PUR8 - ECOLI - GREMLIN Contacts

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PUR8 - Adenylosuccinate lyase

UniProt:	P0AB89	Sequences: MELSSLTAVSPVDGRYGDKVSALRGIFSEYGLLKFRVQVEVRWLQKLAAHAAIKEVPAFAADAIGYLDAIVASFSEEDAARIKTIERTTNHDVKAVEYFLKEKVAEIPELHAVSEFIHFACTSEDINNLSHALMLKTARDEVILPYWRQLIDGIKDLAVQYRDIPLLSRTHGQPATPSTIGKEMANVAYRMERQYRQLNQVEILGKINGAVGNYNAHIAAYPEVDWHQFSEEFVTSLGIQWNPYTTQIEPHDYIAELFDCVARFNTILIDFDRDVWGYIALNHFKQKTIAGEIGSSTMPHKVNPIDFENSEGNLGLSNAVLQHLASKLPVSRWQRDLTDSTVLRNLGVGIGYALIAYQSTLKGVSKLEVNRDHLLDELDHNWEVLAEPIQTVMRRYGIEKPYEKLKELTRGKRVDAEGMKQFIDGLALPEEEKARLKAMTPANYIGRAITMVDELK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11314
Length:	456 (403)
Sequences:	10979 (5747)
Seq/√Len:	286.3

ECOLI - PUR8 ARLY ASPA FUMC
BACSU - PUR8 ARLY FUMC ASPA
HALSA - Q9HS42 ARLY FUMC
SULSO - Q980P8 ARLY FUMC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
51_A	61_A	3.985	1.00
60_A	116_F	3.513	1.00
52_A	232_E	3.365	1.00
373_H	376_D	3.343	1.00
140_D	202_E	3.235	1.00
411_G	415_D	3.075	1.00
48_A	236_S	3.055	1.00
35_F	137_T	2.947	1.00
265_N	317_S	2.931	1.00
148_R	195_Y	2.834	1.00
432_E	435_R	2.813	1.00
151_I	192_E	2.786	1.00
375_L	379_D	2.733	1.00
139_R	257_L	2.724	1.00
153_G	365_S	2.702	1.00
144_L	199_N	2.702	1.00
31_G	351_G	2.686	1.00
417_E	425_G	2.684	1.00
48_A	65_G	2.600	1.00
320_V	349_G	2.596	1.00
180_I	369_V	2.544	1.00
149_Q	361_L	2.508	1.00
144_L	195_Y	2.453	1.00
146_Y	358_Q	2.439	1.00
157_L	160_Q	2.425	1.00
313_N	356_A	2.415	1.00
262_A	321_L	2.328	1.00
232_E	235_T	2.294	1.00
57_P	60_A	2.280	1.00
51_A	58_A	2.275	1.00
396_Y	435_R	2.256	1.00
15_R	105_A	2.252	1.00
287_K	368_E	2.215	1.00
163_D	371_R	2.179	1.00
376_D	380_H	2.090	1.00
151_I	195_Y	2.076	1.00
316_L	345_N	2.075	1.00
156_D	365_S	2.055	1.00
148_R	199_N	2.055	1.00
232_E	236_S	1.995	1.00
156_D	160_Q	1.980	1.00
373_H	377_E	1.956	1.00
197_Q	256_E	1.952	1.00
428_L	431_E	1.942	1.00
153_G	364_V	1.937	1.00
81_R	102_E	1.936	1.00
231_E	235_T	1.935	1.00
266_T	318_N	1.926	1.00
195_Y	199_N	1.896	1.00
34_K	75_S	1.887	1.00
272_D	310_S	1.880	1.00
41_V	65_G	1.877	1.00
375_L	442_A	1.871	1.00
147_W	264_F	1.863	1.00
61_A	65_G	1.852	1.00
38_Q	137_T	1.838	1.00
136_K	206_K	1.806	1.00
203_I	240_Q	1.767	1.00
440_T	443_N	1.764	1.00
155_K	192_E	1.744	1.00
161_Y	164_I	1.742	1.00
58_A	62_D	1.734	1.00
255_A	328_L	1.718	1.00
268_L	310_S	1.689	1.00
371_R	375_L	1.684	1.00
285_K	370_N	1.684	1.00
213_N	247_Q	1.683	1.00
194_Q	267_I	1.675	1.00
151_I	188_A	1.668	1.00
48_A	232_E	1.651	1.00
193_R	246_T	1.647	1.00
62_D	66_Y	1.634	1.00
