GREMLIN Database
FUCA - L-fuculose phosphate aldolase
UniProt: P0AB87 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10348
Length: 215 (196)
Sequences: 6336 (3788)
Seq/√Len: 270.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_D63_K4.8841.00
162_V166_K3.3361.00
97_H183_T3.2281.00
179_Q183_T3.1221.00
106_R185_L2.8011.00
6_L32_V2.6761.00
39_L55_I2.5571.00
9_Q165_E2.5501.00
38_M78_M2.5151.00
196_D200_A2.2781.00
87_A160_C2.2511.00
134_R138_E2.1781.00
79_A138_E2.1351.00
100_A183_T2.1281.00
97_H179_Q2.0821.00
96_V179_Q2.0571.00
107_S122_S2.0551.00
51_T54_H2.0101.00
79_A82_Q2.0091.00
11_I52_E2.0011.00
97_H182_L1.9461.00
39_L57_F1.9311.00
195_S198_E1.9121.00
91_V167_A1.8901.00
32_V164_L1.8651.00
8_R12_D1.8351.00
149_A174_V1.8301.00
34_Y39_L1.7581.00
183_T186_A1.7361.00
16_E20_L1.6651.00
89_A164_L1.6581.00
88_N163_N1.6571.00
58_I74_W1.6531.00
5_K9_Q1.6411.00
163_N166_K1.6241.00
10_I30_V1.5911.00
127_P153_Q1.5861.00
13_T168_L1.5811.00
34_Y37_G1.5421.00
61_N82_Q1.5281.00
20_L172_H1.4931.00
161_E166_K1.4771.00
8_R52_E1.4651.00
157_L174_V1.4561.00
11_I15_L1.4471.00
129_A139_H1.4361.00
109_P181_Y1.4351.00
15_L19_R1.4341.00
105_N153_Q1.4281.00
83_S141_A1.4061.00
83_S145_K1.3901.00
96_V100_A1.3891.00
124_P147_R1.3891.00
32_V89_A1.3851.00
93_N171_A1.3781.00
94_H155_H1.3741.00
84_R87_A1.3561.00
10_I55_I1.3461.00
159_A171_A1.3091.00
79_A83_S1.2901.00
108_I178_A1.2761.00
78_M82_Q1.2571.00
31_S81_Y1.2541.00
64_H67_G1.2451.00
11_I55_I1.2371.00
127_P142_L1.2331.00
31_S90_V1.2291.00
198_E201_V1.2241.00
38_M60_G1.2231.00
101_V185_L1.2221.00
148_K170_L1.2211.00
96_V176_V1.1921.00
138_E142_L1.1891.00
81_Y90_V1.1881.00
16_E19_R1.1861.00
40_I71_S1.1771.00
182_L187_I1.1751.00
33_R88_N1.1721.00
99_T102_S1.1581.00
45_I54_H1.1511.00
181_Y185_L1.1501.00
98_C157_L1.1431.00
57_F66_E1.1391.00
34_Y57_F1.1251.00
13_T164_L1.1231.00
92_H155_H1.1151.00
144_L160_C1.1141.00
139_H142_L1.1101.00
97_H175_E1.1041.00
104_L187_I1.0961.00
17_M30_V1.0891.00
175_E179_Q1.0831.00
42_P45_I1.0751.00
152_L158_I1.0621.00
182_L186_A1.0591.00
93_N157_L1.0541.00
176_V179_Q1.0501.00
17_M91_V1.0491.00
18_T48_E1.0461.00
111_I181_Y1.0371.00
59_D65_E1.0211.00
140_V152_L1.0141.00
127_P139_H1.0141.00
98_C174_V1.0081.00
38_M74_W1.0001.00
114_M119_G0.9941.00
14_C30_V0.9931.00
135_E138_E0.9911.00
149_A159_A0.9861.00
84_R160_C0.9751.00
161_E170_L0.9591.00
197_E201_V0.9551.00
80_A144_L0.9541.00
157_L171_A0.9481.00
20_L168_L0.9411.00
144_L150_T0.9401.00
60_G82_Q0.9401.00
9_Q12_D0.9251.00
95_A98_C0.9211.00
50_L54_H0.9201.00
17_M168_L0.9161.00
96_V183_T0.9121.00
11_I50_L0.9061.00
114_M117_A0.8991.00
13_T30_V0.8931.00
38_M58_I0.8911.00
76_F140_V0.8871.00
185_L189_D0.8851.00
100_A182_L0.8831.00
54_H68_K0.8721.00
126_A139_H0.8671.00
42_P55_I0.8631.00
45_I69_L0.8621.00
5_K8_R0.8421.00
40_I73_E0.8401.00
37_G57_F0.8391.00
6_L34_Y0.8381.00
166_K170_L0.8371.00
9_Q32_V0.8371.00
91_V171_A0.8330.99
95_A171_A0.8320.99
49_K165_E0.8300.99
107_S125_C0.8290.99
76_F158_I0.8250.99
107_S147_R0.8210.99
108_I151_L0.8200.99
118_A173_E0.8160.99
80_A87_A0.8010.99
16_E168_L0.7960.99
14_C47_Y0.7920.99
12_D49_K0.7850.99
79_A141_A0.7830.99
198_E202_V0.7790.99
184_T191_V0.7790.99
108_I177_L0.7710.99
