GREMLIN Database
ALF - Fructose-bisphosphate aldolase class 2
UniProt: P0AB71 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10282
Length: 359 (280)
Sequences: 3053 (1312)
Seq/√Len: 78.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
205_Y209_E4.2131.00
52_K343_I3.6111.00
52_K347_E3.4961.00
302_N306_A3.4871.00
151_L205_Y3.4111.00
24_V28_N3.0761.00
55_A355_A3.0671.00
160_K163_E2.8441.00
53_V351_Q2.7891.00
243_R247_E2.5661.00
61_F139_F2.5061.00
51_A102_G2.4611.00
151_L155_I2.4441.00
48_E343_I2.4431.00
238_T241_I2.4301.00
204_D208_T2.3991.00
272_A352_E2.3961.00
150_S153_E2.3881.00
299_G341_S2.3261.00
21_V106_I2.3231.00
53_V356_I2.3131.00
156_E160_K2.2891.00
24_V30_F2.2731.00
18_V106_I2.1601.00
46_V57_V2.1571.00
223_F242_L2.1521.00
271_T274_E2.0201.00
277_D280_S1.9581.00
53_V347_E1.9481.00
136_K164_R1.9171.00
37_C59_V1.8871.00
121_D164_R1.8751.00
166_S217_F1.8731.00
340_T344_A1.8711.00
44_N339_Q1.8701.00
144_I157_I1.8611.00
301_L304_Y1.8471.00
23_Q27_E1.8441.00
159_S163_E1.8321.00
344_A347_E1.8121.00
351_Q356_I1.8121.00
343_I347_E1.8111.00
19_Q23_Q1.8071.00
204_D248_Y1.8031.00
350_F356_I1.7971.00
146_L149_E1.7841.00
243_R277_D1.7311.00
47_L101_Y1.7301.00
201_E248_Y1.7011.00
47_L105_V1.6671.00
202_D205_Y1.6341.00
243_R281_Y1.6301.00
26_K246_Q1.6221.00
262_F283_V1.6111.00
162_L172_L1.6061.00
34_A60_Q1.6041.00
57_V105_V1.6041.00
239_P277_D1.5841.00
153_E156_E1.5821.00
298_E302_N1.5630.99
136_K168_I1.5620.99
152_Q209_E1.5370.99
300_V334_W1.5210.99
303_Y307_N1.5140.99
151_L202_D1.5090.99
341_S344_A1.5080.99
43_I97_M1.5060.99
92_H96_Q1.4630.99
337_A340_T1.4600.99
199_Q202_D1.4560.99
92_H95_H1.4510.99
161_Y172_L1.4510.99
51_A101_Y1.4500.99
163_E167_K1.4290.99
149_E153_E1.4280.99
300_V338_G1.4160.99
37_C46_V1.4150.99
277_D281_Y1.4090.99
164_R168_I1.4000.99
18_V218_T1.3780.99
272_A276_K1.3770.99
26_K284_V1.3710.99
121_D136_K1.3430.98
299_G302_N1.3410.98
288_I353_L1.3240.98
120_I123_L1.3170.98
249_V259_S1.3140.98
244_D248_Y1.3130.98
49_T346_L1.3110.98
280_S354_N1.2910.98
303_Y310_Y1.2840.98
347_E351_Q1.2800.98
28_N358_V1.2640.98
43_I59_V1.2610.98
239_P281_Y1.2540.97
50_A350_F1.2530.97
108_H141_S1.2450.97
33_P346_L1.2420.97
159_S209_E1.2420.97
37_C43_I1.2350.97
142_H165_M1.2340.97
272_A348_K1.2270.97
20_K24_V1.2260.97
289_D293_Q1.2120.97
188_N195_A1.1960.97
38_V42_S1.1890.97
244_D247_E1.1860.96
43_I94_V1.1770.96
344_A348_K1.1740.96
350_F355_A1.1680.96
49_T53_V1.1650.96
124_L164_R1.1600.96
146_L157_I1.1540.96
117_L121_D1.1410.96
249_V262_F1.1400.96
310_Y333_V1.1360.96
124_L170_M1.1300.95
73_G97_M1.1290.95
142_H172_L1.1240.95
286_M353_L1.1190.95
151_L209_E1.1000.95
95_H99_E1.0960.95
158_C174_I1.0830.94
279_V353_L1.0760.94
182_E187_D1.0730.94
345_R348_K1.0730.94
121_D160_K1.0540.93
152_Q156_E1.0460.93
340_T343_I1.0260.92
305_K308_E1.0250.92
152_Q205_Y1.0220.92
198_T203_V1.0220.92
161_Y164_R1.0210.92
307_N310_Y1.0190.92
246_Q284_V1.0190.92
149_E157_I1.0170.92
50_A57_V1.0150.92
198_T221_A1.0110.92
200_P248_Y1.0100.92
72_K100_H1.0090.92