411_G	426_L	1.625	1.00
146_Y	354_L	1.624	1.00
153_G	361_L	1.608	1.00
361_L	365_S	1.593	1.00
404_K	407_E	1.584	1.00
206_K	240_Q	1.553	1.00
73_S	103_K	1.549	1.00
272_D	360_T	1.546	1.00
323_H	341_T	1.519	1.00
417_E	422_F	1.506	1.00
411_G	425_G	1.495	1.00
157_L	161_Y	1.492	1.00
158_A	188_A	1.491	1.00
310_S	360_T	1.477	1.00
193_R	252_D	1.475	1.00
138_A	354_L	1.459	1.00
262_A	325_A	1.457	1.00
424_D	433_K	1.455	1.00
201_V	260_C	1.453	1.00
322_Q	326_S	1.430	1.00
99_F	103_K	1.424	1.00
34_K	38_Q	1.423	1.00
417_E	421_Q	1.408	1.00
285_K	368_E	1.405	1.00
307_F	363_G	1.405	1.00
41_V	48_A	1.396	1.00
258_F	324_L	1.391	1.00
251_H	339_D	1.384	1.00
149_Q	365_S	1.375	1.00
370_N	373_H	1.372	1.00
49_A	232_E	1.368	1.00
151_I	191_M	1.361	1.00
418_G	421_Q	1.360	1.00
277_G	332_R	1.355	1.00
259_D	263_R	1.349	1.00
31_G	138_A	1.344	1.00
372_D	376_D	1.333	1.00
30_Y	75_S	1.324	1.00
180_I	184_M	1.322	1.00
144_L	202_E	1.312	1.00
155_K	159_V	1.311	1.00
255_A	263_R	1.304	1.00
266_T	328_L	1.300	1.00
318_N	326_S	1.294	1.00
36_R	126_I	1.293	1.00
184_M	187_V	1.291	1.00
135_L	257_L	1.287	1.00
47_L	56_V	1.266	1.00
271_F	360_T	1.260	1.00
55_E	119_F	1.259	1.00
287_K	366_K	1.256	1.00
411_G	422_F	1.239	1.00
164_I	371_R	1.236	1.00
404_K	428_L	1.231	1.00
147_W	191_M	1.226	1.00
159_V	162_R	1.216	1.00
180_I	374_L	1.212	1.00
101_K	114_S	1.211	1.00
316_L	348_V	1.205	1.00
146_Y	149_Q	1.202	1.00
153_G	156_D	1.202	1.00
161_Y	371_R	1.198	1.00
150_L	361_L	1.198	1.00
120_A	221_Y	1.196	1.00
319_A	323_H	1.189	1.00
187_V	334_Q	1.188	1.00
234_V	240_Q	1.180	1.00
95_A	99_F	1.175	1.00
198_L	264_F	1.169	1.00
324_L	346_L	1.169	1.00
162_R	181_G	1.159	1.00
415_D	422_F	1.150	1.00
135_L	346_L	1.150	1.00
150_L	191_M	1.146	1.00
37_V	71_V	1.145	1.00
166_L	374_L	1.145	1.00
63_A	66_Y	1.144	1.00
42_R	236_S	1.141	1.00
275_V	307_F	1.139	1.00
15_R	74_F	1.136	1.00
282_N	373_H	1.135	1.00
321_L	325_A	1.132	1.00
155_K	188_A	1.132	1.00
310_S	356_A	1.127	1.00
187_V	271_F	1.124	1.00
205_G	234_V	1.124	1.00
154_I	271_F	1.106	1.00
150_L	364_V	1.104	1.00
120_A	224_V	1.103	1.00
415_D	425_G	1.101	1.00
149_Q	358_Q	1.100	1.00
80_A	84_T	1.095	1.00
142_V	354_L	1.092	1.00
99_F	102_E	1.091	1.00
144_L	148_R	1.090	1.00
139_R	202_E	1.090	1.00
148_R	152_D	1.088	1.00
163_D	181_G	1.088	1.00
264_F	357_Y	1.086	1.00
136_K	203_I	1.083	1.00
39_V	126_I	1.082	1.00
131_H	343_L	1.076	1.00
157_L	184_M	1.073	1.00
314_L	318_N	1.073	1.00
208_N	234_V	1.069	1.00
254_I	346_L	1.068	1.00
37_V	95_A	1.065	1.00
177_P	378_L	1.061	1.00
157_L	364_V	1.061	1.00
35_F	133_L	1.060	1.00
