GREMLIN Database
KBL - 2-amino-3-ketobutyrate coenzyme A ligase
UniProt: P0AB77 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10512
Length: 398 (358)
Sequences: 6430 (3898)
Seq/√Len: 206.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_K70_D4.1891.00
95_K290_E4.1111.00
308_Q381_T4.0191.00
162_E202_K3.9261.00
154_A160_E3.8111.00
201_D234_R3.7951.00
348_E389_R3.6181.00
192_N195_G3.2091.00
160_E164_R3.1031.00
180_T184_F3.0641.00
287_K290_E2.8591.00
95_K286_I2.8531.00
178_I200_A2.7531.00
308_Q377_P2.7301.00
312_Q384_V2.6101.00
162_E203_Y2.5371.00
301_R305_N2.4851.00
95_K293_E2.3831.00
63_A67_A2.3421.00
256_A261_V2.2781.00
108_Y268_S2.2591.00
194_K229_C2.2571.00
162_E166_K2.2411.00
160_E163_A2.2401.00
221_N227_E2.2351.00
240_G253_Y2.2241.00
256_A260_V2.1791.00
158_M199_L2.1631.00
211_D214_A2.1341.00
103_E258_K2.0561.00
98_A293_E2.0481.00
312_Q381_T2.0431.00
295_G298_L2.0371.00
180_T209_V1.9871.00
60_D287_K1.9691.00
316_A388_T1.9491.00
130_I164_R1.9381.00
62_I69_M1.8881.00
332_L341_F1.8711.00
60_D294_A1.8471.00
195_G198_D1.8351.00
304_A377_P1.8171.00
123_L129_I1.8091.00
376_T379_Q1.8031.00
131_S135_N1.7681.00
344_E347_K1.7531.00
350_I382_R1.7471.00
220_E227_E1.7331.00
312_Q315_A1.7221.00
58_H291_M1.6911.00
119_F179_A1.6821.00
44_V346_Q1.6621.00
63_A70_D1.6621.00
47_F375_H1.6611.00
47_F383_A1.6581.00
105_A255_A1.6551.00
133_A154_A1.6481.00
35_D43_H1.6111.00
169_R176_V1.6031.00
309_F371_M1.6001.00
88_S286_I1.6001.00
129_I143_V1.5941.00
308_Q312_Q1.5871.00
242_L285_S1.5781.00
67_A71_S1.5711.00
99_F223_R1.5661.00
316_A384_V1.5661.00
143_V150_R1.5651.00
141_D269_R1.5441.00
139_I179_A1.5311.00
117_G270_P1.5161.00
336_V340_K1.5081.00
130_I176_V1.5041.00
200_A207_V1.4931.00
97_A105_A1.4921.00
250_S278_A1.4891.00
211_D225_S1.4861.00
334_D337_V1.4651.00
68_G283_A1.4551.00
198_D234_R1.4341.00
166_K203_Y1.4271.00
341_F390_I1.4181.00
96_L289_L1.4131.00
178_I205_A1.4111.00
80_R85_T1.4071.00
128_A168_A1.4061.00
296_S300_D1.4061.00
318_F391_G1.3931.00
62_I66_K1.3811.00
153_Y180_T1.3771.00
249_A285_S1.3671.00
344_E348_E1.3671.00
311_E315_A1.3661.00
215_V246_L1.3651.00
35_D379_Q1.3631.00
352_V367_I1.3581.00
91_E286_I1.3571.00
308_Q380_I1.3411.00
382_R386_A1.3321.00
151_Y164_R1.3191.00
66_K69_M1.3091.00
177_L208_M1.3051.00
305_N377_P1.2911.00
258_K262_E1.2891.00
118_L254_T1.2821.00
158_M192_N1.2801.00
137_A269_R1.2761.00
300_D304_A1.2701.00
130_I168_A1.2641.00
100_L255_A1.2641.00
128_A151_Y1.2541.00
335_A365_A1.2531.00
104_D258_K1.2521.00
161_L178_I1.2501.00
343_R347_K1.2461.00
87_D91_E1.2421.00
67_A70_D1.2391.00
197_C235_V1.2211.00
291_M295_G1.2151.00
76_M276_S1.2071.00
135_N139_I1.2031.00
182_G214_A1.1941.00
158_M195_G1.1881.00
90_K94_Q1.1871.00
85_T90_K1.1861.00
309_F313_M1.1751.00
309_F369_T1.1681.00
118_L208_M1.1661.00
307_R311_E1.1631.00
117_G268_S1.1621.00
182_G225_S1.1591.00
