GREMLIN Database
PNTB - NAD(P) transhydrogenase subunit beta
UniProt: P0AB67 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10745
Length: 462 (449)
Sequences: 1473 (641)
Seq/√Len: 30.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
379_F412_L5.8551.00
399_Q415_W5.7281.00
385_V417_A5.0991.00
341_R378_D4.7381.00
85_E147_C4.6761.00
310_I379_F4.6251.00
413_E416_K4.5211.00
399_Q413_E3.9591.00
435_Q440_F3.8591.00
299_T421_I3.8011.00
334_R368_I3.7961.00
423_F454_S3.7091.00
310_I382_T3.5921.00
427_M448_F3.5601.00
308_S339_N3.5271.00
308_S382_T3.4351.00
312_T414_V3.3581.00
144_G150_I3.3241.00
411_V415_W3.2721.00
157_L160_R3.1151.00
428_N448_F3.0331.00
143_F149_K2.8581.00
140_V144_G2.8001.00
310_I375_I2.6251.00
177_V190_A2.5480.99
310_I412_L2.5050.99
309_V338_I2.4870.99
341_R382_T2.4200.99
453_A457_A2.4180.99
341_R370_L2.3890.99
382_T412_L2.3860.99
91_H94_V2.3490.99
155_L207_A2.3400.99
454_S457_A2.3270.99
73_R77_K2.3120.99
160_R208_S2.2840.99
422_V444_T2.2630.99
400_D441_K2.2590.99
447_L454_S2.2420.99
127_L131_I2.2030.98
447_L458_I2.1910.98
306_S384_T2.1610.98
20_S37_G2.1500.98
196_A200_V2.1320.98
304_K336_R2.1260.98
14_A243_V2.0990.98
379_F382_T2.0490.98
308_S341_R2.0480.98
312_T385_V2.0300.97
419_N445_H1.9990.97
119_N123_T1.9980.97
294_I299_T1.9770.97
9_A43_I1.9750.97
89_I140_V1.9470.97
157_L163_M1.9410.97
126_F175_L1.9200.96
126_F194_M1.9190.96
341_R375_I1.8530.95
449_G454_S1.8410.95
327_A331_E1.8320.95
312_T343_G1.8290.95
133_A198_A1.7800.94
308_S378_D1.7770.94
102_G129_I1.7420.94
166_A169_V1.7410.94
382_T385_V1.7400.94
143_F147_C1.7360.94
402_P407_A1.7270.93
298_E301_E1.7090.93
200_V203_W1.7090.93
169_V173_L1.6980.93
23_G32_Q1.6970.93
377_D413_E1.6910.93
291_H448_F1.6890.93
291_H427_M1.6870.93
330_T342_F1.6740.92
302_L419_N1.6340.91
176_I180_R1.6320.91
421_I447_L1.6250.91
420_V443_N1.6210.91
9_A47_A1.6160.91
156_M160_R1.6110.91
303_L384_T1.6050.91
123_T127_L1.6040.91
397_A437_P1.6010.90
380_A416_K1.5810.90
331_E335_A1.5750.90
137_T199_L1.5680.90
342_F364_V1.5610.89
10_Y238_N1.5600.89
426_S448_F1.5450.89
171_S198_A1.5450.89
166_A200_V1.5440.89
205_L224_Y1.5340.88
209_I276_G1.5310.88
317_M388_I1.5210.88
293_E448_F1.5200.88
225_S258_I1.4990.87
135_T225_S1.4720.86
289_G440_F1.4670.86
74_L89_I1.4640.86
167_A197_I1.4600.86
223_S260_C1.4580.86
87_V161_H1.4380.85
91_H98_A1.4320.85
86_L90_L1.4230.84
173_L176_I1.4080.84
141_V203_W1.4080.84
130_F171_S1.4080.84
203_W207_A1.3940.83
173_L177_V1.3870.83
291_H428_N1.3860.83
394_V414_V1.3820.82
102_G168_L1.3750.82
192_L196_A1.3670.82
171_S175_L1.3630.82
159_N162_K1.3530.81
375_I379_F1.3500.81
294_I421_I1.3470.81
20_S256_S1.3330.80
193_I196_A1.3140.79
329_I459_L1.3040.79
85_E149_K1.2970.78
189_L193_I1.2940.78
198_A286_Q1.2790.77
225_S260_C1.2710.77
287_E290_E1.2690.77
268_I272_A1.2660.77
370_L378_D1.2600.76
