GREMLIN Database
KBAY - D-tagatose-1,6-bisphosphate aldolase subunit KbaY
UniProt: P0AB74 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12768
Length: 286 (276)
Sequences: 3927 (1985)
Seq/√Len: 119.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_R166_L4.0161.00
40_E272_R3.3601.00
40_E268_K3.2651.00
12_D16_N3.0781.00
110_F162_R3.0581.00
110_F114_V2.6271.00
161_K165_E2.5571.00
43_S280_S2.5291.00
41_M276_N2.5141.00
94_V129_C2.4811.00
195_A199_E2.4641.00
190_D193_R2.4601.00
39_S74_N2.4391.00
119_S122_D2.4341.00
91_R123_F2.3811.00
245_A249_E2.3581.00
36_E268_K2.3341.00
109_P112_E2.3181.00
176_I194_L2.3171.00
103_I116_L2.3091.00
34_I45_V2.3041.00
49_G98_V2.2861.00
115_K119_S2.2431.00
215_D277_V2.1861.00
6_T78_A2.1171.00
242_A266_A2.0881.00
41_M272_R2.0871.00
12_D18_Y2.0851.00
125_H170_D2.0331.00
265_D269_E1.9781.00
9_L78_A1.9611.00
95_H123_F1.9461.00
118_K122_D1.9191.00
41_M281_A1.9061.00
191_F220_R1.9051.00
161_K200_V1.8821.00
268_K272_R1.8701.00
195_A224_L1.8511.00
7_K11_Q1.8441.00
214_P217_F1.8141.00
35_L73_Y1.8071.00
6_T171_S1.7991.00
91_R95_H1.7891.00
11_Q15_A1.7671.00
14_Q227_T1.7661.00
220_R223_E1.7621.00
112_E115_K1.7521.00
105_G108_F1.6961.00
121_V131_V1.6891.00
276_N281_A1.6731.00
22_A48_A1.6231.00
158_Q200_V1.5981.00
242_A245_A1.5851.00
95_H127_Q1.5721.00
159_E162_R1.5721.00
275_I281_A1.5631.00
191_F224_L1.5601.00
111_A166_L1.5491.00
25_I47_L1.5371.00
80_H100_S1.5321.00
108_F112_E1.5261.00
45_V77_L1.5241.00
39_S73_Y1.5191.00
35_L77_L1.5061.00
195_A220_R1.4921.00
123_F127_Q1.4891.00
220_R224_L1.4861.00
14_Q198_R1.4651.00
205_L226_V1.4401.00
32_Q264_M1.4371.00
31_I69_Y1.4361.00
156_D159_E1.4311.00
269_E272_R1.4271.00
196_E199_E1.4041.00
178_T213_V1.3961.00
241_G245_A1.3941.00
67_S71_T1.3311.00
21_P271_V1.3271.00
87_L119_S1.3161.00
266_A269_E1.3141.00
110_F159_E1.3121.00
64_A67_S1.3051.00
64_A68_A1.3041.00
270_V273_N1.2931.00
215_D219_R1.2911.00
223_E279_G1.2821.00
25_I34_I1.2721.00
244_K247_F1.2691.00
246_W250_N1.2600.99
25_I31_I1.2300.99
51_P89_D1.2220.99
31_I66_C1.2000.99
193_R197_I1.1950.99
38_C45_V1.1930.99
108_F116_L1.1840.99
262_V265_D1.1740.99
42_R74_N1.1730.99
222_I278_C1.1690.99
60_E92_R1.1690.99
110_F166_L1.1680.99
67_S79_L1.1670.99
120_V131_V1.1630.99
37_V41_M1.1560.99
122_D126_S1.1550.99
37_V271_V1.1540.99
117_V133_A1.1530.99
36_E264_M1.1530.99
17_G223_E1.1490.99
232_A236_K1.1480.99
63_Y79_L1.1300.99
37_V268_K1.1280.99
5_S130_S1.1260.99
243_V263_G1.1240.99
101_A131_V1.1200.99
111_A115_K1.1160.99
193_R196_E1.1140.99
60_E72_T1.1130.99
118_K166_L1.1110.99
201_V205_L1.1110.99
116_L119_S1.1040.99
196_E200_V1.1040.99
87_L91_R1.1000.99
111_A162_R1.0920.98
215_D273_N1.0810.98
101_A120_V1.0770.98
101_A124_C1.0760.98
164_V203_V1.0650.98
246_W253_G1.0640.98
114_V166_L1.0640.98
91_R127_Q1.0610.98
94_V123_F1.0610.98
33_A267_M1.0570.98
94_V127_Q1.0490.98
21_P275_I1.0420.98
105_G116_L1.0400.98
231_V278_C1.0290.98
273_N277_V1.0270.98
