GREMLIN Database
ILVE - Branched-chain-amino-acid aminotransferase
UniProt: P0AB80 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10497
Length: 309 (272)
Sequences: 8632 (5539)
Seq/√Len: 335.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
207_V238_R4.4521.00
141_D267_S4.3081.00
207_V236_E3.1851.00
59_Q76_I3.1711.00
240_Q246_S3.1351.00
208_L230_A3.0941.00
62_H76_I2.9781.00
15_M89_K2.6201.00
219_P224_D2.5851.00
209_F240_Q2.4411.00
287_Q291_G2.4001.00
191_Y241_V2.3721.00
75_S78_E2.2961.00
85_D89_K2.2751.00
233_L288_A2.2141.00
56_E224_D2.2141.00
69_R177_R2.1551.00
143_M180_Y2.1131.00
227_I237_V2.0961.00
81_E85_D2.0351.00
253_V265_V1.9991.00
36_V64_S1.9761.00
85_D88_R1.9501.00
144_V269_D1.9221.00
204_K251_D1.9111.00
233_L284_R1.9001.00
143_M178_H1.8791.00
61_L101_I1.8381.00
34_T103_V1.8311.00
199_N220_G1.8101.00
55_R80_M1.8081.00
195_G198_E1.7521.00
224_D228_K1.7381.00
43_Y261_E1.7131.00
142_A265_V1.7131.00
267_S270_G1.7101.00
66_K72_V1.7061.00
144_V244_R1.6971.00
53_R225_A1.6971.00
248_Y271_I1.6861.00
146_S174_E1.6831.00
174_E178_H1.6761.00
283_K287_Q1.6691.00
65_A101_I1.6421.00
203_V281_V1.6381.00
202_E242_L1.6361.00
18_W24_H1.6211.00
284_R288_A1.6171.00
142_A184_I1.5771.00
70_F101_I1.5701.00
142_A195_G1.5601.00
226_I256_S1.5511.00
253_V268_V1.5501.00
17_R20_D1.5481.00
200_L253_V1.5441.00
36_V65_A1.5271.00
140_I181_Q1.5161.00
267_S272_Q1.5151.00
59_Q63_D1.4951.00
195_G255_M1.4841.00
288_A291_G1.4571.00
54_H80_M1.4521.00
80_M84_R1.4371.00
212_P241_V1.4311.00
54_H58_M1.4281.00
191_Y243_S1.4211.00
201_F256_S1.4161.00
208_L235_I1.4101.00
204_K249_L1.4051.00
55_R59_Q1.4021.00
62_H72_V1.3981.00
223_R239_E1.3951.00
187_D191_Y1.3941.00
141_D266_R1.3881.00
228_K232_E1.3801.00
202_E250_A1.3701.00
92_L95_A1.3691.00
42_C87_I1.3611.00
215_S241_V1.3531.00
63_D66_K1.3521.00
40_I51_V1.3411.00
141_D181_Q1.3271.00
201_F254_F1.3251.00
202_E209_F1.3131.00
29_A102_F1.2991.00
81_E84_R1.2951.00
63_D219_P1.2931.00
184_I200_L1.2901.00
56_E228_K1.2901.00
51_V54_H1.2771.00
230_A235_I1.2671.00
29_A35_S1.2631.00
284_R287_Q1.2621.00
210_T223_R1.2601.00
173_S177_R1.2581.00
53_R56_E1.2481.00
56_E59_Q1.2431.00
203_V208_L1.2311.00
252_E279_G1.2171.00
202_E253_V1.2161.00
133_A138_Q1.2101.00
276_G279_G1.2081.00
27_S102_F1.1971.00
209_F238_R1.1881.00
31_H98_R1.1801.00
84_R88_R1.1711.00
70_F116_Y1.1681.00
257_G260_A1.1661.00
78_E81_E1.1591.00
86_V122_I1.1541.00
235_I281_V1.1511.00
82_A122_I1.1391.00
51_V83_C1.1321.00
10_W82_A1.1271.00
42_C95_A1.1221.00
10_W15_M1.1191.00
64_S159_A1.1121.00
83_C97_I1.1101.00
35_S163_G1.1101.00
230_A285_I1.1081.00
77_D81_E1.1031.00
243_S246_S1.0981.00
82_A120_V1.0961.00
171_V185_A1.0861.00
242_L246_S1.0831.00
36_V61_L1.0831.00
151_A188_V1.0711.00
142_A255_M1.0671.00
15_M86_V1.0661.00
83_C122_I1.0421.00
252_E282_T1.0391.00
30_L102_F1.0311.00
255_M265_V1.0291.00
223_R227_I1.0191.00
67_I159_A1.0181.00
101_I120_V1.0151.00