123_L177_L1.1521.00
96_L242_L1.1481.00
156_N192_N1.1471.00
199_L203_Y1.1381.00
197_C201_D1.1381.00
162_E199_L1.1271.00
100_L215_V1.1261.00
154_A157_D1.1241.00
187_D366_R1.1231.00
357_Y362_K1.1201.00
344_E390_I1.1191.00
286_I290_E1.1181.00
165_L205_A1.1171.00
369_T383_A1.1131.00
126_E174_R1.1131.00
165_L199_L1.1081.00
60_D291_M1.1061.00
305_N308_Q1.1051.00
94_Q98_A1.0991.00
178_I199_L1.0961.00
155_N189_V1.0941.00
197_C207_V1.0881.00
305_N380_I1.0801.00
59_P63_A1.0731.00
104_D261_V1.0661.00
226_H231_V1.0611.00
88_S283_A1.0551.00
341_F391_G1.0451.00
338_A365_A1.0441.00
339_Q354_G1.0401.00
123_L127_D1.0351.00
153_Y184_F1.0301.00
305_N373_A1.0281.00
110_S113_D1.0221.00
350_I383_A1.0211.00
115_N138_S1.0201.00
348_E386_A1.0181.00
303_W306_A1.0161.00
180_T196_V1.0161.00
196_V207_V1.0141.00
64_A68_G1.0101.00
350_I386_A1.0031.00
377_P381_T0.9991.00
283_A287_K0.9981.00
97_A255_A0.9951.00
223_R227_E0.9921.00
163_A167_E0.9911.00
102_M256_A0.9891.00
310_R323_A0.9891.00
96_L253_Y0.9881.00
29_T87_D0.9821.00
164_R167_E0.9781.00
345_L386_A0.9761.00
72_H87_D0.9751.00
257_R260_V0.9741.00
159_Q163_A0.9711.00
102_M255_A0.9691.00
357_Y365_A0.9641.00
63_A66_K0.9590.99
65_A284_A0.9590.99
61_L284_A0.9550.99
104_D265_R0.9550.99
221_N293_E0.9520.99
89_H282_V0.9510.99
90_K104_D0.9500.99
339_Q356_F0.9500.99
113_D274_S0.9480.99
280_A284_A0.9440.99
198_D202_K0.9410.99
131_S143_V0.9400.99
92_L282_V0.9380.99
215_V253_Y0.9330.99
157_D160_E0.9290.99
312_Q316_A0.9280.99
80_R93_E0.9280.99
330_V369_T0.9280.99
88_S282_V0.9270.99
54_G374_A0.9200.99
297_E301_R0.9200.99
45_I379_Q0.9160.99
186_M355_F0.9130.99
190_I229_C0.9090.99
177_L206_L0.9080.99
99_F289_L0.9060.99
102_M238_I0.9060.99
371_M380_I0.9050.99
134_L187_D0.9040.99
190_I218_V0.9040.99
208_M239_T0.9030.99
161_L196_V0.9000.99
287_K291_M0.8970.99
340_K343_R0.8970.99
48_C353_T0.8960.99
301_R304_A0.8940.99
119_F123_L0.8920.99
180_T193_L0.8890.99
332_L337_V0.8880.99
278_A281_I0.8880.99
60_D63_A0.8830.99
221_N296_S0.8830.99
338_A354_G0.8830.99
92_L285_S0.8830.99
263_W267_R0.8830.99
164_R168_A0.8830.99
243_G252_G0.8800.99
301_R377_P0.8770.99
137_A141_D0.8770.99
134_L366_R0.8760.99
131_S152_R0.8740.99
58_H61_L0.8740.99
372_S375_H0.8740.99
78_S82_I0.8680.99
227_E296_S0.8650.99
246_L292_V0.8640.99
225_S229_C0.8610.99
127_D174_R0.8590.99
312_Q385_E0.8580.99
250_S277_L0.8570.99
379_Q382_R0.8500.99
85_T89_H0.8470.99
47_F380_I0.8450.99
91_E95_K0.8440.99
191_A196_V0.8430.99
200_A205_A0.8420.99
127_D177_L0.8400.99
197_C234_R0.8390.99
182_G211_D0.8390.99
237_I260_V0.8370.99
64_A283_A0.8300.99
385_E389_R0.8300.99
58_H298_L0.8300.99
333_G365_A0.8280.99
306_A328_I0.8270.99
45_I350_I0.8250.98
125_A147_K0.8220.98
130_I161_L0.8210.98
109_S250_S0.8200.98
226_H235_V0.8180.98
169_R173_A0.8180.98
218_V325_H0.8160.98
69_M280_A0.8140.98
124_G127_D0.8130.98
116_G270_P0.8070.98
65_A69_M0.8070.98
