KBL - ECOLI - GREMLIN Contacts

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KBL - 2-amino-3-ketobutyrate coenzyme A ligase

UniProt:	P0AB77	Sequences: MRGEFYQQLTNDLETARAEGLFKEERIITSAQQADITVADGSHVINFCANNYLGLANHPDLIAAAKAGMDSHGFGMASVRFICGTQDSHKELEQKLAAFLGMEDAILYSSCFDANGGLFETLLGAEDAIISDALNHASIIDGVRLCKAKRYRYANNDMQELEARLKEAREAGARHVLIATDGVFSMDGVIANLKGVCDLADKYDALVMVDDSHAVGFVGENGRGSHEYCDVMGRVDIITGTLGKALGGASGGYTAARKEVVEWLRQRSRPYLFSNSLAPAIVAASIKVLEMVEAGSELRDRLWANARQFREQMSAAGFTLAGADHAIIPVMLGDAVVAQKFARELQKEGIYVTGFFYPVVPKGQARIRTQMSAAHTPEQITRAVEAFTRIGKQLGVIA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10512
Length:	398 (358)
Sequences:	6430 (3898)
Seq/√Len:	206.0

ECOLI - KBL BIOF
BACSU - BIOF1 BIOF2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
66_K	70_D	4.189	1.00
95_K	290_E	4.111	1.00
308_Q	381_T	4.019	1.00
162_E	202_K	3.926	1.00
154_A	160_E	3.811	1.00
201_D	234_R	3.795	1.00
348_E	389_R	3.618	1.00
192_N	195_G	3.209	1.00
160_E	164_R	3.103	1.00
180_T	184_F	3.064	1.00
287_K	290_E	2.859	1.00
95_K	286_I	2.853	1.00
178_I	200_A	2.753	1.00
308_Q	377_P	2.730	1.00
312_Q	384_V	2.610	1.00
162_E	203_Y	2.537	1.00
301_R	305_N	2.485	1.00
95_K	293_E	2.383	1.00
63_A	67_A	2.342	1.00
256_A	261_V	2.278	1.00
108_Y	268_S	2.259	1.00
194_K	229_C	2.257	1.00
162_E	166_K	2.241	1.00
160_E	163_A	2.240	1.00
221_N	227_E	2.235	1.00
240_G	253_Y	2.224	1.00
256_A	260_V	2.179	1.00
158_M	199_L	2.163	1.00
211_D	214_A	2.134	1.00
103_E	258_K	2.056	1.00
98_A	293_E	2.048	1.00
312_Q	381_T	2.043	1.00
295_G	298_L	2.037	1.00
180_T	209_V	1.987	1.00
60_D	287_K	1.969	1.00
316_A	388_T	1.949	1.00
130_I	164_R	1.938	1.00
62_I	69_M	1.888	1.00
332_L	341_F	1.871	1.00
60_D	294_A	1.847	1.00
195_G	198_D	1.835	1.00
304_A	377_P	1.817	1.00
123_L	129_I	1.809	1.00
376_T	379_Q	1.803	1.00
131_S	135_N	1.768	1.00
344_E	347_K	1.753	1.00
350_I	382_R	1.747	1.00
220_E	227_E	1.733	1.00
312_Q	315_A	1.722	1.00
58_H	291_M	1.691	1.00
119_F	179_A	1.682	1.00
44_V	346_Q	1.662	1.00
63_A	70_D	1.662	1.00
47_F	375_H	1.661	1.00
47_F	383_A	1.658	1.00
105_A	255_A	1.655	1.00
133_A	154_A	1.648	1.00
35_D	43_H	1.611	1.00
169_R	176_V	1.603	1.00
309_F	371_M	1.600	1.00
88_S	286_I	1.600	1.00
129_I	143_V	1.594	1.00
308_Q	312_Q	1.587	1.00
242_L	285_S	1.578	1.00
67_A	71_S	1.571	1.00