403_K407_A1.2570.76
107_L188_V1.2530.76
396_P438_L1.2510.76
151_S155_L1.2310.74
296_A454_S1.2290.74
301_E305_N1.2190.74
125_V218_V1.2170.74
295_T298_E1.2140.73
87_V351_L1.2070.73
173_L193_I1.2060.73
266_S269_S1.2010.73
426_S435_Q1.2010.73
69_A73_R1.1860.72
292_R445_H1.1840.71
326_V388_I1.1770.71
394_V439_F1.1720.71
175_L194_M1.1640.70
399_Q411_V1.1600.70
58_G62_L1.1520.69
144_G149_K1.1510.69
269_S272_A1.1500.69
201_F205_L1.1460.69
317_M326_V1.1430.69
223_S253_A1.1420.69
98_A250_S1.1390.68
220_M267_F1.1370.68
325_P456_D1.1350.68
206_V232_A1.1290.68
152_S218_V1.1270.68
260_C270_V1.1240.67
342_F368_I1.1230.67
91_H248_V1.1090.66
92_S256_S1.1070.66
370_L375_I1.1030.66
435_Q448_F1.1000.66
375_I378_D1.0990.66
294_I445_H1.0860.65
294_I447_L1.0620.63
150_I155_L1.0600.63
332_K335_A1.0590.63
93_F223_S1.0590.63
23_G37_G1.0560.62
400_D437_P1.0550.62
411_V437_P1.0480.62
364_V368_I1.0430.62
135_T246_A1.0410.61
17_F41_M1.0400.61
290_E293_E1.0380.61
326_V330_T1.0360.61
86_L91_H1.0300.61
370_L374_E1.0230.60
427_M435_Q1.0190.60
83_M455_V1.0090.59
343_G370_L1.0080.59
293_E445_H1.0050.59
122_L178_F1.0020.58
85_E394_V0.9980.58
280_S432_A0.9930.58
312_T393_T0.9930.58
93_F385_V0.9930.58
142_A214_M0.9910.58
106_Y182_D0.9840.57
225_S253_A0.9840.57
336_R339_N0.9840.57
141_V149_K0.9830.57
106_Y178_F0.9830.57
98_A253_A0.9820.57
193_I197_I0.9810.57
267_F271_I0.9790.57
308_S381_D0.9760.56
296_A458_I0.9690.56
34_N38_I0.9670.56
343_G375_I0.9660.56
236_L402_P0.9560.55
272_A431_Y0.9520.54
42_A46_I0.9490.54
415_W437_P0.9410.54
330_T364_V0.9400.53
317_M455_V0.9400.53
241_L309_V0.9390.53
107_L373_D0.9380.53
23_G124_E0.9270.52
126_F178_F0.9200.52
378_D412_L0.9170.52
170_V196_A0.9150.52
45_L64_M0.9150.52
8_A12_V0.9140.51
365_P368_I0.9140.51
63_A134_V0.9130.51
93_F225_S0.9130.51
227_W253_A0.9120.51
397_A451_A0.9110.51
429_T435_Q0.9100.51
45_L57_V0.9090.51
400_D415_W0.9090.51
103_F195_T0.9080.51
223_S258_I0.9060.51
41_M44_A0.9040.51
136_F140_V0.9030.51
205_L267_F0.9020.50
380_A413_E0.9000.50
293_E385_V0.8990.50
49_I60_I0.8990.50
90_L225_S0.8980.50
69_A382_T0.8970.50
62_L66_I0.8950.50
161_H272_A0.8940.50
160_R164_N0.8940.50
46_I170_V0.8930.50
257_Y267_F0.8910.50
88_A98_A0.8850.49
155_L204_H0.8770.48
299_T454_S0.8770.48
98_A225_S0.8750.48
93_F125_V0.8740.48
128_G256_S0.8740.48
305_N338_I0.8720.48
88_A91_H0.8710.48
220_M256_S0.8690.48
18_I319_V0.8690.48
287_E440_F0.8660.48
137_T406_I0.8640.47
125_V426_S0.8620.47
299_T447_L0.8610.47
170_V280_S0.8590.47
220_M227_W0.8560.47
370_L373_D0.8540.47
280_S284_D0.8540.47
296_A457_A0.8530.47
458_I461_A0.8510.46
94_V227_W0.8490.46
54_T57_V0.8470.46
351_L368_I0.8470.46
328_E332_K0.8450.46
267_F270_V0.8440.46
203_W208_S0.8430.46
455_V458_I0.8420.46
10_Y48_T0.8420.46
72_I76_K0.8410.46
372_M375_I0.8400.46
400_D461_A0.8370.45
9_A372_M0.8370.45
