GREMLIN Database
AROG - Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive
UniProt: P0AB91 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10079
Length: 350 (340)
Sequences: 2151 (1025)
Seq/√Len: 55.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
242_S245_H6.0671.00
82_E339_R4.9341.00
112_H121_D4.8671.00
45_K50_N4.7531.00
71_E305_L4.1451.00
306_V322_K3.7361.00
329_I337_L3.5231.00
319_A322_K3.4921.00
58_I334_T3.3961.00
307_E330_G3.3161.00
25_K124_R3.2651.00
330_G333_D3.1781.00
276_K307_E3.1681.00
42_A88_E2.9301.00
306_V319_A2.8921.00
283_A340_Q2.8791.00
128_K132_D2.8201.00
275_F327_A2.7281.00
83_L339_R2.7061.00
46_I88_E2.6841.00
77_L81_E2.6431.00
26_F131_L2.4651.00
118_Q121_D2.4631.00
246_V264_I2.4481.00
312_L324_I2.4451.00
69_A129_L2.4081.00
35_T39_A2.2341.00
38_H42_A2.2251.00
81_E84_K2.2171.00
284_D287_Q2.1921.00
113_M324_I2.0861.00
277_K280_D2.0671.00
48_K228_D2.0611.00
275_F307_E2.0541.00
57_V263_M2.0521.00
56_V338_L2.0501.00
250_K295_A2.0261.00
129_L133_I2.0201.00
83_L338_L1.9981.00
71_E320_Y1.9671.00
80_R88_E1.9541.00
307_E333_D1.9511.00
112_H118_Q1.9501.00
266_F282_C1.9331.00
243_A284_D1.8710.99
44_H228_D1.8510.99
142_G157_M1.8360.99
43_I90_V1.8170.99
282_C337_L1.8120.99
41_K45_K1.7950.99
73_A133_I1.7910.99
332_E335_D1.7640.99
34_N38_H1.7430.99
86_E342_A1.7420.99
67_V74_T1.7200.99
79_L339_R1.7190.99
159_W230_H1.7100.99
254_N260_A1.6570.99
74_T136_S1.6060.98
192_T195_V1.6040.98
282_C299_V1.6020.98
56_V299_V1.5920.98
56_V87_L1.5860.98
279_M333_D1.5750.98
75_R305_L1.5740.98
132_D135_D1.5720.98
82_E335_D1.5660.98
301_V329_I1.5600.98
274_Q277_K1.5400.98
276_K333_D1.5350.98
32_A35_T1.5100.98
58_I301_V1.5090.98
167_T185_F1.4920.97
66_P70_K1.4900.97
200_I229_C1.4850.97
286_C341_L1.4810.97
29_T135_D1.4740.97
341_L345_V1.4490.97
17_L22_L1.4370.97
79_L335_D1.4280.97
301_V337_L1.4250.97
70_K132_D1.4060.96
194_K198_D1.4060.96
43_I55_L1.4040.96
20_V215_W1.3980.96
179_L183_V1.3680.96
213_T219_A1.3590.96
248_E252_G1.3560.96
335_D339_R1.3510.95
271_S327_A1.3430.95
263_M297_I1.3360.95
251_E255_K1.3350.95
21_A24_E1.3310.95
32_A134_N1.3300.95
261_Q297_I1.3260.95
6_D214_K1.3260.95
188_G192_T1.3170.95
200_I231_I1.3150.95
55_L90_V1.3120.95
95_F130_L1.3010.94
274_Q279_M1.2830.94
160_G198_D1.2770.94
247_A251_E1.2720.94
28_A33_A1.2670.94
250_K293_E1.2570.93
17_L120_N1.2430.93
180_S209_F1.2340.93
288_Q293_E1.2280.92
264_I285_V1.2220.92
7_D10_I1.2000.92
11_K224_S1.1940.91
70_K74_T1.1820.91
77_L80_R1.1770.91
79_L83_L1.1770.91
178_G223_T1.1770.91
239_P245_H1.1750.91
32_A135_D1.1730.91
211_S221_V1.1720.91
15_E21_A1.1690.90
79_L82_E1.1670.90
41_K44_H1.1660.90
286_C340_Q1.1620.90
71_E75_R1.1620.90
329_I333_D1.1610.90
10_I221_V1.1580.90