86_V124_A1.0091.00
63_D158_A1.0081.00
212_P240_Q1.0041.00
182_E196_A1.0001.00
278_C283_K1.0001.00
100_L121_I0.9931.00
87_I95_A0.9911.00
36_V101_I0.9891.00
139_G266_R0.9871.00
209_F242_L0.9861.00
58_M80_M0.9851.00
212_P239_E0.9851.00
190_G245_E0.9711.00
204_K246_S0.9711.00
201_F223_R0.9691.00
55_R76_I0.9681.00
172_G176_R0.9671.00
201_F227_I0.9671.00
76_I80_M0.9661.00
231_K239_E0.9651.00
37_F165_Y0.9641.00
62_H66_K0.9621.00
67_I158_A0.9551.00
184_I247_L0.9551.00
279_G282_T0.9541.00
145_S183_G0.9511.00
230_A237_V0.9501.00
211_P242_L0.9471.00
174_E177_R0.9421.00
187_D216_S0.9381.00
44_D93_T0.9331.00
59_Q62_H0.9331.00
213_F219_P0.9271.00
220_G256_S0.9271.00
213_F223_R0.9271.00
9_I18_W0.9261.00
286_Q290_F0.9251.00
25_V121_I0.9251.00
11_F21_A0.9241.00
192_I200_L0.9171.00
206_G251_D0.9111.00
72_V101_I0.9061.00
27_S104_G0.8921.00
23_V30_L0.8791.00
58_M76_I0.8741.00
58_M83_C0.8741.00
228_K231_K0.8691.00
283_K286_Q0.8691.00
206_G236_E0.8661.00
69_R173_S0.8651.00
231_K236_E0.8641.00
31_H123_A0.8631.00
27_S106_V0.8571.00
95_A124_A0.8531.00
199_N256_S0.8461.00
63_D67_I0.8461.00
203_V252_E0.8441.00
14_E22_K0.8441.00
58_M62_H0.8401.00
171_V196_A0.8381.00
186_L244_R0.8381.00
280_P284_R0.8361.00
65_A72_V0.8361.00
68_Y166_L0.8291.00
62_H79_L0.8261.00
56_E225_A0.8251.00
15_M82_A0.8241.00
232_E288_A0.8161.00
11_F121_I0.8151.00
281_V284_R0.8111.00
250_A253_V0.8081.00
204_K209_F0.8061.00
31_H100_L0.8041.00
41_R94_S0.8031.00
20_D24_H0.8021.00
279_G283_K0.7991.00
140_I263_T0.7971.00
54_H83_C0.7911.00
86_V90_N0.7911.00
77_D80_M0.7901.00
42_C97_I0.7891.00
230_A233_L0.7881.00
56_E221_I0.7861.00
209_F246_S0.7861.00
65_A70_F0.7801.00
111_N176_R0.7781.00
40_I83_C0.7771.00
22_K25_V0.7741.00
229_L233_L0.7731.00
192_I202_E0.7661.00
227_I231_K0.7661.00
42_C51_V0.7611.00
142_A182_E0.7591.00
280_P283_K0.7581.00
189_N241_V0.7581.00
43_Y52_F0.7551.00
203_V254_F0.7531.00
58_M79_L0.7521.00
52_F225_A0.7511.00
205_D251_D0.7501.00
41_R261_E0.7491.00
171_V183_G0.7470.99
245_E249_L0.7470.99
113_P116_Y0.7460.99
227_I239_E0.7370.99
182_E195_G0.7370.99
200_L211_P0.7350.99
183_G196_A0.7340.99
41_R258_T0.7300.99
34_T169_L0.7270.99
96_Y259_A0.7270.99
144_V186_L0.7250.99
275_E278_C0.7240.99
111_N114_A0.7230.99
78_E82_A0.7210.99
145_S174_E0.7200.99
39_G259_A0.7140.99
140_I255_M0.7090.99
247_L268_V0.7050.99
225_A228_K0.7050.99
112_P116_Y0.7040.99
21_A121_I0.7020.99
33_G164_N0.7020.99
28_H34_T0.6990.99
18_W26_M0.6990.99
194_E218_L0.6950.99
68_Y161_A0.6940.99
96_Y125_F0.6910.99
30_L121_I0.6890.99
245_E248_Y0.6880.99
39_G257_G0.6850.99
138_Q181_Q0.6820.99
40_I99_P0.6820.99
82_A85_D0.6780.99
201_F210_T0.6780.99
198_E255_M0.6760.99
39_G96_Y0.6760.99
226_I285_I0.6760.99
139_G263_T0.6750.99
248_Y269_D0.6750.99
192_I242_L0.6740.99
43_Y94_S0.6730.99
266_R278_C0.6710.99
28_H103_V0.6710.99
147_W174_E0.6690.99
110_V168_S0.6680.99
23_V27_S0.6670.99
148_N153_N0.6620.99
229_L288_A0.6590.99
90_N124_A0.6590.99
