END3 - ECOLI - GREMLIN Contacts

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END3 - Endonuclease III

UniProt:	P0AB83	Sequences: MNKAKRLEILTRLRENNPHPTTELNFSSPFELLIAVLLSAQATDVSVNKATAKLYPVANTPAAMLELGVEGVKTYIKTIGLYNSKAENIIKTCRILLEQHNGEVPEDRAALEALPGVGRKTANVVLNTAFGWPTIAVDTHIFRVCNRTQFAPGKNVEQVEEKLLKVVPAEFKVDCHHWLILHGRYTCIARKPRCGSCIIEDLCEYKEKVDI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10662
Length:	211 (198)
Sequences:	8407 (5309)
Seq/√Len:	377.3

ECOLI - END3 MUTY
BACSU - END3 YFHQ
HALSA - Q9HRQ5 Q9HPQ6 Q9HS56
SULSO - Q97VX0 Q7LXY0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
107_D	110_A	3.823	1.00
60_T	63_A	3.436	1.00
193_R	196_S	3.217	1.00
95_I	99_Q	3.188	1.00
106_E	132_W	2.734	1.00
188_I	193_R	2.637	1.00
95_I	115_P	2.534	1.00
57_V	71_G	2.524	1.00
72_V	90_I	2.397	1.00
90_I	94_R	2.301	1.00
14_R	171_F	2.276	1.00
108_R	112_E	2.242	1.00
74_T	77_K	2.193	1.00
57_V	75_Y	2.153	1.00
100_H	113_A	2.101	1.00
157_E	161_E	2.063	1.00
62_A	97_L	2.013	1.00
28_S	31_E	1.992	1.00
37_L	92_T	1.914	1.00
94_R	98_E	1.914	1.00
59_N	63_A	1.891	1.00
200_E	206_K	1.881	1.00
68_G	71_G	1.852	1.00
84_S	88_N	1.844	1.00
69_V	73_K	1.832	1.00
91_K	115_P	1.826	1.00
88_N	91_K	1.825	1.00
69_V	90_I	1.818	1.00
99_Q	113_A	1.729	1.00
58_A	67_L	1.712	1.00
34_I	89_I	1.702	1.00
62_A	66_E	1.693	1.00
30_F	61_P	1.652	1.00
14_R	174_D	1.636	1.00
97_L	102_G	1.599	1.00
52_A	56_P	1.587	1.00
142_F	159_V	1.581	1.00
20_P	25_N	1.575	1.00
110_A	113_A	1.567	1.00
12_R	201_D	1.563	1.00
160_E	164_L	1.558	1.00
30_F	93_C	1.516	1.00
151_A	162_K	1.501	1.00
27_S	31_E	1.494	1.00
42_A	46_S	1.483	1.00
108_R	134_T	1.467	1.00
53_K	56_P	1.457	1.00
58_A	75_Y	1.423	1.00
31_E	55_Y	1.412	1.00
150_F	204_E	1.400	1.00
84_S	87_E	1.400	1.00
159_V	163_L	1.395	1.00
91_K	94_R	1.393	1.00
108_R	126_L	1.385	1.00
8_E	202_L	1.381	1.00
103_E	106_E	1.354	1.00
53_K	75_Y	1.345	1.00
73_K	82_Y	1.320	1.00
126_L	132_W	1.316	1.00
148_T	199_I	1.316	1.00
12_R	16_N	1.308	1.00
67_L	72_V	1.307	1.00
8_E	11_T	1.306	1.00
171_F	174_D	1.281	1.00
181_L	185_Y	1.278	1.00
106_E	130_F	1.277	1.00
112_E	119_R	1.273	1.00
13_L	17_N	1.270	1.00
167_V	175_C	1.258	1.00
42_A	79_I	1.257	1.00
39_S	44_D	1.236	1.00
148_T	202_L	1.233	1.00
95_I	113_A	1.220	1.00
46_S	49_K	1.218	1.00
70_E	73_K	1.198	1.00
119_R	160_E	1.180	1.00
92_T	114_L	1.162	1.00
49_K	52_A	1.149	1.00
23_E	185_Y	1.140	1.00
91_K	95_I	1.136	1.00
111_L	126_L	1.129	1.00
69_V	87_E	1.129	1.00
95_I	100_H	1.128	1.00
33_L	37_L	1.125	1.00
68_G	90_I	1.123	1.00
145_C	163_L	1.122	1.00
29_P	129_A	1.118	1.00
174_D	178_W	1.094	1.00
157_E	160_E	1.080	1.00