99_F	223_R	1.566	1.00
316_A	384_V	1.566	1.00
143_V	150_R	1.565	1.00
141_D	269_R	1.544	1.00
139_I	179_A	1.531	1.00
117_G	270_P	1.516	1.00
336_V	340_K	1.508	1.00
130_I	176_V	1.504	1.00
200_A	207_V	1.493	1.00
97_A	105_A	1.492	1.00
250_S	278_A	1.489	1.00
211_D	225_S	1.486	1.00
334_D	337_V	1.465	1.00
68_G	283_A	1.455	1.00
198_D	234_R	1.434	1.00
166_K	203_Y	1.427	1.00
341_F	390_I	1.418	1.00
96_L	289_L	1.413	1.00
178_I	205_A	1.411	1.00
80_R	85_T	1.407	1.00
128_A	168_A	1.406	1.00
296_S	300_D	1.406	1.00
318_F	391_G	1.393	1.00
62_I	66_K	1.381	1.00
153_Y	180_T	1.377	1.00
249_A	285_S	1.367	1.00
344_E	348_E	1.367	1.00
311_E	315_A	1.366	1.00
215_V	246_L	1.365	1.00
35_D	379_Q	1.363	1.00
352_V	367_I	1.358	1.00
91_E	286_I	1.357	1.00
308_Q	380_I	1.341	1.00
382_R	386_A	1.332	1.00
151_Y	164_R	1.319	1.00
66_K	69_M	1.309	1.00
177_L	208_M	1.305	1.00
305_N	377_P	1.291	1.00
258_K	262_E	1.289	1.00
118_L	254_T	1.282	1.00
158_M	192_N	1.280	1.00
137_A	269_R	1.276	1.00
300_D	304_A	1.270	1.00
130_I	168_A	1.264	1.00
100_L	255_A	1.264	1.00
128_A	151_Y	1.254	1.00
335_A	365_A	1.253	1.00
104_D	258_K	1.252	1.00
161_L	178_I	1.250	1.00
343_R	347_K	1.246	1.00
87_D	91_E	1.242	1.00
67_A	70_D	1.239	1.00
197_C	235_V	1.221	1.00
291_M	295_G	1.215	1.00
76_M	276_S	1.207	1.00
135_N	139_I	1.203	1.00
182_G	214_A	1.194	1.00
158_M	195_G	1.188	1.00
90_K	94_Q	1.187	1.00
85_T	90_K	1.186	1.00
309_F	313_M	1.175	1.00
309_F	369_T	1.168	1.00
118_L	208_M	1.166	1.00
307_R	311_E	1.163	1.00
117_G	268_S	1.162	1.00
182_G	225_S	1.159	1.00
123_L	177_L	1.152	1.00
96_L	242_L	1.148	1.00
156_N	192_N	1.147	1.00
199_L	203_Y	1.138	1.00
197_C	201_D	1.138	1.00
162_E	199_L	1.127	1.00
100_L	215_V	1.126	1.00
154_A	157_D	1.124	1.00
187_D	366_R	1.123	1.00
357_Y	362_K	1.120	1.00
344_E	390_I	1.119	1.00
286_I	290_E	1.118	1.00
165_L	205_A	1.117	1.00
369_T	383_A	1.113	1.00
126_E	174_R	1.113	1.00
165_L	199_L	1.108	1.00
60_D	291_M	1.106	1.00
305_N	308_Q	1.105	1.00
94_Q	98_A	1.099	1.00
178_I	199_L	1.096	1.00
155_N	189_V	1.094	1.00
197_C	207_V	1.088	1.00
305_N	380_I	1.080	1.00
59_P	63_A	1.073	1.00
104_D	261_V	1.066	1.00
226_H	231_V	1.061	1.00
88_S	283_A	1.055	1.00
341_F	391_G	1.045	1.00
338_A	365_A	1.044	1.00
339_Q	354_G	1.040	1.00
123_L	127_D	1.035	1.00
153_Y	184_F	1.030	1.00
305_N	373_A	1.028	1.00