187_I191_V0.7710.99
83_S142_L0.7660.99
95_A175_E0.7650.99
41_T81_Y0.7610.99
142_L145_K0.7590.99
7_A66_E0.7590.99
188_T191_V0.7490.99
31_S40_I0.7450.99
121_N196_D0.7440.99
33_R60_G0.7410.99
45_I50_L0.7410.99
128_Y152_L0.7360.99
37_G60_G0.7340.99
101_V181_Y0.7300.99
21_G179_Q0.7240.99
41_T50_L0.7150.98
105_N190_P0.7150.98
106_R189_D0.7140.98
101_V178_A0.7120.98
29_N71_S0.7010.98
54_H69_L0.6990.98
126_A129_A0.6990.98
88_N162_V0.6980.98
119_G196_D0.6940.98
159_A170_L0.6940.98
107_S124_P0.6920.98
143_A150_T0.6900.98
73_E136_L0.6870.98
74_W78_M0.6870.98
84_R144_L0.6820.98
122_S147_R0.6820.98
126_A152_L0.6820.98
135_E139_H0.6810.98
7_A39_L0.6770.98
75_R134_R0.6770.98
79_A134_R0.6740.98
121_N200_A0.6740.98
89_A167_A0.6730.98
103_I111_I0.6700.98
46_P49_K0.6690.98
166_K169_W0.6670.98
17_M22_L0.6630.97
82_Q141_A0.6630.97
10_I39_L0.6630.97
109_P122_S0.6630.97
126_A143_A0.6620.97
29_N73_E0.6610.97
104_L189_D0.6560.97
174_V178_A0.6530.97
141_A144_L0.6510.97
195_S201_V0.6480.97
28_G47_Y0.6460.97
102_S151_L0.6450.97
26_T43_T0.6450.97
193_V196_D0.6420.97
104_L184_T0.6420.97
25_G169_W0.6360.97
18_T23_N0.6350.97
111_I185_L0.6330.97
49_K54_H0.6320.97
150_T158_I0.6310.97
60_G78_M0.6300.97
123_I174_V0.6290.97
57_F65_E0.6290.97
23_N30_V0.6290.97
95_A157_L0.6270.96
24_Q176_V0.6230.96
97_H100_A0.6200.96
62_G78_M0.6190.96
196_D199_I0.6180.96
6_L9_Q0.6180.96
80_A158_I0.6170.96
114_M173_E0.6130.96
148_K166_K0.6080.96
194_L199_I0.6070.96
99_T180_L0.6030.96
43_T71_S0.6020.96
112_H115_I0.5990.95
33_R38_M0.5960.95
151_L157_L0.5930.95
7_A52_E0.5920.95
6_L39_L0.5920.95
100_A180_L0.5920.95
184_T190_P0.5920.95
24_Q27_A0.5910.95
148_K162_V0.5880.95
12_D15_L0.5840.95
197_E200_A0.5830.95
99_T156_G0.5830.95
98_C178_A0.5770.94
80_A90_V0.5740.94
101_V182_L0.5740.94
16_E25_G0.5720.94
110_A115_I0.5640.94
116_A119_G0.5630.94
10_I14_C0.5580.93
10_I32_V0.5570.93
101_V106_R0.5570.93
105_N191_V0.5540.93
19_R48_E0.5520.93
113_Y119_G0.5500.93
194_L198_E0.5480.93
104_L182_L0.5470.93
134_R137_S0.5470.93
199_I202_V0.5450.93
113_Y116_A0.5430.92
103_I112_H0.5420.92
86_D162_V0.5410.92
139_H143_A0.5380.92
99_T112_H0.5370.92
91_V159_A0.5360.92
81_Y89_A0.5310.92
169_W176_V0.5310.92
27_A176_V0.5300.92
29_N43_T0.5290.91
122_S125_C0.5280.91
141_A145_K0.5270.91
185_L188_T0.5260.91
84_R148_K0.5250.91
7_A55_I0.5250.91
148_K160_C0.5250.91
43_T72_S0.5240.91
58_I78_M0.5220.91
121_N147_R0.5200.91
18_T24_Q0.5190.91
7_A57_F0.5180.91
18_T47_Y0.5170.91
184_T188_T0.5160.90
84_R145_K0.5150.90
75_R79_A0.5140.90
9_Q164_L0.5120.90
41_T55_I0.5100.90
122_S126_A0.5100.90
125_C153_Q0.5060.90
9_Q163_N0.5050.89
30_V164_L0.5040.89
118_A166_K0.5040.89
14_C41_T0.5010.89
107_S151_L0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1e4cP 3 0.9581 100 0.099 Contact Map
4c24A 3 0.9535 100 0.121 Contact Map
3ocrA 4 0.986 100 0.157 Contact Map
2opiA 3 0.9349 100 0.169 Contact Map
1k0wA 3 0.9349 100 0.195 Contact Map
4xxfA 3 0.9442 100 0.2 Contact Map
4m6rA 3 0.9302 100 0.202 Contact Map
2v9lA 3 0.986 100 0.204 Contact Map
2fk5A 4 0.8744 100 0.207 Contact Map
2z7bA 3 0.9767 100 0.212 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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