14_G	77_E	1.059	1.00
52_A	236_S	1.059	1.00
131_H	254_I	1.055	1.00
287_K	370_N	1.054	1.00
138_A	142_V	1.051	1.00
70_I	78_D	1.046	1.00
269_I	311_E	1.044	1.00
185_A	243_P	1.044	1.00
260_C	264_F	1.043	1.00
63_A	113_V	1.042	1.00
164_I	374_L	1.038	1.00
38_Q	236_S	1.037	1.00
136_K	239_I	1.037	1.00
70_I	77_E	1.036	1.00
410_R	414_V	1.032	1.00
41_V	71_V	1.024	1.00
397_G	405_L	1.023	1.00
257_L	346_L	1.015	1.00
30_Y	34_K	1.013	1.00
168_S	178_S	1.013	1.00
136_K	202_E	1.010	1.00
136_K	140_D	1.003	1.00
189_Y	193_R	1.000	1.00
162_R	179_T	0.996	1.00
169_R	174_P	0.995	1.00
39_V	129_L	0.995	1.00
421_Q	425_G	0.994	1.00
74_F	102_E	0.993	1.00
89_T	98_Y	0.991	1.00
139_R	198_L	0.991	1.00
147_W	195_Y	0.990	1.00
275_V	367_L	0.986	1.00
286_Q	367_L	0.982	1.00
277_G	333_W	0.969	1.00
259_D	321_L	0.966	1.00
36_R	39_V	0.965	1.00
291_G	362_K	0.961	1.00
392_V	395_R	0.960	1.00
34_K	137_T	0.960	1.00
200_Q	256_E	0.959	1.00
396_Y	438_A	0.954	1.00
171_H	308_E	0.954	1.00
51_A	62_D	0.951	1.00
31_G	137_T	0.942	1.00
268_L	357_Y	0.941	1.00
49_A	53_I	0.940	1.00
55_E	221_Y	0.940	1.00
378_L	441_P	0.939	1.00
316_L	344_R	0.931	1.00
424_D	427_A	0.930	1.00
183_E	334_Q	0.930	1.00
57_P	116_F	0.928	1.00
344_R	348_V	0.924	1.00
62_D	65_G	0.920	1.00
179_T	445_I	0.919	1.00
100_L	117_I	0.918	1.00
59_F	63_A	0.907	1.00
35_F	134_M	0.905	1.00
58_A	61_A	0.904	1.00
37_V	70_I	0.903	1.00
164_I	369_V	0.901	1.00
158_A	185_A	0.901	1.00
165_P	378_L	0.900	1.00
282_N	370_N	0.900	1.00
154_I	184_M	0.899	1.00
411_G	414_V	0.897	1.00
154_I	364_V	0.897	1.00
268_L	360_T	0.895	1.00
258_F	321_L	0.892	1.00
259_D	325_A	0.890	1.00
19_K	293_I	0.887	1.00
78_D	81_R	0.886	1.00
309_N	359_S	0.885	1.00
151_I	155_K	0.881	1.00
200_Q	204_L	0.881	1.00
59_F	62_D	0.881	1.00
196_R	200_Q	0.878	1.00
38_Q	233_F	0.874	1.00
178_S	211_V	0.872	1.00
382_W	386_A	0.872	1.00
178_S	245_T	0.869	1.00
258_F	346_L	0.867	1.00
89_T	95_A	0.866	1.00
174_P	381_N	0.865	1.00
154_I	188_A	0.862	1.00
203_I	239_I	0.859	1.00
397_G	404_K	0.858	1.00
152_D	156_D	0.858	1.00
131_H	346_L	0.857	1.00
129_L	205_G	0.857	1.00
408_L	419_M	0.856	1.00
112_A	115_E	0.856	1.00
250_P	267_I	0.854	1.00
172_G	277_G	0.853	1.00
392_V	396_Y	0.853	1.00
188_A	192_E	0.851	1.00
182_K	244_Y	0.851	1.00
172_G	280_A	0.845	1.00
165_P	445_I	0.843	1.00
436_L	439_M	0.843	1.00
434_A	437_K	0.839	1.00
266_T	325_A	0.839	1.00
320_V	348_V	0.839	1.00
269_I	329_P	0.839	1.00
358_Q	361_L	0.837	1.00
70_I	74_F	0.837	1.00
256_E	259_D	0.829	1.00
153_G	157_L	0.828	1.00
183_E	278_Y	0.826	1.00
411_G	417_E	0.825	1.00
43_W	121_C	0.822	1.00