49_T343_I1.0050.92
117_L160_K1.0050.92
304_Y334_W1.0040.92
142_H161_Y1.0020.91
207_Y260_L1.0000.91
200_P244_D0.9950.91
29_N280_S0.9860.91
225_N270_S0.9820.91
275_I286_M0.9820.91
54_K102_G0.9810.91
94_V107_L0.9780.90
51_A54_K0.9690.90
178_C188_N0.9630.90
24_V27_E0.9620.90
49_T347_E0.9600.90
346_L350_F0.9580.89
155_I209_E0.9510.89
24_V358_V0.9510.89
157_I160_K0.9460.89
38_V65_G0.9460.89
33_P350_F0.9400.89
348_K352_E0.9400.89
61_F66_A0.9320.88
33_P353_L0.9240.88
350_F357_D0.9210.88
241_I244_D0.9140.87
96_Q99_E0.9070.87
292_T342_M0.9010.86
142_H170_M0.9010.86
41_D296_T0.9000.86
178_C241_I0.8960.86
238_T244_D0.8960.86
223_F264_F0.8950.86
48_E339_Q0.8940.86
75_K91_A0.8940.86
245_S262_F0.8860.85
174_I216_R0.8840.85
295_A345_R0.8840.85
158_C162_L0.8720.85
241_I245_S0.8690.84
276_K280_S0.8660.84
64_G332_R0.8660.84
63_N113_A0.8640.84
166_S169_G0.8630.84
225_N237_L0.8590.84
197_Y241_I0.8580.84
203_V245_S0.8560.83
205_Y208_T0.8540.83
65_G289_D0.8520.83
189_S193_A0.8490.83
146_L174_I0.8470.83
240_T244_D0.8420.82
242_L283_V0.8370.82
144_I161_Y0.8300.82
35_V46_V0.8290.81
229_V294_W0.8250.81
118_P121_D0.8240.81
63_N119_W0.8210.81
65_G330_D0.8130.80
98_A101_Y0.8110.80
113_A148_E0.8100.80
56_P104_P0.8070.80
62_S332_R0.8050.80
240_T243_R0.8010.79
299_G338_G0.7910.78
174_I206_A0.7910.78
276_K352_E0.7900.78
140_S171_T0.7870.78
49_T350_F0.7810.77
22_F218_T0.7780.77
197_Y238_T0.7760.77
355_A358_V0.7660.76
182_E185_G0.7620.76
275_I353_L0.7610.76
39_G42_S0.7610.76
101_Y105_V0.7570.75
51_A103_V0.7570.75
35_V346_L0.7550.75
296_T335_L0.7540.75
150_S156_E0.7530.75
194_S199_Q0.7510.75
37_C93_H0.7500.75
22_F32_L0.7500.75
144_I149_E0.7470.74
345_R349_A0.7470.74
239_P274_E0.7460.74
46_V346_L0.7460.74
245_S249_V0.7450.74
297_W304_Y0.7420.74
124_L165_M0.7390.73
162_L215_P0.7380.73
29_N354_N0.7320.73
43_I69_I0.7260.72
73_G99_E0.7220.72
112_C120_I0.7210.72
178_C195_A0.7210.72
58_I106_I0.7200.71
17_D169_G0.7180.71
300_V304_Y0.7150.71
223_F237_L0.7150.71
17_D20_K0.7100.70
42_S342_M0.7100.70
38_V289_D0.7030.70
202_D209_E0.7000.69
36_N62_S0.6950.69
203_V221_A0.6930.69
95_H107_L0.6890.68
273_Q276_K0.6880.68
201_E204_D0.6880.68
203_V249_V0.6870.68
53_V350_F0.6870.68
18_V21_V0.6850.68
299_G303_Y0.6840.68
29_N284_V0.6840.68
117_L120_I0.6800.67
124_L168_I0.6790.67
62_S65_G0.6790.67
164_R167_K0.6760.67
35_V57_V0.6750.67
38_V62_S0.6750.67
18_V22_F0.6740.66
54_K357_D0.6740.66
336_R340_T0.6740.66
302_N305_K0.6730.66
174_I210_L0.6730.66
64_G330_D0.6730.66
176_L206_A0.6720.66
30_F55_A0.6710.66
65_G332_R0.6710.66
198_T245_S0.6700.66
120_I124_L0.6700.66
143_M263_V0.6680.66
121_D124_L0.6670.66
21_V284_V0.6640.65
60_Q289_D0.6630.65
114_K157_I0.6590.65
262_F282_G0.6580.65
71_G122_G0.6510.64
225_N242_L0.6470.63
114_K120_I0.6460.63
249_V260_L0.6440.63
22_F171_T0.6430.63
23_Q26_K0.6420.63
203_V290_T0.6420.63
221_A245_S0.6410.63
165_M170_M0.6380.62
121_D168_I0.6380.62
113_A119_W0.6370.62
279_V282_G0.6350.62
199_Q244_D0.6350.62
207_Y249_V0.6340.62
18_V171_T0.6330.62
91_A107_L0.6330.62