99_V133_A0.8360.45
91_H256_S0.8350.45
411_V414_V0.8350.45
96_L256_S0.8340.45
52_P55_G0.8320.45
404_S407_A0.8320.45
105_S235_M0.8300.45
92_S128_G0.8290.45
309_V384_T0.8280.45
300_A461_A0.8270.45
212_A254_I0.8250.44
334_R339_N0.8250.44
100_L232_A0.8250.44
83_M230_A0.8220.44
27_H30_S0.8220.44
79_E86_L0.8220.44
62_L200_V0.8200.44
135_T223_S0.8200.44
291_H426_S0.8200.44
427_M432_A0.8160.44
168_L272_A0.8130.43
143_F231_A0.8120.43
302_L421_I0.8120.43
277_T280_S0.8070.43
20_S36_F0.8070.43
399_Q416_K0.8030.43
287_E435_Q0.8010.42
296_A300_A0.7960.42
401_D404_S0.7960.42
257_Y261_K0.7940.42
224_Y253_A0.7940.42
100_L455_V0.7910.42
248_V355_M0.7910.42
11_I326_V0.7890.42
70_I258_I0.7890.42
418_Q453_A0.7870.41
319_V394_V0.7860.41
299_T302_L0.7820.41
41_M209_I0.7820.41
10_Y60_I0.7810.41
86_L248_V0.7790.41
224_Y266_S0.7780.41
133_A199_L0.7750.40
170_V176_I0.7750.40
388_I455_V0.7730.40
17_F206_V0.7700.40
77_K388_I0.7700.40
209_I217_V0.7690.40
220_M269_S0.7670.40
176_I193_I0.7670.40
298_E305_N0.7650.40
24_L37_G0.7620.39
42_A237_S0.7620.39
103_F123_T0.7600.39
457_A461_A0.7590.39
189_L200_V0.7560.39
292_R442_E0.7560.39
39_A47_A0.7550.39
86_L92_S0.7540.39
162_K165_L0.7540.39
257_Y451_A0.7540.39
65_V68_G0.7520.39
79_E82_E0.7520.39
129_I195_T0.7520.39
125_V206_V0.7500.39
170_V295_T0.7480.38
96_L136_F0.7470.38
297_E461_A0.7470.38
280_S283_G0.7470.38
127_L175_L0.7460.38
385_V412_L0.7460.38
329_I455_V0.7450.38
131_I248_V0.7440.38
303_L329_I0.7440.38
141_V150_I0.7420.38
66_I170_V0.7390.38
205_L271_I0.7380.38
40_G243_V0.7370.38
103_F129_I0.7370.38
292_R373_D0.7360.38
264_N439_F0.7360.38
69_A200_V0.7340.37
19_F200_V0.7340.37
17_F44_A0.7340.37
378_D382_T0.7340.37
332_K374_E0.7310.37
39_A176_I0.7300.37
289_G400_D0.7300.37
161_H256_S0.7300.37
172_F299_T0.7290.37
310_I377_D0.7290.37
303_L445_H0.7270.37
87_V254_I0.7270.37
170_V189_L0.7250.37
401_D437_P0.7250.37
343_G393_T0.7230.37
310_I378_D0.7230.37
236_L271_I0.7220.36
120_I123_T0.7220.36
321_Q434_V0.7210.36
381_D393_T0.7210.36
223_S227_W0.7210.36
206_V235_M0.7180.36
135_T258_I0.7180.36
303_L338_I0.7170.36
19_F36_F0.7130.36
58_G65_V0.7130.36
86_L94_V0.7110.36
162_K166_A0.7110.36
94_V98_A0.7100.36
260_C298_E0.7100.36
194_M197_I0.7090.36
243_V365_P0.7090.36
74_L77_K0.7080.35
326_V342_F0.7080.35
18_I258_I0.7030.35
451_A455_V0.7030.35
92_S98_A0.7020.35
193_I200_V0.7020.35
303_L309_V0.7010.35
80_M219_S0.6980.35
214_M264_N0.6980.35
82_E85_E0.6960.35
102_G324_Y0.6950.34
74_L212_A0.6900.34
102_G442_E0.6880.34
107_L414_V0.6880.34
262_A329_I0.6870.34
78_V458_I0.6860.34
156_M274_G0.6860.34
103_F106_Y0.6850.34
83_M269_S0.6840.34
205_L236_L0.6830.34
330_T337_G0.6820.34
91_H220_M0.6810.33
104_N254_I0.6810.33
62_L65_V0.6810.33
142_A264_N0.6790.33
135_T432_A0.6780.33
24_L325_P0.6780.33
420_V444_T0.6770.33
77_K163_M0.6760.33
171_S194_M0.6760.33