110_S	113_D	1.022	1.00
350_I	383_A	1.021	1.00
115_N	138_S	1.020	1.00
348_E	386_A	1.018	1.00
303_W	306_A	1.016	1.00
180_T	196_V	1.016	1.00
196_V	207_V	1.014	1.00
64_A	68_G	1.010	1.00
350_I	386_A	1.003	1.00
377_P	381_T	0.999	1.00
283_A	287_K	0.998	1.00
97_A	255_A	0.995	1.00
223_R	227_E	0.992	1.00
163_A	167_E	0.991	1.00
102_M	256_A	0.989	1.00
310_R	323_A	0.989	1.00
96_L	253_Y	0.988	1.00
29_T	87_D	0.982	1.00
164_R	167_E	0.978	1.00
345_L	386_A	0.976	1.00
72_H	87_D	0.975	1.00
257_R	260_V	0.974	1.00
159_Q	163_A	0.971	1.00
102_M	255_A	0.969	1.00
357_Y	365_A	0.964	1.00
63_A	66_K	0.959	0.99
65_A	284_A	0.959	0.99
61_L	284_A	0.955	0.99
104_D	265_R	0.955	0.99
221_N	293_E	0.952	0.99
89_H	282_V	0.951	0.99
90_K	104_D	0.950	0.99
339_Q	356_F	0.950	0.99
113_D	274_S	0.948	0.99
280_A	284_A	0.944	0.99
198_D	202_K	0.941	0.99
131_S	143_V	0.940	0.99
92_L	282_V	0.938	0.99
215_V	253_Y	0.933	0.99
157_D	160_E	0.929	0.99
312_Q	316_A	0.928	0.99
80_R	93_E	0.928	0.99
330_V	369_T	0.928	0.99
88_S	282_V	0.927	0.99
54_G	374_A	0.920	0.99
297_E	301_R	0.920	0.99
45_I	379_Q	0.916	0.99
186_M	355_F	0.913	0.99
190_I	229_C	0.909	0.99
177_L	206_L	0.908	0.99
99_F	289_L	0.906	0.99
102_M	238_I	0.906	0.99
371_M	380_I	0.905	0.99
134_L	187_D	0.904	0.99
190_I	218_V	0.904	0.99
208_M	239_T	0.903	0.99
161_L	196_V	0.900	0.99
287_K	291_M	0.897	0.99
340_K	343_R	0.897	0.99
48_C	353_T	0.896	0.99
301_R	304_A	0.894	0.99
119_F	123_L	0.892	0.99
180_T	193_L	0.889	0.99
332_L	337_V	0.888	0.99
278_A	281_I	0.888	0.99
60_D	63_A	0.883	0.99
221_N	296_S	0.883	0.99
338_A	354_G	0.883	0.99
92_L	285_S	0.883	0.99
263_W	267_R	0.883	0.99
164_R	168_A	0.883	0.99
243_G	252_G	0.880	0.99
301_R	377_P	0.877	0.99
137_A	141_D	0.877	0.99
134_L	366_R	0.876	0.99
131_S	152_R	0.874	0.99
58_H	61_L	0.874	0.99
372_S	375_H	0.874	0.99
78_S	82_I	0.868	0.99
227_E	296_S	0.865	0.99
246_L	292_V	0.864	0.99
225_S	229_C	0.861	0.99
127_D	174_R	0.859	0.99
312_Q	385_E	0.858	0.99
250_S	277_L	0.857	0.99
379_Q	382_R	0.850	0.99
85_T	89_H	0.847	0.99
47_F	380_I	0.845	0.99
91_E	95_K	0.844	0.99
191_A	196_V	0.843	0.99
200_A	205_A	0.842	0.99
127_D	177_L	0.840	0.99
197_C	234_R	0.839	0.99
182_G	211_D	0.839	0.99
237_I	260_V	0.837	0.99
64_A	283_A	0.830	0.99
385_E	389_R	0.830	0.99
58_H	298_L	0.830	0.99
333_G	365_A	0.828	0.99
