GREMLIN Database
END3 - Endonuclease III
UniProt: P0AB83 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10662
Length: 211 (198)
Sequences: 8407 (5309)
Seq/√Len: 377.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_D110_A3.8231.00
60_T63_A3.4361.00
193_R196_S3.2171.00
95_I99_Q3.1881.00
106_E132_W2.7341.00
188_I193_R2.6371.00
95_I115_P2.5341.00
57_V71_G2.5241.00
72_V90_I2.3971.00
90_I94_R2.3011.00
14_R171_F2.2761.00
108_R112_E2.2421.00
74_T77_K2.1931.00
57_V75_Y2.1531.00
100_H113_A2.1011.00
157_E161_E2.0631.00
62_A97_L2.0131.00
28_S31_E1.9921.00
37_L92_T1.9141.00
94_R98_E1.9141.00
59_N63_A1.8911.00
200_E206_K1.8811.00
68_G71_G1.8521.00
84_S88_N1.8441.00
69_V73_K1.8321.00
91_K115_P1.8261.00
88_N91_K1.8251.00
69_V90_I1.8181.00
99_Q113_A1.7291.00
58_A67_L1.7121.00
34_I89_I1.7021.00
62_A66_E1.6931.00
30_F61_P1.6521.00
14_R174_D1.6361.00
97_L102_G1.5991.00
52_A56_P1.5871.00
142_F159_V1.5811.00
20_P25_N1.5751.00
110_A113_A1.5671.00
12_R201_D1.5631.00
160_E164_L1.5581.00
30_F93_C1.5161.00
151_A162_K1.5011.00
27_S31_E1.4941.00
42_A46_S1.4831.00
108_R134_T1.4671.00
53_K56_P1.4571.00
58_A75_Y1.4231.00
31_E55_Y1.4121.00
150_F204_E1.4001.00
84_S87_E1.4001.00
159_V163_L1.3951.00
91_K94_R1.3931.00
108_R126_L1.3851.00
8_E202_L1.3811.00
103_E106_E1.3541.00
53_K75_Y1.3451.00
73_K82_Y1.3201.00
126_L132_W1.3161.00
148_T199_I1.3161.00
12_R16_N1.3081.00
67_L72_V1.3071.00
8_E11_T1.3061.00
171_F174_D1.2811.00
181_L185_Y1.2781.00
106_E130_F1.2771.00
112_E119_R1.2731.00
13_L17_N1.2701.00
167_V175_C1.2581.00
42_A79_I1.2571.00
39_S44_D1.2361.00
148_T202_L1.2331.00
95_I113_A1.2201.00
46_S49_K1.2181.00
70_E73_K1.1981.00
119_R160_E1.1801.00
92_T114_L1.1621.00
49_K52_A1.1491.00
23_E185_Y1.1401.00
91_K95_I1.1361.00
111_L126_L1.1291.00
69_V87_E1.1291.00
95_I100_H1.1281.00
33_L37_L1.1251.00
68_G90_I1.1231.00
145_C163_L1.1221.00
29_P129_A1.1181.00
174_D178_W1.0941.00
157_E160_E1.0801.00
100_H110_A1.0681.00
131_G173_V1.0651.00
186_T198_I1.0641.00
34_I55_Y1.0581.00
33_L125_V1.0561.00
69_V86_A1.0541.00
43_T46_S1.0541.00
96_L104_V1.0481.00
155_N158_Q1.0381.00
64_M72_V1.0341.00
153_G158_Q1.0291.00
99_Q110_A1.0161.00
8_E12_R1.0111.00
199_I202_L1.0091.00
31_E51_T0.9961.00
160_E163_L0.9871.00
10_L14_R0.9801.00
30_F64_M0.9671.00
126_L134_T0.9661.00
64_M93_C0.9631.00
51_T55_Y0.9621.00
11_T15_E0.9561.00
182_H186_T0.9511.00
48_N52_A0.9501.00
133_P169_A0.9471.00
69_V94_R0.9241.00
9_I199_I0.9231.00
92_T95_I0.9231.00
61_P97_L0.9201.00
87_E91_K0.9171.00
169_A172_K0.9131.00
194_C203_C0.9111.00
45_V49_K0.9101.00
153_G159_V0.9091.00
25_N52_A0.9071.00
92_T96_L0.9051.00
187_C194_C0.8981.00
182_H198_I0.8941.00
33_L92_T0.8931.00
71_G75_Y0.8881.00
127_N136_A0.8861.00
145_C179_L0.8781.00
187_C197_C0.8741.00
127_N176_H0.8711.00
12_R15_E0.8691.00
65_L93_C0.8661.00
16_N198_I0.8591.00
40_A121_T0.8571.00
65_L97_L0.8521.00
26_F31_E0.8521.00
117_V121_T0.8451.00
50_A53_K0.8411.00
36_V125_V0.8401.00
109_A112_E0.8391.00
67_L71_G0.8381.00
108_R132_W0.8301.00
108_R123_N0.8291.00
175_C179_L0.8231.00
7_L11_T0.8231.00
161_E164_L0.8211.00
156_V160_E0.8181.00
53_K78_T0.8171.00
12_R198_I0.8161.00
186_T196_S0.8141.00
26_F32_L0.8141.00
135_I172_K0.8071.00
126_L130_F0.8061.00
46_S78_T0.7991.00