65_D68_A1.1480.90
108_I126_A1.1460.90
78_A81_E1.1440.89
264_I296_I1.1440.89
13_I221_V1.1420.89
68_A320_Y1.1370.89
134_N140_A1.1320.89
75_R331_W1.1300.89
18_P21_A1.1290.89
31_N135_D1.1280.89
15_E217_H1.1270.89
43_I158_S1.1140.88
69_A133_I1.1040.88
75_R79_L1.1040.88
77_L138_L1.0930.87
244_K248_E1.0930.87
287_Q291_G1.0910.87
289_I344_A1.0900.87
279_M337_L1.0820.87
9_R224_S1.0690.86
147_M221_V1.0660.86
29_T32_A1.0650.86
78_A335_D1.0640.86
313_E316_E1.0640.86
47_L261_Q1.0630.86
107_L125_I1.0620.86
243_A291_G1.0580.85
290_A340_Q1.0480.85
180_S223_T1.0430.85
43_I88_E1.0390.84
23_L214_K1.0360.84
194_K252_G1.0320.84
151_Q180_S1.0320.84
74_T78_A1.0290.84
83_L342_A1.0280.84
70_K136_S1.0270.84
147_M171_V1.0240.83
28_A32_A0.9980.82
252_G255_K0.9910.81
279_M327_A0.9910.81
80_R138_L0.9900.81
130_L140_A0.9810.81
208_C222_N0.9780.81
67_V71_E0.9760.80
95_F108_I0.9670.80
95_F126_A0.9620.79
333_D336_A0.9540.79
247_A295_A0.9510.79
121_D125_I0.9430.78
22_L123_L0.9430.78
43_I46_I0.9420.78
286_C344_A0.9360.78
70_K128_K0.9330.77
36_V40_R0.9320.77
286_C345_V0.9300.77
90_V190_D0.9190.76
49_G261_Q0.9180.76
109_N117_F0.9060.75
238_E269_A0.9010.75
39_A43_I0.8980.75
280_D283_A0.8980.75
22_L124_R0.8970.74
71_E74_T0.8970.74
253_L259_P0.8930.74
47_L55_L0.8930.74
246_V288_Q0.8900.74
160_G181_C0.8880.74
313_E317_P0.8790.73
68_A304_H0.8740.73
83_L86_E0.8700.72
282_C341_L0.8670.72
253_L260_A0.8640.72
175_L229_C0.8630.72
28_A156_L0.8600.71
341_L344_A0.8550.71
11_K222_N0.8530.71
306_V332_E0.8520.71
55_L297_I0.8500.70
79_L338_L0.8490.70
286_C289_I0.8480.70
83_L87_L0.8430.70
262_V295_A0.8410.70
78_A82_E0.8400.70
282_C301_V0.8390.69
193_I248_E0.8340.69
288_Q296_I0.8300.69
144_F198_D0.8270.68
44_H47_L0.8270.68
266_F299_V0.8260.68
21_A217_H0.8250.68
133_I138_L0.8240.68
30_E34_N0.8230.68
21_A25_K0.8190.68
188_G195_V0.8190.68
213_T217_H0.8150.67
249_V262_V0.8080.67
231_I249_V0.8080.67
276_K279_M0.8070.66
71_E306_V0.8060.66
312_L315_G0.8000.66
83_L89_I0.7970.65
117_F232_I0.7940.65
150_P180_S0.7900.65
144_F200_I0.7820.64
243_A287_Q0.7810.64
49_G297_I0.7800.64
73_A93_V0.7800.64
57_V298_G0.7800.64
42_A45_K0.7740.63
336_A340_Q0.7720.63
141_A232_I0.7710.63
93_V140_A0.7700.63
313_E318_L0.7650.62
201_N256_A0.7630.62
299_V338_L0.7620.62
151_Q209_F0.7540.61
147_M181_C0.7520.61
95_F140_A0.7520.61
126_A153_L0.7510.61
39_A88_E0.7510.61
108_I180_S0.7500.61
119_I210_L0.7500.61
17_L21_A0.7500.61
42_A46_I0.7490.61
95_F146_D0.7490.61
275_F330_G0.7480.61
331_W335_D0.7410.60
283_A287_Q0.7410.60
109_N119_I0.7400.60
131_L156_L0.7380.59
150_P209_F0.7360.59
167_T263_M0.7330.59
107_L126_A0.7310.59
130_L144_F0.7290.59
279_M301_V0.7280.58
309_N322_K0.7270.58
167_T192_T0.7240.58