51_A	56_V	0.820	1.00
73_S	76_E	0.819	1.00
60_A	63_A	0.817	1.00
160_Q	368_E	0.815	1.00
277_G	281_L	0.814	1.00
22_A	25_G	0.814	1.00
408_L	422_F	0.812	1.00
379_D	420_K	0.811	0.99
146_Y	361_L	0.811	0.99
139_R	205_G	0.808	0.99
28_S	337_L	0.805	0.99
27_F	138_A	0.804	0.99
154_I	191_M	0.804	0.99
64_I	113_V	0.804	0.99
191_M	357_Y	0.801	0.99
161_Y	369_V	0.801	0.99
41_V	236_S	0.795	0.99
257_L	350_I	0.793	0.99
206_K	247_Q	0.793	0.99
252_D	267_I	0.792	0.99
318_N	322_Q	0.791	0.99
147_W	357_Y	0.786	0.99
408_L	423_I	0.785	0.99
75_S	78_D	0.782	0.99
407_E	426_L	0.780	0.99
420_K	424_D	0.780	0.99
204_L	253_Y	0.779	0.99
316_L	320_V	0.776	0.99
327_K	341_T	0.774	0.99
287_K	290_A	0.772	0.99
28_S	359_S	0.770	0.99
316_L	352_Y	0.770	0.99
420_K	433_K	0.770	0.99
48_A	52_A	0.770	0.99
412_K	422_F	0.769	0.99
265_N	353_A	0.766	0.99
166_L	183_E	0.766	0.99
167_L	281_L	0.763	0.99
139_R	201_V	0.762	0.99
369_V	374_L	0.762	0.99
315_G	323_H	0.760	0.99
249_E	334_Q	0.759	0.99
207_I	233_F	0.757	0.99
272_D	307_F	0.756	0.99
245_T	334_Q	0.756	0.99
160_Q	371_R	0.755	0.99
17_G	24_R	0.755	0.99
207_I	241_W	0.752	0.99
50_H	53_I	0.750	0.99
383_E	386_A	0.748	0.99
52_A	58_A	0.747	0.99
315_G	327_K	0.747	0.99
150_L	357_Y	0.747	0.99
32_L	127_N	0.746	0.99
257_L	261_V	0.746	0.99
164_I	179_T	0.746	0.99
190_R	267_I	0.744	0.99
283_H	286_Q	0.743	0.99
163_D	442_A	0.740	0.99
427_A	433_K	0.737	0.99
323_H	345_N	0.736	0.99
47_L	61_A	0.736	0.99
278_Y	333_W	0.728	0.99
197_Q	252_D	0.728	0.99
408_L	426_L	0.726	0.99
140_D	239_I	0.725	0.99
363_G	367_L	0.724	0.99
372_D	375_L	0.722	0.99
255_A	324_L	0.719	0.99
403_E	407_E	0.719	0.99
60_A	113_V	0.718	0.99
208_N	233_F	0.717	0.99
184_M	374_L	0.716	0.99
73_S	102_E	0.716	0.99
152_D	155_K	0.715	0.99
156_D	159_V	0.712	0.99
138_A	350_I	0.710	0.99
190_R	250_P	0.710	0.99
193_R	204_L	0.709	0.99
70_I	73_S	0.708	0.99
424_D	437_K	0.708	0.99
132_A	253_Y	0.708	0.99
435_R	438_A	0.705	0.99
246_T	252_D	0.705	0.99
70_I	75_S	0.705	0.99
41_V	61_A	0.704	0.99
194_Q	263_R	0.702	0.99
167_L	378_L	0.700	0.99
214_Y	297_T	0.699	0.99
36_R	95_A	0.696	0.98
149_Q	153_G	0.696	0.98
89_T	94_K	0.695	0.98
255_A	325_A	0.694	0.98
51_A	65_G	0.692	0.98
47_L	117_I	0.691	0.98
191_M	194_Q	0.691	0.98
136_K	240_Q	0.690	0.98
407_E	411_G	0.690	0.98
148_R	192_E	0.690	0.98
254_I	324_L	0.689	0.98
261_V	353_A	0.689	0.98
134_M	350_I	0.688	0.98
143_I	354_L	0.686	0.98
264_F	353_A	0.685	0.98
164_I	375_L	0.683	0.98
273_R	311_E	0.681	0.98
196_R	204_L	0.680	0.98
186_N	270_D	0.679	0.98
56_V	119_F	0.678	0.98
90_N	289_I	0.678	0.98
318_N	325_A	0.677	0.98