306_A	328_I	0.827	0.99
45_I	350_I	0.825	0.98
125_A	147_K	0.822	0.98
130_I	161_L	0.821	0.98
109_S	250_S	0.820	0.98
226_H	235_V	0.818	0.98
169_R	173_A	0.818	0.98
218_V	325_H	0.816	0.98
69_M	280_A	0.814	0.98
124_G	127_D	0.813	0.98
116_G	270_P	0.807	0.98
65_A	69_M	0.807	0.98
60_D	295_G	0.806	0.98
309_F	328_I	0.803	0.98
159_Q	195_G	0.803	0.98
340_K	344_E	0.803	0.98
190_I	325_H	0.802	0.98
133_A	152_R	0.801	0.98
130_I	196_V	0.801	0.98
303_W	307_R	0.799	0.98
48_C	83_C	0.792	0.98
194_K	228_Y	0.787	0.98
183_V	190_I	0.784	0.98
240_G	255_A	0.784	0.98
301_R	376_T	0.784	0.98
158_M	196_V	0.783	0.98
65_A	74_F	0.783	0.98
153_Y	161_L	0.782	0.98
302_L	306_A	0.781	0.98
119_F	177_L	0.781	0.98
126_E	149_K	0.780	0.98
190_I	228_Y	0.779	0.98
383_A	387_F	0.771	0.98
68_G	88_S	0.768	0.98
64_A	287_K	0.766	0.98
57_N	62_I	0.764	0.97
128_A	174_R	0.762	0.97
156_N	181_D	0.762	0.97
348_E	390_I	0.760	0.97
168_A	176_V	0.758	0.97
114_A	118_L	0.757	0.97
377_P	380_I	0.756	0.97
119_F	208_M	0.756	0.97
215_V	240_G	0.751	0.97
382_R	385_E	0.750	0.97
369_T	387_F	0.749	0.97
130_I	151_Y	0.749	0.97
92_L	286_I	0.747	0.97
131_S	140_I	0.747	0.97
299_R	303_W	0.744	0.97
131_S	150_R	0.744	0.97
346_Q	351_Y	0.743	0.97
214_A	225_S	0.742	0.97
106_I	261_V	0.742	0.97
330_V	387_F	0.741	0.97
140_I	144_R	0.741	0.97
163_A	166_K	0.738	0.97
112_F	116_G	0.736	0.97
52_Y	213_H	0.736	0.97
277_L	282_V	0.736	0.97
254_T	264_L	0.735	0.97
89_H	107_L	0.733	0.97
34_A	379_Q	0.732	0.97
219_G	224_G	0.732	0.97
385_E	388_T	0.729	0.97
162_E	195_G	0.727	0.97
69_M	74_F	0.727	0.97
86_Q	89_H	0.726	0.97
80_R	271_Y	0.725	0.97
114_A	239_T	0.724	0.97
68_G	72_H	0.722	0.96
108_Y	117_G	0.716	0.96
226_H	238_I	0.715	0.96
135_N	181_D	0.713	0.96
314_S	320_L	0.713	0.96
156_N	189_V	0.712	0.96
91_E	290_E	0.711	0.96
106_I	265_R	0.711	0.96
159_Q	162_E	0.711	0.96
59_P	62_I	0.709	0.96
101_G	232_M	0.709	0.96
56_A	77_A	0.708	0.96
88_S	91_E	0.707	0.96
318_F	387_F	0.705	0.96
298_L	301_R	0.705	0.96
108_Y	254_T	0.704	0.96
116_G	120_E	0.703	0.96
304_A	308_Q	0.703	0.96
316_A	385_E	0.701	0.96
337_V	340_K	0.697	0.96
197_C	231_V	0.695	0.96
321_A	331_M	0.693	0.96
55_L	298_L	0.693	0.96
176_V	205_A	0.690	0.95
183_V	214_A	0.687	0.95
118_L	239_T	0.687	0.95
193_L	209_V	0.681	0.95
313_M	387_F	0.680	0.95
158_M	161_L	0.679	0.95
