GREMLIN Database
APBE - FAD:protein FMN transferase
UniProt: P0AB85 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12073
Length: 351 (296)
Sequences: 3723 (2987)
Seq/√Len: 173.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_A100_S4.3901.00
146_Q150_D3.4361.00
121_M185_T3.3441.00
68_Q71_A3.1791.00
294_T297_E2.9381.00
104_A163_V2.8741.00
108_T165_N2.6711.00
117_T304_G2.6701.00
157_G160_H2.5391.00
194_H197_R2.3711.00
267_K282_E2.3101.00
64_K202_E2.3061.00
68_Q194_H2.2971.00
120_A307_V2.2731.00
114_G158_L2.2671.00
73_D80_K2.2221.00
76_L106_I2.1521.00
113_I300_A2.1451.00
109_T296_L2.1441.00
250_H293_P2.1411.00
254_T287_S2.1091.00
131_L152_M2.1071.00
114_G123_I2.0921.00
292_A298_A2.0921.00
74_Q80_K2.0651.00
72_D191_A2.0561.00
65_I195_L1.9871.00
64_K198_L1.9861.00
207_Y218_R1.9761.00
109_T112_R1.9711.00
242_Q327_I1.9661.00
301_W322_L1.9501.00
198_L202_E1.9401.00
68_Q198_L1.9331.00
318_R337_W1.9271.00
47_R210_S1.8571.00
308_L316_V1.8551.00
290_V305_L1.8531.00
71_A102_A1.8501.00
145_S148_Q1.8401.00
96_P171_Y1.8051.00
104_A165_N1.7811.00
107_V170_Q1.7631.00
312_K315_E1.7491.00
200_E207_Y1.7301.00
328_T332_D1.7061.00
200_E218_R1.7031.00
193_D294_T1.6531.00
323_A338_M1.6251.00
36_V49_S1.6241.00
196_A216_N1.6171.00
160_H174_K1.6161.00
142_Q148_Q1.6071.00
196_A207_Y1.5651.00
125_V129_V1.5561.00
124_T156_T1.5461.00
305_L313_A1.5451.00
228_R246_D1.5301.00
86_M90_D1.5131.00
38_E47_R1.5021.00
313_A326_M1.4941.00
146_Q279_R1.4901.00
110_S123_I1.4351.00
124_T161_L1.4251.00
208_L217_S1.4241.00
75_L100_S1.4011.00
72_D76_L1.3921.00
118_D312_K1.3901.00
69_L195_L1.3791.00
245_V291_I1.3721.00
116_K301_W1.3721.00
253_S295_A1.3681.00
232_Q259_R1.3601.00
130_N180_Y1.3581.00
162_T173_Q1.3561.00
261_Y268_R1.3541.00
196_A200_E1.3531.00
124_T157_G1.3511.00
34_V51_P1.3511.00
160_H173_Q1.3481.00
250_H291_I1.3461.00
85_L103_M1.3431.00
68_Q72_D1.3411.00
335_K339_S1.3331.00
285_L326_M1.3321.00
214_A253_S1.3291.00
122_D157_G1.3211.00
73_D77_S1.3181.00
71_A75_L1.3111.00
112_R116_K1.3061.00
42_M191_A1.2931.00
288_V326_M1.2891.00
189_G299_D1.2861.00
123_I181_V1.2841.00
221_N225_L1.2571.00
75_L103_M1.2491.00
76_L187_G1.2451.00
263_E266_G1.2411.00
96_P169_Q1.2391.00
185_T303_T1.2381.00
149_I279_R1.2381.00
317_V324_V1.2341.00
257_S286_V1.2341.00
153_K278_G1.2301.00
314_K318_R1.2291.00
155_K178_D1.2231.00
110_S186_V1.2211.00
263_E268_R1.2021.00