100_H	110_A	1.068	1.00
131_G	173_V	1.065	1.00
186_T	198_I	1.064	1.00
34_I	55_Y	1.058	1.00
33_L	125_V	1.056	1.00
69_V	86_A	1.054	1.00
43_T	46_S	1.054	1.00
96_L	104_V	1.048	1.00
155_N	158_Q	1.038	1.00
64_M	72_V	1.034	1.00
153_G	158_Q	1.029	1.00
99_Q	110_A	1.016	1.00
8_E	12_R	1.011	1.00
199_I	202_L	1.009	1.00
31_E	51_T	0.996	1.00
160_E	163_L	0.987	1.00
10_L	14_R	0.980	1.00
30_F	64_M	0.967	1.00
126_L	134_T	0.966	1.00
64_M	93_C	0.963	1.00
51_T	55_Y	0.962	1.00
11_T	15_E	0.956	1.00
182_H	186_T	0.951	1.00
48_N	52_A	0.950	1.00
133_P	169_A	0.947	1.00
69_V	94_R	0.924	1.00
9_I	199_I	0.923	1.00
92_T	95_I	0.923	1.00
61_P	97_L	0.920	1.00
87_E	91_K	0.917	1.00
169_A	172_K	0.913	1.00
194_C	203_C	0.911	1.00
45_V	49_K	0.910	1.00
153_G	159_V	0.909	1.00
25_N	52_A	0.907	1.00
92_T	96_L	0.905	1.00
187_C	194_C	0.898	1.00
182_H	198_I	0.894	1.00
33_L	92_T	0.893	1.00
71_G	75_Y	0.888	1.00
127_N	136_A	0.886	1.00
145_C	179_L	0.878	1.00
187_C	197_C	0.874	1.00
127_N	176_H	0.871	1.00
12_R	15_E	0.869	1.00
65_L	93_C	0.866	1.00
16_N	198_I	0.859	1.00
40_A	121_T	0.857	1.00
65_L	97_L	0.852	1.00
26_F	31_E	0.852	1.00
117_V	121_T	0.845	1.00
50_A	53_K	0.841	1.00
36_V	125_V	0.840	1.00
109_A	112_E	0.839	1.00
67_L	71_G	0.838	1.00
108_R	132_W	0.830	1.00
108_R	123_N	0.829	1.00
175_C	179_L	0.823	1.00
7_L	11_T	0.823	1.00
161_E	164_L	0.821	1.00
156_V	160_E	0.818	1.00
53_K	78_T	0.817	1.00
12_R	198_I	0.816	1.00
186_T	196_S	0.814	1.00
26_F	32_L	0.814	1.00
135_I	172_K	0.807	1.00
126_L	130_F	0.806	1.00
46_S	78_T	0.799	1.00
156_V	159_V	0.795	1.00
136_A	176_H	0.793	1.00
34_I	92_T	0.791	1.00
9_I	12_R	0.789	1.00
162_K	165_K	0.786	1.00
158_Q	162_K	0.785	1.00
104_V	111_L	0.783	1.00
146_N	159_V	0.781	1.00
71_G	74_T	0.778	1.00
58_A	71_G	0.770	1.00
127_N	173_V	0.769	1.00
53_K	57_V	0.768	1.00
61_P	104_V	0.767	1.00
146_N	151_A	0.764	1.00
161_E	165_K	0.757	1.00
142_F	146_N	0.751	1.00
46_S	79_I	0.749	1.00
49_K	53_K	0.739	1.00
164_L	172_K	0.738	1.00
19_H	24_L	0.728	1.00
123_N	135_I	0.728	1.00
31_E	59_N	0.726	1.00
36_V	121_T	0.723	1.00
108_R	122_A	0.722	1.00
11_T	14_R	0.717	1.00
89_I	93_C	0.715	1.00
128_T	173_V	0.711	1.00
20_P	23_E	0.709	1.00
144_V	182_H	0.701	0.99
65_L	90_I	0.693	0.99
65_L	94_R	0.688	0.99
19_H	23_E	0.685	0.99
13_L	177_H	0.683	0.99
12_R	17_N	0.681	0.99
38_L	47_V	0.677	0.99
96_L	102_G	0.676	0.99
117_V	122_A	0.675	0.99
36_V	128_T	0.675	0.99
45_V	48_N	0.673	0.99
32_L	129_A	0.671	0.99
86_A	89_I	0.668	0.99
65_L	68_G	0.664	0.99
158_Q	161_E	0.664	0.99
8_E	201_D	0.663	0.99
38_L	79_I	0.662	0.99
135_I	164_L	0.661	0.99
119_R	123_N	0.659	0.99
62_A	102_G	0.656	0.99