156_N	184_F	0.677	0.95
288_V	292_V	0.673	0.95
45_I	382_R	0.673	0.95
82_I	353_T	0.672	0.95
82_I	355_F	0.670	0.95
341_F	345_L	0.664	0.94
384_V	388_T	0.663	0.94
65_A	283_A	0.662	0.94
165_L	203_Y	0.655	0.94
341_F	367_I	0.654	0.94
42_S	349_G	0.653	0.94
100_L	289_L	0.652	0.94
241_T	252_G	0.652	0.94
310_R	322_G	0.649	0.94
76_M	279_P	0.648	0.94
105_A	253_Y	0.646	0.94
290_E	294_A	0.645	0.94
208_M	237_I	0.645	0.94
123_L	208_M	0.643	0.93
56_A	247_G	0.642	0.93
310_R	328_I	0.641	0.93
313_M	369_T	0.640	0.93
103_E	257_R	0.638	0.93
219_G	222_G	0.636	0.93
297_E	300_D	0.636	0.93
292_V	299_R	0.631	0.93
102_M	257_R	0.629	0.93
133_A	364_Q	0.628	0.93
128_A	176_V	0.628	0.93
131_S	139_I	0.626	0.92
261_V	265_R	0.626	0.92
220_E	228_Y	0.626	0.92
95_K	289_L	0.626	0.92
220_E	296_S	0.626	0.92
151_Y	168_A	0.626	0.92
218_V	228_Y	0.625	0.92
116_G	142_G	0.621	0.92
72_H	88_S	0.620	0.92
250_S	281_I	0.620	0.92
200_A	236_D	0.618	0.92
228_Y	324_D	0.618	0.92
122_L	237_I	0.618	0.92
183_V	325_H	0.617	0.92
110_S	250_S	0.616	0.92
237_I	256_A	0.616	0.92
100_L	105_A	0.615	0.92
319_T	333_G	0.614	0.92
119_F	139_I	0.614	0.92
153_Y	156_N	0.613	0.92
310_R	324_D	0.613	0.92
133_A	150_R	0.613	0.92
151_Y	167_E	0.612	0.92
175_H	206_L	0.611	0.92
312_Q	388_T	0.610	0.92
54_G	372_S	0.610	0.92
91_E	94_Q	0.609	0.91
305_N	371_M	0.605	0.91
378_E	382_R	0.605	0.91
140_I	152_R	0.603	0.91
106_I	271_Y	0.603	0.91
223_R	293_E	0.601	0.91
94_Q	104_D	0.600	0.91
165_L	176_V	0.598	0.91
109_S	113_D	0.598	0.91
194_K	198_D	0.597	0.91
61_L	288_V	0.596	0.91
284_A	288_V	0.595	0.91
220_E	300_D	0.592	0.90
127_D	175_H	0.591	0.90
355_F	359_V	0.591	0.90
127_D	146_C	0.590	0.90
201_D	236_D	0.590	0.90
80_R	274_S	0.589	0.90
176_V	204_D	0.588	0.90
216_G	245_A	0.588	0.90
301_R	373_A	0.587	0.90
311_E	314_S	0.586	0.90
99_F	292_V	0.586	0.90
209_V	226_H	0.585	0.90
211_D	238_I	0.583	0.90
132_D	155_N	0.582	0.90
141_D	144_R	0.581	0.89
313_M	384_V	0.580	0.89
51_N	56_A	0.580	0.89
156_N	180_T	0.580	0.89
296_S	299_R	0.580	0.89
243_G	275_N	0.579	0.89
89_H	276_S	0.577	0.89
310_R	314_S	0.576	0.89
381_T	384_V	0.573	0.89
213_H	244_K	0.573	0.89
153_Y	178_I	0.573	0.89
99_F	293_E	0.571	0.89
170_E	173_A	0.570	0.89
342_A	346_Q	0.570	0.89
183_V	218_V	0.568	0.88
198_D	201_D	0.568	0.88
217_F	302_L	0.564	0.88