99_V163_V1.1971.00
84_A103_M1.1941.00
193_D295_A1.1931.00
284_N329_K1.1731.00
102_A105_D1.1691.00
111_L114_G1.1671.00
285_L309_G1.1631.00
41_T69_L1.1631.00
162_T171_Y1.1611.00
34_V49_S1.1581.00
301_W316_V1.1561.00
109_T297_E1.1501.00
39_G66_Q1.1451.00
36_V47_R1.1391.00
254_T289_T1.1381.00
228_R244_V1.1341.00
83_S86_M1.1321.00
132_W280_P1.1301.00
129_V182_D1.1271.00
253_S302_D1.1261.00
66_Q70_D1.1181.00
120_A276_Q1.1131.00
143_I264_L1.1061.00
234_P258_Y1.1031.00
192_A216_N1.1011.00
101_E105_D1.0961.00
51_P222_G1.0931.00
226_P246_D1.0911.00
151_A154_A1.0891.00
315_E319_R1.0891.00
214_A295_A1.0851.00
220_M248_N1.0821.00
309_G312_K1.0761.00
255_S302_D1.0681.00
77_S80_K1.0641.00
75_L102_A1.0591.00
190_Y194_H1.0571.00
192_A211_V1.0531.00
84_A87_R1.0501.00
292_A297_E1.0481.00
104_A164_I1.0481.00
88_F181_V1.0380.99
106_I296_L1.0370.99
61_L202_E1.0370.99
42_M73_D1.0370.99
161_L181_V1.0350.99
148_Q151_A1.0300.99
309_G313_A1.0280.99
328_T334_F1.0270.99
87_R90_D1.0240.99
62_K66_Q1.0200.99
111_L115_A1.0190.99
98_P169_Q1.0190.99
310_P328_T1.0110.99
318_R340_P1.0060.99
235_T286_V1.0040.99
85_L183_L1.0010.99
150_D153_K0.9990.99
120_A274_D0.9950.99
46_W211_V0.9920.99
70_D80_K0.9880.99
114_G159_Q0.9870.99
252_I289_T0.9860.99
286_V329_K0.9860.99
69_L211_V0.9780.99
184_S188_E0.9780.99
105_D194_H0.9700.99
325_Y339_S0.9690.99
120_A308_L0.9630.99
164_I169_Q0.9610.99
257_S268_R0.9470.99
199_M207_Y0.9440.99
99_V170_Q0.9420.99
230_A241_V0.9390.99
69_L191_A0.9370.99
272_V306_M0.9340.99
147_E150_D0.9290.99
61_L198_L0.9270.99
111_L158_L0.9210.99
198_L201_Q0.9130.99
115_A159_Q0.9100.99
78_T130_N0.9100.99
305_L324_V0.9070.99
155_K179_L0.9070.99
126_G180_Y0.8960.98
131_L144_P0.8930.98
216_N251_G0.8920.98
232_Q239_N0.8890.98
305_L317_V0.8880.98
336_T339_S0.8850.98
217_S247_I0.8840.98
116_K316_V0.8800.98
276_Q312_K0.8790.98
65_I199_M0.8780.98
258_Y287_S0.8740.98
48_A199_M0.8730.98
102_A190_Y0.8720.98
121_M186_V0.8720.98
42_M188_E0.8700.98
68_Q102_A0.8690.98
192_A209_V0.8680.98
288_V306_M0.8670.98
310_P334_F0.8630.98
235_T257_S0.8560.98
252_I291_I0.8560.98
113_I297_E0.8550.98
63_E67_T0.8530.98
247_I252_I0.8530.98
37_L63_E0.8500.98
210_S253_S0.8490.98
308_L312_K0.8450.98
93_S172_L0.8440.98
43_G77_S0.8410.98
99_V104_A0.8410.98
37_L62_K0.8370.98
128_L149_I0.8310.97
208_L215_L0.8300.97
78_T184_S0.8290.97
88_F170_Q0.8270.97
125_V128_L0.8230.97
96_P162_T0.8120.97