12_D15_A1.0180.98
269_E273_N1.0160.98
192_Q196_E1.0110.98
37_V272_R1.0110.98
51_P86_S1.0090.97
174_V197_I1.0090.97
265_D268_K1.0040.97
198_R227_T1.0030.97
94_V124_C0.9940.97
61_E69_Y0.9940.97
243_V259_Y0.9920.97
8_Y12_D0.9910.97
21_P278_C0.9870.97
157_P200_V0.9870.97
190_D196_E0.9810.97
86_S89_D0.9790.97
272_R276_N0.9770.97
66_C79_L0.9740.97
157_P196_E0.9630.97
99_R130_S0.9620.97
26_H53_T0.9590.97
192_Q195_A0.9560.97
133_A169_V0.9530.96
49_G62_I0.9530.96
68_A71_T0.9520.96
160_A201_V0.9510.96
31_I47_L0.9500.96
238_A270_V0.9490.96
10_L171_S0.9490.96
9_L20_V0.9420.96
38_C275_I0.9410.96
140_G143_D0.9290.96
112_E116_L0.9260.96
73_Y77_L0.9210.96
154_L193_R0.9170.96
133_A163_F0.9160.96
34_I271_V0.9070.95
57_I62_I0.9030.95
253_G258_Y0.9020.95
18_Y43_S0.8990.95
17_G227_T0.8950.95
26_H30_T0.8890.95
43_S279_G0.8880.95
176_I207_L0.8850.95
44_P76_P0.8800.94
207_L221_T0.8740.94
137_R152_A0.8690.94
160_A197_I0.8660.94
5_S128_D0.8640.94
117_V121_V0.8590.94
155_T160_A0.8570.94
191_F217_F0.8530.93
63_Y67_S0.8450.93
271_V275_I0.8440.93
275_I280_S0.8400.93
229_V278_C0.8400.93
182_L237_I0.8390.93
5_S8_Y0.8360.93
219_R223_E0.8360.93
218_V229_V0.8350.93
123_F126_S0.8280.92
50_T232_A0.8250.92
50_T53_T0.8230.92
23_F45_V0.8160.92
125_H128_D0.8130.92
48_A232_A0.8060.91
38_C75_M0.8040.91
158_Q161_K0.7990.91
27_N30_T0.7990.91
101_A129_C0.7960.91
48_A80_H0.7930.91
28_A65_L0.7920.91
39_S75_M0.7860.90
155_T174_V0.7840.90
10_L20_V0.7800.90
53_T232_A0.7790.90
164_V201_V0.7780.90
162_R165_E0.7770.90
197_I201_V0.7770.90
234_E274_K0.7750.90
109_P115_K0.7710.90
8_Y11_Q0.7710.90
149_A152_A0.7700.89
245_A248_A0.7700.89
124_C129_C0.7690.89
135_L164_V0.7680.89
37_V275_I0.7680.89
23_F271_V0.7670.89
120_V123_F0.7670.89
86_S90_I0.7670.89
141_V146_S0.7670.89
219_R279_G0.7610.89
178_T189_I0.7600.89
194_L226_V0.7590.89
103_I120_V0.7580.89
24_N50_T0.7570.89
70_S73_Y0.7530.88
88_D92_R0.7530.88
43_S282_N0.7500.88
23_F34_I0.7460.88
61_E65_L0.7450.88
262_V266_A0.7420.88
157_P193_R0.7390.87
49_G54_F0.7370.87
235_L267_M0.7370.87
6_T130_S0.7260.87
85_E107_H0.7250.86
214_P218_V0.7230.86
222_I225_G0.7180.86
250_N253_G0.7160.86
121_V125_H0.7140.86
218_V278_C0.7080.85
78_A130_S0.7070.85
103_I108_F0.7040.85
242_A263_G0.7040.85
255_D258_Y0.6990.84
70_S77_L0.6990.84
244_K248_A0.6970.84
26_H232_A0.6960.84
6_T9_L0.6920.84
267_M271_V0.6920.84
194_L224_L0.6910.84
110_F135_L0.6890.84
239_F260_M0.6890.84
93_K98_V0.6880.83
135_L160_A0.6870.83
9_L12_D0.6860.83
26_H50_T0.6820.83
50_T257_R0.6820.83
63_Y96_A0.6780.83
135_L163_F0.6770.82
11_Q14_Q0.6740.82
240_A247_F0.6730.82
59_L92_R0.6730.82
155_T197_I0.6710.82
10_L130_S0.6690.82
54_F89_D0.6690.82
275_I282_N0.6670.82
6_T10_L0.6670.82
87_L120_V0.6660.81
105_G133_A0.6640.81
247_F259_Y0.6620.81
183_Y225_G0.6600.81
133_A167_T0.6570.81
139_G210_A0.6570.81
171_S206_V0.6570.81
84_H90_I0.6540.80
39_S42_R0.6520.80
151_S156_D0.6500.80
31_I65_L0.6490.80
242_A246_W0.6480.80
6_T46_I0.6480.80