31_R246_A0.6750.33
98_A128_G0.6750.33
246_A297_E0.6740.33
200_V204_H0.6740.33
164_N204_H0.6730.33
101_V231_A0.6730.33
77_K143_F0.6720.33
133_A308_S0.6720.33
94_V369_V0.6700.33
230_A239_D0.6690.33
363_K434_V0.6630.32
297_E416_K0.6620.32
227_W431_Y0.6610.32
223_S270_V0.6600.32
327_A342_F0.6600.32
428_N435_Q0.6600.32
332_K336_R0.6590.32
44_A242_I0.6590.32
437_P443_N0.6580.32
12_V183_S0.6580.32
103_F192_L0.6570.32
37_G371_E0.6570.32
33_G434_V0.6560.32
54_T150_I0.6560.32
100_L451_A0.6560.32
294_I302_L0.6550.32
53_D56_N0.6530.32
131_I428_N0.6530.32
204_H208_S0.6480.31
155_L208_S0.6470.31
58_G193_I0.6460.31
152_S216_V0.6460.31
338_I386_L0.6450.31
38_I42_A0.6450.31
21_L448_F0.6450.31
439_F446_M0.6450.31
391_N425_R0.6440.31
99_V256_S0.6430.31
87_V372_M0.6430.31
19_F44_A0.6400.31
164_N209_I0.6400.31
337_G364_V0.6390.31
93_F351_L0.6380.31
156_M208_S0.6380.31
341_R380_A0.6380.31
52_P147_C0.6370.30
5_L174_L0.6370.30
434_V461_A0.6330.30
166_A203_W0.6330.30
135_T253_A0.6320.30
41_M80_M0.6320.30
343_G382_T0.6310.30
393_T407_A0.6300.30
23_G88_A0.6300.30
137_T440_F0.6280.30
374_E420_V0.6270.30
393_T413_E0.6250.30
334_R369_V0.6240.30
173_L196_A0.6230.30
231_A235_M0.6210.29
161_H431_Y0.6190.29
163_M196_A0.6190.29
201_F243_V0.6190.29
256_S369_V0.6180.29
5_L200_V0.6170.29
69_A283_G0.6170.29
25_S394_V0.6160.29
152_S155_L0.6140.29
41_M355_M0.6140.29
31_R437_P0.6130.29
423_F457_A0.6130.29
242_I380_A0.6130.29
45_L332_K0.6110.29
143_F251_S0.6110.29
270_V404_S0.6110.29
80_M355_M0.6100.29
65_V169_V0.6100.29
19_F65_V0.6100.29
278_D434_V0.6100.29
315_Y319_V0.6090.29
397_A454_S0.6080.29
20_S351_L0.6070.28
81_T328_E0.6060.28
157_L204_H0.6050.28
12_V203_W0.6050.28
283_G378_D0.6050.28
22_A27_H0.6040.28
310_I380_A0.6040.28
104_N420_V0.6040.28
167_A324_Y0.6030.28
194_M198_A0.6030.28
331_E377_D0.6030.28
289_G422_V0.6020.28
61_L403_K0.6010.28
310_I343_G0.6010.28
93_F135_T0.6010.28
240_L244_T0.6010.28
294_I298_E0.5990.28
225_S246_A0.5990.28
21_L86_L0.5960.28
173_L307_H0.5960.28
26_K365_P0.5960.28
179_V281_S0.5950.28
60_I105_S0.5940.28
125_V204_H0.5940.28
225_S248_V0.5940.28
374_E460_K0.5930.28
88_A342_F0.5930.28
224_Y270_V0.5910.27
330_T363_K0.5910.27
413_E449_G0.5890.27
87_V95_G0.5890.27
425_R439_F0.5880.27
206_V217_V0.5880.27
225_S305_N0.5860.27
6_V51_G0.5860.27
90_L93_F0.5850.27
220_M271_I0.5850.27
148_G431_Y0.5850.27
50_F56_N0.5840.27
92_S253_A0.5840.27
21_L25_S0.5840.27
162_K173_L0.5840.27
221_L251_S0.5810.27
13_A40_G0.5800.27
38_I256_S0.5800.27
250_S267_F0.5790.27
219_S355_M0.5790.27
127_L174_L0.5790.27
375_I412_L0.5770.27
98_A229_A0.5770.27
51_G54_T0.5760.26
81_T424_K0.5750.26
36_F153_K0.5750.26
423_F455_V0.5740.26
137_T241_L0.5740.26
309_V455_V0.5720.26
273_G300_A0.5710.26
319_V404_S0.5710.26
355_M396_P0.5710.26
177_V193_I0.5690.26
375_I382_T0.5670.26