100_L163_G0.6560.99
232_E292_L0.6560.99
59_Q224_D0.6550.99
210_T239_E0.6530.99
21_A25_V0.6530.99
30_L100_L0.6530.99
274_G278_C0.6520.99
145_S171_V0.6510.99
182_E198_E0.6510.99
172_G182_E0.6490.99
204_K250_A0.6480.99
161_A166_L0.6470.99
102_F121_I0.6460.99
175_A179_G0.6450.99
73_S78_E0.6440.99
247_L253_V0.6410.98
269_D272_Q0.6410.98
186_L192_I0.6390.98
15_M85_D0.6380.98
38_E64_S0.6350.98
260_A263_T0.6340.98
173_S176_R0.6290.98
11_F16_V0.6280.98
212_P215_S0.6270.98
151_A154_T0.6260.98
143_M269_D0.6250.98
172_G197_G0.6250.98
9_I21_A0.6240.98
178_H270_G0.6220.98
36_V68_Y0.6210.98
141_D180_Y0.6210.98
112_P173_S0.6210.98
208_L254_F0.6190.98
83_C99_P0.6160.98
190_G244_R0.6140.98
66_K71_P0.6130.98
51_V84_R0.6120.98
202_E247_L0.6120.98
261_E290_F0.6080.98
184_I253_V0.6070.98
160_K218_L0.6070.98
262_I285_I0.5990.98
244_R248_Y0.5970.98
160_K194_E0.5920.97
165_Y218_L0.5910.97
86_V89_K0.5890.97
62_H75_S0.5880.97
61_L99_P0.5880.97
288_A292_L0.5860.97
92_L124_A0.5860.97
150_A154_T0.5860.97
269_D273_V0.5860.97
214_T241_V0.5840.97
143_M174_E0.5790.97
16_V19_E0.5760.97
246_S249_L0.5760.97
261_E289_F0.5740.97
225_A229_L0.5730.97
51_V97_I0.5720.97
225_A289_F0.5720.97
44_D94_S0.5710.97
24_H105_D0.5690.97
148_N186_L0.5690.97
149_R165_Y0.5640.97
54_H84_R0.5620.96
165_Y168_S0.5610.96
53_R221_I0.5590.96
32_Y164_N0.5570.96
26_M105_D0.5550.96
96_Y108_M0.5540.96
138_Q277_R0.5540.96
201_F208_L0.5540.96
34_T70_F0.5520.96
158_A215_S0.5510.96
229_L232_E0.5510.96
98_R163_G0.5510.96
38_E61_L0.5490.96
272_Q275_E0.5480.96
264_P279_G0.5450.96
208_L281_V0.5440.96
274_G279_G0.5420.96
206_G235_I0.5420.96
150_A157_T0.5410.96
155_I163_G0.5400.96
52_F258_T0.5390.96
111_N115_G0.5390.96
16_V21_A0.5380.96
40_I54_H0.5370.95
200_L247_L0.5360.95
150_A167_S0.5350.95
18_W90_N0.5350.95
51_V87_I0.5340.95
36_V161_A0.5330.95
213_F239_E0.5320.95
231_K237_V0.5310.95
199_N219_P0.5300.95
282_T285_I0.5290.95
203_V206_G0.5260.95
225_A292_L0.5240.95
102_F163_G0.5240.95
175_A183_G0.5230.95
36_V159_A0.5230.95
40_I58_M0.5230.95
26_M31_H0.5230.95
222_T289_F0.5210.95
221_I224_D0.5210.95
207_V240_Q0.5200.95
35_S100_L0.5200.95
226_I262_I0.5130.94
209_F251_D0.5130.94
13_G82_A0.5130.94
273_V276_G0.5120.94
98_R165_Y0.5090.94
28_H108_M0.5080.94
144_V268_V0.5070.94
97_I124_A0.5060.94
254_F282_T0.5060.94
171_V174_E0.5040.94
222_T258_T0.5030.94
83_C86_V0.5020.94
117_S121_I0.5010.93
35_S161_A0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iyeA 5 0.9838 100 0.126 Contact Map
3u0gA 5 0.9709 100 0.141 Contact Map
2eiyA 5 0.9838 100 0.143 Contact Map
4chiA 2 0.9612 100 0.162 Contact Map
3dtgA 2 0.9773 100 0.166 Contact Map
3uzoA 2 0.9676 100 0.18 Contact Map
2coiA 2 0.9547 100 0.181 Contact Map
4dqnA 2 0.9709 100 0.185 Contact Map
4tm5A 2 0.9159 100 0.193 Contact Map
4cmfA 4 0.9676 100 0.194 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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