142_V	146_Y	0.676	0.98
148_R	151_I	0.675	0.98
246_T	267_I	0.675	0.98
373_H	380_H	0.673	0.98
37_V	75_S	0.672	0.98
414_V	417_E	0.671	0.98
159_V	163_D	0.671	0.98
161_Y	180_I	0.671	0.98
289_I	366_K	0.669	0.98
47_L	64_I	0.666	0.98
392_V	435_R	0.665	0.98
139_R	144_L	0.665	0.98
197_Q	200_Q	0.661	0.98
113_V	116_F	0.661	0.98
70_I	79_A	0.659	0.98
437_K	443_N	0.659	0.98
102_E	105_A	0.658	0.98
377_E	380_H	0.657	0.98
48_A	61_A	0.656	0.98
166_L	178_S	0.656	0.98
359_S	362_K	0.655	0.98
269_I	326_S	0.653	0.98
271_F	364_V	0.651	0.98
411_G	428_L	0.651	0.98
47_L	65_G	0.648	0.98
382_W	385_L	0.646	0.98
437_K	440_T	0.646	0.98
98_Y	102_E	0.646	0.98
24_R	28_S	0.645	0.97
379_D	418_G	0.643	0.97
262_A	266_T	0.643	0.97
26_I	31_G	0.642	0.97
24_R	306_D	0.642	0.97
140_D	199_N	0.640	0.97
56_V	60_A	0.640	0.97
415_D	418_G	0.639	0.97
408_L	428_L	0.639	0.97
320_V	350_I	0.638	0.97
112_A	403_E	0.636	0.97
143_I	261_V	0.636	0.97
190_R	249_E	0.636	0.97
72_A	75_S	0.633	0.97
81_R	84_T	0.632	0.97
29_E	83_K	0.632	0.97
313_N	352_Y	0.632	0.97
201_V	256_E	0.631	0.97
420_K	426_L	0.631	0.97
283_H	377_E	0.630	0.97
55_E	120_A	0.630	0.97
187_V	190_R	0.630	0.97
201_V	257_L	0.628	0.97
158_A	162_R	0.628	0.97
72_A	76_E	0.628	0.97
100_L	104_V	0.626	0.97
196_R	199_N	0.621	0.97
346_L	350_I	0.620	0.97
284_F	367_L	0.620	0.97
255_A	259_D	0.618	0.97
78_D	103_K	0.618	0.97
422_F	426_L	0.617	0.97
194_Q	197_Q	0.617	0.97
385_L	444_Y	0.616	0.97
310_S	363_G	0.616	0.97
322_Q	325_A	0.615	0.97
315_G	326_S	0.615	0.97
85_I	92_D	0.614	0.97
53_I	221_Y	0.611	0.97
257_L	351_G	0.610	0.96
405_L	409_T	0.610	0.96
157_L	367_L	0.609	0.96
36_R	91_H	0.608	0.96
291_G	366_K	0.607	0.96
19_K	22_A	0.607	0.96
52_A	225_D	0.604	0.96
146_Y	357_Y	0.604	0.96
272_D	311_E	0.604	0.96
105_A	114_S	0.604	0.96
191_M	264_F	0.603	0.96
323_H	327_K	0.602	0.96
261_V	264_F	0.602	0.96
147_W	198_L	0.601	0.96
73_S	78_D	0.600	0.96
412_K	417_E	0.599	0.96
428_L	432_E	0.595	0.96
28_S	362_K	0.593	0.96
192_E	196_R	0.593	0.96
263_R	328_L	0.592	0.96
39_V	130_S	0.591	0.96
230_S	234_V	0.591	0.96
345_N	348_V	0.591	0.96
116_F	119_F	0.590	0.96
203_I	234_V	0.589	0.96
101_K	104_V	0.589	0.96
417_E	423_I	0.588	0.96
169_R	281_L	0.587	0.96
48_A	51_A	0.585	0.96
143_I	353_A	0.584	0.96
191_M	268_L	0.584	0.96
210_A	297_T	0.583	0.95
319_A	322_Q	0.581	0.95
442_A	445_I	0.581	0.95
51_A	59_F	0.581	0.95
189_Y	192_E	0.580	0.95
421_Q	433_K	0.579	0.95
143_I	350_I	0.579	0.95
198_L	260_C	0.579	0.95
56_V	64_I	0.578	0.95
234_V	239_I	0.578	0.95
135_L	347_G	0.578	0.95
189_Y	243_P	0.577	0.95
256_E	263_R	0.576	0.95