60_D295_G0.8060.98
309_F328_I0.8030.98
159_Q195_G0.8030.98
340_K344_E0.8030.98
190_I325_H0.8020.98
133_A152_R0.8010.98
130_I196_V0.8010.98
303_W307_R0.7990.98
48_C83_C0.7920.98
194_K228_Y0.7870.98
183_V190_I0.7840.98
240_G255_A0.7840.98
301_R376_T0.7840.98
158_M196_V0.7830.98
65_A74_F0.7830.98
153_Y161_L0.7820.98
302_L306_A0.7810.98
119_F177_L0.7810.98
126_E149_K0.7800.98
190_I228_Y0.7790.98
383_A387_F0.7710.98
68_G88_S0.7680.98
64_A287_K0.7660.98
57_N62_I0.7640.97
128_A174_R0.7620.97
156_N181_D0.7620.97
348_E390_I0.7600.97
168_A176_V0.7580.97
114_A118_L0.7570.97
377_P380_I0.7560.97
119_F208_M0.7560.97
215_V240_G0.7510.97
382_R385_E0.7500.97
369_T387_F0.7490.97
130_I151_Y0.7490.97
92_L286_I0.7470.97
131_S140_I0.7470.97
299_R303_W0.7440.97
131_S150_R0.7440.97
346_Q351_Y0.7430.97
214_A225_S0.7420.97
106_I261_V0.7420.97
330_V387_F0.7410.97
140_I144_R0.7410.97
163_A166_K0.7380.97
112_F116_G0.7360.97
52_Y213_H0.7360.97
277_L282_V0.7360.97
254_T264_L0.7350.97
89_H107_L0.7330.97
34_A379_Q0.7320.97
219_G224_G0.7320.97
385_E388_T0.7290.97
162_E195_G0.7270.97
69_M74_F0.7270.97
86_Q89_H0.7260.97
80_R271_Y0.7250.97
114_A239_T0.7240.97
68_G72_H0.7220.96
108_Y117_G0.7160.96
226_H238_I0.7150.96
135_N181_D0.7130.96
314_S320_L0.7130.96
156_N189_V0.7120.96
91_E290_E0.7110.96
106_I265_R0.7110.96
159_Q162_E0.7110.96
59_P62_I0.7090.96
101_G232_M0.7090.96
56_A77_A0.7080.96
88_S91_E0.7070.96
318_F387_F0.7050.96
298_L301_R0.7050.96
108_Y254_T0.7040.96
116_G120_E0.7030.96
304_A308_Q0.7030.96
316_A385_E0.7010.96
337_V340_K0.6970.96
197_C231_V0.6950.96
321_A331_M0.6930.96
55_L298_L0.6930.96
176_V205_A0.6900.95
183_V214_A0.6870.95
118_L239_T0.6870.95
193_L209_V0.6810.95
313_M387_F0.6800.95
158_M161_L0.6790.95
156_N184_F0.6770.95
288_V292_V0.6730.95
45_I382_R0.6730.95
82_I353_T0.6720.95
82_I355_F0.6700.95
341_F345_L0.6640.94
384_V388_T0.6630.94
65_A283_A0.6620.94
165_L203_Y0.6550.94
341_F367_I0.6540.94
42_S349_G0.6530.94
100_L289_L0.6520.94
241_T252_G0.6520.94
310_R322_G0.6490.94
76_M279_P0.6480.94
105_A253_Y0.6460.94
290_E294_A0.6450.94
208_M237_I0.6450.94
123_L208_M0.6430.93
56_A247_G0.6420.93
310_R328_I0.6410.93
313_M369_T0.6400.93
103_E257_R0.6380.93
219_G222_G0.6360.93
297_E300_D0.6360.93
292_V299_R0.6310.93
102_M257_R0.6290.93
133_A364_Q0.6280.93
128_A176_V0.6280.93
131_S139_I0.6260.92
261_V265_R0.6260.92
220_E228_Y0.6260.92
95_K289_L0.6260.92
220_E296_S0.6260.92
151_Y168_A0.6260.92
218_V228_Y0.6250.92
116_G142_G0.6210.92
72_H88_S0.6200.92
250_S281_I0.6200.92
200_A236_D0.6180.92
228_Y324_D0.6180.92
122_L237_I0.6180.92
183_V325_H0.6170.92
110_S250_S0.6160.92
237_I256_A0.6160.92
100_L105_A0.6150.92
319_T333_G0.6140.92
119_F139_I0.6140.92
153_Y156_N0.6130.92
310_R324_D0.6130.92
133_A150_R0.6130.92
151_Y167_E0.6120.92
175_H206_L0.6110.92
312_Q388_T0.6100.92
54_G372_S0.6100.92
91_E94_Q0.6090.91
305_N371_M0.6050.91