202_L	206_K	0.652	0.99
194_C	197_C	0.651	0.99
97_L	100_H	0.648	0.99
58_A	72_V	0.646	0.99
182_H	185_Y	0.645	0.99
108_R	119_R	0.645	0.99
75_Y	78_T	0.642	0.99
47_V	79_I	0.641	0.99
61_P	93_C	0.633	0.99
125_V	129_A	0.633	0.99
127_N	134_T	0.632	0.99
19_H	22_T	0.629	0.99
155_N	159_V	0.627	0.99
135_I	175_C	0.625	0.99
86_A	90_I	0.624	0.99
111_L	125_V	0.620	0.99
9_I	13_L	0.618	0.99
67_L	90_I	0.614	0.99
171_F	178_W	0.614	0.99
187_C	203_C	0.613	0.99
147_R	192_P	0.611	0.99
107_D	126_L	0.610	0.99
141_I	179_L	0.609	0.99
112_E	122_A	0.608	0.99
7_L	171_F	0.607	0.99
59_N	64_M	0.607	0.99
20_P	181_L	0.606	0.98
106_E	110_A	0.605	0.98
123_N	160_E	0.605	0.98
113_A	126_L	0.604	0.98
34_I	37_L	0.604	0.98
17_N	20_P	0.603	0.98
12_R	202_L	0.601	0.98
31_E	64_M	0.600	0.98
200_E	205_Y	0.599	0.98
10_L	171_F	0.598	0.98
135_I	167_V	0.597	0.98
10_L	174_D	0.597	0.98
134_T	172_K	0.595	0.98
111_L	117_V	0.590	0.98
9_I	178_W	0.589	0.98
128_T	177_H	0.588	0.98
95_I	114_L	0.587	0.98
63_A	66_E	0.587	0.98
146_N	153_G	0.587	0.98
73_K	86_A	0.586	0.98
94_R	97_L	0.584	0.98
72_V	76_I	0.584	0.98
103_E	130_F	0.582	0.98
121_T	125_V	0.581	0.98
14_R	178_W	0.581	0.98
28_S	59_N	0.575	0.98
117_V	125_V	0.571	0.98
119_R	157_E	0.568	0.98
37_L	89_I	0.565	0.98
137_V	141_I	0.563	0.98
188_I	191_K	0.563	0.98
123_N	136_A	0.559	0.97
192_P	203_C	0.556	0.97
23_E	181_L	0.555	0.97
50_A	79_I	0.553	0.97
49_K	78_T	0.548	0.97
33_L	96_L	0.548	0.97
149_Q	166_V	0.547	0.97
17_N	181_L	0.545	0.97
167_V	172_K	0.541	0.97
22_T	128_T	0.541	0.97
35_A	51_T	0.537	0.97
139_T	189_A	0.535	0.97
195_G	200_E	0.534	0.97
168_P	172_K	0.534	0.97
28_S	32_L	0.533	0.97
10_L	13_L	0.531	0.97
147_R	194_C	0.528	0.96
133_P	170_E	0.526	0.96
120_K	140_H	0.524	0.96
148_T	204_E	0.519	0.96
197_C	203_C	0.519	0.96
137_V	142_F	0.517	0.96
133_P	173_V	0.516	0.96
120_K	137_V	0.514	0.96
144_V	148_T	0.512	0.96
147_R	187_C	0.511	0.96
123_N	134_T	0.510	0.96
29_P	130_F	0.508	0.96
107_D	132_W	0.507	0.96
39_S	180_I	0.507	0.96
145_C	148_T	0.507	0.96
95_I	98_E	0.505	0.95
172_K	176_H	0.500	0.95
38_L	54_L	0.500	0.95
147_R	188_I	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2abkA	1	1	100	0.172	Contact Map
1ornA	1	1	100	0.188	Contact Map
1kg2A	1	0.9905	100	0.192	Contact Map
3fspA	1	0.9905	100	0.193	Contact Map
4unfA	1	0.9905	100	0.197	Contact Map
3n5nX	1	0.9905	100	0.203	Contact Map
4uobA	1	1	100	0.209	Contact Map
1keaA	2	0.9763	100	0.217	Contact Map
1pu6A	1	0.8863	100	0.333	Contact Map
3n0uA	1	0.891	100	0.458	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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