166_L	278_Y	0.575	0.95
393_M	397_G	0.574	0.95
178_S	182_K	0.573	0.95
38_Q	71_V	0.573	0.95
442_A	446_G	0.573	0.95
275_V	360_T	0.572	0.95
144_L	260_C	0.571	0.95
70_I	81_R	0.571	0.95
53_I	225_D	0.571	0.95
57_P	61_A	0.571	0.95
11_P	14_G	0.571	0.95
183_E	274_D	0.570	0.95
371_R	374_L	0.569	0.95
311_E	338_T	0.569	0.95
165_P	441_P	0.567	0.95
323_H	342_V	0.566	0.95
306_D	363_G	0.565	0.95
137_T	140_D	0.564	0.95
343_L	347_G	0.564	0.95
70_I	99_F	0.563	0.95
73_S	77_E	0.563	0.95
27_F	356_A	0.563	0.95
85_I	88_T	0.561	0.94
74_F	77_E	0.560	0.94
269_I	330_V	0.560	0.94
38_Q	42_R	0.560	0.94
155_K	158_A	0.559	0.94
176_T	211_V	0.558	0.94
252_D	256_E	0.558	0.94
263_R	267_I	0.554	0.94
184_M	367_L	0.553	0.94
277_G	280_A	0.552	0.94
82_I	344_R	0.551	0.94
381_N	384_V	0.551	0.94
41_V	72_A	0.550	0.94
161_Y	181_G	0.549	0.94
77_E	82_I	0.549	0.94
193_R	256_E	0.547	0.94
150_L	153_G	0.545	0.94
104_V	113_V	0.544	0.93
233_F	236_S	0.544	0.93
194_Q	260_C	0.544	0.93
275_V	364_V	0.543	0.93
145_P	149_Q	0.541	0.93
35_F	38_Q	0.541	0.93
79_A	83_K	0.540	0.93
259_D	262_A	0.540	0.93
53_I	232_E	0.540	0.93
43_W	233_F	0.536	0.93
94_K	98_Y	0.536	0.93
413_R	416_A	0.534	0.93
241_W	247_Q	0.533	0.93
185_A	188_A	0.531	0.93
197_Q	263_R	0.529	0.93
31_G	142_V	0.528	0.92
71_V	75_S	0.527	0.92
77_E	81_R	0.527	0.92
258_F	349_G	0.527	0.92
84_T	87_R	0.526	0.92
172_G	332_R	0.524	0.92
290_A	414_V	0.523	0.92
47_L	50_H	0.523	0.92
78_D	83_K	0.523	0.92
317_S	352_Y	0.523	0.92
22_A	26_I	0.522	0.92
200_Q	203_I	0.520	0.92
79_A	82_I	0.520	0.92
34_K	71_V	0.519	0.92
231_E	234_V	0.517	0.92
310_S	314_L	0.516	0.92
157_L	180_I	0.515	0.92
167_L	377_E	0.514	0.91
376_D	379_D	0.514	0.91
285_K	292_E	0.513	0.91
275_V	286_Q	0.513	0.91
121_C	126_I	0.512	0.91
37_V	72_A	0.512	0.91
407_E	428_L	0.512	0.91
144_L	147_W	0.512	0.91
171_H	337_L	0.511	0.91
19_K	25_G	0.511	0.91
261_V	317_S	0.510	0.91
255_A	266_T	0.510	0.91
27_F	292_E	0.509	0.91
66_Y	102_E	0.509	0.91
348_V	352_Y	0.508	0.91
123_S	206_K	0.507	0.91
191_M	271_F	0.503	0.91
50_H	55_E	0.500	0.90

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ptrA	4	0.9868	100	0.174	Contact Map
3bhgA	4	0.9759	100	0.182	Contact Map
4efcA	4	0.9649	100	0.218	Contact Map
1re5A	4	0.9408	100	0.218	Contact Map
2qgaB	4	0.9737	100	0.221	Contact Map
3c8tA	4	0.8969	100	0.226	Contact Map
1q5nA	4	0.9145	100	0.228	Contact Map
1c3cA	4	0.9079	100	0.229	Contact Map
4mx2A	5	0.9496	100	0.23	Contact Map
1k7wA	4	0.9123	100	0.234	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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