276_K354_N0.6290.61
106_I171_T0.6250.61
31_A242_L0.6240.61
151_L176_L0.6220.60
303_Y306_A0.6200.60
62_S289_D0.6180.60
45_A342_M0.6180.60
274_E277_D0.6140.59
198_T206_A0.6140.59
156_E209_E0.6130.59
235_V270_S0.6080.59
333_V337_A0.6070.58
337_A341_S0.6070.58
37_C60_Q0.6070.58
95_H98_A0.6060.58
273_Q277_D0.6040.58
301_L305_K0.6030.58
183_E231_K0.6020.58
229_V291_D0.6010.58
21_V32_L0.6000.58
223_F281_Y0.6000.58
267_G288_I0.5990.57
264_F278_S0.5990.57
20_K23_Q0.5990.57
143_M177_G0.5990.57
226_V235_V0.5980.57
299_G337_A0.5980.57
93_H96_Q0.5970.57
292_T338_G0.5950.57
94_V140_S0.5940.57
230_Y275_I0.5920.57
297_W334_W0.5920.57
275_I282_G0.5900.56
304_Y308_E0.5890.56
17_D171_T0.5870.56
35_V350_F0.5840.56
114_K119_W0.5830.55
335_L338_G0.5830.55
155_I205_Y0.5820.55
275_I279_V0.5810.55
107_L140_S0.5780.55
189_S194_S0.5760.54
136_K167_K0.5750.54
162_L210_L0.5740.54
294_W298_E0.5730.54
289_D332_R0.5720.54
333_V336_R0.5710.54
296_T338_G0.5700.54
288_I292_T0.5670.53
114_K118_P0.5660.53
42_S292_T0.5650.53
279_V286_M0.5640.53
38_V112_C0.5630.53
118_P122_G0.5630.53
57_V350_F0.5580.52
41_D68_F0.5580.52
56_P358_V0.5580.52
342_M346_L0.5550.52
242_L281_Y0.5540.52
47_L103_V0.5520.51
21_V24_V0.5520.51
54_K344_A0.5500.51
33_P288_I0.5490.51
161_Y170_M0.5490.51
293_Q332_R0.5480.51
172_L210_L0.5480.51
91_A95_H0.5460.51
291_D345_R0.5460.51
182_E186_V0.5450.51
354_N357_D0.5440.50
230_Y235_V0.5440.50
62_S330_D0.5430.50
271_T275_I0.5420.50
48_E101_Y0.5410.50
275_I288_I0.5370.49
62_S331_P0.5370.49
33_P342_M0.5360.49
26_K259_S0.5350.49
113_A186_V0.5340.49
68_F332_R0.5340.49
26_K260_L0.5330.49
294_W297_W0.5330.49
180_G267_G0.5330.49
63_N67_S0.5310.49
52_K340_T0.5310.49
96_Q100_H0.5300.49
65_G293_Q0.5300.49
178_C189_S0.5300.49
231_K290_T0.5290.48
185_G189_S0.5270.48
75_K95_H0.5270.48
162_L166_S0.5240.48
206_A222_S0.5230.48
40_T93_H0.5220.48
181_G184_D0.5220.48
107_L137_P0.5200.47
47_L59_V0.5190.47
175_E227_H0.5190.47
176_L199_Q0.5180.47
289_D331_P0.5170.47
93_H97_M0.5170.47
112_C139_F0.5160.47
62_S68_F0.5160.47
200_P241_I0.5150.47
176_L207_Y0.5150.47
113_A333_V0.5140.47
42_S296_T0.5130.46
38_V331_P0.5110.46
293_Q329_Y0.5110.46
144_I176_L0.5100.46
203_V268_S0.5100.46
275_I352_E0.5100.46
306_A309_A0.5090.46
246_Q262_F0.5090.46
226_V329_Y0.5080.46
267_G289_D0.5070.46
296_T334_W0.5060.46
42_S289_D0.5060.46
336_R339_Q0.5050.45
246_Q260_L0.5050.45
39_G331_P0.5030.45
38_V332_R0.5030.45
71_G137_P0.5030.45
179_T182_E0.5020.45
174_I199_Q0.5010.45
298_E357_D0.5000.45
27_E306_A0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dosA 2 0.9554 100 0.125 Contact Map
3qm3A 4 0.9694 100 0.131 Contact Map
3elfA 4 0.8997 100 0.179 Contact Map
3n9rA 3 0.7632 100 0.206 Contact Map
1rvgA 3 0.7883 100 0.209 Contact Map
1gvfA 3 0.766 100 0.212 Contact Map
2iswA 2 0.7493 100 0.216 Contact Map
4to8A 2 0.766 100 0.225 Contact Map
3pm6A 2 0.805 100 0.236 Contact Map
3txvA 2 0.7298 100 0.38 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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