151_Q154_A0.7240.58
282_C286_C0.7210.58
201_N311_S0.7200.58
101_T201_N0.7200.58
95_F230_H0.7190.57
113_M155_D0.7190.57
170_Q174_E0.7170.57
102_V205_A0.7140.57
193_I264_I0.7120.57
286_C290_A0.7110.57
18_P217_H0.7080.56
33_A37_A0.7060.56
262_V297_I0.7050.56
274_Q280_D0.7040.56
80_R89_I0.7040.56
21_A152_Y0.7000.55
144_F175_L0.6940.55
263_M298_G0.6920.55
86_E343_N0.6910.55
304_H322_K0.6910.55
16_L120_N0.6910.55
205_A232_I0.6900.54
287_Q290_A0.6870.54
144_F157_M0.6870.54
20_V24_E0.6870.54
95_F159_W0.6860.54
197_I260_A0.6860.54
342_A345_V0.6830.54
243_A247_A0.6820.54
66_P125_I0.6810.53
330_G336_A0.6800.53
128_K131_L0.6790.53
181_C269_A0.6790.53
192_T232_I0.6770.53
133_I139_P0.6760.53
149_T210_L0.6760.53
54_L289_I0.6730.53
54_L299_V0.6730.53
141_A227_G0.6720.52
171_V175_L0.6710.52
89_I338_L0.6710.52
231_I262_V0.6700.52
250_K262_V0.6640.52
142_G181_C0.6620.51
197_I253_L0.6600.51
21_A215_W0.6600.51
68_A322_K0.6580.51
57_V179_L0.6570.51
197_I256_A0.6560.51
167_T199_A0.6520.50
49_G262_V0.6520.50
10_I178_G0.6510.50
115_N171_V0.6510.50
17_L24_E0.6500.50
304_H327_A0.6500.50
35_T137_G0.6500.50
157_M160_G0.6480.50
73_A138_L0.6460.50
120_N220_I0.6440.49
83_L335_D0.6430.49
244_K280_D0.6420.49
35_T134_N0.6410.49
118_Q296_I0.6400.49
39_A80_R0.6390.49
7_D212_V0.6390.49
112_H125_I0.6380.49
148_I212_V0.6360.49
192_T236_G0.6360.49
144_F160_G0.6350.48
37_A263_M0.6340.48
39_A139_P0.6340.48
254_N294_K0.6330.48
238_E245_H0.6320.48
54_L341_L0.6300.48
174_E208_C0.6290.48
109_N146_D0.6250.47
6_D155_D0.6240.47
290_A345_V0.6220.47
119_I227_G0.6220.47
154_A181_C0.6200.47
247_A250_K0.6200.47
274_Q327_A0.6190.47
210_L221_V0.6180.47
247_A289_I0.6180.47
81_E85_D0.6160.46
52_D345_V0.6150.46
197_I249_V0.6150.46
68_A319_A0.6140.46
272_S329_I0.6120.46
43_I182_P0.6110.46
133_I140_A0.6100.46
43_I47_L0.6100.46
169_S174_E0.6100.46
45_K48_K0.6100.46
182_P249_V0.6090.46
313_E319_A0.6070.45
31_N35_T0.6060.45
140_A181_C0.6060.45
39_A138_L0.6040.45
33_A218_S0.6030.45
38_H335_D0.6030.45
95_F144_F0.6020.45
167_T188_G0.6010.45
14_K262_V0.6010.45
46_I53_R0.6000.45
193_I249_V0.5980.44
55_L169_S0.5970.44
188_G232_I0.5970.44
29_T48_K0.5950.44
243_A277_K0.5950.44
197_I201_N0.5940.44
150_P223_T0.5920.44
150_P179_L0.5900.44
244_K247_A0.5890.44
244_K287_Q0.5880.43
286_C337_L0.5880.43
198_D201_N0.5870.43
133_I136_S0.5860.43
107_L174_E0.5840.43
201_N205_A0.5840.43
34_N37_A0.5840.43
14_K222_N0.5830.43
47_L228_D0.5830.43
73_A140_A0.5820.43
290_A344_A0.5820.43
266_F301_V0.5820.43
42_A52_D0.5820.43
129_L207_H0.5810.43
10_I93_V0.5810.43
208_C239_P0.5790.42
52_D86_E0.5790.42
282_C329_I0.5760.42
340_Q344_A0.5760.42
63_I93_V0.5750.42
213_T220_I0.5750.42
144_F181_C0.5750.42
160_G183_V0.5750.42