206_R218_R0.8090.97
82_D86_M0.7980.97
161_L179_L0.7970.97
236_D240_A0.7960.97
217_S227_W0.7950.97
274_D277_T0.7930.97
192_A295_A0.7900.97
194_H198_L0.7890.97
186_V296_L0.7880.96
188_E253_S0.7880.96
124_T158_L0.7820.96
197_R201_Q0.7810.96
127_P180_Y0.7790.96
315_E318_R0.7790.96
275_P307_V0.7780.96
132_W269_L0.7780.96
299_D303_T0.7750.96
143_I269_L0.7740.96
251_G298_A0.7700.96
199_M204_I0.7700.96
105_D296_L0.7590.96
196_A218_R0.7560.96
226_P248_N0.7540.95
103_M183_L0.7510.95
187_G214_A0.7510.95
132_W279_R0.7480.95
104_A108_T0.7480.95
214_A302_D0.7450.95
38_E45_F0.7370.95
217_S250_H0.7370.95
204_I207_Y0.7350.95
255_S271_H0.7350.95
161_L170_Q0.7340.95
251_G292_A0.7300.95
122_D158_L0.7280.95
128_L273_I0.7280.95
102_A194_H0.7270.94
270_S306_M0.7260.94
313_A316_V0.7250.94
78_T126_G0.7210.94
91_S95_S0.7200.94
135_G141_V0.7190.94
71_A194_H0.7160.94
60_E64_K0.7070.94
196_A209_V0.7070.94
44_T212_G0.7060.94
75_L84_A0.7040.94
200_E216_N0.7010.93
44_T188_E0.7010.93
262_Y269_L0.7010.93
182_D260_N0.7010.93
149_I153_K0.7010.93
48_A65_I0.7000.93
316_V320_E0.6990.93
231_I289_T0.6980.93
88_F97_W0.6970.93
220_M226_P0.6970.93
43_G79_Y0.6960.93
127_P155_K0.6940.93
206_R220_M0.6920.93
253_S298_A0.6890.93
316_V319_R0.6830.92
324_V336_T0.6820.92
255_S303_T0.6820.92
272_V303_T0.6810.92
88_F107_V0.6790.92
41_T46_W0.6780.92
62_K65_I0.6780.92
51_P206_R0.6760.92
126_G129_V0.6750.92
210_S215_L0.6700.92
206_R221_N0.6660.92
148_Q152_M0.6640.91
45_F210_S0.6630.91
284_N310_P0.6630.91
155_K174_K0.6630.91
251_G295_A0.6630.91
73_D191_A0.6610.91
313_A317_V0.6610.91
245_V252_I0.6610.91
113_I304_G0.6600.91
106_I190_Y0.6590.91
274_D281_I0.6580.91
233_K236_D0.6560.91
109_T294_T0.6560.91
217_S249_G0.6550.91
337_W340_P0.6500.91
132_W144_P0.6480.90
39_G70_D0.6470.90
313_A324_V0.6460.90
309_G326_M0.6440.90
113_I301_W0.6430.90
133_G136_P0.6420.90
61_L204_I0.6420.90
107_V111_L0.6410.90
308_L313_A0.6410.90
221_N226_P0.6390.90
41_T73_D0.6380.90
192_A214_A0.6360.90
96_P173_Q0.6360.90
247_I250_H0.6340.89
110_S183_L0.6320.89
184_S214_A0.6300.89
107_V172_L0.6280.89
50_I61_L0.6270.89
131_L148_Q0.6260.89
330_E333_S0.6230.89
318_R336_T0.6220.89
61_L65_I0.6200.88
250_H323_A0.6200.88
64_K68_Q0.6170.88
257_S270_S0.6170.88
81_K90_D0.6140.88
233_K240_A0.6140.88
235_T331_G0.6130.88
171_Y174_K0.6130.88
164_I171_Y0.6130.88
129_V133_G0.6130.88
41_T211_V0.6110.88
285_L288_V0.6100.88