311_I340_V0.5670.26
229_A260_C0.5670.26
219_S354_H0.5670.26
325_P386_L0.5660.26
169_V172_F0.5650.26
405_P438_L0.5650.26
292_R381_D0.5630.26
20_S35_N0.5630.26
212_A310_I0.5620.26
64_M374_E0.5620.26
416_K432_A0.5610.26
281_S287_E0.5610.26
166_A284_D0.5610.26
326_V386_L0.5610.26
14_A269_S0.5610.26
220_M257_Y0.5610.26
415_W441_K0.5600.25
63_A342_F0.5590.25
103_F191_L0.5580.25
298_E303_L0.5580.25
432_A435_Q0.5580.25
134_V296_A0.5580.25
120_I454_S0.5570.25
15_I123_T0.5570.25
423_F458_I0.5570.25
61_L64_M0.5550.25
42_A98_A0.5550.25
90_L298_E0.5520.25
161_H274_G0.5510.25
386_L455_V0.5510.25
227_W369_V0.5510.25
152_S379_F0.5510.25
343_G368_I0.5510.25
5_L284_D0.5490.25
74_L90_L0.5470.25
40_G275_F0.5450.25
38_I369_V0.5440.25
140_V284_D0.5430.24
394_V423_F0.5420.24
161_H224_Y0.5410.24
281_S456_D0.5410.24
169_V197_I0.5400.24
326_V447_L0.5390.24
159_N306_S0.5390.24
250_S256_S0.5380.24
272_A403_K0.5370.24
91_H227_W0.5350.24
401_D407_A0.5350.24
141_V201_F0.5350.24
423_F453_A0.5340.24
173_L295_T0.5330.24
151_S403_K0.5330.24
290_E440_F0.5320.24
95_G248_V0.5310.24
328_E331_E0.5310.24
229_A248_V0.5310.24
16_L426_S0.5300.24
15_I343_G0.5300.24
251_S254_I0.5290.24
177_V181_T0.5290.24
137_T212_A0.5290.24
21_L128_G0.5290.24
28_E367_D0.5280.24
149_K199_L0.5270.24
12_V43_I0.5270.24
29_T33_G0.5270.24
74_L86_L0.5270.24
105_S121_H0.5260.23
5_L11_I0.5250.23
25_S37_G0.5250.23
30_S171_S0.5240.23
158_P415_W0.5230.23
34_N90_L0.5220.23
325_P342_F0.5200.23
17_F354_H0.5200.23
83_M89_I0.5190.23
69_A339_N0.5190.23
126_F179_V0.5180.23
310_I341_R0.5180.23
11_I26_K0.5180.23
144_G148_G0.5180.23
250_S271_I0.5180.23
379_F414_V0.5170.23
44_A80_M0.5170.23
394_V422_V0.5160.23
98_A260_C0.5150.23
83_M90_L0.5150.23
16_L90_L0.5140.23
291_H432_A0.5140.23
60_I238_N0.5140.23
71_G260_C0.5140.23
167_A381_D0.5130.23
209_I214_M0.5130.23
46_I280_S0.5130.23
266_S418_Q0.5120.23
79_E262_A0.5120.23
262_A432_A0.5110.23
160_R207_A0.5110.23
64_M280_S0.5110.23
151_S327_A0.5100.23
253_A258_I0.5100.23
19_F166_A0.5080.22
61_L196_A0.5070.22
428_N432_A0.5070.22
261_K459_L0.5070.22
76_K82_E0.5070.22
196_A330_T0.5060.22
85_E143_F0.5060.22
266_S388_I0.5060.22
172_F182_D0.5060.22
371_E452_K0.5040.22
206_V219_S0.5030.22
26_K325_P0.5030.22
419_N458_I0.5020.22
35_N196_A0.5020.22
167_A200_V0.5020.22
321_Q433_G0.5020.22
175_L235_M0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o9uB 2 0.9459 100 0.022 Contact Map
2fsvC 1 0.3745 100 0.477 Contact Map
1djlA 1 0.3874 100 0.477 Contact Map
1pnoA 1 0.3874 100 0.518 Contact Map
1d4oA 1 0.3766 100 0.519 Contact Map
2bruC 1 0.3615 100 0.52 Contact Map
4j1tC 1 0.3766 100 0.521 Contact Map
4o93B 1 0.5714 100 0.545 Contact Map
3cf4G 2 0.3333 96 0.965 Contact Map
1ytlA 1 0.2706 95.5 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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