156_V159_V0.7951.00
136_A176_H0.7931.00
34_I92_T0.7911.00
9_I12_R0.7891.00
162_K165_K0.7861.00
158_Q162_K0.7851.00
104_V111_L0.7831.00
146_N159_V0.7811.00
71_G74_T0.7781.00
58_A71_G0.7701.00
127_N173_V0.7691.00
53_K57_V0.7681.00
61_P104_V0.7671.00
146_N151_A0.7641.00
161_E165_K0.7571.00
142_F146_N0.7511.00
46_S79_I0.7491.00
49_K53_K0.7391.00
164_L172_K0.7381.00
19_H24_L0.7281.00
123_N135_I0.7281.00
31_E59_N0.7261.00
36_V121_T0.7231.00
108_R122_A0.7221.00
11_T14_R0.7171.00
89_I93_C0.7151.00
128_T173_V0.7111.00
20_P23_E0.7091.00
144_V182_H0.7010.99
65_L90_I0.6930.99
65_L94_R0.6880.99
19_H23_E0.6850.99
13_L177_H0.6830.99
12_R17_N0.6810.99
38_L47_V0.6770.99
96_L102_G0.6760.99
117_V122_A0.6750.99
36_V128_T0.6750.99
45_V48_N0.6730.99
32_L129_A0.6710.99
86_A89_I0.6680.99
65_L68_G0.6640.99
158_Q161_E0.6640.99
8_E201_D0.6630.99
38_L79_I0.6620.99
135_I164_L0.6610.99
119_R123_N0.6590.99
62_A102_G0.6560.99
202_L206_K0.6520.99
194_C197_C0.6510.99
97_L100_H0.6480.99
58_A72_V0.6460.99
182_H185_Y0.6450.99
108_R119_R0.6450.99
75_Y78_T0.6420.99
47_V79_I0.6410.99
61_P93_C0.6330.99
125_V129_A0.6330.99
127_N134_T0.6320.99
19_H22_T0.6290.99
155_N159_V0.6270.99
135_I175_C0.6250.99
86_A90_I0.6240.99
111_L125_V0.6200.99
9_I13_L0.6180.99
67_L90_I0.6140.99
171_F178_W0.6140.99
187_C203_C0.6130.99
147_R192_P0.6110.99
107_D126_L0.6100.99
141_I179_L0.6090.99
112_E122_A0.6080.99
7_L171_F0.6070.99
59_N64_M0.6070.99
20_P181_L0.6060.98
106_E110_A0.6050.98
123_N160_E0.6050.98
113_A126_L0.6040.98
34_I37_L0.6040.98
17_N20_P0.6030.98
12_R202_L0.6010.98
31_E64_M0.6000.98
200_E205_Y0.5990.98
10_L171_F0.5980.98
135_I167_V0.5970.98
10_L174_D0.5970.98
134_T172_K0.5950.98
111_L117_V0.5900.98
9_I178_W0.5890.98
128_T177_H0.5880.98
95_I114_L0.5870.98
63_A66_E0.5870.98
146_N153_G0.5870.98
73_K86_A0.5860.98
94_R97_L0.5840.98
72_V76_I0.5840.98
103_E130_F0.5820.98
121_T125_V0.5810.98
14_R178_W0.5810.98
28_S59_N0.5750.98
117_V125_V0.5710.98
119_R157_E0.5680.98
37_L89_I0.5650.98
137_V141_I0.5630.98
188_I191_K0.5630.98
123_N136_A0.5590.97
192_P203_C0.5560.97
23_E181_L0.5550.97
50_A79_I0.5530.97
49_K78_T0.5480.97
33_L96_L0.5480.97
149_Q166_V0.5470.97
17_N181_L0.5450.97
167_V172_K0.5410.97
22_T128_T0.5410.97
35_A51_T0.5370.97
139_T189_A0.5350.97
195_G200_E0.5340.97
168_P172_K0.5340.97
28_S32_L0.5330.97
10_L13_L0.5310.97
147_R194_C0.5280.96
133_P170_E0.5260.96
120_K140_H0.5240.96
148_T204_E0.5190.96
197_C203_C0.5190.96
137_V142_F0.5170.96
133_P173_V0.5160.96
120_K137_V0.5140.96
144_V148_T0.5120.96
147_R187_C0.5110.96
123_N134_T0.5100.96
29_P130_F0.5080.96
107_D132_W0.5070.96
39_S180_I0.5070.96
145_C148_T0.5070.96
95_I98_E0.5050.95
172_K176_H0.5000.95
38_L54_L0.5000.95
147_R188_I0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2abkA 1 1 100 0.172 Contact Map
1ornA 1 1 100 0.188 Contact Map
1kg2A 1 0.9905 100 0.192 Contact Map
3fspA 1 0.9905 100 0.193 Contact Map
4unfA 1 0.9905 100 0.197 Contact Map
3n5nX 1 0.9905 100 0.203 Contact Map
4uobA 1 1 100 0.209 Contact Map
1keaA 2 0.9763 100 0.217 Contact Map
1pu6A 1 0.8863 100 0.333 Contact Map
3n0uA 1 0.891 100 0.458 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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