52_G257_R0.6470.80
141_V144_D0.6470.80
183_Y187_P0.6470.80
121_V168_G0.6420.79
63_Y98_V0.6410.79
237_I241_G0.6400.79
51_P85_E0.6390.79
32_Q36_E0.6370.79
23_F275_I0.6370.79
42_R282_N0.6370.79
46_I78_A0.6360.78
169_V203_V0.6340.78
29_E239_F0.6330.78
164_V169_V0.6320.78
87_L123_F0.6300.78
246_W249_E0.6280.78
154_L190_D0.6280.78
270_V274_K0.6270.77
239_F263_G0.6260.77
218_V231_V0.6210.77
68_A72_T0.6180.76
5_S99_R0.6160.76
216_E219_R0.6160.76
197_I205_L0.6150.76
53_T255_D0.6060.75
159_E166_L0.6010.74
18_Y279_G0.6010.74
92_R96_A0.6000.74
174_V194_L0.5970.74
113_N136_G0.5960.74
35_L47_L0.5950.74
176_I224_L0.5940.74
231_V234_E0.5930.73
13_A18_Y0.5930.73
158_Q162_R0.5890.73
189_I221_T0.5880.73
78_A99_R0.5880.73
90_I120_V0.5850.72
26_H256_P0.5840.72
15_A196_E0.5810.72
158_Q196_E0.5790.72
33_A37_V0.5790.72
185_K233_T0.5780.72
116_L120_V0.5770.71
114_V162_R0.5760.71
14_Q202_D0.5760.71
62_I66_C0.5750.71
219_R277_V0.5730.71
43_S275_I0.5730.71
94_V101_A0.5720.71
24_N56_H0.5710.71
236_K255_D0.5710.71
26_H49_G0.5700.70
211_S234_E0.5700.70
35_L75_M0.5700.70
130_S171_S0.5680.70
28_A57_I0.5670.70
198_R202_D0.5650.70
111_A114_V0.5650.70
94_V125_H0.5640.70
140_G145_M0.5640.70
181_G187_P0.5610.69
30_T53_T0.5610.69
17_G198_R0.5600.69
25_I62_I0.5580.69
246_W262_V0.5570.69
63_Y70_S0.5520.68
140_G144_D0.5510.68
231_V274_K0.5510.68
176_I221_T0.5500.68
242_A262_V0.5500.68
137_R193_R0.5480.68
41_M275_I0.5480.68
133_A156_D0.5470.67
15_A249_E0.5450.67
256_P259_Y0.5450.67
179_A187_P0.5450.67
226_V229_V0.5450.67
210_A231_V0.5440.67
51_P55_K0.5420.67
135_L156_D0.5380.66
19_A194_L0.5370.66
258_Y262_V0.5370.66
89_D92_R0.5360.66
6_T99_R0.5350.66
265_D276_N0.5350.66
218_V277_V0.5330.65
261_R265_D0.5310.65
79_L99_R0.5310.65
45_V275_I0.5300.65
155_T163_F0.5290.65
62_I65_L0.5290.65
118_K121_V0.5270.65
174_V226_V0.5260.64
110_F172_L0.5250.64
59_L96_A0.5240.64
92_R95_H0.5230.64
10_L14_Q0.5220.64
185_K188_K0.5200.63
87_L116_L0.5200.63
39_S72_T0.5190.63
160_A174_V0.5190.63
156_D193_R0.5180.63
28_A61_E0.5170.63
213_V217_F0.5140.63
141_V145_M0.5140.63
14_Q203_V0.5120.62
236_K256_P0.5110.62
121_V167_T0.5100.62
210_A214_P0.5090.62
124_C131_V0.5080.62
236_K240_A0.5080.62
67_S73_Y0.5080.62
115_K166_L0.5080.62
157_P161_K0.5060.61
65_L68_A0.5060.61
237_I240_A0.5060.61
9_L171_S0.5050.61
62_I69_Y0.5030.61
243_V260_M0.5030.61
156_D196_E0.5030.61
87_L90_I0.5020.61
182_L212_D0.5020.61
33_A264_M0.5010.61
152_A175_A0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gvfA 3 0.965 100 0.029 Contact Map
3n9rA 3 0.9545 100 0.044 Contact Map
1rvgA 3 0.986 100 0.046 Contact Map
2iswA 2 0.9441 100 0.049 Contact Map
4to8A 2 0.9685 100 0.05 Contact Map
3elfA 4 0.951 100 0.083 Contact Map
3pm6A 2 0.972 100 0.102 Contact Map
3qm3A 4 0.9755 100 0.104 Contact Map
1dosA 2 0.9406 100 0.105 Contact Map
3txvA 2 0.8601 100 0.245 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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