342_A	354_G	0.563	0.88
55_L	61_L	0.563	0.88
31_A	34_A	0.563	0.88
222_G	299_R	0.562	0.88
45_I	383_A	0.561	0.88
308_Q	384_V	0.561	0.88
135_N	143_V	0.561	0.88
44_V	351_Y	0.560	0.88
197_C	200_A	0.559	0.88
136_H	244_K	0.556	0.87
30_S	33_Q	0.555	0.87
218_V	225_S	0.554	0.87
109_S	277_L	0.551	0.87
275_N	359_V	0.550	0.87
239_T	252_G	0.550	0.87
100_L	253_Y	0.549	0.87
345_L	352_V	0.549	0.87
331_M	366_R	0.549	0.87
226_H	232_M	0.547	0.86
339_Q	343_R	0.545	0.86
65_A	280_A	0.544	0.86
128_A	170_E	0.544	0.86
182_G	218_V	0.544	0.86
33_Q	36_I	0.544	0.86
273_F	359_V	0.542	0.86
302_L	305_N	0.540	0.86
332_L	338_A	0.540	0.86
384_V	387_F	0.538	0.86
74_F	280_A	0.538	0.86
291_M	298_L	0.537	0.85
73_G	280_A	0.536	0.85
135_N	184_F	0.535	0.85
129_I	146_C	0.535	0.85
190_I	225_S	0.535	0.85
189_V	366_R	0.534	0.85
95_K	98_A	0.532	0.85
99_F	215_V	0.531	0.85
153_Y	181_D	0.530	0.85
298_L	305_N	0.530	0.85
55_L	291_M	0.527	0.84
154_A	164_R	0.527	0.84
42_S	347_K	0.527	0.84
352_V	369_T	0.527	0.84
64_A	67_A	0.526	0.84
136_H	213_H	0.525	0.84
378_E	381_T	0.525	0.84
309_F	312_Q	0.525	0.84
158_M	162_E	0.522	0.84
309_F	383_A	0.521	0.84
154_A	163_A	0.521	0.84
118_L	237_I	0.521	0.84
65_A	68_G	0.520	0.84
306_A	326_A	0.517	0.83
381_T	385_E	0.515	0.83
218_V	303_W	0.514	0.83
79_V	111_C	0.513	0.83
333_G	338_A	0.513	0.83
341_F	344_E	0.513	0.83
123_L	148_A	0.513	0.83
100_L	238_I	0.512	0.83
71_S	91_E	0.512	0.83
356_F	359_V	0.511	0.83
149_K	174_R	0.508	0.82
211_D	226_H	0.507	0.82
109_S	252_G	0.507	0.82
304_A	307_R	0.506	0.82
206_L	260_V	0.506	0.82
206_L	236_D	0.506	0.82
335_A	362_K	0.505	0.82
169_R	204_D	0.504	0.82
263_W	272_L	0.504	0.82
68_G	71_S	0.503	0.82
67_A	287_K	0.503	0.82
323_A	328_I	0.502	0.81
159_Q	166_K	0.502	0.81
62_I	70_D	0.500	0.81
237_I	254_T	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2w8tA	2	0.9874	100	0.467	Contact Map
3wy7A	2	0.9296	100	0.476	Contact Map
1fc4A	2	1	100	0.514	Contact Map
2bwnA	2	0.9749	100	0.517	Contact Map
3kkiA	2	0.9598	100	0.52	Contact Map
1bs0A	2	0.9548	100	0.529	Contact Map
3tqxA	2	0.9925	100	0.533	Contact Map
3a2bA	2	0.9799	100	0.546	Contact Map
4iw7A	2	0.8342	100	0.58	Contact Map
1vefA	2	0.8869	100	0.661	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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