251_E254_N0.5740.42
309_N327_A0.5740.42
168_E185_F0.5730.42
212_V219_A0.5720.42
19_P209_F0.5720.42
250_K254_N0.5720.42
168_E189_T0.5700.42
75_R332_E0.5700.42
140_A158_S0.5700.42
17_L245_H0.5690.41
195_V198_D0.5690.41
155_D263_M0.5680.41
93_V133_I0.5680.41
160_G205_A0.5680.41
244_K291_G0.5670.41
283_A344_A0.5660.41
262_V293_E0.5660.41
10_I150_P0.5650.41
161_A168_E0.5640.41
8_L33_A0.5640.41
7_D13_I0.5640.41
63_I208_C0.5640.41
332_E336_A0.5640.41
236_G269_A0.5630.41
339_R343_N0.5620.41
49_G293_E0.5620.41
44_H227_G0.5620.41
17_L124_R0.5600.40
107_L167_T0.5570.40
112_H115_N0.5560.40
13_I123_L0.5550.40
289_I292_G0.5540.40
146_D213_T0.5540.40
6_D10_I0.5520.40
146_D174_E0.5520.40
174_E211_S0.5510.40
142_G147_M0.5510.40
108_I150_P0.5490.39
238_E272_S0.5480.39
24_E215_W0.5480.39
78_A339_R0.5480.39
171_V212_V0.5470.39
147_M215_W0.5460.39
275_F279_M0.5450.39
214_K232_I0.5440.39
55_L263_M0.5440.39
239_P242_S0.5430.39
67_V320_Y0.5430.39
130_L146_D0.5420.39
109_N149_T0.5420.39
110_D166_T0.5420.39
246_V285_V0.5420.39
9_R228_D0.5410.39
17_L199_A0.5410.39
195_V236_G0.5400.38
266_F322_K0.5400.38
45_K276_K0.5380.38
247_A291_G0.5370.38
26_F128_K0.5360.38
130_L159_W0.5350.38
171_V211_S0.5350.38
22_L199_A0.5330.38
19_P217_H0.5320.38
293_E296_I0.5300.37
105_K109_N0.5290.37
113_M312_L0.5290.37
294_K343_N0.5280.37
44_H48_K0.5280.37
67_V317_P0.5260.37
108_I151_Q0.5260.37
204_G229_C0.5260.37
306_V327_A0.5260.37
6_D147_M0.5250.37
288_Q292_G0.5250.37
282_C333_D0.5240.37
272_S280_D0.5230.37
266_F285_V0.5230.37
42_A275_F0.5230.37
159_W185_F0.5220.37
64_H304_H0.5210.36
141_A157_M0.5200.36
129_L312_L0.5190.36
171_V221_V0.5180.36
237_K258_L0.5180.36
147_M212_V0.5180.36
167_T189_T0.5170.36
212_V221_V0.5160.36
161_A167_T0.5150.36
126_A150_P0.5150.36
30_E33_A0.5140.36
245_H284_D0.5140.36
337_L340_Q0.5130.36
271_S278_Q0.5130.36
148_I180_S0.5120.36
148_I223_T0.5120.36
166_T288_Q0.5110.35
277_K283_A0.5110.35
266_F319_A0.5100.35
63_I69_A0.5060.35
16_L160_G0.5060.35
77_L202_A0.5050.35
29_T33_A0.5050.35
88_E334_T0.5040.35
339_R344_A0.5040.35
22_L149_T0.5030.35
35_T47_L0.5030.35
121_D128_K0.5020.35
75_R306_V0.5020.35
168_E178_G0.5020.35
117_F207_H0.5010.35
84_K245_H0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1of8A 2 0.9686 100 0.201 Contact Map
1n8fA 2 0.98 100 0.203 Contact Map
4umaA 3 0.9514 100 0.239 Contact Map
3tqkA 2 0.9714 100 0.243 Contact Map
4lu0A 4 0.7086 100 0.679 Contact Map
2nwrA 4 0.6886 100 0.68 Contact Map
1o60A 4 0.7257 100 0.701 Contact Map
3fs2A 4 0.7114 100 0.712 Contact Map
1vs1A 4 0.7286 100 0.713 Contact Map
3sz8A 4 0.7229 100 0.715 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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