378_E382_R0.6050.91
140_I152_R0.6030.91
106_I271_Y0.6030.91
223_R293_E0.6010.91
94_Q104_D0.6000.91
165_L176_V0.5980.91
109_S113_D0.5980.91
194_K198_D0.5970.91
61_L288_V0.5960.91
284_A288_V0.5950.91
220_E300_D0.5920.90
127_D175_H0.5910.90
355_F359_V0.5910.90
127_D146_C0.5900.90
201_D236_D0.5900.90
80_R274_S0.5890.90
176_V204_D0.5880.90
216_G245_A0.5880.90
301_R373_A0.5870.90
311_E314_S0.5860.90
99_F292_V0.5860.90
209_V226_H0.5850.90
211_D238_I0.5830.90
132_D155_N0.5820.90
141_D144_R0.5810.89
313_M384_V0.5800.89
51_N56_A0.5800.89
156_N180_T0.5800.89
296_S299_R0.5800.89
243_G275_N0.5790.89
89_H276_S0.5770.89
310_R314_S0.5760.89
381_T384_V0.5730.89
213_H244_K0.5730.89
153_Y178_I0.5730.89
99_F293_E0.5710.89
170_E173_A0.5700.89
342_A346_Q0.5700.89
183_V218_V0.5680.88
198_D201_D0.5680.88
217_F302_L0.5640.88
342_A354_G0.5630.88
55_L61_L0.5630.88
31_A34_A0.5630.88
222_G299_R0.5620.88
45_I383_A0.5610.88
308_Q384_V0.5610.88
135_N143_V0.5610.88
44_V351_Y0.5600.88
197_C200_A0.5590.88
136_H244_K0.5560.87
30_S33_Q0.5550.87
218_V225_S0.5540.87
109_S277_L0.5510.87
275_N359_V0.5500.87
239_T252_G0.5500.87
100_L253_Y0.5490.87
345_L352_V0.5490.87
331_M366_R0.5490.87
226_H232_M0.5470.86
339_Q343_R0.5450.86
65_A280_A0.5440.86
128_A170_E0.5440.86
182_G218_V0.5440.86
33_Q36_I0.5440.86
273_F359_V0.5420.86
302_L305_N0.5400.86
332_L338_A0.5400.86
384_V387_F0.5380.86
74_F280_A0.5380.86
291_M298_L0.5370.85
73_G280_A0.5360.85
135_N184_F0.5350.85
129_I146_C0.5350.85
190_I225_S0.5350.85
189_V366_R0.5340.85
95_K98_A0.5320.85
99_F215_V0.5310.85
153_Y181_D0.5300.85
298_L305_N0.5300.85
55_L291_M0.5270.84
154_A164_R0.5270.84
42_S347_K0.5270.84
352_V369_T0.5270.84
64_A67_A0.5260.84
136_H213_H0.5250.84
378_E381_T0.5250.84
309_F312_Q0.5250.84
158_M162_E0.5220.84
309_F383_A0.5210.84
154_A163_A0.5210.84
118_L237_I0.5210.84
65_A68_G0.5200.84
306_A326_A0.5170.83
381_T385_E0.5150.83
218_V303_W0.5140.83
79_V111_C0.5130.83
333_G338_A0.5130.83
341_F344_E0.5130.83
123_L148_A0.5130.83
100_L238_I0.5120.83
71_S91_E0.5120.83
356_F359_V0.5110.83
149_K174_R0.5080.82
211_D226_H0.5070.82
109_S252_G0.5070.82
304_A307_R0.5060.82
206_L260_V0.5060.82
206_L236_D0.5060.82
335_A362_K0.5050.82
169_R204_D0.5040.82
263_W272_L0.5040.82
68_G71_S0.5030.82
67_A287_K0.5030.82
323_A328_I0.5020.81
159_Q166_K0.5020.81
62_I70_D0.5000.81
237_I254_T0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w8tA 2 0.9874 100 0.467 Contact Map
3wy7A 2 0.9296 100 0.476 Contact Map
1fc4A 2 1 100 0.514 Contact Map
2bwnA 2 0.9749 100 0.517 Contact Map
3kkiA 2 0.9598 100 0.52 Contact Map
1bs0A 2 0.9548 100 0.529 Contact Map
3tqxA 2 0.9925 100 0.533 Contact Map
3a2bA 2 0.9799 100 0.546 Contact Map
4iw7A 2 0.8342 100 0.58 Contact Map
1vefA 2 0.8869 100 0.661 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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