172_L179_L0.6070.87
85_L88_F0.6070.87
126_G182_D0.6060.87
39_G46_W0.6060.87
208_L227_W0.6040.87
325_Y333_S0.6040.87
113_I186_V0.6020.87
109_T113_I0.6010.87
281_I307_V0.5980.86
46_W66_Q0.5970.86
293_P321_G0.5950.86
183_L187_G0.5940.86
64_K67_T0.5930.86
310_P326_M0.5920.86
122_D156_T0.5910.86
304_G307_V0.5900.86
125_V182_D0.5890.86
43_G78_T0.5880.86
206_R222_G0.5850.85
123_I183_L0.5840.85
46_W62_K0.5820.85
257_S306_M0.5800.85
107_V183_L0.5800.85
37_L59_A0.5790.85
88_F91_S0.5790.85
127_P156_T0.5750.84
78_T85_L0.5740.84
250_H292_A0.5730.84
188_E214_A0.5730.84
188_E260_N0.5720.84
81_K86_M0.5700.84
105_D197_R0.5690.84
128_L156_T0.5680.84
108_T112_R0.5680.84
78_T180_Y0.5680.84
273_I280_P0.5650.83
271_H303_T0.5640.83
125_V156_T0.5640.83
126_G135_G0.5610.83
310_P314_K0.5600.83
251_G289_T0.5600.83
133_G138_Q0.5570.82
304_G308_L0.5570.82
107_V123_I0.5570.82
111_L159_Q0.5570.82
91_S97_W0.5560.82
51_P221_N0.5550.82
266_G269_L0.5540.82
330_E335_K0.5530.82
35_T62_K0.5520.82
98_P166_Q0.5510.82
257_S329_K0.5500.82
40_K45_F0.5500.82
236_D239_N0.5490.82
93_S97_W0.5490.82
115_A118_D0.5490.82
128_L132_W0.5480.81
93_S177_P0.5480.81
170_Q174_K0.5470.81
234_P287_S0.5470.81
110_S121_M0.5460.81
128_L153_K0.5460.81
193_D216_N0.5450.81
41_T66_Q0.5400.80
191_A195_L0.5390.80
111_L161_L0.5390.80
317_V322_L0.5360.80
160_H179_L0.5340.80
311_E315_E0.5330.80
219_G249_G0.5320.79
129_V273_I0.5310.79
37_L66_Q0.5310.79
65_I69_L0.5300.79
50_I204_I0.5290.79
93_S96_P0.5290.79
40_K43_G0.5280.79
247_I289_T0.5260.79
292_A322_L0.5250.79
270_S280_P0.5240.78
70_D73_D0.5220.78
174_K177_P0.5190.78
76_L103_M0.5180.78
131_L149_I0.5150.77
305_L316_V0.5150.77
221_N224_G0.5080.76
138_Q141_V0.5040.76
333_S339_S0.5040.76
105_D109_T0.5040.76
314_K334_F0.5030.76
285_L310_P0.5020.75
304_G316_V0.5020.75
188_E255_S0.5020.75
335_K340_P0.5010.75
284_N309_G0.5000.75
144_P149_I0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ig1A 1 0.9003 100 0.124 Contact Map
2o18A 4 0.886 100 0.128 Contact Map
1vrmA 1 0.8689 100 0.147 Contact Map
2o34A 1 0.6667 100 0.682 Contact Map
2jyaA 1 0.2222 33.9 0.965 Contact Map
2ljuA 1 0.2906 23.1 0.968 Contact Map
2i33A 2 0.208 14.4 0.971 Contact Map
4gveA 1 0.3846 14.3 0.971 Contact Map
3jz3A 2 0.4501 13.7 0.971 Contact Map
2bfdB 2 0.1652 13 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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