5760.88
68_L71_D0.5760.88
333_S337_N0.5750.88
103_A145_F0.5740.88
248_V259_L0.5740.88
163_V342_L0.5730.88
93_L200_K0.5720.88
250_A263_A0.5720.88
77_E219_K0.5710.88
337_N378_I0.5700.88
250_A256_A0.5700.88
157_S373_P0.5690.87
164_S362_V0.5670.87
303_E350_G0.5660.87
218_I224_F0.5650.87
258_I262_V0.5640.87
348_I365_N0.5640.87
141_M405_T0.5600.87
227_G236_V0.5590.87
42_H53_V0.5590.87
35_A38_T0.5590.87
222_A228_W0.5560.86
222_A233_L0.5550.86
394_N401_Y0.5540.86
7_I38_T0.5520.86
340_T343_V0.5520.86
99_V194_L0.5520.86
226_T242_E0.5510.86
235_L241_L0.5510.86
225_K241_L0.5470.85
114_A155_I0.5470.85
234_L237_G0.5460.85
224_F232_L0.5450.85
295_G299_A0.5450.85
46_I291_L0.5440.85
27_S37_V0.5430.85
48_V52_I0.5420.85
225_K234_L0.5410.85
394_N402_Y0.5410.85
173_R176_A0.5400.85
373_P378_I0.5400.85
184_I188_V0.5390.84
60_F110_A0.5380.84
222_A239_F0.5370.84
406_G414_L0.5370.84
244_L247_P0.5350.84
106_A114_A0.5350.84
278_A283_V0.5350.84
252_A260_F0.5340.84
106_A111_N0.5330.84
157_S338_M0.5330.84
216_E303_E0.5320.84
318_W419_A0.5310.84
246_I253_A0.5270.83
148_D382_A0.5260.83
410_T417_T0.5250.83
195_H201_D0.5250.83
71_D124_A0.5240.83
67_S109_F0.5210.82
44_G298_N0.5210.82
6_A214_P0.5200.82
150_A157_S0.5190.82
204_Q330_F0.5160.82
336_N373_P0.5150.82
303_E306_S0.5140.82
17_W21_G0.5140.82
195_H200_K0.5130.82
223_T236_V0.5120.81
380_S386_W0.5110.81
253_A256_A0.5070.81
112_D333_S0.5070.81
395_M402_Y0.5060.81
159_L373_P0.5060.81
220_D273_K0.5050.81
21_G32_A0.5040.80
219_K223_T0.5040.80
251_I254_V0.5040.80
127_L130_G0.5030.80
150_A286_S0.5020.80
21_G28_A0.5020.80
340_T344_G0.5020.80
23_G26_W0.5010.80
22_L27_S0.5010.80
304_Y330_F0.5000.80
324_T328_T0.5000.80
174_E359_E0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.9301 100 0.413 Contact Map
4r1iA 2 0.9627 99.9 0.68 Contact Map
4r0cA 3 0.9604 99.9 0.718 Contact Map
4dx5A 3 0.3869 22.8 0.959 Contact Map
3w9iA 3 0.3683 22.4 0.96 Contact Map
3giaA 1 0.4336 15.9 0.962 Contact Map
4pd6A 3 0.7832 13.8 0.963 Contact Map
3qe7A 2 0.4522 13.3 0.964 Contact Map
3aqpA 1 0.3543 11 0.965 Contact Map
4k0jA 3 0.3497 10.2 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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